Primary Site >> Colorectal Cancer
Gene >> PTPA
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Ref: Alterations of the PPP2R1B gene in human lung and colon cancer. PMID: 9765152 |
Ref: Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A. PMID: 10462539 Ref: Alterations of the PPP1R3 gene in human cancer. PMID: 10485448 |
Ref: Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms. PMID: 10713707 Ref: Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding. PMID: 10862053 |
Ref: Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene. PMID: 11313937 |
Ref: Anticancer activity and protein phosphatase 1 and 2A inhibition of a new generation of cantharidin analogues. PMID: 12003183 |
Ref: Serine/threonine protein phosphatase inhibition enhances the effect of thymidylate synthase inhibition. PMID: 14648018 Ref: Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity. PMID: 15050639 Ref: Radiosensitization of tumour cells by cantharidin and some analogues. PMID: 15204704 Ref: Protein phosphatase 2A, a negative regulator of the ERK signaling pathway, is activated by tyrosine phosphorylation of putative HLA class II-associated protein I (PHAPI)/pp32 in response to the antiproliferative lectin, jacalin. PMID: 15247276 Ref: Dynamic evolution of the adenine nucleotide translocase interactome during chemotherapy-induced apoptosis. PMID: 15377997 |
Ref: Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells. PMID: 16524888 Ref: Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/beta-catenin pathway activity. PMID: 16728434 Ref: Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. PMID: 16878161 |
Ref: Comparison of the rapid pro-apoptotic effect of trans-beta-nitrostyrenes with delayed apoptosis induced by the standard agent 5-fluorouracil in colon cancer cells. PMID: 17136318 Ref: CIP2A inhibits PP2A in human malignancies. PMID: 17632056 Ref: [Mechanism of Wnt signaling pathway regulation by a truncated mutant of Axin2 in colorectal cancer]. PMID: 17927870 |
Ref: Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias. PMID: 18213449 |
Ref: Differential IL-4/Stat6 activities correlate with differential expression of regulatory genes SOCS-1, SHP-1, and PP2A in colon cancer cells. PMID: 18536936 |
Ref: B55beta-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer. PMID: 21075311 |
Ref: Silibinin suppresses the maintenance of colorectal cancer stem-like cells by inhibiting PP2A/AKT/mTOR pathways. PMID: 22213051 Ref: Retroviral cyclin enhances cyclin-dependent kinase-8 activity. PMID: 22379099 Ref: GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and Akt pathway after epirubicin treatment in colon cancer DLD-1 cells. PMID: 22529978 Ref: Role of FBXL20 in human colorectal adenocarcinoma. PMID: 23023584 Ref: Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27. PMID: 23185379 |
Ref: Colon cancer stem cells resist antiangiogenesis therapy-induced apoptosis. PMID: 23017941 Ref: Differential effect of adenosine receptors on growth of human colon cancer HCT 116 and HT-29 cell lines. PMID: 23454010 Ref: Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. PMID: 23454242 Ref: The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells. PMID: 24030632 |
Ref: PP2A inhibition is a common event in colorectal cancer and its restoration using FTY720 shows promising therapeutic potential. PMID: 24448818 Ref: Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis. PMID: 24470239 Ref: Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer. PMID: 24581231 Ref: Protein phosphatase-2A is down-regulated in patients within clear cell renal cell carcinoma. PMID: 24696731 Ref: Involvement of SET in the Wnt signaling pathway and the development of human colorectal cancer. PMID: 24944693 Ref: Hyperphosphorylation of PP2A in colorectal cancer and the potential therapeutic value showed by its forskolin-induced dephosphorylation and activation. PMID: 24997451 Ref: Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): an oncoprotein with many hands. PMID: 25015035 Ref: The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer. PMID: 25023051 Ref: Green tea polyphenol EGCG suppresses Wnt/beta-catenin signaling by promoting GSK-3beta- and PP2A-independent beta-catenin phosphorylation/degradation. PMID: 25352148 |
Ref: Protein phosphatase 2A is essential to maintain active Wnt signaling and its Abeta tumor suppressor subunit is not expressed in colon cancer cells. PMID: 25252130 Ref: Deregulation of the PP2A inhibitor SET shows promising therapeutic implications and determines poor clinical outcome in patients with metastatic colorectal cancer. PMID: 25388166 Ref: An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis. PMID: 25746002 Ref: Protein phosphatase methylesterase-1 (PME-1) expression predicts a favorable clinical outcome in colorectal cancer. PMID: 26377365 Ref: Greatwall promotes cell transformation by hyperactivating AKT in human malignancies. PMID: 26613407 Ref: PP2A Level in Colorectal Cancer Cells Predicts the Response of p38 Targeted Therapy. PMID: 26844254 |
Ref: The B56gamma3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1. PMID: 26684356 Ref: FTY720-induced enhancement of autophagy protects cells from FTY720 cytotoxicity in colorectal cancer. PMID: 26985637 Ref: HDAC1 controls CIP2A transcription in human colorectal cancer cells. PMID: 27029072 Ref: PAR2-dependent activation of GSK3beta regulates the survival of colon stem/progenitor cells. PMID: 27313176 |
Ref: Downregulation of microRNA-199b predicts unfavorable prognosis and emerges as a novel therapeutic target which contributes to PP2A inhibition in metastatic colorectal cancer. PMID: 27517624 Ref: The depletion of ATM inhibits colon cancer proliferation and migration via B56gamma2-mediated Chk1/p53/CD44 cascades. PMID: 28093285 Ref: The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1alpha Levels and Colorectal Cancer Cell Survival under Hypoxia. PMID: 28199842 Ref: Targeting PP2A activates AMPK signaling to inhibit colorectal cancer cells. PMID: 29221169 |
Ref: Protein phosphatase 2A (PP2A) inhibitor CIP2A indicates resistance to radiotherapy in rectal cancer. PMID: 29441695 Ref: Ethoxysanguinarine inhibits viability and induces apoptosis of colorectal cancer cells by inhibiting CIP2A. PMID: 29568959 Ref: Analysis of Potential Alterations Affecting SETBP1 as a Novel Contributing Mechanism to Inhibit PP2A in Colorectal Cancer Patients. PMID: 29796729 Ref: KIAA1199 promotes metastasis of colorectal cancer cells via microtubule destabilization regulated by a PP2A/stathmin pathway. PMID: 30202098 Ref: Kisspeptin Inhibits Colorectal Cancer Cell Invasiveness by Activating PKR and PP2A. PMID: 30275201 |