Primary Site >> Colorectal Cancer

Gene >> PTGER2

Journal: Cancer Immunol Immunother. 1996 Sep;43(1):1-9.
Title: The role of cyclic AMP and oxygen intermediates in the inhibition of cellular immunity in cancer.
Author: Uotila, P
PMID: 8917629
Journal: Eur J Pharmacol. 1999 Feb 12;367(1):131-8.
Title: Nonsteroidal anti-inflammatory drugs may prevent colon cancer through suppression of hepatocyte growth factor expression.
Author: Ota, S|Tanaka, Y|Bamba, H|Kato, A|Matsuzaki, F
PMID: 10082276
Journal: J Exp Clin Cancer Res. 2000 Jun;19(2):219-23.
Title: Effect of prostaglandin E1 on vascular endothelial growth factor production by human macrophages and colon cancer cells.
Author: Bamba, H|Ota, S|Kato, A|Kawamoto, C|Matsuzaki, F
PMID: 10965822
Journal: Nat Med. 2001 Sep;7(9):1048-51.
Title: Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice.
Author: Sonoshita, M|Takaku, K|Sasaki, N|Sugimoto, Y|Ushikubi, F|Narumiya, S|Oshima, M|Taketo, M M
PMID: 11533709
Journal: Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8921-6.
Title: Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2.
Author: Nishihara, Hiroshi|Kizaka-Kondoh, Shinae|Insel, Paul A|Eckmann, Lars
PMID: 12837940
Journal: World J Gastroenterol. 2005 Jan 21;11(3):344-7.
Title: Expression pattern of epithelial cell adhesion molecule on normal and malignant colon tissues.
Author: Xie, Xin|Wang, Chun-Yan|Cao, Yun-Xin|Wang, Wei|Zhuang, Ran|Chen, Li-Hua|Dang, Na-Na|Fang, Liang|Jin, Bo-Quan
PMID: 15637741
Journal: Science. 2005 Dec 2;310(5753):1504-10.
Title: Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.
Author: Castellone, Maria Domenica|Teramoto, Hidemi|Williams, Bart O|Druey, Kirk M|Gutkind, J Silvio
PMID: 16293724
Journal: Anticancer Res. 2006 Jul-Aug;26(4B):2857-61.
Title: Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis.
Author: Keith, Robert L|Geraci, Mark W|Nana-Sinkam, S Patrick|Breyer, Richard M|Hudish, Tyler M|Meyer, Amy M|Malkinson, Alvin M|Dwyer-Nield, Lori D
PMID: 16886605
Journal: Adv Anat Pathol. 2006 Sep;13(5):270-4.
Title: Signal transduction cross-talk during colorectal tumorigenesis.
Author: Liu, Xiuli|Lazenby, Audrey J|Siegal, Gene P
PMID: 16998321
Journal: Biochem Biophys Res Commun. 2007 Aug 3;359(3):568-73.
Title: Indomethacin decreases EP2 prostanoid receptor expression in colon cancer cells.
Author: Fujino, Hiromichi|Chen, Xiao-bo|Regan, John W|Murayama, Toshihiko
PMID: 17555711
Journal: Exp Cell Res. 2007 Aug 15;313(14):2969-79.
Title: The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells.
Author: Cherukuri, Durga Prasad|Chen, Xiao B O|Goulet, Anne-Christine|Young, Robert N|Han, Yongxin|Heimark, Ronald L|Regan, John W|Meuillet, Emmanuelle|Nelson, Mark A
PMID: 17631291
Journal: Mod Pathol. 2008 Jan;21(1):15-21.
Title: Prostanoid receptor EP1 expression in breast cancer.
Author: Thorat, Mangesh A|Morimiya, Akira|Mehrotra, Sanjana|Konger, Raymond|Badve, Sunil S
PMID: 17906615
Journal: APMIS. 2008 Jun;116(6):445-56.
Title: Dendritic cell infiltration pattern along the colorectal adenoma-carcinoma sequence.
Author: Yuan, Aping|Steigen, Sonja E|Goll, Rasmus|Vonen, Barthold|Husbekk, Anne|Cui, Guanglin|Florholmen, Jon
PMID: 18754318
Journal: BMC Cell Biol. 2008 Dec 2;9:63.
Title: Prostaglandin E2-EP1 and EP2 receptor signaling promotes apical junctional complex disassembly of Caco-2 human colorectal cancer cells.
Author: Tanaka, Marcelo N|Diaz, Bruno L|de Souza, Wanderley|Morgado-Diaz, Jose A
PMID: 19055708
Journal: Carcinogenesis. 2010 Mar;31(3):466-72.
Title: Polymorphisms in fatty-acid-metabolism-related genes are associated with colorectal cancer risk.
Author: Hoeft, Birgit|Linseisen, Jakob|Beckmann, Lars|Muller-Decker, Karin|Canzian, Federico|Husing, Anika|Kaaks, Rudolf|Vogel, Ulla|Jakobsen, Marianne U|Overvad, Kim|Hansen, Rikke D|Knuppel, Sven|Boeing, Heiner|Trichopoulou, Antonia|Koumantaki, Yvoni|Trichopoulo
PMID: 20042636
Journal: Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):822-31.
Title: PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.
Author: Baba, Yoshifumi|Nosho, Katsuhiko|Shima, Kaori|Goessling, Wolfram|Chan, Andrew T|Ng, Kimmie|Chan, Jennifer A|Giovannucci, Edward L|Fuchs, Charles S|Ogino, Shuji
PMID: 20200425
Journal: BMC Gastroenterol. 2010 Jan 26;10:9.
