Primary Site >> Colorectal Cancer

Gene >> PTP4A3

Journal: Clin Cancer Res. 2003 Nov 15;9(15):5607-15.
Title: PRL-3 expression in metastatic cancers.
Author: Bardelli, Alberto|Saha, Saurabh|Sager, Jason A|Romans, Kathy E|Xin, Baozhong|Markowitz, Sanford D|Lengauer, Christoph|Velculescu, Victor E|Kinzler, Kenneth W|Vogelstein, Bert
PMID: 14654542
Journal: J Mol Endocrinol. 2003 Feb;30(1):31-47.
Title: Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein.
Author: Trott, J F|Hovey, R C|Koduri, S|Vonderhaar, B K
PMID: 12580759
Journal: Hybrid Hybridomics. 2004 Feb;23(1):23-7.
Title: Preparation and characterization of monoclonal antibody against protein tyrosine phosphatase PRL-3.
Author: Peng, Lirong|Li, Yan|Meng, Ling|Shou, Chengchao
PMID: 15000845
Journal: J Cancer Res Clin Oncol. 2004 Sep;130(9):521-6. Epub 2004 May 6.
Title: The association of the expression level of protein tyrosine phosphatase PRL-3 protein with liver metastasis and prognosis of patients with colorectal cancer.
Author: Peng, Lirong|Ning, Jinying|Meng, Ling|Shou, Chengchao
PMID: 15133662
Journal: Pathobiology. 2004;71(4):176-84.
Title: Expression of PRL-3 phosphatase in human gastric carcinomas: close correlation with invasion and metastasis.
Author: Miskad, Upik Anderiani|Semba, Shuho|Kato, Hirotaka|Yokozaki, Hiroshi
PMID: 15263806
Journal: Cancer Biol Ther. 2004 Oct;3(10):945-51. Epub 2004 Oct 27.
Title: Catalytic domain of PRL-3 plays an essential role in tumor metastasis: formation of PRL-3 tumors inside the blood vessels.
Author: Guo, Ke|Li, Jie|Tang, Jing Ping|Koh, Vicki|Gan, Bin Qi|Zeng, Qi
PMID: 15326366
Journal: Clin Cancer Res. 2004 Nov 1;10(21):7318-28.
Title: High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases.
Author: Kato, Hirotaka|Semba, Shuho|Miskad, Upik A|Seo, Yasushi|Kasuga, Masato|Yokozaki, Hiroshi
PMID: 15534108
Journal: J Biol Chem. 2004 Mar 19;279(12):11882-9. Epub 2004 Jan 1.
Title: Structural insights into molecular function of the metastasis-associated phosphatase PRL-3.
Author: Kozlov, Guennadi|Cheng, Jing|Ziomek, Edmund|Banville, Denis|Gehring, Kalle|Ekiel, Irena
PMID: 14704153
Journal: Cell Oncol. 2005;27(1):57-65.
Title: DNA copy number changes at 8q11-24 in metastasized colorectal cancer.
Author: Buffart, T E|Coffa, J|Hermsen, M A J A|Carvalho, B|van der Sijp, J R M|Ylstra, B|Pals, G|Schouten, J P|Meijer, G A
PMID: 15750208
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2005 May;8(3):237-40.
Title: [Expression of phosphatase of regenerating liver-3 mRNA and its clinical implications in human colorectal carcinoma].
Author: Zhao, Gao-ping|Zhou, Zong-guang|Lei, Wen-zhang|Yu, Yong-yang|Zheng, Xue-lian|Gao, Hong-kai
PMID: 16167237
Journal: Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6835-9.
Title: PRL-3 phosphatase is implicated in ovarian cancer growth.
Author: Polato, Federica|Codegoni, Annamaria|Fruscio, Robert|Perego, Patrizia|Mangioni, Costantino|Saha, Saurabh|Bardelli, Alberto|Broggini, Massimo
PMID: 16203771
Journal: Biochem Biophys Res Commun. 2006 Mar 31;342(1):179-83.
Title: Identification of integrin alpha1 as an interacting protein of protein tyrosine phosphatase PRL-3.
