Primary Site >> Colorectal Cancer
Gene >> PTP4A3
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein. PMID: 12580759 Ref: PRL-3 expression in metastatic cancers. PMID: 14654542 |
Ref: Structural insights into molecular function of the metastasis-associated phosphatase PRL-3. PMID: 14704153 Ref: Preparation and characterization of monoclonal antibody against protein tyrosine phosphatase PRL-3. PMID: 15000845 Ref: The association of the expression level of protein tyrosine phosphatase PRL-3 protein with liver metastasis and prognosis of patients with colorectal cancer. PMID: 15133662 Ref: Expression of PRL-3 phosphatase in human gastric carcinomas: close correlation with invasion and metastasis. PMID: 15263806 Ref: Catalytic domain of PRL-3 plays an essential role in tumor metastasis: formation of PRL-3 tumors inside the blood vessels. PMID: 15326366 Ref: High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases. PMID: 15534108 |
Ref: DNA copy number changes at 8q11-24 in metastasized colorectal cancer. PMID: 15750208 Ref: [Expression of phosphatase of regenerating liver-3 mRNA and its clinical implications in human colorectal carcinoma]. PMID: 16167237 Ref: PRL-3 phosphatase is implicated in ovarian cancer growth. PMID: 16203771 |
Ref: Identification of integrin alpha1 as an interacting protein of protein tyrosine phosphatase PRL-3. PMID: 16472776 Ref: Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function. PMID: 16505094 Ref: PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility. PMID: 16540666 Ref: Expression of PRL proteins at invasive margin of rectal cancers in relation to preoperative radiotherapy. PMID: 16626893 Ref: PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo. PMID: 17018620 |
Ref: PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation. PMID: 17192274 Ref: Expression of the human phosphatases of regenerating liver (PRLs) in colonic adenocarcinoma and its correlation with lymph node metastasis. PMID: 17440740 Ref: [Cloning of human PRL-3 gene and construction of its prokaryotic expression vector]. PMID: 17545077 |
Ref: [Expression of the zinc finger transcriptional factor Snail in colorectal carcinoma and its significance]. PMID: 18250032 Ref: Monoclonal antibodies target intracellular PRL phosphatases to inhibit cancer metastases in mice. PMID: 18364570 Ref: [Construction of the life cycle of Angiostrongylus cantonensis in laboratory]. PMID: 18495588 Ref: [Expression of phosphatase of regeneration liver-3 in human colorectal carcinoma and its prognosis value]. PMID: 18803057 Ref: PRL-3 is essentially overexpressed in primary colorectal tumours and associates with tumour aggressiveness. PMID: 19002188 |
Ref: PRL-3 promotes epithelial mesenchymal transition by regulating cadherin directly. PMID: 19440036 Ref: 2-D Difference in gel electrophoresis combined with Pro-Q Diamond staining: a successful approach for the identification of kinase/phosphatase targets. PMID: 19639567 Ref: PTP4A3 expression increases strongly in lymph node metastases from colorectal carcinoma. PMID: 19846928 Ref: PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin beta1-ERK1/2 and-MMP2 signaling. PMID: 19930715 |
Ref: Stathmin, a new target of PRL-3 identified by proteomic methods, plays a key role in progression and metastasis of colorectal cancer. PMID: 20806969 |
Ref: Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis. PMID: 21084277 Ref: PRL-3, an emerging marker of carcinogenesis, is strongly associated with poor prognosis. PMID: 21291404 Ref: Immunohistochemical assessment of PRL-3 (PTP4A3) expression in tumor buds, invasion front, central region of tumor and metastases of colorectal cancer. PMID: 21555304 Ref: Snail as a key regulator of PRL-3 gene in colorectal cancer. PMID: 21811102 |
Ref: PRL-3 activates NF-kappaB signaling pathway by interacting with RAP1. PMID: 23178297 Ref: Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer. PMID: 23555575 Ref: Src-mediated phosphorylation of the tyrosine phosphatase PRL-3 is required for PRL-3 promotion of Rho activation, motility and invasion. PMID: 23691193 Ref: Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells. PMID: 23726031 |
Ref: Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility. PMID: 24403062 Ref: Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner. PMID: 24885636 Ref: Deletion of Ptp4a3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice. PMID: 24950307 |
Ref: Molecular targets and pathways involved in liver metastasis of colorectal cancer. PMID: 26104118 |
Ref: Genomic gain of the PRL-3 gene may represent poor prognosis of primary colorectal cancer, and associate with liver metastasis. PMID: 26563151 Ref: PRL-3 promotes cell adhesion by interacting with JAM2 in colon cancer. PMID: 27588115 |
Ref: PRL-3 promotes telomere deprotection and chromosomal instability. PMID: 28482095 |
Ref: A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion. PMID: 29746167 |