Primary Site >> Colorectal Cancer
Gene >> RRM2
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Ref: Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit. PMID: 11489836 |
Ref: Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors. PMID: 15096505 |
Ref: Variance in the expression of 5-Fluorouracil pathway genes in colorectal cancer. PMID: 15814641 Ref: Novel genetic variations of the p53R2 gene in patients with colorectal adenoma and controls. PMID: 16127747 Ref: In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant. PMID: 16230416 |
Ref: What is the best sequence of chemotherapy in advanced colorectal cancer? Final results of a five-arm study. PMID: 16340193 Ref: Suppression of lung tumor formation by the regulatory subunit of ribonucleotide reductase. PMID: 16818620 |
Ref: Ribonucleotide reductase subunits M2 and p53R2 are potential biomarkers for metastasis of colon cancer. PMID: 17311703 |
Ref: Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer. PMID: 18097604 |
Ref: E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. PMID: 19585502 |
Ref: A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets. PMID: 20473941 Ref: KRAS-mediated up-regulation of RRM2 expression is essential for the proliferation of colorectal cancer cell lines. PMID: 21873171 |
Ref: SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expression. PMID: 22496461 Ref: Emerging roles of the ribonucleotide reductase M2 in colorectal cancer and ultraviolet-induced DNA damage repair. PMID: 23002339 |
Ref: Ribonucleotide reductase small subunit M2 serves as a prognostic biomarker and predicts poor survival of colorectal cancers. PMID: 23113760 |
Ref: High expression of ribonucleotide reductase subunit M2 correlates with poor prognosis of hepatocellular carcinoma. PMID: 25368754 |
Ref: Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA. PMID: 25602583 Ref: E2F1 promote the aggressiveness of human colorectal cancer by activating the ribonucleotide reductase small subunit M2. PMID: 26093293 |
Ref: The combination of tetraiodothyroacetic acid and cetuximab inhibits cell proliferation in colorectal cancers with different K-ras status. PMID: 26980146 Ref: Repositioning of a cyclin-dependent kinase inhibitor GW8510 as a ribonucleotide reductase M2 inhibitor to treat human colorectal cancer. PMID: 27551518 Ref: Molecular profile of 5-fluorouracil pathway genes in colorectal carcinoma. PMID: 27733154 Ref: CREB1 directly activates the transcription of ribonucleotide reductase small subunit M2 and promotes the aggressiveness of human colorectal cancer. PMID: 27801665 |
Ref: Next-generation sequencing reveals lymph node metastasis associated genetic markers in colorectal cancer. PMID: 28672935 Ref: Involvement of miR-155/FOXO3a and miR-222/PTEN in acquired radioresistance of colorectal cancer cell line. PMID: 28879560 Ref: SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer. PMID: 29114070 |
Ref: miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation. PMID: 29731918 Ref: Nano-Diamino-Tetrac (NDAT) Enhances Resveratrol-Induced Antiproliferation by Action on the RRM2 Pathway in Colorectal Cancers. PMID: 30027502 |