Author: Peng, Lirong|Jin, Genglin|Wang, Li|Guo, Jianpin|Meng, Lin|Shou, Chengchao
PMID: 16472776
Journal: Cancer Res. 2006 Oct 1;66(19):9625-35.
Title: PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo.
Author: Guo, Ke|Li, Jie|Wang, Haihe|Osato, Motomi|Tang, Jing Ping|Quah, Samantha Yiling|Gan, Bin Qi|Zeng, Qi
PMID: 17018620
Journal: Int J Radiat Oncol Biol Phys. 2006 Jun 1;65(2):452-8. Epub 2006 Apr 19.
Title: Expression of PRL proteins at invasive margin of rectal cancers in relation to preoperative radiotherapy.
Author: Wallin, Asa R|Svanvik, Joar|Adell, Gunnar|Sun, Xiao-Feng
PMID: 16626893
Journal: Cancer Res. 2006 Mar 15;66(6):3153-61.
Title: PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility.
Author: Fiordalisi, James J|Keller, Patricia J|Cox, Adrienne D
PMID: 16540666
Journal: Mol Cancer Ther. 2006 Feb;5(2):219-29.
Title: Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function.
Author: Rouleau, Cecile|Roy, Andre|St Martin, Thia|Dufault, Michael R|Boutin, Paula|Liu, Dapei|Zhang, Mindy|Puorro-Radzwill, Kristin|Rulli, Lori|Reczek, Dave|Bagley, Rebecca|Byrne, Ann|Weber, William|Roberts, Bruce|Klinger, Katherine|Brondyk, William|Nacht, Maria
PMID: 16505094
Journal: J Biol Chem. 2007 Feb 23;282(8):5413-9. Epub 2006 Dec 27.
Title: PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation.
Author: Liang, Fubo|Liang, Jiao|Wang, Wei-Qing|Sun, Jin-Peng|Udho, Eshwar|Zhang, Zhong-Yin
PMID: 17192274
Journal: Int J Colorectal Dis. 2007 Oct;22(10):1179-84. Epub 2007 Apr 18.
Title: Expression of the human phosphatases of regenerating liver (PRLs) in colonic adenocarcinoma and its correlation with lymph node metastasis.
Author: Wang, Ying|Li, Zhao-Fa|He, Jin|Li, Yi-Lei|Zhu, Gui-Bin|Zhang, Li-Hong|Li, Yu-Lin
PMID: 17440740
Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2007 May;27(5):641-3.
Title: [Cloning of human PRL-3 gene and construction of its prokaryotic expression vector].
Author: Zhou, Jun|Li, Jian-ming|Liu, Yu-hong|Ding, Yan-qing
PMID: 17545077
Journal: Br J Cancer. 2008 Nov 18;99(10):1718-25.
Title: PRL-3 is essentially overexpressed in primary colorectal tumours and associates with tumour aggressiveness.
Author: Mollevi, D G|Aytes, A|Padulles, L|Martinez-Iniesta, M|Baixeras, N|Salazar, R|Ramos, E|Figueras, J|Capella, G|Villanueva, A
PMID: 19002188
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2008 Sep;11(5):487-91.
Title: [Expression of phosphatase of regeneration liver-3 in human colorectal carcinoma and its prognosis value].
Author: Zhao, Gao-ping|Zhou, Zong-guang|Lei, Wen-zhang|Wang, Cun|Zheng, Xue-lian|Zheng, Yang-chun
PMID: 18803057
Journal: Cancer Biol Ther. 2008 May;7(5):750-7. Epub 2008 May 20.
Title: Monoclonal antibodies target intracellular PRL phosphatases to inhibit cancer metastases in mice.
Author: Guo, Ke|Tang, Jing Ping|Tan, Cheng Peow Bobby|Wang, Haihe|Zeng, Qi
PMID: 18364570
Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2008 Feb;28(2):162-5.
Title: [Expression of the zinc finger transcriptional factor Snail in colorectal carcinoma and its significance].
