Primary Site >> Colorectal Cancer

Gene >> PTGS1

Journal: Cancer Res. 1995 Jun 15;55(12):2556-9.
Title: Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.
Author: Kargman, S L|O'Neill, G P|Vickers, P J|Evans, J F|Mancini, J A|Jothy, S
PMID: 7780968
Journal: Cancer Res. 1995 Sep 1;55(17):3785-9.
Title: Expression of cyclooxygenase-1 and -2 in human colorectal cancer.
Author: Sano, H|Kawahito, Y|Wilder, R L|Hashiramoto, A|Mukai, S|Asai, K|Kimura, S|Kato, H|Kondo, M|Hla, T
PMID: 7641194
Journal: Cancer Lett. 1997 Jun 24;116(2):213-23.
Title: Production of arachidonic acid metabolites by the colon adenocarcinoma cell line HT29 cl.19A and their effect on chloride secretion.
Author: Battu, S|Clement, G|Heyman, M|Wal, J M|Cook-Moreau, J|Desjeux, J F|Beneytout, J L
PMID: 9215866
Journal: Ann Med. 1997 Jun;29(3):247-52.
Title: Cyclo-oxygenase and colon cancer: clues to the aspirin effect?
Author: Gustafson-Svard, C|Lilja, I|Hallbook, O|Sjodahl, R
PMID: 9240630
Journal: J Biol Chem. 1997 Aug 22;272(34):21455-60.
Title: Tumorigenic transformation of immortalized ECV endothelial cells by cyclooxygenase-1 overexpression.
Author: Narko, K|Ristimaki, A|MacPhee, M|Smith, E|Haudenschild, C C|Hla, T
PMID: 9261162
Journal: Eur J Pharmacol. 1998 Nov 6;360(2-3):273-80.
Title: Induction of apoptotic DNA fragmentation by nonsteroidal anti-inflammatory drugs in cultured rat gastric mucosal cells.
Author: Kusuhara, H|Matsuyuki, H|Matsuura, M|Imayoshi, T|Okumoto, T|Matsui, H
PMID: 9851595
Journal: Annu Rev Pharmacol Toxicol. 1998;38:97-120.
Title: Cyclooxygenases 1 and 2.
Author: Vane, J R|Bakhle, Y S|Botting, R M
PMID: 9597150
Journal: J Natl Cancer Inst. 1998 Mar 18;90(6):455-60.
Title: Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer.
Author: Hwang, D|Scollard, D|Byrne, J|Levine, E
PMID: 9521170
Journal: Carcinogenesis. 1998 Jan;19(1):49-53.
Title: The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers.
Author: DuBois, R N|Gupta, R|Brockman, J|Reddy, B S|Krakow, S L|Lazar, M A
PMID: 9472692
Journal: J Histochem Cytochem. 1998 Jan;46(1):77-84.
Title: Expression of prostaglandin G/H synthase type 1, but not type 2, in human ovarian adenocarcinomas.
Author: Dore, M|Cote, L C|Mitchell, A|Sirois, J
PMID: 9405496
Journal: Am J Orthop (Belle Mead NJ). 1999 Mar;28(3 Suppl):8-12.
Title: Role of cyclooxygenase-1 and -2 in health and disease.
Author: Lipsky, P E
PMID: 10193997
Journal: Biochim Biophys Acta. 1999 Apr 19;1438(1):120-30.
Title: Growth stimulation and induction of epidermal growth factor receptor by overexpression of cyclooxygenases 1 and 2 in human colon carcinoma cells.
Author: Kinoshita, T|Takahashi, Y|Sakashita, T|Inoue, H|Tanabe, T|Yoshimoto, T
PMID: 10216286
Journal: J Natl Cancer Inst. 1999 Aug 18;91(16):1398-403.
Title: Induction of prostaglandin G/H synthase-2 in a canine model of spontaneous prostatic adenocarcinoma.
Author: Tremblay, C|Dore, M|Bochsler, P N|Sirois, J
PMID: 10451445
Journal: Eur Respir J. 1999 Aug;14(2):412-8.
Title: Expression and localization of cyclo-oxygenase isoforms in non-small cell lung cancer.
Author: Watkins, D N|Lenzo, J C|Segal, A|Garlepp, M J|Thompson, P J
PMID: 10515422
Journal: Oncogene. 1999 Dec 20;18(55):7908-16.
Title: The role of cyclooxygenases in inflammation, cancer, and development.
