Primary Site >> Stomach Cancer

Gene >> RAC1

Journal: Mol Microbiol. 2001 May;40(4):815-23.
Title: Pathogenicity island-dependent activation of Rho GTPases Rac1 and Cdc42 in Helicobacter pylori infection.
Author: Churin, Y|Kardalinou, E|Meyer, T F|Naumann, M
PMID: 11401689
Journal: Int J Cancer. 2001 Mar 15;91(6):783-8.
Title: Localization of IQGAP1 is inversely correlated with intercellular adhesion mediated by e-cadherin in gastric cancers.
Author: Takemoto, H|Doki, Y|Shiozaki, H|Imamura, H|Utsunomiya, T|Miyata, H|Yano, M|Inoue, M|Fujiwara, Y|Monden, M
PMID: 11275980
Journal: Zhonghua Zhong Liu Za Zhi. 2003 Sep;25(5):441-4.
Title: [Rac subfamily expression and activity in gastrointestinal cancer cell lines].
Author: Pan, Yang-lin|Bi, Feng|Liu, Na|Du, Jing-ping|Jiang, Hai-ping|Xue, Yan|Fan, Dai-ming
PMID: 14575565
Journal: Biochem Biophys Res Commun. 2004 Mar 12;315(3):686-91.
Title: Expression of seven main Rho family members in gastric carcinoma.
Author: Pan, Yanglin|Bi, Feng|Liu, Na|Xue, Yan|Yao, Xuebiao|Zheng, Yi|Fan, Daiming
PMID: 14975755
Journal: Biochem Biophys Res Commun. 2004 Aug 6;320(4):1309-1315.
Title: Inhibition of endothelial cell proliferation by targeting Rac1 GTPase with small interference RNA in tumor cells.
Author: Xue, Yan|Bi, Feng|Zhang, Xueyong|Pan, Yanglin|Liu, Na|Zheng, Yi|Fan, Daiming
PMID: 15303276
Journal: Zhonghua Zhong Liu Za Zhi. 2004 Sep;26(9):517-20.
Title: [Expressions and activities of Rho GTPases in hypoxia and its relationship with tumor angiogenesis].
Author: Xue, Yan|Bi, Feng|Liu, Wen-chao|Pan, Yang-lin|Han, Zhe-yi|Liu, Na|Liu, Chang-jiang|Shen, Hui-qin|Zhang, Xue-yong
PMID: 15555278
Journal: J Biol Chem. 2005 Feb 11;280(6):4279-88. Epub 2004 Nov 23.
Title: NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages.
Author: Basak, Chaitali|Pathak, Sushil Kumar|Bhattacharyya, Asima|Mandal, Debabrata|Pathak, Shresh|Kundu, Manikuntala
PMID: 15561713
Journal: Genes Chromosomes Cancer. 2005 Mar;42(3):280-6.
Title: Nucleotide variants within the IQGAP1 gene in diffuse-type gastric cancers.
Author: Morris, Leah E|Bloom, George S|Frierson, Henry F Jr|Powell, Steven M
PMID: 15611933
Journal: J Biol Chem. 2005 Aug 5;280(31):28357-64. Epub 2005 Jun 16.
Title: Cell adhesion status-dependent histone acetylation is regulated through intracellular contractility-related signaling activities.
Author: Kim, Yong-Bae|Yu, Jiyon|Lee, Sung-Yul|Lee, Mi-Sook|Ko, Seong-Gyu|Ye, Sang-Kyu|Jong, Hyun-Soon|Kim, Tae-You|Bang, Yung-Jue|Lee, Jung Weon
PMID: 15961394
Journal: J Exp Med. 2005 Nov 7;202(9):1235-47.
Title: Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion.
Author: Suzuki, Masato|Mimuro, Hitomi|Suzuki, Toshihiko|Park, Morag|Yamamoto, Tadashi|Sasakawa, Chihiro
PMID: 16275761
Journal: Int J Cancer. 2006 Jun 15;118(12):2965-72.
Title: Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation.
