Literatures

Primary Site >> Liver Cancer

Gene >> RB1

1.
Journal:	Oncogene. 1991 Dec;6(12):2353-6.
Title:	A familial RB1 mutation detected by the HOT technique is homozygous in a second primary neoplasm.
Author:	Weir-Thompson, E\|Condie, A\|Leonard, R C\|Prosser, J
PMID:	1662795

2.
Journal:	J Med Virol. 1994 Sep;44(1):67-73.
Title:	RB tumor suppressor gene expression in hepatocellular carcinomas from patients infected with the hepatitis B virus.
Author:	Hsia, C C\|Di Bisceglie, A M\|Kleiner, D E Jr\|Farshid, M\|Tabor, E
PMID:	7798888

3.
Journal:	Liver. 1994 Dec;14(6):295-301.
Title:	Immunohistochemical analysis of retinoblastoma gene product (pRB) expression in malignant and non-malignant liver diseases.
Author:	Kawakita, N\|Seki, S\|Sakaguchi, H\|Yanai, A\|Nakatani, K\|Yamada, T\|Kitada, T\|Sakai, Y\|Kuroki, T\|Kobayashi, K
PMID:	7877433

4.
Journal:	Cancer Res. 1994 Aug 1;54(15):4177-82.
Title:	Deletions of chromosome 13q, mutations in Retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma.
Author:	Zhang, X\|Xu, H J\|Murakami, Y\|Sachse, R\|Yashima, K\|Hirohashi, S\|Hu, S X\|Benedict, W F\|Sekiya, T
PMID:	8033150

5.
Journal:	Hum Pathol. 1995 Apr;26(4):366-74.
Title:	Expression of the retinoblastoma gene product in human hepatocellular carcinoma.
Author:	Seki, S\|Kawakita, N\|Yanai, A\|Kitada, T\|Sakai, Y\|Nakatani, K\|Yamada, T\|Sakaguchi, H\|Kuroki, T
PMID:	7535739

6.
Journal:	Arch Biochem Biophys. 1997 Feb 15;338(2):220-6.
Title:	Identification of positive and negative regulatory elements of the human cytochrome P4501A2 (CYP1A2) gene.
Author:	Chung, I\|Bresnick, E
PMID:	9028875

7.
Journal:	Oncogene. 1997 Jul 3;15(1):63-70.
Title:	Resistance to p53-mediated growth arrest and apoptosis in Hep 3B hepatoma cells.
Author:	Friedman, S L\|Shaulian, E\|Littlewood, T\|Resnitzky, D\|Oren, M
PMID:	9233778

8.
Journal:	Acta Virol. 1997 Jun;41(3):125-9.
Title:	Effect of hepatitis B virus X protein on the expression of retinoblastoma gene product.
Author:	Farshid, M\|Nedjar, S\|Mitchell, F\|Biswas, R
PMID:	9385399

9.
Journal:	Cancer Res. 1998 Jan 1;58(1):123-34.
Title:	Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha.
Author:	Santoni-Rugiu, E\|Jensen, M R\|Thorgeirsson, S S
PMID:	9426068

10.
Journal:	Hepatogastroenterology. 1998 Sep-Oct;45(23):1635-42.
Title:	Cell cycle regulators and human hepatocarcinogenesis.
Author:	Hui, A M\|Makuuchi, M\|Li, X
PMID:	9840120

11.
Journal:	Cancer Lett. 1998 Sep 25;131(2):177-83.
Title:	Overexpression of cyclin D1 and cdk4 in tumorigenesis of sporadic hepatoblastomas.
Author:	Kim, H\|Ham, E K\|Kim, Y I\|Chi, J G\|Lee, H S\|Park, S H\|Jung, Y M\|Myung, N K\|Lee, M J\|Jang, J J
PMID:	9851251

12.
Journal:	Hepatology. 1999 Jul;30(1):90-9.
Title:	Expression and prognostic roles of the G1-S modulators in hepatocellular carcinoma: p27 independently predicts the recurrence.
Author:	Ito, Y\|Matsuura, N\|Sakon, M\|Miyoshi, E\|Noda, K\|Takeda, T\|Umeshita, K\|Nagano, H\|Nakamori, S\|Dono, K\|Tsujimoto, M\|Nakahara, M\|Nakao, K\|Taniguchi, N\|Monden, M
PMID:	10385644

13.
Journal:	Zhonghua Gan Zang Bing Za Zhi. 1999 Jun;7(2):94-5.
Title:	[The expression of p16, CDK4 and pRb in hepatocellular carcinomas].
Author:	Luo, D\|Liu, Q\|Su, J
PMID:	10488417

14.
Journal:	World J Gastroenterol. 1999 Dec;5(6):470-476.
Title:	Characterization of six tumor suppressor genes and microsatellite instability in hepatocellular carcinoma in southern African blacks.
Author:	Martins, C\|Kedda, M A\|Kew, M C
PMID:	11819494

15.
Journal:	Nat Med. 2000 Jan;6(1):96-9.
Title:	Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas.
Author:	Higashitsuji, H\|Itoh, K\|Nagao, T\|Dawson, S\|Nonoguchi, K\|Kido, T\|Mayer, R J\|Arii, S\|Fujita, J
PMID:	10613832

16.
Journal:	J Hepatol. 2000 Aug;33(2):254-65.
Title:	P53 but not p16INK4a induces growth arrest in retinoblastoma-deficient hepatocellular carcinoma cells.
Author:	Morel, A P\|Unsal, K\|Cagatay, T\|Ponchel, F\|Carr, B\|Ozturk, M
PMID:	10952243