Author: Williams, C S|Mann, M|DuBois, R N
PMID: 10630643
Journal: Int J Colorectal Dis. 1999 Nov;14(4-5):212-8.
Title: Cellular localization of cyclo-oxygenase isozymes in Crohn's disease and colorectal cancer.
Author: Muller-Decker, K|Albert, C|Lukanov, T|Winde, G|Marks, F|Furstenberger, G
PMID: 10647629
Journal: IDrugs. 1999 Jul;2(7):664-6.
Title: COX-2 inhibitors--IBC conference. 12-13 April 1999, Coronado, CA, USA.
Author: Dionne, R
PMID: 16127636
Journal: Aliment Pharmacol Ther. 2000 Apr;14 Suppl 1:64-7.
Title: Review article: cyclooxygenase--a target for colon cancer prevention.
Author: Dubois, R N
PMID: 10807405
Journal: Annu Rev Biochem. 2000;69:145-82.
Title: Cyclooxygenases: structural, cellular, and molecular biology.
Author: Smith, W L|DeWitt, D L|Garavito, R M
PMID: 10966456
Journal: Cancer Lett. 2000 Aug 31;157(1):9-14.
Title: Suppressive effect of the herbal medicine Oren-gedoku-to on cyclooxygenase-2 activity and azoxymethane-induced aberrant crypt foci development in rats.
Author: Fukutake, M|Miura, N|Yamamoto, M|Fukuda, K|Iijima, O|Ishikawa, H|Kubo, M|Okada, M|Komatsu, Y|Sasaki, H|Wakabayashi, K|Ishige, A|Amagaya, S
PMID: 10893436
Journal: Ann Surg. 2001 Feb;233(2):183-8.
Title: Clinicopathologic association of cyclooxygenase 1 and cyclooxygenase 2 expression in gastric adenocarcinoma.
Author: Chen, C N|Sung, C T|Lin, M T|Lee, P H|Chang, K J
PMID: 11176123
Journal: Gut. 2001 May;48(5):660-6.
Title: Non-steroidal anti-inflammatory drugs with activity against either cyclooxygenase 1 or cyclooxygenase 2 inhibit colorectal cancer in a DMH rodent model by inducing apoptosis and inhibiting cell proliferation.
Author: Brown, W A|Skinner, S A|Malcontenti-Wilson, C|Vogiagis, D|O'Brien, P E
PMID: 11302965
Journal: J Urol. 2001 May;165(5):1468-72.
Title: Expression of cyclooxygenase-2 in patients with bladder carcinoma.
Author: Yoshimura, R|Sano, H|Mitsuhashi, M|Kohno, M|Chargui, J|Wada, S
PMID: 11342898
Journal: Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):447-53.
Title: Colonic mucosal prostaglandin E2 and cyclooxygenase expression before and after low aspirin doses in subjects at high risk or at normal risk for colorectal cancer.
Author: Krishnan, K|Ruffin, M T|Normolle, D|Shureiqi, I|Burney, K|Bailey, J|Peters-Golden, M|Rock, C L|Boland, C R|Brenner, D E
PMID: 11352853
Journal: Carcinogenesis. 2001 Jun;22(6):869-74.
Title: Rat colorectal tumours treated with a range of non-steroidal anti-inflammatory drugs show altered cyclooxygenase-2 and cyclooxygenase-1 splice variant mRNA expression levels.
Author: Vogiagis, D|Brown, W|Glare, E M|O'Brien, P E
PMID: 11375891
Journal: Acta Neuropathol. 2001 Aug;102(2):181-7.
Title: Expression of prostaglandin H synthase-2 in human brain tumors.
Author: Matsuo, M|Yonemitsu, N|Zaitsu, M|Ishii, K|Hamasaki, Y|Fukuyama, K|Tabuchi, K|Miyazaki, S
PMID: 11563634
Journal: J Pharmacol Exp Ther. 2001 Nov;299(2):468-76.
Title: Functional characterization of cyclooxygenase-2 polymorphisms.
Author: Fritsche, E|Baek, S J|King, L M|Zeldin, D C|Eling, T E|Bell, D A
PMID: 11602656
Journal: Curr Opin Anaesthesiol. 2001 Oct;14(5):527-32.
Title: Cyclooxygenase-2 and antagonists in pain management.
Author: Samad, T|Abdi, S
PMID: 17019141
Journal: Jpn J Clin Oncol. 2002 May;32(5):167-71.