Author: Xue, Yan|Bi, Feng|Zhang, Xueyong|Zhang, Siyuan|Pan, Yanglin|Liu, Na|Shi, Yongquan|Yao, Xuebiao|Zheng, Yi|Fan, Daiming
PMID: 16395716
Journal: Zhonghua Yi Xue Za Zhi. 2006 Dec 12;86(46):3264-8.
Title: [The effect of calcyclin binding protein on gastric cancer cell proliferation].
Author: Ning, Xiao-xuan|Sun, Shi-ren|Li, Yuan|Gong, Wei-qin|Liu, Li-Li|Sun, Li|Liang, Jie|Pan, Yang-lin|Cheng, Yi|Wu, Kai-chun|Fan, Dai-ming
PMID: 17313807
Journal: Infect Immun. 2007 Mar;75(3):1203-13.
Title: Helicobacter pylori CagA induces AGS cell elongation through a cell retraction defect that is independent of Cdc42, Rac1, and Arp2/3.
Author: Bourzac, Kevin M|Botham, Crystal M|Guillemin, Karen
PMID: 17194805
Journal: Am J Pathol. 2007 Jul;171(1):68-78.
Title: Phosphorylation of ephrin-B1 regulates dissemination of gastric scirrhous carcinoma.
Author: Tanaka, Masamitsu|Kamata, Reiko|Takigahira, Misato|Yanagihara, Kazuyoshi|Sakai, Ryuichi
PMID: 17591954
Journal: Mod Pathol. 2008 May;21(5):544-52.
Title: Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer.
Author: Walch, Axel|Seidl, Stefan|Hermannstadter, Christine|Rauser, Sandra|Deplazes, Joelle|Langer, Rupert|von Weyhern, Claus Hann|Sarbia, Mario|Busch, Raymonde|Feith, Marcus|Gillen, Sonja|Hofler, Heinz|Luber, Birgit
PMID: 18246045
Journal: J Cell Biochem. 2008 Jun 1;104(3):1102-12.
Title: Lysophosphatidic acid promotes cell invasion by up-regulating the urokinase-type plasminogen activator receptor in human gastric cancer cells.
Author: Kim, Mi Ha|Park, Jung Sun|Chang, Hee Jung|Baek, Min Kyung|Kim, Hyeong Rok|Shin, Boo Ahn|Ahn, Bong Whan|Jung, Young Do
PMID: 18247343
Journal: J Exp Clin Cancer Res. 2009 Jun 4;28:73.
Title: Reactive oxygen species regulate urokinase plasminogen activator expression and cell invasion via mitogen-activated protein kinase pathways after treatment with hepatocyte growth factor in stomach cancer cells.
Author: Lee, Kyung Hee|Kim, Sang Woon|Kim, Jae-Ryong
PMID: 19497102
Journal: Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Jul;40(4):588-92.
Title: [The effect of Rac1 siRNA on the biological behaviors of gastrointestinal cancer cells].
Author: Huang, Juan|Lan, Nan|Liu, Ming|Chen, Ji|Zhou, Ji-Tao|Zhu, Ya-Jie|Liu, Su-Rui|Tang, Qiu-Lin|Chen, Xiang-Zheng|Bi, Feng
PMID: 19764550
Journal: Eur J Pharmacol. 2010 Jun 10;635(1-3):40-8.
Title: Icariin exterts negative effects on human gastric cancer cell invasion and migration by vasodilator-stimulated phosphoprotein via Rac1 pathway.
Author: Wang, Yongping|Dong, Huimin|Zhu, Meng|Ou, Yangwen|Zhang, Jie|Luo, Hesheng|Luo, Ruoyu|Wu, Junzhu|Mao, Ming|Liu, Xiaoheng|Zhang, Jingwei|Wei, Lei
PMID: 20307526
Journal: Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2508-16.
Title: Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-kappaB activity and downregulation of PI3K/AKT/small GTPase signals.
Author: Ho, Hsieh-Hsun|Chang, Chi-Sen|Ho, Wei-Chi|Liao, Sheng-You|Wu, Cheng-Hsun|Wang, Chau-Jong
PMID: 20600540
Journal: Mol Med Rep. 2011 Jul-Aug;4(4):697-703.