17.
Journal:	Cancer Lett. 2000 Nov 10;160(1):81-8.
Title:	5-Aza-2'-deoxycytidine leads to down-regulation of aberrant p16INK4A RNA transcripts and restores the functional retinoblastoma protein pathway in hepatocellular carcinoma cell lines.
Author:	Suh, S I\|Pyun, H Y\|Cho, J W\|Baek, W K\|Park, J B\|Kwon, T\|Park, J W\|Suh, M H\|Carson, D A
PMID:	11098088

18.
Journal:	DNA Cell Biol. 2001 Feb;20(2):75-80.
Title:	Hepatitis B viral X protein overcomes inhibition of E2F1 activity by pRb on the human Rb gene promoter.
Author:	Choi, B H\|Choi, M\|Jeon, H Y\|Rho, H M
PMID:	11244564

19.
Journal:	Anticancer Res. 2001 Jan-Feb;21(1B):657-62.
Title:	Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas.
Author:	Ohashi, R\|Gao, C\|Miyazaki, M\|Hamazaki, K\|Tsuji, T\|Inoue, Y\|Uemura, T\|Hirai, R\|Shimizu, N\|Namba, M
PMID:	11299822

20.
Journal:	Mol Carcinog. 2001 Mar;30(3):138-50.
Title:	Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular carci
Author:	Park, T J\|Kim, H S\|Byun, K H\|Jang, J J\|Lee, Y S\|Lim, I K
PMID:	11301474

21.
Journal:	Hepatology. 2001 May;33(5):1087-97.
Title:	Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines.
Author:	Koga, H\|Sakisaka, S\|Harada, M\|Takagi, T\|Hanada, S\|Taniguchi, E\|Kawaguchi, T\|Sasatomi, K\|Kimura, R\|Hashimoto, O\|Ueno, T\|Yano, H\|Kojiro, M\|Sata, M
PMID:	11343236

22.
Journal:	Oncology. 2001;60(4):346-54.
Title:	Disruption of the p16/cyclin D1/retinoblastoma protein pathway in the majority of human hepatocellular carcinomas.
Author:	Azechi, H\|Nishida, N\|Fukuda, Y\|Nishimura, T\|Minata, M\|Katsuma, H\|Kuno, M\|Ito, T\|Komeda, T\|Kita, R\|Takahashi, R\|Nakao, K
PMID:	11408803

23.
Journal:	J Interferon Cytokine Res. 2001 Jun;21(6):399-408.
Title:	Selective expression of nonsecreted interferon by an adenoviral vector confers antiproliferative and antiviral properties and causes reduction of tumor growth in nude mice.
Author:	Ahmed, C M\|Wills, K N\|Sugarman, B J\|Johnson, D E\|Ramachandra, M\|Nagabhushan, T L\|Howe, J A
PMID:	11440637

24.
Journal:	J Biol Chem. 2001 Nov 2;276(44):40968-76.
Title:	High intensity ERK signal mediates hepatocyte growth factor-induced proliferation inhibition of the human hepatocellular carcinoma cell line HepG2.
Author:	Tsukada, Y\|Miyazawa, K\|Kitamura, N
PMID:	11533045

25.
Journal:	Comp Biochem Physiol B Biochem Mol Biol. 2001 Oct;130(3):385-91.
Title:	Isolation and characterization of the retinoblastoma protein from fish.
Author:	Rotchell, J M\|Scoggins, B\|Blair, J B\|Ostrander, G K
PMID:	11567901

26.
Journal:	Int J Oncol. 2002 Feb;20(2):235-45.
Title:	Suppression of tumorigenicity of rat liver tumor cells by human chromosome 13: evidence against the involvement of pRb and BRCA2.
Author:	Rider, Michelle A\|Butz, Genelle M\|Ricketts, Sharon L\|Newberry, Suzanne T\|Grisham, Joe W\|Coleman, William B
PMID:	11788883

27.
Journal:	Mol Cells. 2002 Jun 30;13(3):481-7.
Title:	Quantification of tumor suppressor mRNA expression by poly-competitive RT-PCR using a TS-IS that contained multiple internal competitors.
Author:	Jung, Hee-Jung\|Chae, Ji Hyung\|Kim, Hoguen\|Park, Jeon Han\|Lee, Jong Soo\|Choi, Woong Hwan\|Kim, Chul Geun
PMID:	12132590

28.
Journal:	Hepatology. 2002 Aug;36(2):427-32.
Title:	Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma.
Author:	Roncalli, Massimo\|Bianchi, Paolo\|Bruni, Barbara\|Laghi, Luigi\|Destro, Annarita\|Di Gioia, Sonia\|Gennari, Leandro\|Tommasini, Maurizio\|Malesci, Alberto\|Coggi, Guido
PMID:	12143052

29.
Journal:	J Exp Clin Cancer Res. 2002 Sep;21(3):321-7.
Title:	Brain metastasis from hepatocellular carcinoma associated with hepatitis B virus.
Author:	Frati, A\|Salvati, M\|Giarnieri, E\|Santoro, A\|Rocchi, G\|Frati, L
PMID:	12385572

30.
Journal:	Mech Ageing Dev. 2002 Nov;123(12):1665-80.
Title:	Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats.
Author:	Lim, In Kyoung
PMID:	12470904

31.
Journal:	Exp Cell Res. 2003 Jan 15;282(2):78-89.
Title:	Downregulation of p21(waf/cip-1) mediates apoptosis of human hepatocellular carcinoma cells in response to interferon-gamma.
Author:	Detjen, Katharina M\|Murphy, Derek\|Welzel, Martina\|Farwig, Katrin\|Wiedenmann, Bertram\|Rosewicz, Stefan
PMID:	12531694