Title: Cyclooxygenase-2 overexpression in colorectal cancer is associated with non-polypoid growth.
Author: Tsunozaki, Hidefumi|Yoshinaga, Keigo|Kumagai, Jirou|Sugihara, Kenichi
PMID: 12110643
Journal: Int J Radiat Oncol Biol Phys. 2002 Aug 1;53(5):1314-8.
Title: Pronounced radiosensitization of cultured human cancer cells by COX inhibitor under acidic microenvironment.
Author: Shah, Tushar|Ryu, Samuel|Lee, Ho Jun|Brown, Stephen|Kim, Jae Ho
PMID: 12128134
Journal: Adv Exp Med Biol. 2002;507:85-92.
Title: Inhibition of ultraviolet light B-induced cutaneous inflammation by a specific cyclooxygenase-2 inhibitor.
Author: Wilgus, T A|Parrett, M L|Ross, M S|Tober, K L|Robertson, F M|Oberyszyn, T M
PMID: 12664569
Journal: J Biol Chem. 2003 Sep 26;278(39):37937-47.
Title: Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2.
Author: Murakami, Makoto|Nakashima, Karin|Kamei, Daisuke|Masuda, Seiko|Ishikawa, Yukio|Ishii, Toshiharu|Ohmiya, Yoshihiro|Watanabe, Kikuko|Kudo, Ichiro
PMID: 12835322
Journal: Wien Med Wochenschr. 2003;153(5-6):104-15.
Title: [Epidemiological studies for evaluating the role of cyclooxygenase in chemoprevention of malignant tumors].
Author: Schernhammer, Eva S|Dittrich, Christian
PMID: 12705063
Journal: Can J Physiol Pharmacol. 2003 May;81(5):443-50.
Title: Prostaglandin-independent effects of aspirin on cell cycle and putrescine synthesis in human colon carcinoma cells.
Author: Eklou-Kalonji, E|Andriamihaja, M|Reinaud, P|Mayeur, C|Camous, S|Robert, V|Charpigny, G|Blachier, F
PMID: 12774850
Journal: Annu Rev Biophys Biomol Struct. 2003;32:183-206.
Title: The structure of mammalian cyclooxygenases.
Author: Garavito, R Michael|Mulichak, Anne M
PMID: 12574066
Journal: J Biol Chem. 2003 Jul 11;278(28):25790-801.
Title: Gene modulation by the cyclooxygenase inhibitor, sulindac sulfide, in human colorectal carcinoma cells: possible link to apoptosis.
Author: Bottone, Frank G Jr|Martinez, Jeanelle M|Collins, Jennifer B|Afshari, Cynthia A|Eling, Thomas E
PMID: 12734198
Journal: Carcinogenesis. 2004 Mar;25(3):419-23.
Title: Bile acids induce cyclooxygenase-2 expression in human pancreatic cancer cell lines.
Author: Tucker, Olga N|Dannenberg, Andrew J|Yang, Eun K|Fahey, Thomas J 3rd
PMID: 14656949
Journal: Nutr Cancer. 2004;48(2):207-13.
Title: Colon cancer proliferating desulfosinigrin in wasabi (Wasabia japonica).
Author: Weil, Marvin J|Zhang, Yanjun|Nair, Muraleedharan G
PMID: 15231456
Journal: Br J Cancer. 2004 Sep 13;91(6):1015-8.
Title: RNA profiling of cyclooxygenases 1 and 2 in colorectal cancer.
Author: Church, R D|Yu, J|Fleshman, J W|Shannon, W D|Govindan, R|McLeod, H L
PMID: 15328521
Journal: Prostaglandins Leukot Essent Fatty Acids. 2005 Nov;73(5):343-50.
Title: Intron 1 retaining cyclooxygenase 1 splice variant is induced by osmotic stress in human intestinal epithelial cells.
Author: Nurmi, J T|Puolakkainen, P A|Rautonen, N E
PMID: 16115753
Journal: Curr Opin Clin Nutr Metab Care. 2006 Mar;9(2):89-94.
Title: Cyclooxygenase-2 inhibitors: what went wrong?
Author: James, Michael J|Cleland, Leslie G
PMID: 16477171
Journal: Crit Rev Oncol Hematol. 2006 Jul;59(1):51-64.
Title: Cyclooxygenase-2 as a target for anticancer drug development.