Author: Gao, Wei-zhe|Li, Jian-ming|Yang, Fa-da|Zhou, Jun|Ding, Yan-qing
PMID: 18250032
Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2008 Apr;28(4):551-4.
Title: [Construction of the life cycle of Angiostrongylus cantonensis in laboratory].
Author: Gu, Jin-bao|Liu, Ming|Li, Hua|Luo, Yu-li|Li, Xiao-xu|Chen, Xiao-guang|Zhan, Xi-mei
PMID: 18495588
Journal: Cancer Biol Ther. 2009 Jul;8(14):1352-9. Epub 2009 Jul 7.
Title: PRL-3 promotes epithelial mesenchymal transition by regulating cadherin directly.
Author: Liu, Yuhong|Zhou, Jun|Chen, Juanzhi|Gao, Weizhe|Le, Yi|Ding, Yanqing|Li, Jianming
PMID: 19440036
Journal: Electrophoresis. 2009 Jul;30(14):2469-76.
Title: 2-D Difference in gel electrophoresis combined with Pro-Q Diamond staining: a successful approach for the identification of kinase/phosphatase targets.
Author: Orsatti, Laura|Forte, Eleonora|Tomei, Licia|Caterino, Marianna|Pessi, Antonello|Talamo, Fabio
PMID: 19639567
Journal: Anticancer Res. 2009 Oct;29(10):3913-6.
Title: PTP4A3 expression increases strongly in lymph node metastases from colorectal carcinoma.
Author: Guzinska-Ustymowicz, Katarzyna|Pryczynicz, Anna|Kemona, Andrzej
PMID: 19846928
Journal: Mol Cancer. 2009 Nov 24;8:110.
Title: PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin beta1-ERK1/2 and-MMP2 signaling.
Author: Peng, Lirong|Xing, Xiaofang|Li, Weijun|Qu, Like|Meng, Lin|Lian, Shenyi|Jiang, Beihai|Wu, Jian|Shou, Chengchao
PMID: 19930715
Journal: J Proteome Res. 2010 Oct 1;9(10):4897-905.
Title: Stathmin, a new target of PRL-3 identified by proteomic methods, plays a key role in progression and metastasis of colorectal cancer.
Author: Zheng, Ping|Liu, Yong-Xia|Chen, Lin|Liu, Xun-Hua|Xiao, Zheng-Quan|Zhao, Liang|Li, Guang-Qiu|Zhou, Jun|Ding, Yan-Qing|Li, Jian-Ming
PMID: 20806969
Journal: Cancer Res. 2011 Jan 1;71(1):234-44.
Title: Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis.
Author: Jiang, Yanjun|Liu, Xiao-Qiong|Rajput, Ashwani|Geng, Liying|Ongchin, Melanie|Zeng, Qi|Taylor, Gregory S|Wang, Jing
PMID: 21084277
Journal: Anticancer Agents Med Chem. 2011 Jan;11(1):99-108.
Title: PRL-3, an emerging marker of carcinogenesis, is strongly associated with poor prognosis.
Author: Guzinska-Ustymowicz, Katarzyna|Pryczynicz, Anna
PMID: 21291404
Journal: Adv Med Sci. 2011;56(1):39-43.
Title: Immunohistochemical assessment of PRL-3 (PTP4A3) expression in tumor buds, invasion front, central region of tumor and metastases of colorectal cancer.
Author: Guzinska-Ustymowicz, K|Pryczynicz, A|Kemona, A|Ustymowicz, M
PMID: 21555304
Journal: Cancer Biol Ther. 2011 Oct 15;12(8):742-9.
Title: Snail as a key regulator of PRL-3 gene in colorectal cancer.
Author: Zheng, Ping|Meng, Hui-Min|Gao, Wei-Zhe|Chen, Lin|Liu, Xun-Hua|Xiao, Zheng-Quan|Liu, Yong-Xia|Sui, Hong-Mei|Zhou, Jun|Liu, Yu-Hong|Li, Jian-Ming
PMID: 21811102
Journal: Biochem Biophys Res Commun. 2013 Jan 4;430(1):196-201.