32.
Journal:	Mech Ageing Dev. 2003 May;124(5):697-708.
Title:	Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fisher 344 male rats [Mechanisms of Ageing and Development 123 (2002) 1665-1680].
Author:	Lim, In Kyoung
PMID:	12825548

33.
Journal:	J Gastroenterol. 2003;38(8):751-8.
Title:	Role of a novel oncogenic protein, gankyrin, in hepatocyte proliferation.
Author:	Iwai, Akio\|Marusawa, Hiroyuki\|Kiuchi, Tetsuya\|Higashitsuji, Hiroaki\|Tanaka, Koichi\|Fujita, Jun\|Chiba, Tsutomu
PMID:	14505129

34.
Journal:	J Clin Pathol. 2003 Dec;56(12):904-9.
Title:	SV40 Tag DNA sequences, present in a small proportion of human hepatocellular carcinomas, are associated with reduced survival.
Author:	Wong, N A C S\|Rae, F\|Herriot, M M\|Mayer, N J\|Brewster, D H\|Harrison, D J
PMID:	14645347

35.
Journal:	Apoptosis. 2004 Mar;9(2):211-21.
Title:	p53 dephosphorylation and p21(Cip1/Waf1) translocation correlate with caspase-3 activation in TGF-beta1-induced apoptosis of HuH-7 cells.
Author:	Fan, G\|Ma, X\|Wong, P Y\|Rodrigues, C M P\|Steer, C J
PMID:	15004518

36.
Journal:	Clin Cancer Res. 2004 Mar 15;10(6):2150-7.
Title:	Orthotopic implantation of human hepatocellular carcinoma in mice: analysis of tumor progression and establishment of the BCLC-9 cell line.
Author:	Armengol, Carolina\|Tarafa, Gemma\|Boix, Loreto\|Sole, Manel\|Queralt, Rosa\|Costa, Dolors\|Bachs, Oriol\|Bruix, Jordi\|Capella, Gabriel
PMID:	15041736

37.
Journal:	Int J Oncol. 2004 May;24(5):1205-11.
Title:	Expression of G1 phase-related cell cycle molecules in naturally developing hepatocellular carcinoma of Long-Evans Cinnamon rats.
Author:	Kita, Yuko\|Masaki, Tsutomu\|Funakoshi, Fumi\|Yoshida, Shuhei\|Tanaka, Misuzu\|Kurokohchi, Kazutaka\|Uchida, Naohito\|Watanabe, Seishiro\|Matsumoto, Kozo\|Kuriyama, Shigeki
PMID:	15067343

38.
Journal:	J Hepatol. 2004 Jun;40(6):957-62.
Title:	Mitoinhibitory effects of the tumor promoter 2-acetylaminofluorene in rat liver: loss of E2F-1 and E2F-3 expression and cdk 2 kinase activity in late G1.
Author:	Ohlson, Lena C E\|Koroxenidou, Lena\|Porsch-Hallstrom, Inger
PMID:	15158336

39.
Journal:	Hepatology. 2004 Sep;40(3):677-86.
Title:	Reduced expression of cell cycle regulator p18(INK4C) in human hepatocellular carcinoma.
Author:	Morishita, Asahiro\|Masaki, Tsutomu\|Yoshiji, Hitoshi\|Nakai, Seiji\|Ogi, Tomohiro\|Miyauchi, Yoshiaki\|Yoshida, Shuhei\|Funaki, Toshiharu\|Uchida, Naohito\|Kita, Yuko\|Funakoshi, Fumi\|Usuki, Hisashi\|Okada, Setsuo\|Izuishi, Kunihiko\|Watanabe, Seishiro\|Kurokohchi, Ka
PMID:	15349907

40.
Journal:	Int J Oncol. 2004 Nov;25(5):1289-96.
Title:	Inhibition of human hepatocellular carcinoma by L-proline-m-bis (2-chloroethyl) amino-L-phenylalanyl-L-norvaline ethyl ester hydrochloride (MF13) in vitro and in vivo.
Author:	Hu, Qiong-Ying\|Li, Jian-Nong\|Song, Dan-Qing\|Wang, Yan-Ling\|Bekesi, George\|Weisz, Imre\|Jiang, Jian-Dong
PMID:	15492817

41.
Journal:	Int J Oncol. 2004 Dec;25(6):1839-47.
Title:	Extracellular signal-regulated kinase induces cyclin D1 and Cdk-2 expression and phosphorylation of retinoblastoma in hepatocellular carcinoma.
Author:	Huynh, H\|Do, P T\|Nguyen, T H\|Chow, P\|Tan, P H\|Quach, T H\|Van, T\|Soo, K C\|Tran, E
PMID:	15547725

42.
Journal:	Hum Pathol. 2004 Dec;35(12):1505-14.
Title:	Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis.
Author:	Ishikawa, Akira\|Sasaki, Motoko\|Sato, Yasunori\|Ohira, Shusaku\|Chen, Miin-Fu\|Huang, Shiu-Feng\|Oda, Koji\|Nimura, Yuji\|Nakanuma, Yasuni
PMID:	15619210

43.
Journal:	J Biochem. 2004 Nov;136(5):701-9.
Title:	Involvement of down-regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human hepatocellular carcinoma cell line HepG2.
Author:	Tsukada, Yu-ichi\|Tanaka, Toshiaki\|Miyazawa, Keiji\|Kitamura, Naomi
PMID:	15632311

