Primary Site >> Colorectal Cancer

Gene >> PTPA

Journal: Science. 1998 Oct 9;282(5387):284-7.
Title: Alterations of the PPP2R1B gene in human lung and colon cancer.
Author: Wang, S S|Esplin, E D|Li, J L|Huang, L|Gazdar, A|Minna, J|Evans, G A
PMID: 9765152
Journal: Mol Pharmacol. 1999 Sep;56(3):515-25.
Title: Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A.
Author: Rajesh, D|Schell, K|Verma, A K
PMID: 10462539
Journal: Cancer Res. 1999 Sep 1;59(17):4170-4.
Title: Alterations of the PPP1R3 gene in human cancer.
Author: Kohno, T|Takakura, S|Yamada, T|Okamoto, A|Tanaka, T|Yokota, J
PMID: 10485448
Journal: Oncogene. 2000 Feb 24;19(9):1191-5.
Title: Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms.
Author: Calin, G A|di Iasio, M G|Caprini, E|Vorechovsky, I|Natali, P G|Sozzi, G|Croce, C M|Barbanti-Brodano, G|Russo, G|Negrini, M
PMID: 10713707
Journal: Genes Chromosomes Cancer. 2000 Aug;28(4):443-53.
Title: Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding.
Author: Webster, M T|Rozycka, M|Sara, E|Davis, E|Smalley, M|Young, N|Dale, T C|Wooster, R
PMID: 10862053
Journal: Oncogene. 2001 Apr 5;20(15):1892-9.
Title: Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene.
Author: Ruediger, R|Pham, H T|Walter, G
PMID: 11313937
Journal: Invest New Drugs. 2002 Feb;20(1):1-11.
Title: Anticancer activity and protein phosphatase 1 and 2A inhibition of a new generation of cantharidin analogues.
Author: Sakoff, Jennette A|Ackland, Stephen P|Baldwin, Monique L|Keane, Mirella A|McCluskey, Adam
PMID: 12003183
Journal: Cancer Chemother Pharmacol. 2004 Mar;53(3):225-32.
Title: Serine/threonine protein phosphatase inhibition enhances the effect of thymidylate synthase inhibition.
Author: Sakoff, Jennette A|Howitt, Ian J|Ackland, Stephen P|McCluskey, Adam
PMID: 14648018
Journal: Bioorg Med Chem Lett. 2004 Apr 19;14(8):1969-73.
Title: Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity.
Author: Hart, Matthew E|Chamberlin, A Richard|Walkom, Cecilia|Sakoff, Jennette A|McCluskey, Adam
PMID: 15050639
Journal: Int J Radiat Biol. 2004 Apr;80(4):269-79.
Title: Radiosensitization of tumour cells by cantharidin and some analogues.
Author: Price, W A|Stobbe, C C|Park, S-J|Chapman, J D
PMID: 15204704
Journal: J Biol Chem. 2004 Oct 1;279(40):41377-83.
Title: Protein phosphatase 2A, a negative regulator of the ERK signaling pathway, is activated by tyrosine phosphorylation of putative HLA class II-associated protein I (PHAPI)/pp32 in response to the antiproliferative lectin, jacalin.
Author: Yu, Lu-Gang|Packman, Len C|Weldon, Mike|Hamlett, Jane|Rhodes, Jonathan M
PMID: 15247276
Journal: Oncogene. 2004 Oct 21;23(49):8049-64.
Title: Dynamic evolution of the adenine nucleotide translocase interactome during chemotherapy-induced apoptosis.
Author: Verrier, Florence|Deniaud, Aurelien|Lebras, Morgane|Metivier, Didier|Kroemer, Guido|Mignotte, Bernard|Jan, Gwenael|Brenner, Catherine
PMID: 15377997
Journal: Oncogene. 2006 Oct 19;25(49):6447-56.
Title: Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A.
Author: Bos, C L|Kodach, L L|van den Brink, G R|Diks, S H|van Santen, M M|Richel, D J|Peppelenbosch, M P|Hardwick, J C H
PMID: 16878161
Journal: Carcinogenesis. 2006 Dec;27(12):2371-82.
Title: Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/beta-catenin pathway activity.
Author: Bos, Carina L|Diks, Sander H|Hardwick, James C H|Walburg, Kimberley V|Peppelenbosch, Maikel P|Richel, Dick J
PMID: 16728434
Journal: Carcinogenesis. 2006 Sep;27(9):1812-27. Epub 2006 Mar 7.