Title: RhoC protein stimulates migration of gastric cancer cells through interaction with scaffold protein IQGAP1.
Author: Wu, Yan|Chen, Yong-Chang|Sang, Jian-Rong|Xu, Wen-Rong
PMID: 21537845
Journal: Clin Exp Metastasis. 2011 Oct;28(7):627-36.
Title: RhoA/ROCK signaling mediates plasticity of scirrhous gastric carcinoma motility.
Author: Matsuoka, Tasuku|Yashiro, Masakazu|Kato, Yukihiro|Shinto, Osamu|Kashiwagi, Shinichiro|Hirakawa, Kosei
PMID: 21667311
Journal: Zhonghua Zhong Liu Za Zhi. 2011 Sep;33(9):676-80.
Title: [Biological significance of relationship between nuclear localization of Rac1 and progression of gastric carcinoma].
Author: Su, Long|Xu, Wei|Yan, Guang-zhi|Luo, Wei|Wang, Ying-li|Chen, Shuang|Zhang, Yang|Liu, Li-hua
PMID: 22340048
Journal: Mol Cancer Ther. 2012 Feb;11(2):298-307.
Title: An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis.
Author: Hanaki, Hideaki|Yamamoto, Hideki|Sakane, Hiroshi|Matsumoto, Shinji|Ohdan, Hideki|Sato, Akira|Kikuchi, Akira
PMID: 22101459
Journal: J Biol Chem. 2012 Apr 6;287(15):12132-41.
Title: Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells.
Author: Chen, Guang|Chen, Si-Meng|Wang, Xiang|Ding, Xiao-Fei|Ding, Jian|Meng, Ling-Hua
PMID: 22337890
Journal: Oncol Lett. 2013 Aug;6(2):463-467.
Title: Reduced expression of Rho GDP dissociation inhibitor 2 mRNA is associated with lymph node metastasis in gastric carcinoma.
Author: Shida, Atsuo|Fujioka, Shuichi|Takahashi, Naoto|Aoki, Hiroaki|Okamoto, Tomoyoshi|Mitsumori, Norio|Omura, Nobuo|Yanaga, Katsuhiko
PMID: 24137348
Journal: PLoS One. 2013 Jun 14;8(6):e66737.
Title: Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.
Author: Gomes, Catarina|Osorio, Hugo|Pinto, Marta Teixeira|Campos, Diana|Oliveira, Maria Jose|Reis, Celso A
PMID: 23799130
Journal: PLoS One. 2013 Apr 16;8(4):e61674.
Title: PKG II inhibits EGF/EGFR-induced migration of gastric cancer cells.
Author: Jiang, Lu|Lan, Ting|Chen, Yongchang|Sang, Jianrong|Li, Yueying|Wu, Min|Tao, Yan|Wang, Ying|Qian, Hai|Gu, Luo
PMID: 23613900
Journal: Onkologie. 2013;36(3):102-7.
Title: Expression of Rac1, HIF-1alpha, and VEGF in gastric carcinoma: correlation with angiogenesis and prognosis.
Author: Zhan, Hongjie|Liang, Han|Liu, Xiangyu|Deng, Jingyu|Wang, Baogui|Hao, Xishan
PMID: 23485997
Journal: Int J Oncol. 2013 Feb;42(2):565-73.
Title: The activation of proteinase-activated receptor-1 (PAR1) promotes gastric cancer cell alteration of cellular morphology related to cell motility and invasion.
Author: Fujimoto, Daisuke|Hirono, Yasuo|Goi, Takanori|Katayama, Kanji|Matsukawa, Shigeru|Yamaguchi, Akio
PMID: 23242308
Journal: Biomol NMR Assign. 2013 Oct;7(2):121-8.
Title: Backbone assignment and secondary structure of Rnd1, an unusual Rho family small GTPase.
Author: Cao, Shufen|Mao, Xi'an|Liu, Deli|Buck, Matthias
PMID: 22618864
Journal: Asian Pac J Cancer Prev. 2013;14(1):201-8.
