Primary Site >> Colorectal Cancer

Gene >> RALA

Journal: J Biol Chem. 2004 Jul 9;279(28):29247-54. Epub 2004 Apr 9.
Title: The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death.
Author: Rabizadeh, Shahrooz|Xavier, Ramnik J|Ishiguro, Kazuhiro|Bernabeortiz, Juliocesar|Lopez-Ilasaca, Marco|Khokhlatchev, Andrei|Mollahan, Pamela|Pfeifer, Gerd P|Avruch, Joseph|Seed, Brian
PMID: 15075335
Journal: Cancer Res. 2007 May 1;67(9):4382-9.
Title: Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1).
Author: Singhal, Sharad S|Singhal, Jyotsana|Yadav, Sushma|Dwivedi, Seema|Boor, Paul J|Awasthi, Yogesh C|Awasthi, Sanjay
PMID: 17483352
Journal: BMC Cancer. 2009 Dec 12;9:435.
Title: Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway.
Author: Tseng, Ya-Shih|Lee, Jenq-Chang|Huang, Chi-Ying F|Liu, Hsiao-Sheng
PMID: 20003375
Journal: Cancer Res. 2011 Jan 1;71(1):206-15.
Title: Activation and involvement of Ral GTPases in colorectal cancer.
Author: Martin, Timothy D|Samuel, Jonathan C|Routh, Elizabeth D|Der, Channing J|Yeh, Jen Jen
PMID: 21199803
Journal: J Natl Cancer Inst. 2012 Feb 8;104(3):228-39.
Title: Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome.
Author: Ihle, Nathan T|Byers, Lauren A|Kim, Edward S|Saintigny, Pierre|Lee, J Jack|Blumenschein, George R|Tsao, Anne|Liu, Suyu|Larsen, Jill E|Wang, Jing|Diao, Lixia|Coombes, Kevin R|Chen, Lu|Zhang, Shuxing|Abdelmelek, Mena F|Tang, Ximing|Papadimitrakopoulou, Vass
PMID: 22247021
Journal: Small GTPases. 2012 Apr-Jun;3(2):126-30.
Title: Differential involvement of RalA and RalB in colorectal cancer.
Author: Martin, Timothy D|Der, Channing J
PMID: 22790202
Journal: Enzymes. 2013;34 Pt. B:1-23.
Title: Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras.GTP-effector interaction.
Author: Shima, Fumi|Yoshikawa, Yoko|Matsumoto, Shigeyuki|Kataoka, Tohru
PMID: 25034098
Journal: Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7.
Title: In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.
Author: Shima, Fumi|Yoshikawa, Yoko|Ye, Min|Araki, Mitsugu|Matsumoto, Shigeyuki|Liao, Jingling|Hu, Lizhi|Sugimoto, Takeshi|Ijiri, Yuichi|Takeda, Azusa|Nishiyama, Yuko|Sato, Chie|Muraoka, Shin|Tamura, Atsuo|Osoda, Tsutomu|Tsuda, Ken-ichiro|Miyakawa, Tomoya|Fukunis
PMID: 23630290
Journal: Oncogene. 2013 Feb 14;32(7):894-902.
Title: Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer.
Author: Saito, R|Shirakawa, R|Nishiyama, H|Kobayashi, T|Kawato, M|Kanno, T|Nishizawa, K|Matsui, Y|Ohbayashi, T|Horiguchi, M|Nakamura, T|Ikeda, T|Yamane, K|Nakayama, E|Nakamura, E|Toda, Y|Kimura, T|Kita, T|Ogawa, O|Horiuchi, H
PMID: 22450745
Journal: Biochem Pharmacol. 2014 Mar 15;88(2):150-7.
Title: Paris saponin VII inhibits growth of colorectal cancer cells through Ras signaling pathway.
Author: Li, Yuhua|Sun, Yang|Fan, Lei|Zhang, Feng|Meng, Jin|Han, Jin|Guo, Xin|Zhang, Dian|Zhang, Rong|Yue, Zhenggang|Mei, Qibing
PMID: 24462916
Journal: Cell Biochem Biophys. 2015 Mar;71(2):579-85.
Title: RLIP76 blockade by siRNA inhibits proliferation, enhances apoptosis, and suppresses invasion in HT29 colon cancer cells.
Author: Zhang, Yi|Song, Xilin|Gong, Weipeng|Zhu, Zhenyu|Liu, Xin|Hou, Qingsheng|Sun, Yanlai|Chai, Jie|Zou, Lei|Guan, Jie
PMID: 25213293
Journal: Mol Carcinog. 2015 Nov;54(11):1430-41.
Title: Protein phosphatase 2A is essential to maintain active Wnt signaling and its Abeta tumor suppressor subunit is not expressed in colon cancer cells.
Author: Carmen Figueroa-Aldariz, M|Castaneda-Patlan, M Cristina|Santoyo-Ramos, Paula|Zentella, Alejandro|Robles-Flores, Martha
PMID: 25252130
Journal: Oncotarget. 2015 Mar 20;6(8):5903-17.
Title: Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer.
Author: Aguilera, Oscar|Gonzalez-Sancho, Jose Manuel|Zazo, Sandra|Rincon, Raul|Fernandez, Agustin F|Tapia, Olga|Canals, Francesc|Morte, Beatriz|Calvanese, Vincenzo|Orgaz, Jose L|Niell, Nuria|Aguilar, Susana|Freije, Jose M|Grana, Osvaldo|Pisano, David G|Borrero, A
PMID: 25788273
Journal: Oncotarget. 2015 May 30;6(15):13334-46.
Title: Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancer.
Author: Gyorffy, Balazs|Stelniec-Klotz, Iwona|Sigler, Christian|Kasack, Katharina|Redmer, Torben|Qian, Yu|Schafer, Reinhold
PMID: 26033452
Journal: Clin Cancer Res. 2016 Jan 1;22(1):230-242.
Title: EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer.
Author: Dunne, Philip D|Dasgupta, Sonali|Blayney, Jaine K|McArt, Darragh G|Redmond, Keara L|Weir, Jessica-Anne|Bradley, Conor A|Sasazuki, Takehiko|Shirasawa, Senji|Wang, Tingting|Srivastava, Supriya|Ong, Chee Wee|Arthur, Ken|Salto-Tellez, Manuel|Wilson, Richard H
PMID: 26283684
Journal: Pharmacol Rev. 2018 Jan;70(1):1-11.
Title: RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer.
Author: Yan, Chao|Theodorescu, Dan
PMID: 29196555
Journal: Int J Clin Oncol. 2018 Oct;23(5):917-923.
Title: Multi-panel assay of serum autoantibodies in colorectal cancer.
Author: Ushigome, Mitsunori|Nabeya, Yoshihiro|Soda, Hiroaki|Takiguchi, Nobuhiro|Kuwajima, Akiko|Tagawa, Masatoshi|Matsushita, Kazuyuki|Koike, Junichi|Funahashi, Kimihiko|Shimada, Hideaki
PMID: 29691673