Title: Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells.
Author: Guichard, Cecile|Pedruzzi, Eric|Fay, Michele|Marie, Jean-Claude|Braut-Boucher, Francoise|Daniel, Fanny|Grodet, Alain|Gougerot-Pocidalo, Marie-Anne|Chastre, Eric|Kotelevets, Larissa|Lizard, Gerard|Vandewalle, Alain|Driss, Fathi|Ogier-Denis, Eric
PMID: 16524888
Journal: Apoptosis. 2007 Jan;12(1):235-46.
Title: Comparison of the rapid pro-apoptotic effect of trans-beta-nitrostyrenes with delayed apoptosis induced by the standard agent 5-fluorouracil in colon cancer cells.
Author: Werner, Jens Martin|Eger, Kurt|Jurgen Steinfelder, Hans
PMID: 17136318
Journal: Cell. 2007 Jul 13;130(1):51-62.
Title: CIP2A inhibits PP2A in human malignancies.
Author: Junttila, Melissa R|Puustinen, Pietri|Niemela, Minna|Ahola, Raija|Arnold, Hugh|Bottzauw, Trine|Ala-aho, Risto|Nielsen, Christina|Ivaska, Johanna|Taya, Yoichi|Lu, Shi-Long|Lin, Shujun|Chan, Edward K L|Wang, Xiao-Jing|Grenman, Reidar|Kast, Juergen|Kallunki,
PMID: 17632056
Journal: Ai Zheng. 2007 Oct;26(10):1041-6.
Title: [Mechanism of Wnt signaling pathway regulation by a truncated mutant of Axin2 in colorectal cancer].
Author: Wang, Feng-Wei|Wen, Ling|Zhu, Si-Wei|Yao, Qiang|Cai, Yu-Mei|Ma, Gang
PMID: 17927870
Journal: Cancer Metastasis Rev. 2008 Jun;27(2):159-68.
Title: Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias.
Author: Perrotti, Danilo|Neviani, Paolo
PMID: 18213449
Journal: J Cancer Res Clin Oncol. 2009 Jan;135(1):131-40.
Title: Differential IL-4/Stat6 activities correlate with differential expression of regulatory genes SOCS-1, SHP-1, and PP2A in colon cancer cells.
Author: Yuan, Qin|Li, Pin Dong|Li, Ben Hui|Yang, Xian Zi|Xu, Shuang Bing|Liu, Xiao Hong|Zhou, Fu Xiang|Zhang, Wen Jie
PMID: 18536936
Journal: Cancer Cell. 2010 Nov 16;18(5):459-71.
Title: B55beta-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer.
Author: Tan, Jing|Lee, Puay Leng|Li, Zhimei|Jiang, Xia|Lim, Yaw Chyn|Hooi, Shing Chuan|Yu, Qiang
PMID: 21075311
Journal: J Cell Biochem. 2012 May;113(5):1733-43.
Title: Silibinin suppresses the maintenance of colorectal cancer stem-like cells by inhibiting PP2A/AKT/mTOR pathways.
Author: Wang, Jir-You|Chang, Chia-Chi|Chiang, Chao-Ching|Chen, Wei-Ming|Hung, Shih-Chieh
PMID: 22213051
Journal: J Virol. 2012 May;86(10):5742-51.
Title: Retroviral cyclin enhances cyclin-dependent kinase-8 activity.
Author: Rovnak, Joel|Brewster, Connie D|Quackenbush, Sandra L
PMID: 22379099
Journal: PLoS One. 2012;7(4):e35123.
Title: GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and Akt pathway after epirubicin treatment in colon cancer DLD-1 cells.
Author: Chang, Yu-Jia|Huang, Yi-Ping|Li, Zih-Ling|Chen, Ching-Hsein
PMID: 22529978
Journal: Oncol Rep. 2012 Dec;28(6):2290-8.
Title: Role of FBXL20 in human colorectal adenocarcinoma.
Author: Zhu, Jianjun|Li, Kai|Dong, Lei|Chen, Yao
PMID: 23023584
Journal: PLoS One. 2012;7(11):e49605.
Title: Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27.
Author: Lin, Shih-Pei|Lee, Yi-Ting|Wang, Jir-You|Miller, Stephanie A|Chiou, Shih-Hwa|Hung, Mien-Chie|Hung, Shih-Chieh
PMID: 23185379
Journal: Mol Cancer Ther. 2013 Nov;12(11):2483-93.