44.
Journal:	Mol Carcinog. 2005 Feb;42(2):109-20.
Title:	Tumorigenesis in p27/p53- and p18/p53-double null mice: functional collaboration between the pRb and p53 pathways.
Author:	Damo, Lorna A\|Snyder, Paul W\|Franklin, David S
PMID:	15584024

45.
Journal:	Int J Oncol. 2005 Feb;26(2):467-73.
Title:	Integration of the hepatitis B virus X fragment in hepatocellular carcinoma and its effects on the expression of multiple molecules: a key to the cell cycle and apoptosis.
Author:	Peng, Zhihai\|Zhang, Yi\|Gu, Wei\|Wang, Zhaowen\|Li, Dapeng\|Zhang, Fang\|Qiu, Guoqiang\|Xie, Keping
PMID:	15645132

46.
Journal:	Cancer Res. 2005 Jun 1;65(11):4568-77.
Title:	Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy.
Author:	Mayhew, Christopher N\|Bosco, Emily E\|Fox, Sejal R\|Okaya, Tomohisa\|Tarapore, Pheruza\|Schwemberger, Sandy J\|Babcock, George F\|Lentsch, Alex B\|Fukasawa, Kenji\|Knudsen, Erik S
PMID:	15930274

47.
Journal:	Ai Zheng. 2005 Jun;24(6):757-68.
Title:	[Molecular genetic and epigenetic mechanisms of hepatocarcinogenesis].
Author:	Xue, Kai-Xian
PMID:	15946497

48.
Journal:	Tumour Biol. 2005 Nov-Dec;26(6):300-5.
Title:	Effect of promoter methylation of the p16 gene on phosphorylation of retinoblastoma gene product and growth of hepatocellular carcinoma cells.
Author:	Maeta, Yoshiko\|Shiota, Goshi\|Okano, Jun-ichi\|Murawaki, Yoshikazu
PMID:	16254459

49.
Journal:	Cancer Lett. 2006 Feb 28;233(2):271-8.
Title:	DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma.
Author:	Park, Hye-Jung\|Yu, Eunsil\|Shim, Yhong-Hee
PMID:	15885882

50.
Journal:	Cancer Chemother Pharmacol. 2006 Jan;57(2):268-73.
Title:	Antiproliferative activity of contragestazol (DL111-IT) in murine and human tumor models in vitro and in vivo.
Author:	Yang, Bo\|He, Qiao-jun\|Zhu, Dan-yan\|Lou, Yi-jia\|Fang, Rui-ying
PMID:	16133535

51.
Journal:	Transplantation. 2006 Sep 27;82(6):753-8.
Title:	Utility of cell-cycle modulators to predict vascular invasion and recurrence after surgical treatment of hepatocellular carcinoma.
Author:	Ramos, Emilio\|Llado, Laura\|Serrano, Teresa\|Figueras, Agnes\|Lastra, Raquel\|Torras, Jaume\|Figueras, Juan\|Rafecas, Antoni\|Fabregat, Juan
PMID:	17006321

52.
Journal:	Genes Chromosomes Cancer. 2007 Feb;46(2):118-29.
Title:	Profiling genomic copy number changes in retinoblastoma beyond loss of RB1.
Author:	Bowles, Ella\|Corson, Timothy W\|Bayani, Jane\|Squire, Jeremy A\|Wong, Nathalie\|Lai, Paul B-S\|Gallie, Brenda L
PMID:	17099872

53.
Journal:	Mol Ther. 2007 Mar;15(3):598-607.
Title:	Targeting interferon-alpha increases antitumor efficacy and reduces hepatotoxicity of E1A-mutated spread-enhanced oncolytic adenovirus.
Author:	Shashkova, Elena V\|Spencer, Jacqueline F\|Wold, William S M\|Doronin, Konstantin
PMID:	17191072

54.
Journal:	World J Gastroenterol. 2007 Jan 28;13(4):588-93.
Title:	Immunohistochemical analysis of p53, cyclinD1, RB1, c-fos and N-ras gene expression in hepatocellular carcinoma in Iran.
Author:	Moghaddam, S J\|Haghighi, E N\|Samiee, S\|Shahid, N\|Keramati, A R\|Dadgar, S\|Zali, M R
PMID:	17278226

55.
Journal:	Structure. 2007 Feb;15(2):179-89.
Title:	Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome.
Author:	Nakamura, Yoshihiro\|Nakano, Kazumi\|Umehara, Takashi\|Kimura, Mayumi\|Hayashizaki, Yoshihide\|Tanaka, Akiko\|Horikoshi, Masami\|Padmanabhan, Balasundaram\|Yokoyama, Shigeyuki
PMID:	17292836

56.
Journal:	Oncogene. 2007 Nov 1;26(50):7103-10.
Title:	Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation.
Author:	Kitisin, K\|Ganesan, N\|Tang, Y\|Jogunoori, W\|Volpe, E A\|Kim, S S\|Katuri, V\|Kallakury, B\|Pishvaian, M\|Albanese, C\|Mendelson, J\|Zasloff, M\|Rashid, A\|Fishbein, T\|Evans, S R T\|Sidawy, A\|Reddy, E P\|Mishra, B\|Johnson, L B\|Shetty, K\|Mishra, L
PMID:	17546056

57.
Journal:	Cancer Res. 2007 Jun 15;67(12):5771-8.
Title:	Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway.
Author:	Jung, Jin Kyu\|Arora, Payal\|Pagano, Joseph S\|Jang, Kyung Lib
PMID:	17575144

