Primary Site >> Liver Cancer
Gene >> RB1
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Ref: A familial RB1 mutation detected by the HOT technique is homozygous in a second primary neoplasm. PMID: 1662795 |
Ref: RB tumor suppressor gene expression in hepatocellular carcinomas from patients infected with the hepatitis B virus. PMID: 7798888 Ref: Immunohistochemical analysis of retinoblastoma gene product (pRB) expression in malignant and non-malignant liver diseases. PMID: 7877433 Ref: Deletions of chromosome 13q, mutations in Retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma. PMID: 8033150 |
Ref: Expression of the retinoblastoma gene product in human hepatocellular carcinoma. PMID: 7535739 |
Ref: Identification of positive and negative regulatory elements of the human cytochrome P4501A2 (CYP1A2) gene. PMID: 9028875 Ref: Resistance to p53-mediated growth arrest and apoptosis in Hep 3B hepatoma cells. PMID: 9233778 Ref: Effect of hepatitis B virus X protein on the expression of retinoblastoma gene product. PMID: 9385399 |
Ref: Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha. PMID: 9426068 Ref: Cell cycle regulators and human hepatocarcinogenesis. PMID: 9840120 Ref: Overexpression of cyclin D1 and cdk4 in tumorigenesis of sporadic hepatoblastomas. PMID: 9851251 |
Ref: Expression and prognostic roles of the G1-S modulators in hepatocellular carcinoma: p27 independently predicts the recurrence. PMID: 10385644 Ref: [The expression of p16, CDK4 and pRb in hepatocellular carcinomas]. PMID: 10488417 Ref: Characterization of six tumor suppressor genes and microsatellite instability in hepatocellular carcinoma in southern African blacks. PMID: 11819494 |
Ref: Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas. PMID: 10613832 Ref: P53 but not p16INK4a induces growth arrest in retinoblastoma-deficient hepatocellular carcinoma cells. PMID: 10952243 Ref: 5-Aza-2'-deoxycytidine leads to down-regulation of aberrant p16INK4A RNA transcripts and restores the functional retinoblastoma protein pathway in hepatocellular carcinoma cell lines. PMID: 11098088 |
Ref: Hepatitis B viral X protein overcomes inhibition of E2F1 activity by pRb on the human Rb gene promoter. PMID: 11244564 Ref: Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas. PMID: 11299822 Ref: Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular carci PMID: 11301474 Ref: Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines. PMID: 11343236 Ref: Disruption of the p16/cyclin D1/retinoblastoma protein pathway in the majority of human hepatocellular carcinomas. PMID: 11408803 Ref: Selective expression of nonsecreted interferon by an adenoviral vector confers antiproliferative and antiviral properties and causes reduction of tumor growth in nude mice. PMID: 11440637 Ref: High intensity ERK signal mediates hepatocyte growth factor-induced proliferation inhibition of the human hepatocellular carcinoma cell line HepG2. PMID: 11533045 Ref: Isolation and characterization of the retinoblastoma protein from fish. PMID: 11567901 |
Ref: Suppression of tumorigenicity of rat liver tumor cells by human chromosome 13: evidence against the involvement of pRb and BRCA2. PMID: 11788883 Ref: Quantification of tumor suppressor mRNA expression by poly-competitive RT-PCR using a TS-IS that contained multiple internal competitors. PMID: 12132590 Ref: Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma. PMID: 12143052 Ref: Brain metastasis from hepatocellular carcinoma associated with hepatitis B virus. PMID: 12385572 Ref: Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats. PMID: 12470904 |
Ref: Downregulation of p21(waf/cip-1) mediates apoptosis of human hepatocellular carcinoma cells in response to interferon-gamma. PMID: 12531694 Ref: Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fisher 344 male rats [Mechanisms of Ageing and Development 123 (2002) 1665-1680]. PMID: 12825548 Ref: Role of a novel oncogenic protein, gankyrin, in hepatocyte proliferation. PMID: 14505129 Ref: SV40 Tag DNA sequences, present in a small proportion of human hepatocellular carcinomas, are associated with reduced survival. PMID: 14645347 |