Title: The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells.
Author: Sreevalsan, Sandeep|Safe, Stephen
PMID: 24030632
Journal: Cancer Lett. 2013 Jul 10;335(1):9-18.
Title: Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer.
Author: Seshacharyulu, Parthasarathy|Pandey, Poomy|Datta, Kaustubh|Batra, Surinder K
PMID: 23454242
Journal: Cancer Lett. 2013 Jan 28;328(2):226-34.
Title: Colon cancer stem cells resist antiangiogenesis therapy-induced apoptosis.
Author: Lin, Shih-Pei|Lee, Yi-Ting|Yang, Shung-Haur|Miller, Stephanie A|Chiou, Shih-Hwa|Hung, Mien-Chie|Hung, Shih-Chieh
PMID: 23017941
Journal: Arch Biochem Biophys. 2013 May;533(1-2):47-54.
Title: Differential effect of adenosine receptors on growth of human colon cancer HCT 116 and HT-29 cell lines.
Author: Sakowicz-Burkiewicz, Monika|Kitowska, Agnieszka|Grden, Marzena|Maciejewska, Izabela|Szutowicz, Andrzej|Pawelczyk, Tadeusz
PMID: 23454010
Journal: Mol Cancer Ther. 2014 Apr;13(4):938-47.
Title: PP2A inhibition is a common event in colorectal cancer and its restoration using FTY720 shows promising therapeutic potential.
Author: Cristobal, Ion|Manso, Rebeca|Rincon, Raul|Carames, Cristina|Senin, Clara|Borrero, Aurea|Martinez-Useros, Javier|Rodriguez, Maria|Zazo, Sandra|Aguilera, Oscar|Madoz-Gurpide, Juan|Rojo, Federico|Garcia-Foncillas, Jesus
PMID: 24448818
Journal: Hepatology. 2014 Jun;59(6):2238-50.
Title: Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis.
Author: Bera, Rabindranath|Chiou, Chih-Yung|Yu, Ming-Chin|Peng, Jei-Ming|He, Chung-Ru|Hsu, Chih-Yun|Huang, Hsiao-Ling|Ho, Uda Y|Lin, Shi-Ming|Lin, Yu-Jr|Hsieh, Sen-Yung
PMID: 24470239
Journal: BMC Cancer. 2014 Mar 1;14:145.
Title: Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer.
Author: Agarwal, Ekta|Chaudhuri, Anathbandhu|Leiphrakpam, Premila D|Haferbier, Katie L|Brattain, Michael G|Chowdhury, Sanjib
PMID: 24581231
Journal: Int J Clin Exp Pathol. 2014 Feb 15;7(3):1147-53. eCollection 2014.
Title: Protein phosphatase-2A is down-regulated in patients within clear cell renal cell carcinoma.
Author: Li, Jun|Sheng, Chang|Li, Wei|Zheng, Jun-Hua
PMID: 24696731
Journal: Oncol Lett. 2014 Apr;7(4):1203-1208.
Title: Involvement of SET in the Wnt signaling pathway and the development of human colorectal cancer.
Author: Dong, Lei|Zhu, Jianjun|Wen, Xiaoxia|Jiang, Tingting|Chen, Yao
PMID: 24944693
Journal: Biochim Biophys Acta. 2014 Sep;1842(9):1823-9.
Title: Hyperphosphorylation of PP2A in colorectal cancer and the potential therapeutic value showed by its forskolin-induced dephosphorylation and activation.
Author: Cristobal, Ion|Rincon, Raul|Manso, Rebeca|Madoz-Gurpide, Juan|Carames, Cristina|del Puerto-Nevado, Laura|Rojo, Federico|Garcia-Foncillas, Jesus
PMID: 24997451
Journal: Oncotarget. 2014 Jul 15;5(13):4581-602.
Title: Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): an oncoprotein with many hands.
Author: De, Pradip|Carlson, Jennifer|Leyland-Jones, Brian|Dey, Nandini
PMID: 25015035
Journal: Med Oncol. 2014 Aug;31(8):92.
Title: The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer.
Author: Wen, Xiaoxia|Zhu, Jianjun|Dong, Lei|Chen, Yao
PMID: 25023051
Journal: Biofactors. 2014 Nov-Dec;40(6):586-95.
Title: Green tea polyphenol EGCG suppresses Wnt/beta-catenin signaling by promoting GSK-3beta- and PP2A-independent beta-catenin phosphorylation/degradation.
