Primary Site >> Colorectal Cancer
Gene >> PTGS1
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Ref: Expression of cyclooxygenase-1 and -2 in human colorectal cancer. PMID: 7641194 Ref: Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. PMID: 7780968 |
Ref: Production of arachidonic acid metabolites by the colon adenocarcinoma cell line HT29 cl.19A and their effect on chloride secretion. PMID: 9215866 Ref: Cyclo-oxygenase and colon cancer: clues to the aspirin effect? PMID: 9240630 Ref: Tumorigenic transformation of immortalized ECV endothelial cells by cyclooxygenase-1 overexpression. PMID: 9261162 |
Ref: Expression of prostaglandin G/H synthase type 1, but not type 2, in human ovarian adenocarcinomas. PMID: 9405496 Ref: The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers. PMID: 9472692 Ref: Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. PMID: 9521170 Ref: Cyclooxygenases 1 and 2. PMID: 9597150 Ref: Induction of apoptotic DNA fragmentation by nonsteroidal anti-inflammatory drugs in cultured rat gastric mucosal cells. PMID: 9851595 |
Ref: Role of cyclooxygenase-1 and -2 in health and disease. PMID: 10193997 Ref: Growth stimulation and induction of epidermal growth factor receptor by overexpression of cyclooxygenases 1 and 2 in human colon carcinoma cells. PMID: 10216286 Ref: Induction of prostaglandin G/H synthase-2 in a canine model of spontaneous prostatic adenocarcinoma. PMID: 10451445 Ref: Expression and localization of cyclo-oxygenase isoforms in non-small cell lung cancer. PMID: 10515422 Ref: The role of cyclooxygenases in inflammation, cancer, and development. PMID: 10630643 Ref: Cellular localization of cyclo-oxygenase isozymes in Crohn's disease and colorectal cancer. PMID: 10647629 Ref: COX-2 inhibitors--IBC conference. 12-13 April 1999, Coronado, CA, USA. PMID: 16127636 |
Ref: Review article: cyclooxygenase--a target for colon cancer prevention. PMID: 10807405 Ref: Suppressive effect of the herbal medicine Oren-gedoku-to on cyclooxygenase-2 activity and azoxymethane-induced aberrant crypt foci development in rats. PMID: 10893436 Ref: Cyclooxygenases: structural, cellular, and molecular biology. PMID: 10966456 |
Ref: Clinicopathologic association of cyclooxygenase 1 and cyclooxygenase 2 expression in gastric adenocarcinoma. PMID: 11176123 Ref: Non-steroidal anti-inflammatory drugs with activity against either cyclooxygenase 1 or cyclooxygenase 2 inhibit colorectal cancer in a DMH rodent model by inducing apoptosis and inhibiting cell proliferation. PMID: 11302965 Ref: Expression of cyclooxygenase-2 in patients with bladder carcinoma. PMID: 11342898 Ref: Colonic mucosal prostaglandin E2 and cyclooxygenase expression before and after low aspirin doses in subjects at high risk or at normal risk for colorectal cancer. PMID: 11352853 Ref: Rat colorectal tumours treated with a range of non-steroidal anti-inflammatory drugs show altered cyclooxygenase-2 and cyclooxygenase-1 splice variant mRNA expression levels. PMID: 11375891 Ref: Expression of prostaglandin H synthase-2 in human brain tumors. PMID: 11563634 Ref: Functional characterization of cyclooxygenase-2 polymorphisms. PMID: 11602656 Ref: Cyclooxygenase-2 and antagonists in pain management. PMID: 17019141 |
Ref: Cyclooxygenase-2 overexpression in colorectal cancer is associated with non-polypoid growth. PMID: 12110643 Ref: Pronounced radiosensitization of cultured human cancer cells by COX inhibitor under acidic microenvironment. PMID: 12128134 Ref: Inhibition of ultraviolet light B-induced cutaneous inflammation by a specific cyclooxygenase-2 inhibitor. PMID: 12664569 |