Ref: p53 dephosphorylation and p21(Cip1/Waf1) translocation correlate with caspase-3 activation in TGF-beta1-induced apoptosis of HuH-7 cells. PMID: 15004518 Ref: Orthotopic implantation of human hepatocellular carcinoma in mice: analysis of tumor progression and establishment of the BCLC-9 cell line. PMID: 15041736 Ref: Expression of G1 phase-related cell cycle molecules in naturally developing hepatocellular carcinoma of Long-Evans Cinnamon rats. PMID: 15067343 Ref: Mitoinhibitory effects of the tumor promoter 2-acetylaminofluorene in rat liver: loss of E2F-1 and E2F-3 expression and cdk 2 kinase activity in late G1. PMID: 15158336 Ref: Reduced expression of cell cycle regulator p18(INK4C) in human hepatocellular carcinoma. PMID: 15349907 Ref: Inhibition of human hepatocellular carcinoma by L-proline-m-bis (2-chloroethyl) amino-L-phenylalanyl-L-norvaline ethyl ester hydrochloride (MF13) in vitro and in vivo. PMID: 15492817 Ref: Extracellular signal-regulated kinase induces cyclin D1 and Cdk-2 expression and phosphorylation of retinoblastoma in hepatocellular carcinoma. PMID: 15547725 Ref: Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis. PMID: 15619210 Ref: Involvement of down-regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human hepatocellular carcinoma cell line HepG2. PMID: 15632311 |
Ref: Tumorigenesis in p27/p53- and p18/p53-double null mice: functional collaboration between the pRb and p53 pathways. PMID: 15584024 Ref: Integration of the hepatitis B virus X fragment in hepatocellular carcinoma and its effects on the expression of multiple molecules: a key to the cell cycle and apoptosis. PMID: 15645132 Ref: Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy. PMID: 15930274 Ref: [Molecular genetic and epigenetic mechanisms of hepatocarcinogenesis]. PMID: 15946497 Ref: Effect of promoter methylation of the p16 gene on phosphorylation of retinoblastoma gene product and growth of hepatocellular carcinoma cells. PMID: 16254459 |
Ref: DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma. PMID: 15885882 Ref: Antiproliferative activity of contragestazol (DL111-IT) in murine and human tumor models in vitro and in vivo. PMID: 16133535 Ref: Utility of cell-cycle modulators to predict vascular invasion and recurrence after surgical treatment of hepatocellular carcinoma. PMID: 17006321 |
Ref: Profiling genomic copy number changes in retinoblastoma beyond loss of RB1. PMID: 17099872 Ref: Targeting interferon-alpha increases antitumor efficacy and reduces hepatotoxicity of E1A-mutated spread-enhanced oncolytic adenovirus. PMID: 17191072 Ref: Immunohistochemical analysis of p53, cyclinD1, RB1, c-fos and N-ras gene expression in hepatocellular carcinoma in Iran. PMID: 17278226 Ref: Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome. PMID: 17292836 Ref: Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation. PMID: 17546056 Ref: Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway. PMID: 17575144 Ref: Hepatitis C virus induces E6AP-dependent degradation of the retinoblastoma protein. PMID: 17907805 Ref: Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest. PMID: 18021445 Ref: Targeting Interferon-alpha Increases Antitumor Efficacy and Reduces Hepatotoxicity of E1A-mutated Spread-enhanced Oncolytic Adenovirus. PMID: 28182898 |
Ref: Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells. PMID: 17621266 Ref: Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis. PMID: 18704924 Ref: [Impact of epigallocatechin gallate on gene expression profiles of human hepatocellular carcinoma cell lines BEL7404/ADM and BEL7402/5-FU]. PMID: 18851785 |
Ref: Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels. PMID: 19041685 Ref: Senescence and immortality in hepatocellular carcinoma. PMID: 19070423 Ref: Genetic and epigenetic control of molecular alterations in hepatocellular carcinoma. PMID: 19429855 Ref: Down-regulation of the HGF/MET autocrine loop induced by celecoxib and mediated by P-gp in MDR-positive human hepatocellular carcinoma cell line. PMID: 19447220 Ref: Panaxydol inhibits the proliferation and induces the differentiation of human hepatocarcinoma cell line HepG2. PMID: 19450571 Ref: Molecular mechanisms underlying hepatocellular carcinoma. PMID: 21994573 |
Ref: Lobaplatin arrests cell cycle progression in human hepatocellular carcinoma cells. PMID: 21034513 |