Author: Oh, Sangtaek|Gwak, Jungsug|Park, Seoyoung|Yang, Chung S
PMID: 25352148
Journal: Elife. 2015 Nov 27;4.
Title: Greatwall promotes cell transformation by hyperactivating AKT in human malignancies.
Author: Vera, Jorge|Lartigue, Lydia|Vigneron, Suzanne|Gadea, Gilles|Gire, Veronique|Del Rio, Maguy|Soubeyran, Isabelle|Chibon, Frederic|Lorca, Thierry|Castro, Anna
PMID: 26613407
Journal: EBioMedicine. 2015 Dec 15;2(12):1848-9.
Title: PP2A Level in Colorectal Cancer Cells Predicts the Response of p38 Targeted Therapy.
Author: Shang, Chaowei|Huang, Shile
PMID: 26844254
Journal: Cancer Med. 2015 Dec;4(12):1798-808.
Title: Protein phosphatase methylesterase-1 (PME-1) expression predicts a favorable clinical outcome in colorectal cancer.
Author: Kaur, Amanpreet|Elzagheid, Adam|Birkman, Eva-Maria|Avoranta, Tuulia|Kytola, Ville|Korkeila, Eija|Syrjanen, Kari|Westermarck, Jukka|Sundstrom, Jari
PMID: 26377365
Journal: Oncogene. 2015 Dec 3;34(49):5971-82.
Title: An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis.
Author: Zhu, G|Fan, Z|Ding, M|Zhang, H|Mu, L|Ding, Y|Zhang, Y|Jia, B|Chen, L|Chang, Z|Wu, W
PMID: 25746002
Journal: Clin Cancer Res. 2015 Jan 15;21(2):347-56.
Title: Deregulation of the PP2A inhibitor SET shows promising therapeutic implications and determines poor clinical outcome in patients with metastatic colorectal cancer.
Author: Cristobal, Ion|Rincon, Raul|Manso, Rebeca|Carames, Cristina|Zazo, Sandra|Madoz-Gurpide, Juan|Rojo, Federico|Garcia-Foncillas, Jesus
PMID: 25388166
Journal: Mol Carcinog. 2015 Nov;54(11):1430-41.
Title: Protein phosphatase 2A is essential to maintain active Wnt signaling and its Abeta tumor suppressor subunit is not expressed in colon cancer cells.
Author: Carmen Figueroa-Aldariz, M|Castaneda-Patlan, M Cristina|Santoyo-Ramos, Paula|Zentella, Alejandro|Robles-Flores, Martha
PMID: 25252130
Journal: Oncotarget. 2016 Jan 26;7(4):4542-58.
Title: The B56gamma3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1.
Author: Lai, Tai-Yu|Yen, Chia-Jui|Tsai, Hung-Wen|Yang, Yu-San|Hong, Wei-Fu|Chiang, Chi-Wu
PMID: 26684356
Journal: Oncol Rep. 2016 May;35(5):2833-42.
Title: FTY720-induced enhancement of autophagy protects cells from FTY720 cytotoxicity in colorectal cancer.
Author: Li, Juan|Wang, Shu-Wei|Zhang, Dong-Sheng|Sun, Ye|Zhu, Chun-Yan|Fei, Qiang|Hu, Jun|Zhang, Chuan|Sun, Yue-Ming
PMID: 26985637
Journal: Oncotarget. 2016 May 3;7(18):25862-71.
Title: HDAC1 controls CIP2A transcription in human colorectal cancer cells.
Author: Balliu, Manjola|Cellai, Cristina|Lulli, Matteo|Laurenzana, Anna|Torre, Eugenio|Vannucchi, Alessandro Maria|Paoletti, Francesco
PMID: 27029072
Journal: Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G221-36.
Title: PAR2-dependent activation of GSK3beta regulates the survival of colon stem/progenitor cells.
Author: Nasri, Imen|Bonnet, Delphine|Zwarycz, Bailey|d'Aldebert, Emilie|Khou, Sokchea|Mezghani-Jarraya, Raoudha|Quaranta, Muriel|Rolland, Corinne|Bonnart, Chrystelle|Mas, Emmanuel|Ferrand, Audrey|Cenac, Nicolas|Magness, Scott|Van Landeghem, Laurianne|Vergnolle, N
PMID: 27313176
Journal: Oncotarget. 2017 Jun 20;8(25):40169-40180.