58.
Journal:	PLoS Pathog. 2007 Sep 7;3(9):1335-47.
Title:	Hepatitis C virus induces E6AP-dependent degradation of the retinoblastoma protein.
Author:	Munakata, Tsubasa\|Liang, Yuqiong\|Kim, Seungtaek\|McGivern, David R\|Huibregtse, Jon\|Nomoto, Akio\|Lemon, Stanley M
PMID:	17907805

59.
Journal:	BMC Cancer. 2007 Nov 19;7:215.
Title:	Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest.
Author:	Sheahan, Sharon\|Bellamy, Christopher O\|Dunbar, Donald R\|Harrison, David J\|Prost, Sandrine
PMID:	18021445

60.
Journal:	Mol Ther. 2007 Mar;15(3):598-607.
Title:	Targeting Interferon-alpha Increases Antitumor Efficacy and Reduces Hepatotoxicity of E1A-mutated Spread-enhanced Oncolytic Adenovirus.
Author:	Shashkova, Elena V\|Spencer, Jacqueline F\|Wold, William S M\|Doronin, Konstantin
PMID:	28182898

61.
Journal:	Oncogene. 2008 Jan 10;27(3):332-8.
Title:	Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells.
Author:	Chang, T-W\|Chen, C-C\|Chen, K-Y\|Su, J-H\|Chang, J-H\|Chang, M-C
PMID:	17621266

62.
Journal:	Hepatology. 2008 Oct;48(4):1128-37.
Title:	Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis.
Author:	Baek, Hye Jung\|Lim, Sung Chul\|Kitisin, Krit\|Jogunoori, Wilma\|Tang, Yi\|Marshall, M Blair\|Mishra, Bibhuti\|Kim, Tae Hyun\|Cho, Kwan Ho\|Kim, Sang Soo\|Mishra, Lopa
PMID:	18704924

63.
Journal:	Ai Zheng. 2008 Oct;27(10):1056-64.
Title:	[Impact of epigallocatechin gallate on gene expression profiles of human hepatocellular carcinoma cell lines BEL7404/ADM and BEL7402/5-FU].
Author:	Tang, Hai-Hua\|Zhou, Ming\|Liang, Gang
PMID:	18851785

64.
Journal:	Biochimie. 2009 Mar;91(3):373-82.
Title:	Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels.
Author:	Baiz, Daniele\|Pozzato, Gabriele\|Dapas, Barbara\|Farra, Rossella\|Scaggiante, Bruna\|Grassi, Mario\|Uxa, Laura\|Giansante, Carlo\|Zennaro, Cristina\|Guarnieri, Gianfranco\|Grassi, Gabriele
PMID:	19041685

65.
Journal:	Cancer Lett. 2009 Dec 1;286(1):103-13.
Title:	Senescence and immortality in hepatocellular carcinoma.
Author:	Ozturk, Mehmet\|Arslan-Ergul, Ayca\|Bagislar, Sevgi\|Senturk, Serif\|Yuzugullu, Haluk
PMID:	19070423

66.
Journal:	Exp Biol Med (Maywood). 2009 Jul;234(7):726-36.
Title:	Genetic and epigenetic control of molecular alterations in hepatocellular carcinoma.
Author:	Feo, Francesco\|Frau, Maddalena\|Tomasi, Maria L\|Brozzetti, Stefania\|Pascale, Rosa M
PMID:	19429855

67.
Journal:	Biochem Pharmacol. 2009 Jul 1;78(1):21-32.
Title:	Down-regulation of the HGF/MET autocrine loop induced by celecoxib and mediated by P-gp in MDR-positive human hepatocellular carcinoma cell line.
Author:	Mazzanti, Roberto\|Platini, Francesca\|Bottini, Consuelo\|Fantappie, Ornella\|Solazzo, Michela\|Tessitore, Luciana
PMID:	19447220

68.
Journal:	Chem Biol Interact. 2009 Sep 14;181(1):138-43.
Title:	Panaxydol inhibits the proliferation and induces the differentiation of human hepatocarcinoma cell line HepG2.
Author:	Guo, Lingchen\|Song, Li\|Wang, Zejian\|Zhao, Wenjuan\|Mao, Wenwei\|Yin, Ming
PMID:	19450571

69.
Journal:	Viruses. 2009 Dec;1(3):852-72.
Title:	Molecular mechanisms underlying hepatocellular carcinoma.
Author:	Merle, Philippe\|Trepo, Christian
PMID:	21994573

70.
Journal:	J Hematol Oncol. 2010 Oct 31;3:43.
Title:	Lobaplatin arrests cell cycle progression in human hepatocellular carcinoma cells.
Author:	Wu, Qiong\|Qin, Shu-Kui\|Teng, Feng-Meng\|Chen, Chang-Jie\|Wang, Rui
PMID:	21034513

71.
Journal:	Int J Cancer. 2011 Jun 15;128(12):2980-93.
Title:	Adenoviral-mediated RNA interference targeting URG11 inhibits growth of human hepatocellular carcinoma.
Author:	Fan, Rui\|Li, Xiaohua\|Du, Wenqi\|Zou, Xue\|Du, Rui\|Zhao, Lina\|Luo, Guanhong\|Mo, Ping\|Xia, Lin\|Pan, Yanglin\|Shi, Yongquan\|Lian, Zhaorui\|Feitelson, Mark A\|Nie, Yongzhan\|Liu, Jie\|Fan, Daiming
PMID:	20725996