Ref: The structure of mammalian cyclooxygenases. PMID: 12574066 Ref: [Epidemiological studies for evaluating the role of cyclooxygenase in chemoprevention of malignant tumors]. PMID: 12705063 Ref: Gene modulation by the cyclooxygenase inhibitor, sulindac sulfide, in human colorectal carcinoma cells: possible link to apoptosis. PMID: 12734198 Ref: Prostaglandin-independent effects of aspirin on cell cycle and putrescine synthesis in human colon carcinoma cells. PMID: 12774850 Ref: Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. PMID: 12835322 |
Ref: Bile acids induce cyclooxygenase-2 expression in human pancreatic cancer cell lines. PMID: 14656949 Ref: Colon cancer proliferating desulfosinigrin in wasabi (Wasabia japonica). PMID: 15231456 Ref: RNA profiling of cyclooxygenases 1 and 2 in colorectal cancer. PMID: 15328521 |
Ref: Intron 1 retaining cyclooxygenase 1 splice variant is induced by osmotic stress in human intestinal epithelial cells. PMID: 16115753 |
Ref: Cyclooxygenase-2 inhibitors: what went wrong? PMID: 16477171 Ref: Cyclooxygenase-2 as a target for anticancer drug development. PMID: 16531064 Ref: Cohort study of COX-1 and COX-2 expression in canine rectal and bladder tumours. PMID: 16573762 Ref: Polymorphisms within inflammatory genes and colorectal cancer. PMID: 17062130 |
Ref: Aspirin: recent developments. PMID: 18038215 Ref: Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis. PMID: 18339887 Ref: Increased colorectal epithelial cell proliferation and crypt fission associated with obesity and roux-en-Y gastric bypass. PMID: 18559555 Ref: Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study. PMID: 18992148 |
Ref: Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. PMID: 19457650 |
Ref: Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect. PMID: 20627873 Ref: Polymorphisms in inflammatory pathway genes and their association with colorectal cancer risk. PMID: 21351261 |
Ref: Aspirin: old drug, new uses and challenges. PMID: 21062358 |
Ref: The non-steroidal anti-inflammatory drug indomethacin activates the eIF2alpha kinase PKR, causing a translational block in human colorectal cancer cells. PMID: 22268531 |
Ref: 6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1. PMID: 24220240 Ref: Role of genetic polymorphisms in NFKB-mediated inflammatory pathways in response to primary chemoradiation therapy for rectal cancer. PMID: 25304949 Ref: Comparison analysis in synchronous and metachronous metastatic colorectal cancer based on microarray expression profile. PMID: 25699354 |
Ref: Mitochondrial microsatellite instability in patients with metastatic colorectal cancer. PMID: 25697538 |
Ref: Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue. PMID: 27548026 |
Ref: Unlocking Aspirin's Chemopreventive Activity: Role of Irreversibly Inhibiting Platelet Cyclooxygenase-1. PMID: 27998883 Ref: Novel Thiourea Derivatives Bearing Sulfonamide Moiety as Anticancer Agents Through COX-2 Inhibition. PMID: 28356021 |
Ref: Could Aspirin and Diets High in Fiber Act Synergistically to Reduce the Risk of Colon Cancer in Humans? PMID: 29316620 Ref: Prostaglandin-endoperoxide synthase 2 (cyclooxygenase-2), a complex target for colorectal cancer prevention and therapy. PMID: 29421522 Ref: A supercritical CO2 extract of neem leaf (A. indica) and its bioactive liminoid, nimbolide, suppresses colon cancer in preclinical models by modulating pro-inflammatory pathways. PMID: 29697164 Ref: Downregulation of cyclooxygenase1 stimulates mitochondrial apoptosis through the NFkappaB signaling pathway in colorectal cancer cells. PMID: 30320345 |