Title: Prostaglandin E2-induced colonic secretion in patients with and without colorectal neoplasia.
Author: Kaltoft, Nicolai|Tilotta, Maria C|Witte, Anne-Barbara|Osbak, Philip S|Poulsen, Steen S|Bindslev, Niels|Hansen, Mark B
PMID: 20100359
Journal: Cancer Prev Res (Phila). 2012 Jun;5(6):855-63.
Title: A study of prostaglandin pathway genes and interactions with current nonsteroidal anti-inflammatory drug use in colorectal adenoma.
Author: Edwards, Todd L|Shrubsole, Martha J|Cai, Qiuyin|Li, Guoliang|Dai, Qi|Rex, Douglas K|Ulbright, Thomas M|Fu, Zhenming|Murff, Harvey J|Smalley, Walter|Ness, Reid|Zheng, Wei
PMID: 22551900
Journal: Biochim Biophys Acta. 2012 Sep;1821(9):1224-34.
Title: HT-29 human colon cancer cell proliferation is regulated by cytosolic phospholipase A(2)alpha dependent PGE(2)via both PKA and PKB pathways.
Author: Kisslov, Liz|Hadad, Nurit|Rosengraten, Marina|Levy, Rachel
PMID: 22728329
Journal: Carcinogenesis. 2014 Sep;35(9):2121-6.
Title: Genetic variation in prostaglandin synthesis and related pathways, NSAID use and colorectal cancer risk in the Colon Cancer Family Registry.
Author: Resler, Alexa J|Makar, Karen W|Heath, Laura|Whitton, John|Potter, John D|Poole, Elizabeth M|Habermann, Nina|Scherer, Dominique|Duggan, David|Wang, Hansong|Lindor, Noralane M|Passarelli, Michael N|Baron, John A|Newcomb, Polly A|Le Marchand, Loic|Ulrich, Co
PMID: 24908683
Journal: Free Radic Res. 2014 Nov;48(11):1311-21.
Title: Generation of ROS by CAY10598 leads to inactivation of STAT3 signaling and induction of apoptosis in human colon cancer HCT116 cells.
Author: Chae, I G|Kim, D-H|Kundu, J|Jeong, C-H|Kundu, J K|Chun, K-S
PMID: 25096910
Journal: Mol Cells. 2014 Dec 31;37(12):899-906.
Title: Prostaglandin E2 reverses curcumin-induced inhibition of survival signal pathways in human colorectal carcinoma (HCT-15) cell lines.
Author: Shehzad, Adeeb|Ul Islam, Salman|Lee, Jaetae|Lee, Young Sup
PMID: 25431425
Journal: Cancer Res. 2015 Jul 15;75(14):2822-32.
Title: Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth.
Author: Ma, Xiaojun|Aoki, Tomohiro|Tsuruyama, Tatsuaki|Narumiya, Shuh
PMID: 26018088
Journal: Oncogene. 2016 May 19;35(20):2602-14.
Title: Dysregulated CRTC1 activity is a novel component of PGE2 signaling that contributes to colon cancer growth.
Author: Schumacher, Y|Aparicio, T|Ourabah, S|Baraille, F|Martin, A|Wind, P|Dentin, R|Postic, C|Guilmeau, S
PMID: 26300003
Journal: Nutr Cancer. 2016 Oct;68(7):1192-201.
Title: Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue.
Author: Sidahmed, ElKhansa|Sen, Ananda|Ren, Jianwei|Patel, Arsh|Turgeon, D Kim|Ruffin, Mack T|Brenner, Dean E|Djuric, Zora
PMID: 27548026
Journal: World J Gastroenterol. 2017 Feb 21;23(7):1171-1179.
Title: Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation.
Author: Hsu, Hsi-Hsien|Chen, Ming-Cheng|Day, Cecilia Hsuan|Lin, Yueh-Min|Li, Shin-Yi|Tu, Chuan-Chou|Padma, Viswanadha Vijaya|Shih, Hui-Nung|Kuo, Wei-Wen|Huang, Chih-Yang
PMID: 28275297
Journal: Int J Mol Sci. 2017 May 25;18(6). pii: ijms18061132.
Title: Prostaglandin E2-Induced COX-2 Expressions via EP2 and EP4 Signaling Pathways in Human LoVo Colon Cancer Cells.
Author: Hsu, Hsi-Hsien|Lin, Yueh-Min|Shen, Chia-Yao|Shibu, Marthandam Asokan|Li, Shin-Yi|Chang, Sheng-Huang|Lin, Chien-Chung|Chen, Ray-Jade|Viswanadha, Vijaya Padma|Shih, Hui-Nung|Huang, Chih-Yang
PMID: 28587064
Journal: Cancer Res. 2017 Aug 15;77(16):4305-4316.
Title: Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness.
Author: Hou, Pei-Chi|Li, Yo-Hua|Lin, Shih-Chieh|Lin, Shau-Chieh|Lee, Jenq-Chang|Lin, Bo-Wen|Liou, Jing-Ping|Chang, Jang-Yang|Kuo, Ching-Chuan|Liu, Yi-Min|Sun, H Sunny|Tsai, Shaw-Jenq
PMID: 28652251
Journal: Inflamm Regen. 2017 Mar 1;37:4.
Title: Prostaglandin E2-EP2 signaling as a node of chronic inflammation in the colon tumor microenvironment.
Author: Aoki, Tomohiro|Narumiya, Shuh
PMID: 29259703