Title: Downregulation of microRNA-199b predicts unfavorable prognosis and emerges as a novel therapeutic target which contributes to PP2A inhibition in metastatic colorectal cancer.
Author: Cristobal, Ion|Carames, Cristina|Rincon, Raul|Manso, Rebeca|Madoz-Gurpide, Juan|Torrejon, Blanca|Gonzalez-Alonso, Paula|Rojo, Federico|Garcia-Foncillas, Jesus
PMID: 27517624
Journal: Cancer Lett. 2017 Apr 1;390:48-57.
Title: The depletion of ATM inhibits colon cancer proliferation and migration via B56gamma2-mediated Chk1/p53/CD44 cascades.
Author: Liu, Rui|Tang, Jiajia|Ding, Chaodong|Liang, Weicheng|Zhang, Li|Chen, Tianke|Xiong, Yan|Dai, Xiaowei|Li, Wenfeng|Xu, Yunsheng|Hu, Jin|Lu, Liting|Liao, Wanqin|Lu, Xincheng
PMID: 28093285
Journal: Cell Rep. 2017 Feb 14;18(7):1699-1712.
Title: The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1alpha Levels and Colorectal Cancer Cell Survival under Hypoxia.
Author: Di Conza, Giusy|Trusso Cafarello, Sarah|Loroch, Stefan|Mennerich, Daniela|Deschoemaeker, Sofie|Di Matteo, Mario|Ehling, Manuel|Gevaert, Kris|Prenen, Hans|Zahedi, Rene Peiman|Sickmann, Albert|Kietzmann, Thomas|Moretti, Fabiola|Mazzone, Massimiliano
PMID: 28199842
Journal: Oncotarget. 2017 Sep 28;8(56):95810-95823.
Title: Targeting PP2A activates AMPK signaling to inhibit colorectal cancer cells.
Author: Dai, Cuiping|Zhang, Xuning|Xie, Da|Tang, Peipei|Li, Chunmei|Zuo, Yi|Jiang, Baofei|Xue, Caiping
PMID: 29221169
Journal: Cancer Med. 2018 Mar;7(3):698-706.
Title: Protein phosphatase 2A (PP2A) inhibitor CIP2A indicates resistance to radiotherapy in rectal cancer.
Author: Birkman, Eva-Maria|Elzagheid, Adam|Jokilehto, Terhi|Avoranta, Tuulia|Korkeila, Eija|Kulmala, Jarmo|Syrjanen, Kari|Westermarck, Jukka|Sundstrom, Jari
PMID: 29441695
Journal: Int J Oncol. 2018 Mar 16.
Title: Ethoxysanguinarine inhibits viability and induces apoptosis of colorectal cancer cells by inhibiting CIP2A.
Author: Jin, Lan|Si, Yuan|Hong, Xing|Liu, Pengfei|Zhu, Beibei|Yu, Huiliang|Zhao, Xinhua|Qin, Shanshan|Xiong, Mengyuan|Liu, Ying|Luo, Zhiguo|Guo, Yang
PMID: 29568959
Journal: World J Surg. 2018 May 23. pii: 10.1007/s00268-018-4684-9.
Title: Analysis of Potential Alterations Affecting SETBP1 as a Novel Contributing Mechanism to Inhibit PP2A in Colorectal Cancer Patients.
Author: Torrejon, Blanca|Cristobal, Ion|Carames, Cristina|Prieto-Potin, Ivan|Chamizo, Cristina|Santos, Andrea|Sanz-Alvarez, Marta|Serna-Blasco, Roberto|Luque, Melania|Madoz-Gurpide, Juan|Rojo, Federico|Garcia-Foncillas, Jesus
PMID: 29796729
Journal: Oncogene. 2018 Sep 10. pii: 10.1038/s41388-018-0493-8.
Title: KIAA1199 promotes metastasis of colorectal cancer cells via microtubule destabilization regulated by a PP2A/stathmin pathway.
Author: Zhao, Lei|Zhang, Dejun|Shen, Qiong|Jin, Min|Lin, Zhenyu|Ma, Hong|Huang, Shaoyi|Zhou, Pengfei|Wu, Gang|Zhang, Tao
PMID: 30202098
Journal: Anticancer Res. 2018 Oct;38(10):5791-5798.
Title: Kisspeptin Inhibits Colorectal Cancer Cell Invasiveness by Activating PKR and PP2A.
Author: Kim, Jeong Nam|Kim, Tae Hun|Yoon, Ji-Hye|Cho, Sung-Gook
PMID: 30275201