Title: Effects of Tiam 1 on invasive capacity of gastric cancer cells in vitro and underlying mechanisms.
Author: Zhu, Jin-Ming|Yu, Pei-Wu
PMID: 23534724
Journal: Asia Pac J Clin Oncol. 2014 Jun;10(2):e33-9.
Title: Expression and significance of Rac1, Pak1 and Rock1 in gastric carcinoma.
Author: Wu, Yong-jun|Tang, Yi|Li, Zhen-feng|Li, Zheng|Zhao, Yi|Wu, Zhen-jiang|Su, Qi
PMID: 23298303
Journal: Int J Cancer. 2014 Oct 1;135(7):1553-63.
Title: VEGF-C mediates RhoGDI2-induced gastric cancer cell metastasis and cisplatin resistance.
Author: Cho, Hee Jun|Kim, In-Kyu|Park, Sun-Mi|Baek, Kyoung Eun|Nam, In-Koo|Park, Seung-Ho|Ryu, Ki-Jun|Choi, Jungil|Ryu, Jinhyun|Hong, Soon-Chan|Jeong, Sang-Ho|Lee, Young-Joon|Ko, Gyung-Hyuck|Kim, Jae|Won Lee, Chang|Soo Kang, Sang|Yoo, Jiyun
PMID: 24585459
Journal: Oncol Rep. 2015 Nov;34(5):2357-64.
Title: p120-catenin participates in the progress of gastric cancer through regulating the Rac1 and Pak1 signaling pathway.
Author: Li, Tong-Fei|Qin, Sheng-Hui|Ruan, Xu-Zhi|Wang, Xi
PMID: 26324182
Journal: Oncol Lett. 2015 Jul;10(1):502-508.
Title: Type II cyclic guanosine monophosphate-dependent protein kinase inhibits Rac1 activation in gastric cancer cells.
Author: Wang, Ying|Chen, Yongchang|Wu, Min|Lan, Ting|Wu, Yan|Li, Yueying|Qian, Hai
PMID: 26171059
Journal: Cancer Cell Int. 2015 Apr 15;15:41.
Title: RhoGDI2 up-regulates P-glycoprotein expression via Rac1 in gastric cancer cells.
Author: Zheng, Zhong|Liu, Bingya|Wu, Xiaohua
PMID: 25901126
Journal: Int J Oncol. 2015 Mar;46(3):1343-53.
Title: Rac1 is correlated with aggressiveness and a potential therapeutic target for gastric cancer.
Author: Ji, Jun|Feng, Xiaojing|Shi, Min|Cai, Qu|Yu, Yingyan|Zhu, Zhenggang|Zhang, Jun
PMID: 25585795
Journal: Oncogene. 2015 Jan 29;34(5):650-60.
Title: Asporin activates coordinated invasion of scirrhous gastric cancer and cancer-associated fibroblasts.
Author: Satoyoshi, R|Kuriyama, S|Aiba, N|Yashiro, M|Tanaka, M
PMID: 24441039
Journal: Int J Oncol. 2016 Jan;48(1):199-206.
Title: TIPE2 functions as a metastasis suppressor via negatively regulating beta-catenin through activating GSK3beta in gastric cancer.
Author: Wu, Jie|Zhang, Haitao|Xu, Chun|Xu, Hong|Zhou, Xiumin|Xie, Yufeng|Tao, Min
PMID: 26530498
Journal: Oncotarget. 2016 Mar 1;7(9):10498-512.
Title: Diallyl disulfide suppresses epithelial-mesenchymal transition, invasion and proliferation by downregulation of LIMK1 in gastric cancer.
Author: Su, Bo|Su, Jian|Zeng, Ying|Liu, Fang|Xia, Hong|Ma, Yan-Hua|Zhou, Zhi-Gang|Zhang, Shuo|Yang, Bang-Min|Wu, You-Hua|Zeng, Xi|Ai, Xiao-Hong|Ling, Hui|Jiang, Hao|Su, Qi
PMID: 26871290
Journal: Cancer Gene Ther. 2016 Apr;23(4):98-106.