72.
Journal:	Hepatology. 2011 Apr;53(4):1226-36.
Title:	Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53.
Author:	Calvisi, Diego F\|Simile, Maria M\|Ladu, Sara\|Frau, Maddalena\|Evert, Matthias\|Tomasi, Maria L\|Demartis, Maria I\|Daino, Lucia\|Seddaiu, Maria A\|Brozzetti, Stefania\|Feo, Francesco\|Pascale, Rosa M
PMID:	21480327

73.
Journal:	Hepatology. 2011 May;53(5):1641-50.
Title:	Loss of transforming growth factor beta adaptor protein beta-2 spectrin leads to delayed liver regeneration in mice.
Author:	Thenappan, Arun\|Shukla, Vivek\|Abdul Khalek, Feras J\|Li, Ying\|Shetty, Kirti\|Liu, Pu\|Li, Lu\|Johnson, Randy L\|Johnson, Lynt\|Mishra, Lopa
PMID:	21520177

74.
Journal:	Dig Liver Dis. 2011 Dec;43(12):1006-14.
Title:	Effects of E2F1-cyclin E1-E2 circuit down regulation in hepatocellular carcinoma cells.
Author:	Farra, Rossella\|Dapas, Barbara\|Pozzato, Gabriele\|Scaggiante, Bruna\|Agostini, Francesco\|Zennaro, Cristina\|Grassi, Mario\|Rosso, Natalia\|Giansante, Carlo\|Fiotti, Nicola\|Grassi, Gabriele
PMID:	21831731

75.
Journal:	J Exp Med. 2011 Sep 26;208(10):1963-76.
Title:	Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.
Author:	Viatour, Patrick\|Ehmer, Ursula\|Saddic, Louis A\|Dorrell, Craig\|Andersen, Jesper B\|Lin, Chenwei\|Zmoos, Anne-Flore\|Mazur, Pawel K\|Schaffer, Bethany E\|Ostermeier, Austin\|Vogel, Hannes\|Sylvester, Karl G\|Thorgeirsson, Snorri S\|Grompe, Markus\|Sage, Julien
PMID:	21875955

76.
Journal:	PLoS One. 2011;6(11):e28103.
Title:	Aberrant regulation of HDAC2 mediates proliferation of hepatocellular carcinoma cells by deregulating expression of G1/S cell cycle proteins.
Author:	Noh, Ji Heon\|Jung, Kwang Hwa\|Kim, Jeong Kyu\|Eun, Jung Woo\|Bae, Hyun Jin\|Xie, Hong Jian\|Chang, Young Gyoon\|Kim, Min Gyu\|Park, Won Sang\|Lee, Jung Young\|Nam, Suk Woo
PMID:	22132221

77.
Journal:	Nucleic Acids Res. 2012 May;40(10):4615-25.
Title:	MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein.
Author:	Zhu, Ying\|Lu, Yang\|Zhang, Qi\|Liu, Jing-Jing\|Li, Tuan-Jie\|Yang, Jian-Rong\|Zeng, Chunxian\|Zhuang, Shi-Mei
PMID:	22210897

78.
Journal:	Virchows Arch. 2012 May;460(5):439-46.
Title:	E2F-1 is overexpressed and pro-apoptotic in human hepatocellular carcinoma.
Author:	Palaiologou, Marina\|Koskinas, John\|Karanikolas, Menelaos\|Fatourou, Evangelia\|Tiniakos, Dina G
PMID:	22450712

79.
Journal:	PLoS One. 2012;7(4):e34265.
Title:	HDAC1 inactivation induces mitotic defect and caspase-independent autophagic cell death in liver cancer.
Author:	Xie, Hong Jian\|Noh, Ji Heon\|Kim, Jeong Kyu\|Jung, Kwang Hwa\|Eun, Jung Woo\|Bae, Hyun Jin\|Kim, Min Gyu\|Chang, Young Gyoon\|Lee, Jung Young\|Park, Hanna\|Nam, Suk Woo
PMID:	22496786

80.
Journal:	Cell Cycle. 2012 May 1;11(9):1773-81.
Title:	Activation of multiple cancer pathways and tumor maintenance function of the 3q amplified oncogene FNDC3B.
Author:	Cai, Chunlin\|Rajaram, Megha\|Zhou, Xin\|Liu, Qing\|Marchica, John\|Li, Jinyu\|Powers, R Scott
PMID:	22510613

81.
Journal:	Apoptosis. 2012 Aug;17(8):842-51.
Title:	Apoptosis induced by 1,3,6,7-tetrahydroxyxanthone in Hepatocellular carcinoma and proteomic analysis.
Author:	Fu, Wei-ming\|Zhang, Jin-fang\|Wang, Hua\|Tan, Hong-sheng\|Wang, Wei-mao\|Chen, Shih-Chi\|Zhu, Xiao\|Chan, Tak-ming\|Tse, Ching-man\|Leung, Kwong-sak\|Lu, Gang\|Xu, Hong-xi\|Kung, Hsiang-fu
PMID:	22610480

82.
Journal:	Hepatology. 2013 Jan;57(1):171-82.
Title:	Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice.
Author:	Lin, Heng\|Yan, Jun\|Wang, Ziyan\|Hua, Fang\|Yu, Jiaojiao\|Sun, Wei\|Li, Ke\|Liu, Hong\|Yang, Hongzhen\|Lv, Qi\|Xue, Jianfei\|Hu, Zhuo-Wei
PMID:	22859216

83.
Journal:	Int J Oncol. 2013 Nov;43(5):1503-10.
Title:	Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway.
Author:	Yi, Gao\|He, Zhimin\|Zhou, Xinke\|Xian, Lewu\|Yuan, Taize\|Jia, Xiaoting\|Hong, Jian\|He, Lu\|Liu, Jifang
PMID:	23982736