Author: Meric, Jean-Baptiste|Rottey, Sylvie|Olaussen, Ken|Soria, Jean-Charles|Khayat, David|Rixe, Olivier|Spano, Jean-Philippe
PMID: 16531064
Journal: J Small Anim Pract. 2006 Apr;47(4):196-200.
Title: Cohort study of COX-1 and COX-2 expression in canine rectal and bladder tumours.
Author: Knottenbelt, C|Mellor, D|Nixon, C|Thompson, H|Argyle, D J
PMID: 16573762
Journal: J Negat Results Biomed. 2006 Oct 24;5:15.
Title: Polymorphisms within inflammatory genes and colorectal cancer.
Author: Landi, Stefano|Gemignani, Federica|Bottari, Fabio|Gioia-Patricola, Lydie|Guino, Elisabet|Cambray, Maria|Biondo, Sebastiano|Capella, Gabriel|Boldrini, Laura|Canzian, Federico|Moreno, Victor
PMID: 17062130
Journal: Cell Mol Life Sci. 2008 Feb;65(3):354-8.
Title: Aspirin: recent developments.
Author: Yasuda, O|Takemura, Y|Kawamoto, H|Rakugi, H
PMID: 18038215
Journal: Cancer Res. 2008 Mar 15;68(6):2043-50.
Title: Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis.
Author: Singh, Rana P|Gu, Mallikarjuna|Agarwal, Rajesh
PMID: 18339887
Journal: Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1401-10.
Title: Increased colorectal epithelial cell proliferation and crypt fission associated with obesity and roux-en-Y gastric bypass.
Author: Sainsbury, Anita|Goodlad, Robert A|Perry, Sarah L|Pollard, Stephen G|Robins, Gerard G|Hull, Mark A
PMID: 18559555
Journal: BMC Cancer. 2008 Nov 7;8:326.
Title: Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
Author: Kury, Sebastien|Buecher, Bruno|Robiou-du-Pont, Sebastien|Scoul, Catherine|Colman, Helene|Le Neel, Tanguy|Le Houerou, Claire|Faroux, Roger|Ollivry, Jean|Lafraise, Bernard|Chupin, Louis-Dominique|Sebille, Veronique|Bezieau, Stephane
PMID: 18992148
Journal: Prostaglandins Leukot Essent Fatty Acids. 2009 May-Jun;80(5-6):239-45.
Title: Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms.
Author: Kawakami, Yuki|Nakamura, Tomomi|Hosokawa, Tomoko|Suzuki-Yamamoto, Toshiko|Yamashita, Hiromi|Kimoto, Masumi|Tsuji, Hideaki|Yoshida, Hideki|Hada, Takahiko|Takahashi, Yoshitaka
PMID: 19457650
Journal: Carcinogenesis. 2010 Nov;31(11):1982-90.
Title: Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect.
Author: Huang, Liqun|Zhu, Caihua|Sun, Yu|Xie, Gang|Mackenzie, Gerardo G|Qiao, George|Komninou, Despina|Rigas, Basil
PMID: 20627873
Journal: Int J Cancer. 2010 Dec 15;127(12):2822-30.
Title: Polymorphisms in inflammatory pathway genes and their association with colorectal cancer risk.
Author: Frank, Bernd|Hoffmeister, Michael|Klopp, Norman|Illig, Thomas|Chang-Claude, Jenny|Brenner, Hermann
PMID: 21351261
Journal: J Gastroenterol Hepatol. 2011 Mar;26(3):426-31.
Title: Aspirin: old drug, new uses and challenges.
Author: Yeomans, Neville D
PMID: 21062358
Journal: Biochem J. 2012 Apr 15;443(2):379-86.
Title: The non-steroidal anti-inflammatory drug indomethacin activates the eIF2alpha kinase PKR, causing a translational block in human colorectal cancer cells.
Author: Brunelli, Claudia|Amici, Carla|Angelini, Mara|Fracassi, Chiara|Belardo, Giuseppe|Santoro, M Gabriella
PMID: 22268531
Journal: Cancer Res. 2014 Jan 1;74(1):243-52.
Title: 6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1.
Author: Li, Haitao|Zhu, Feng|Chen, Hanyong|Cheng, Ka Wing|Zykova, Tatyana|Oi, Naomi|Lubet, Ronald A|Bode, Ann M|Wang, Mingfu|Dong, Zigang
PMID: 24220240
Journal: Int J Radiat Oncol Biol Phys. 2014 Nov 1;90(3):595-602.