Title: Adenovirus-directed expression of TIPE2 suppresses gastric cancer growth via induction of apoptosis and inhibition of AKT and ERK1/2 signaling.
Author: Zhu, Y|Tao, M|Wu, J|Meng, Y|Xu, C|Tian, Y|Zhou, X|Xiang, J|Zhang, H|Xie, Y
PMID: 26987289
Journal: Cancer Chemother Pharmacol. 2016 Aug;78(2):249-58.
Title: Rho GTPases: RAC1 polymorphisms affected platinum-based chemotherapy toxicity in lung cancer patients.
Author: Zou, Ting|Yin, Jiye|Zheng, Wei|Xiao, Ling|Tan, Liming|Chen, Juan|Wang, Ying|Li, Xiangping|Qian, Chenyue|Cui, Jiajia|Zhang, Wei|Zhou, Honghao|Liu, Zhaoqian
PMID: 27299748
Journal: Oncotarget. 2016 Oct 4;7(40):65418-65428.
Title: Cross-linked hyaluronic acid gel inhibits metastasis and growth of gastric and hepatic cancer cells: in vitro and in vivo studies.
Author: Lan, Ting|Pang, Ji|Wu, Yan|Zhu, Miaolin|Yao, Xiaoyuan|Wu, Min|Qian, Hai|Zhang, Zhenyu|Gao, Jizong|Chen, Yongchang
PMID: 27589842
Journal: Clin Genet. 2017 Apr;91(4):520-528.
Title: Emerging roles of RAC1 in treating lung cancer patients.
Author: Zou, T|Mao, X|Yin, J|Li, X|Chen, J|Zhu, T|Li, Q|Zhou, H|Liu, Z
PMID: 27790713
Journal: Mol Med Rep. 2017 Oct;16(4):5729-5737.
Title: Type II cGMPdependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells.
Author: Wu, Min|Wu, Yan|Qian, Hai|Tao, Yan|Pang, Ji|Wang, Ying|Chen, Yongchang
PMID: 28849123
Journal: Biochemistry (Mosc). 2017 Jun;82(6):707-714.
Title: MicroRNA-630 Suppresses Epithelial-to-Mesenchymal Transition by Regulating FoxM1 in Gastric Cancer Cells.
Author: Feng, Jing|Wang, Xiaojuan|Zhu, Weihua|Chen, Si|Feng, Changwei
PMID: 28601080
Journal: Br J Biomed Sci. 2017 Jul;74(3):133-137.
Title: The clinical value of Vav3 in peripheral blood for predicting lymphatic metastasis of gastric cancer.
Author: Tan, B|Li, Y|Wang, C|Tan, M|Fan, L|Zhao, Q|Wang, D|Jia, N
PMID: 28513273
Journal: Tumour Biol. 2017 May;39(5):1010428317698392.
Title: Upregulated Vav2 in gastric cancer tissues promotes tumor invasion and metastasis.
Author: Tan, Bi-Bo|Li, Yong|Fan, Li-Qiao|Zhao, Qun|Liu, Qing-Wei|Liu, Yu|Wang, Dong|Jia, Nan
PMID: 28459214
Journal: Onco Targets Ther. 2017 Feb 3;10:627-643.
Title: Asparaginyl endopeptidase improves the resistance of microtubule-targeting drugs in gastric cancer through IQGAP1 modulating the EGFR/JNK/ERK signaling pathway.
Author: Cui, Yuehong|Li, Qian|Li, Hong|Wang, Yan|Wang, Hongshan|Chen, Weidong|Zhang, Shangmin|Cao, Jian|Liu, Tianshu
PMID: 28223821
Journal: PLoS One. 2017 Jan 18;12(1):e0170298.
Title: miR 1296-5p Inhibits the Migration and Invasion of Gastric Cancer Cells by Repressing ERBB2 Expression.