84.
Journal:	Oncogene. 2014 May 15;33(20):2557-67.
Title:	MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma.
Author:	Bae, H J\|Noh, J H\|Kim, J K\|Eun, J W\|Jung, K H\|Kim, M G\|Chang, Y G\|Shen, Q\|Kim, S-J\|Park, W S\|Lee, J Y\|Nam, S W
PMID:	23728341

85.
Journal:	Tumour Biol. 2014 Mar;35(3):2795-802.
Title:	Promoter hypermethylation of p14 (ARF) , RB, and INK4 gene family in hepatocellular carcinoma with hepatitis B virus infection.
Author:	Zhang, Ji-Cai\|Gao, Bo\|Yu, Zong-Tao\|Liu, Xiao-Bo\|Lu, Jun\|Xie, Fei\|Luo, Hai-Jun\|Li, Hai-Ping
PMID:	24254306

86.
Journal:	Curr Med Chem. 2014;21(9):1072-81.
Title:	A systemic approach to cancer treatment: tumor cell reprogramming focused on endocrine-related cancers.
Author:	Biava, P M\|Nicolini, A\|Ferrari, P\|Carpi, A\|Sell, S
PMID:	24304275

87.
Journal:	Int J Oncol. 2014 Jul;45(1):47-56.
Title:	The effects of fucodian on senescence are controlled by the p16INK4a-pRb and p14Arf-p53 pathways in hepatocellular carcinoma and hepatic cell lines.
Author:	Min, Eun-Young\|Kim, In-Hye\|Lee, Jungim\|Kim, Eun-Young\|Choi, Youn-Hee\|Nam, Taek-Jeong
PMID:	24807532

88.
Journal:	J Pathol. 2014 Aug;233(4):392-401.
Title:	Deregulation of RB1 expression by loss of imprinting in human hepatocellular carcinoma.
Author:	Anwar, Sumadi Lukman\|Krech, Till\|Hasemeier, Britta\|Schipper, Elisa\|Schweitzer, Nora\|Vogel, Arndt\|Kreipe, Hans\|Lehmann, Ulrich
PMID:	24838394

89.
Journal:	Asian Pac J Cancer Prev. 2014;15(9):3959-63.
Title:	Tissue microarray immunohistochemical profiles of p53 and pRB in hepatocellular carcinoma and hepatoblastoma.
Author:	Azlin, Abdul Hadi\|Looi, Lai Meng\|Cheah, Phaik Leng
PMID:	24935581

90.
Journal:	Gut. 2015 Jan;64(1):156-67.
Title:	Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4.
Author:	Li, Liang\|Tang, Jing\|Zhang, Baohua\|Yang, Wen\|LiuGao, Miyang\|Wang, Ruoyu\|Tan, Yexiong\|Fan, Jianling\|Chang, Yanxin\|Fu, Jing\|Jiang, Feng\|Chen, Caiyang\|Yang, Yingcheng\|Gu, Jin\|Wu, Dingming\|Guo, Linna\|Cao, Dan\|Li, Hengyu\|Cao, Guangwen\|Wu, Mengchao\|Zhang, Micha
PMID:	24572141

91.
Journal:	Liver Int. 2015 Apr;35(4):1403-15.
Title:	Suppressing the CDC37 cochaperone in hepatocellular carcinoma cells inhibits cell cycle progression and cell growth.
Author:	Wang, Zhanhui\|Wei, Wei\|Sun, Chris K\|Chua, Mei-Sze\|So, Samuel
PMID:	25098386

92.
Journal:	Biochimie. 2015 May;112:85-95.
Title:	Impairment of the Pin1/E2F1 axis in the anti-proliferative effect of bortezomib in hepatocellular carcinoma cells.
Author:	Farra, Rossella\|Dapas, Barbara\|Baiz, Daniele\|Tonon, Federica\|Chiaretti, Sara\|Del Sal, Giannino\|Rustighi, Alessandra\|Elvassore, Nicola\|Pozzato, Gabriele\|Grassi, Mario\|Grassi, Gabriele
PMID:	25742740

93.
Journal:	PLoS One. 2015 Apr 24;10(4):e0124266.
Title:	MicroRNA let-7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma.
Author:	Zhu, Xiuming\|Wu, Lingjiao\|Yao, Jian\|Jiang, Han\|Wang, Qiangfeng\|Yang, Zhijian\|Wu, Fusheng
PMID:	25909324

94.
Journal:	Oncotarget. 2015 Sep 29;6(29):27736-50.
Title:	MicroRNA-424 inhibits Akt3/E2F3 axis and tumor growth in hepatocellular carcinoma.
Author:	Yang, Hao\|Zheng, Wei\|Shuai, Xiao\|Chang, Rui-Min\|Yu, Lei\|Fang, Feng\|Yang, Lian-Yue
PMID:	26315541

95.
Journal:	J Exp Clin Cancer Res. 2015 Nov 14;34:140.
Title:	Hepatitis C virus core protein modulates pRb2/p130 expression in human hepatocellular carcinoma cell lines through promoter methylation.
Author:	Mileo, Anna Maria\|Mattarocci, Stefano\|Matarrese, Paola\|Anticoli, Simona\|Abbruzzese, Claudia\|Catone, Stefania\|Sacco, Rodolfo\|Paggi, Marco G\|Ruggieri, Anna
PMID:	26576645