Title: PRL-3 activates NF-kappaB signaling pathway by interacting with RAP1.
Author: Lian, Shenyi|Meng, Lin|Liu, Caiyun|Xing, Xiaofang|Song, Qian|Dong, Bin|Han, Yong|Yang, Yongyong|Peng, Lirong|Qu, Like|Shou, Chengchao
PMID: 23178297
Journal: Bioorg Med Chem Lett. 2013 Jul 1;23(13):3769-74.
Title: Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells.
Author: Min, Garam|Lee, Su-Kyung|Kim, Hye-Nan|Han, Young-Min|Lee, Rhan-Hee|Jeong, Dae Gwin|Han, Dong Cho|Kwon, Byoung-Mog
PMID: 23726031
Journal: PLoS One. 2013 May 17;8(5):e64309.
Title: Src-mediated phosphorylation of the tyrosine phosphatase PRL-3 is required for PRL-3 promotion of Rho activation, motility and invasion.
Author: Fiordalisi, James J|Dewar, Brian J|Graves, Lee M|Madigan, James P|Cox, Adrienne D
PMID: 23691193
Journal: PLoS One. 2013;8(3):e58300.
Title: Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer.
Author: Zimmerman, Mark W|Homanics, Gregg E|Lazo, John S
PMID: 23555575
Journal: J Biol Chem. 2014 Feb 28;289(9):5904-13.
Title: Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility.
Author: Zimmerman, Mark W|McQueeney, Kelley E|Isenberg, Jeffrey S|Pitt, Bruce R|Wasserloos, Karla A|Homanics, Gregg E|Lazo, John S
PMID: 24403062
Journal: BMC Cancer. 2014 May 10;14:330.
Title: Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner.
Author: Xu, Heyang|Lai, Wei|Zhang, Yang|Liu, Lu|Luo, Xingxi|Zeng, Yujie|Wu, Heng|Lan, Qiusheng|Chu, Zhonghua
PMID: 24885636
Journal: Stem Cell Res. 2014 Jul;13(1):164-171.
Title: Deletion of Ptp4a3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice.
Author: Cramer, Julie M|Zimmerman, Mark W|Thompson, Tim|Homanics, Gregg E|Lazo, John S|Lagasse, Eric
PMID: 24950307
Journal: Clin Exp Metastasis. 2015 Aug;32(6):623-35.
Title: Molecular targets and pathways involved in liver metastasis of colorectal cancer.
Author: Weidle, Ulrich H|Birzele, Fabian|Kruger, Achim
PMID: 26104118
Journal: Clin Exp Metastasis. 2016 Jan;33(1):3-13.
Title: Genomic gain of the PRL-3 gene may represent poor prognosis of primary colorectal cancer, and associate with liver metastasis.
Author: Nakayama, N|Yamashita, K|Tanaka, T|Kawamata, H|Ooki, A|Sato, T|Nakamura, T|Watanabe, M
PMID: 26563151
Journal: Oncol Lett. 2016 Sep;12(3):1661-1666.
Title: PRL-3 promotes cell adhesion by interacting with JAM2 in colon cancer.
Author: Lian, Shenyi|Meng, Lin|Xing, Xiaofang|Yang, Yongyong|Qu, Like|Shou, Chengchao
PMID: 27588115
Journal: Nucleic Acids Res. 2017 Jun 20;45(11):6546-6571.
Title: PRL-3 promotes telomere deprotection and chromosomal instability.
Author: Lian, Shenyi|Meng, Lin|Yang, Yongyong|Ma, Ting|Xing, Xiaofang|Feng, Qin|Song, Qian|Liu, Caiyun|Tian, Zhihua|Qu, Like|Shou, Chengchao
PMID: 28482095
Journal: FASEB J. 2018 Oct;32(10):5661-5673.
Title: A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion.
Author: McQueeney, Kelley E|Salamoun, Joseph M|Ahn, Jennifer G|Pekic, Paula|Blanco, Isabella K|Struckman, Heather L|Sharlow, Elizabeth R|Wipf, Peter|Lazo, John S
PMID: 29746167