Author: Shan, Xia|Wen, Wei|Zhu, Danxia|Yan, Ting|Cheng, Wenfang|Huang, Zebo|Zhang, Lan|Zhang, Huo|Wang, Tongshan|Zhu, Wei|Zhu, Yichao|Zhu, Jun
PMID: 28099468
Journal: Biomed Pharmacother. 2017 Feb;86:434-440.
Title: Traditional Chinese medicine Jianpi Bushen therapy suppresses the onset of pre-metastatic niche in a murine model of spontaneous lung metastasis.
Author: Zhu, Xiaoyun|Zhou, Yu|Xu, Qiu|Wu, Jie
PMID: 28012398
Journal: Oncogene. 2017 Jun 8;36(23):3213-3222.
Title: Rho GTPases: Anti- or pro-neoplastic targets?
Author: Zandvakili, I|Lin, Y|Morris, J C|Zheng, Y
PMID: 27991930
Journal: J Exp Clin Cancer Res. 2018 Mar 27;37(1):71.
Title: miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis.
Author: Li, Xiaowei|Jiang, Mingzuo|Chen, Di|Xu, Bing|Wang, Rui|Chu, Yi|Wang, Weijie|Zhou, Lin|Lei, Zhijie|Nie, Yongzhan|Fan, Daiming|Shang, Yulong|Wu, Kaichun|Liang, Jie
PMID: 29587866
Journal: Oncol Rep. 2018 Jun;39(6):2797-2806.
Title: Diallyl disulfide inhibits TGFbeta1induced upregulation of Rac1 and betacatenin in epithelialmesenchymal transition and tumor growth of gastric cancer.
Author: Su, Bo|Su, Jian|Zeng, Ying|Ding, En|Liu, Fang|Tan, Tuo|Xia, Hong|Wu, You-Hua|Zeng, Xi|Ling, Hui|Jiang, Hao|Ai, Xiao-Hong|Su, Qi
PMID: 29620286
Journal: Mol Carcinog. 2018 Sep;57(9):1144-1155.
Title: PIEZO1 functions as a potential oncogene by promoting cell proliferation and migration in gastric carcinogenesis.
Author: Zhang, Jinglin|Zhou, Yuhang|Huang, Tingting|Wu, Feng|Liu, Liping|Kwan, Johnny S H|Cheng, Alfred S L|Yu, Jun|To, Ka Fai|Kang, Wei
PMID: 29683214
Journal: Biomed Pharmacother. 2018 Jul;103:823-828.
Title: Inhibition of gastric cancer by local anesthetic bupivacaine through multiple mechanisms independent of sodium channel blockade.
Author: Dan, Jiapeng|Gong, Xiaodan|Li, Dezhan|Zhu, Guanhua|Wang, Lishen|Li, Fang
PMID: 29684861
Journal: Gastric Cancer. 2018 Jun 1. pii: 10.1007/s10120-018-0841-y.
Title: Multi-marker analysis of genomic annotation on gastric cancer GWAS data from Chinese populations.
Author: Yu, Fei|Tian, Tian|Deng, Bin|Wang, Tianpei|Qi, Qi|Zhu, Meng|Yan, Caiwang|Ding, Hui|Wang, Jinchen|Dai, Juncheng|Ma, Hongxia|Ding, Yanbing|Jin, Guangfu
PMID: 29859005
Journal: Biomed Rep. 2018 Aug;9(2):147-155.
Title: miR-124-3p acts as a potential marker and suppresses tumor growth in gastric cancer.
Author: Liu, Feng|Hu, Hongjuan|Zhao, Jianfu|Zhang, Zhiwei|Ai, Xiaohong|Tang, Liyun|Xie, Liming
PMID: 30013778
Journal: Cell Physiol Biochem. 2018;48(4):1457-1467.
Title: Neogenin-1 Promotes Cell Proliferation, Motility, and Adhesion by Up-Regulation of Zinc Finger E-Box Binding Homeobox 1 Via Activating the Rac1/PI3K/AKT Pathway in Gastric Cancer Cells.
Author: Qu, Hengyi|Sun, Huabo|Wang, Xueping
PMID: 30064133