96.
Journal:	Toxicol Rep. 2015 Jan 25;2:322-332.
Title:	Upregulation of cyclin-dependent kinase inhibitors CDKN1B and CDKN1C in hepatocellular carcinoma-derived cells via goniothalamin-mediated protein stabilization and epigenetic modifications.
Author:	Peng, Yu-Ting\|Wu, Wen-Ren\|Chen, Lih-Ren\|Kuo, Kung-Kai\|Tsai, Cheng-Hui\|Huang, Yu-Ting\|Lan, Yu-Hsuan\|Chang, Fang-Rong\|Wu, Yang-Chang\|Shiue, Yow-Ling
PMID:	28962365

97.
Journal:	Mol Med Rep. 2016 Jan;13(1):315-20.
Title:	UHRF1 promotes human osteosarcoma cell invasion by downregulating the expression of Ecadherin in an Rb1dependent manner.
Author:	Liu, Wei\|Qiao, Rui Hong\|Wang, Dong Ming\|Huang, Xiao Wei\|Li, Bing\|Wang, Dong
PMID:	26548607

98.
Journal:	J Cell Physiol. 2016 Jul;231(7):1438-49.
Title:	The Spectrum of E2F in Liver Disease--Mediated Regulation in Biology and Cancer.
Author:	Huntington, Justin T\|Tang, Xing\|Kent, Lindsey N\|Schmidt, Carl R\|Leone, Gustavo
PMID:	26566968

99.
Journal:	Asian Pac J Trop Med. 2016 Apr;9(4):344-350.
Title:	Ethanol extract of Kalopanax septemlobus leaf inhibits HepG2 human hepatocellular carcinoma cell proliferation via inducing cell cycle arrest at G1 phase.
Author:	Park, Cheol\|Jeong, Ji-Suk\|Jeong, Jin-Woo\|Kim, Sung Ok\|Kim, Yong-Joo\|Kim, Gi-Young\|Hong, Su-Hyun\|Choi, Yung Hyun
PMID:	27086152

100.
Journal:	Oncotarget. 2016 Jul 26;7(30):48309-48320.
Title:	A p53-independent apoptotic mechanism of adenoviral mutant E1A was involved in its selective antitumor activity for human cancer.
Author:	Fang, Lin\|Cheng, Qian\|Zhao, Jingjing\|Ge, Yan\|Zhu, Qi\|Zhao, Min\|Zhang, Jie\|Zhang, Qi\|Li, Liantao\|Liu, Junjie\|Zheng, Junnian
PMID:	27340782

101.
Journal:	Oncol Lett. 2016 Dec;12(6):5177-5182.
Title:	miR-1297 promotes cell proliferation by inhibiting RB1 in liver cancer.
Author:	Liu, Chengyong\|Wang, Chunying\|Wang, Ji\|Huang, Haibin
PMID:	28105225

102.
Journal:	Oncotarget. 2017 Apr 4;8(14):23775-23786.
Title:	A novel lncRNA, GASL1, inhibits cell proliferation and restricts E2F1 activity.
Author:	Gasri-Plotnitsky, Lital\|Ovadia, Aviv\|Shamalov, Katerina\|Nizri-Megnaji, Tali\|Meir, Shimrit\|Zurer, Irit\|Cohen, Cyrille J\|Ginsberg, Doron
PMID:	28423601

103.
Journal:	Oncotarget. 2017 Jul 25;8(30):49093-49109.
Title:	HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372.
Author:	An, Jiahui\|Xu, Jie\|Li, Jiao\|Jia, Song\|Li, Xiaonan\|Lu, Yanan\|Yang, Yuxin\|Lin, Zhuojia\|Xin, Xiaoru\|Wu, Mengying\|Zheng, Qidi\|Pu, Hu\|Gui, Xin\|Li, Tianming\|Lu, Dongdong
PMID:	28467776

104.
Journal:	Artif Cells Nanomed Biotechnol. 2018 Nov;46(7):1301-1313.
Title:	Gankyrin: a novel promising therapeutic target for hepatocellular carcinoma.
Author:	Zamani, Parvin\|Matbou Riahi, Maryam\|Momtazi-Borojeni, Amir Abbas\|Jamialahmadi, Khadijeh
PMID:	29025272

105.
Journal:	Exp Ther Med. 2018 Feb;15(2):1360-1366.
Title:	Downregulation of NIMA-related kinase-7 inhibits cell proliferation by inducing cell cycle arrest in human retinoblastoma cells.
Author:	Zhang, Jian\|Wang, Li\|Zhang, Yongkang
PMID:	29434721

106.
Journal:	J Virol. 2018 Apr 13;92(9). pii: JVI.02036-17.
Title:	Hepatitis C Virus core+1/ARF Protein Modulates the Cyclin D1/pRb Pathway and Promotes Carcinogenesis.
Author:	Moustafa, Savvina\|Karakasiliotis, Ioannis\|Mavromara, Penelope
PMID:	29444947

107.
Journal:	Methods Mol Biol. 2018;1726:35-47.
Title:	Detection of Aberrant DNA Methylation Patterns in the RB1 Gene.
Author:	Anwar, Sumadi Lukman\|Lehmann, Ulrich
PMID:	29468542

108.
Journal:	Biomed Pharmacother. 2018 Sep;105:326-333.
Title:	Downregulation of circular RNA hsa_circ_0001649 indicates poor prognosis for retinoblastoma and regulates cell proliferation and apoptosis via AKT/mTOR signaling pathway.
Author:	Xing, Lichen\|Zhang, Leiming\|Feng, Yali\|Cui, Zhe\|Ding, Lin
PMID:	29864621