Ref: Adenoviral-mediated RNA interference targeting URG11 inhibits growth of human hepatocellular carcinoma. PMID: 20725996 Ref: Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53. PMID: 21480327 Ref: Loss of transforming growth factor beta adaptor protein beta-2 spectrin leads to delayed liver regeneration in mice. PMID: 21520177 Ref: Effects of E2F1-cyclin E1-E2 circuit down regulation in hepatocellular carcinoma cells. PMID: 21831731 Ref: Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. PMID: 21875955 Ref: Aberrant regulation of HDAC2 mediates proliferation of hepatocellular carcinoma cells by deregulating expression of G1/S cell cycle proteins. PMID: 22132221 |
Ref: MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein. PMID: 22210897 Ref: E2F-1 is overexpressed and pro-apoptotic in human hepatocellular carcinoma. PMID: 22450712 Ref: HDAC1 inactivation induces mitotic defect and caspase-independent autophagic cell death in liver cancer. PMID: 22496786 Ref: Activation of multiple cancer pathways and tumor maintenance function of the 3q amplified oncogene FNDC3B. PMID: 22510613 Ref: Apoptosis induced by 1,3,6,7-tetrahydroxyxanthone in Hepatocellular carcinoma and proteomic analysis. PMID: 22610480 |
Ref: Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice. PMID: 22859216 Ref: Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway. PMID: 23982736 |
Ref: MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma. PMID: 23728341 Ref: Promoter hypermethylation of p14 (ARF) , RB, and INK4 gene family in hepatocellular carcinoma with hepatitis B virus infection. PMID: 24254306 Ref: A systemic approach to cancer treatment: tumor cell reprogramming focused on endocrine-related cancers. PMID: 24304275 Ref: The effects of fucodian on senescence are controlled by the p16INK4a-pRb and p14Arf-p53 pathways in hepatocellular carcinoma and hepatic cell lines. PMID: 24807532 Ref: Deregulation of RB1 expression by loss of imprinting in human hepatocellular carcinoma. PMID: 24838394 Ref: Tissue microarray immunohistochemical profiles of p53 and pRB in hepatocellular carcinoma and hepatoblastoma. PMID: 24935581 |
Ref: Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4. PMID: 24572141 Ref: Suppressing the CDC37 cochaperone in hepatocellular carcinoma cells inhibits cell cycle progression and cell growth. PMID: 25098386 Ref: Impairment of the Pin1/E2F1 axis in the anti-proliferative effect of bortezomib in hepatocellular carcinoma cells. PMID: 25742740 Ref: MicroRNA let-7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma. PMID: 25909324 Ref: MicroRNA-424 inhibits Akt3/E2F3 axis and tumor growth in hepatocellular carcinoma. PMID: 26315541 Ref: Hepatitis C virus core protein modulates pRb2/p130 expression in human hepatocellular carcinoma cell lines through promoter methylation. PMID: 26576645 Ref: Upregulation of cyclin-dependent kinase inhibitors CDKN1B and CDKN1C in hepatocellular carcinoma-derived cells via goniothalamin-mediated protein stabilization and epigenetic modifications. PMID: 28962365 |
Ref: UHRF1 promotes human osteosarcoma cell invasion by downregulating the expression of Ecadherin in an Rb1dependent manner. PMID: 26548607 Ref: The Spectrum of E2F in Liver Disease--Mediated Regulation in Biology and Cancer. PMID: 26566968 Ref: Ethanol extract of Kalopanax septemlobus leaf inhibits HepG2 human hepatocellular carcinoma cell proliferation via inducing cell cycle arrest at G1 phase. PMID: 27086152 Ref: A p53-independent apoptotic mechanism of adenoviral mutant E1A was involved in its selective antitumor activity for human cancer. PMID: 27340782 Ref: miR-1297 promotes cell proliferation by inhibiting RB1 in liver cancer. PMID: 28105225 |
Ref: A novel lncRNA, GASL1, inhibits cell proliferation and restricts E2F1 activity. PMID: 28423601 Ref: HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372. PMID: 28467776 |
Ref: Gankyrin: a novel promising therapeutic target for hepatocellular carcinoma. PMID: 29025272 Ref: Downregulation of NIMA-related kinase-7 inhibits cell proliferation by inducing cell cycle arrest in human retinoblastoma cells. PMID: 29434721 Ref: Hepatitis C Virus core+1/ARF Protein Modulates the Cyclin D1/pRb Pathway and Promotes Carcinogenesis. PMID: 29444947 Ref: Detection of Aberrant DNA Methylation Patterns in the RB1 Gene. PMID: 29468542 Ref: Downregulation of circular RNA hsa_circ_0001649 indicates poor prognosis for retinoblastoma and regulates cell proliferation and apoptosis via AKT/mTOR signaling pathway. PMID: 29864621 |