Title: Role of genetic polymorphisms in NFKB-mediated inflammatory pathways in response to primary chemoradiation therapy for rectal cancer.
Author: Dzhugashvili, Maia|Luengo-Gil, Gines|Garcia, Teresa|Gonzalez-Conejero, Rocio|Conesa-Zamora, Pablo|Escolar, Pedro Pablo|Calvo, Felipe|Vicente, Vicente|Ayala de la Pena, Francisco
PMID: 25304949
Journal: Hepatogastroenterology. 2014 Nov-Dec;61(136):2215-8.
Title: Comparison analysis in synchronous and metachronous metastatic colorectal cancer based on microarray expression profile.
Author: Wang, Da-dong|Xu, Yong|Tu, Yu-liang|Tan, Xiang-long|Zhu, Zi-man|Han, Ming-ming|Dou, Chun-qing|Zeng, Jian-ping|Tan, Jing-wang|Du, Jun-dong|Jiao, Hua-bou|Cai, Shou-wang
PMID: 25699354
Journal: Virchows Arch. 2015 May;466(5):495-502.
Title: Mitochondrial microsatellite instability in patients with metastatic colorectal cancer.
Author: Venderbosch, S|van Vliet, S|Craenmehr, M H C|Simmer, F|de Haan, A F J|Punt, C J A|Koopman, M|Nagtegaal, I D
PMID: 25697538
Journal: Nutr Cancer. 2016 Oct;68(7):1192-201.
Title: Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue.
Author: Sidahmed, ElKhansa|Sen, Ananda|Ren, Jianwei|Patel, Arsh|Turgeon, D Kim|Ruffin, Mack T|Brenner, Dean E|Djuric, Zora
PMID: 27548026
Journal: Cancer Prev Res (Phila). 2017 Feb;10(2):142-152.
Title: Unlocking Aspirin's Chemopreventive Activity: Role of Irreversibly Inhibiting Platelet Cyclooxygenase-1.
Author: Lichtenberger, Lenard M|Fang, Dexing|Bick, Roger J|Poindexter, Brian J|Phan, Tri|Bergeron, Angela L|Pradhan, Subhashree|Dial, Elizabeth J|Vijayan, K Vinod
PMID: 27998883
Journal: Anticancer Agents Med Chem. 2017;17(10):1411-1425.
Title: Novel Thiourea Derivatives Bearing Sulfonamide Moiety as Anticancer Agents Through COX-2 Inhibition.
Author: Ghorab, Mostafa M|El-Gaby, Mohamed S A|Alsaid, Mansour S|Elshaier, Yaseen A M M|Soliman, Aiten M|El-Senduny, Fardous F|Badria, Farid A|Sherif, Abdelrahman Y A
PMID: 28356021
Journal: Int J Mol Sci. 2018 Jan 6;19(1). pii: ijms19010166.
Title: Could Aspirin and Diets High in Fiber Act Synergistically to Reduce the Risk of Colon Cancer in Humans?
Author: Pan, Pan|Huang, Yi-Wen|Oshima, Kiyoko|Yearsley, Martha|Zhang, Jianying|Yu, Jianhua|Arnold, Mark|Wang, Li-Shu
PMID: 29316620
Journal: Transl Res. 2018 Jun;196:42-61.
Title: Prostaglandin-endoperoxide synthase 2 (cyclooxygenase-2), a complex target for colorectal cancer prevention and therapy.
Author: Benelli, Roberto|Vene, Roberta|Ferrari, Nicoletta
PMID: 29421522
Journal: Mol Carcinog. 2018 Sep;57(9):1156-1165.
Title: A supercritical CO2 extract of neem leaf (A. indica) and its bioactive liminoid, nimbolide, suppresses colon cancer in preclinical models by modulating pro-inflammatory pathways.
Author: Patel, Mandakini J|Tripathy, Shreya|Mukhopadhyay, Keya D|Wangjam, Tamna|Cabang, April B|Morris, Jay|Wargovich, Michael J
PMID: 29697164
Journal: Oncol Rep. 2018 Oct 12.
Title: Downregulation of cyclooxygenase1 stimulates mitochondrial apoptosis through the NFkappaB signaling pathway in colorectal cancer cells.
Author: Ding, Lei|Gu, Huan|Lan, Zhenwei|Lei, Qingchun|Wang, Wenxue|Ruan, Jiangfei|Yu, Min|Lin, Jie|Cui, Qinghua
PMID: 30320345