Primary Site >> Pancreatic Cancer
Gene >> PTCH1
| 1. | |||||||||||
| Journal: | Int J Oncol. 2004 Dec;25(6):1875-80. | ||||||||||
| Title: | KIF27 is one of orthologs for Drosophila Costal-2. | ||||||||||
| Author: | Katoh, Yuriko|Katoh, Masaru | ||||||||||
| PMID: | 15547729 | ||||||||||
| 2. | |||||||||||
| Journal: | Int J Oncol. 2005 Feb;26(2):545-9. | ||||||||||
| Title: | Identification and characterization of rat Desert hedgehog and Indian hedgehog genes in silico. | ||||||||||
| Author: | Katoh, Yuriko|Katoh, Masaru | ||||||||||
| PMID: | 15645142 | ||||||||||
| 3. | |||||||||||
| Journal: | Cancer Biol Ther. 2005 Oct;4(10):1050-4. Epub 2005 Oct 18. | ||||||||||
| Title: | Hedgehog signaling pathway and gastric cancer. | ||||||||||
| Author: | Katoh, Yuriko|Katoh, Masaru | ||||||||||
| PMID: | 16258256 | ||||||||||
| 4. | |||||||||||
| Journal: | Pancreas. 2006 Jul;33(1):38-44. | ||||||||||
| Title: | Aberrant expression of PTCH (patched gene) and Smo (smoothened gene) in human pancreatic cancerous tissues and its association with hyperglycemia. | ||||||||||
| Author: | Shao, Jianguo|Zhang, Ling|Gao, Jun|Li, Zhaoshen|Chen, Zhirong | ||||||||||
| PMID: | 16804411 | ||||||||||
| 5. | |||||||||||
| Journal: | Gene Ther. 2006 Nov;13(22):1587-94. Epub 2006 Jul 6. | ||||||||||
| Title: | Antisense Smo under the control of the PTCH1 promoter delivered by an adenoviral vector inhibits the growth of human pancreatic cancer. | ||||||||||
| Author: | Gao, J|Li, Z|Chen, Z|Shao, J|Zhang, L|Xu, G|Tu, Z|Gong, Y | ||||||||||
| PMID: | 16826192 | ||||||||||
| 6. | |||||||||||
| Journal: | Int J Mol Med. 2006 Dec;18(6):1019-23. | ||||||||||
| Title: | Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). | ||||||||||
| Author: | Katoh, Yuriko|Katoh, Masaru | ||||||||||
| PMID: | 17089004 | ||||||||||
| 7. | |||||||||||
| Journal: | Pancreas. 2007 Apr;34(3):340-6. | ||||||||||
| Title: | Sonic hedgehog signaling pathway in pancreatic cystic neoplasms and ductal adenocarcinoma. | ||||||||||
| Author: | Liu, Maw-Sen|Yang, Po-Yi|Yeh, Ta-Sen | ||||||||||
| PMID: | 17414057 | ||||||||||
| 8. | |||||||||||
| Journal: | Anticancer Res. 2007 Nov-Dec;27(6A):3743-7. | ||||||||||
| Title: | Anti-patched-1 antibodies suppress hedgehog signaling pathway and pancreatic cancer proliferation. | ||||||||||
| Author: | Nakamura, Masafumi|Kubo, Makoto|Yanai, Kosuke|Mikami, Yoshiko|Ikebe, Mio|Nagai, Shuntaro|Yamaguchi, Koji|Tanaka, Masao|Katano, Mitsuo | ||||||||||
| PMID: | 17970037 | ||||||||||
| 9. | |||||||||||
| Journal: | Cancer Sci. 2008 Jun;99(6):1131-8. | ||||||||||
| Title: | Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells. | ||||||||||
| Author: | Yamazaki, Madoka|Nakamura, Kazumasa|Mizukami, Yusuke|Ii, Masaaki|Sasajima, Junpei|Sugiyama, Yoshiaki|Nishikawa, Tomoya|Nakano, Yasuhiro|Yanagawa, Nobuyuki|Sato, Kazuya|Maemoto, Atsuo|Tanno, Satoshi|Okumura, Toshikatsu|Karasaki, Hidenori|Kono, Toru|Fujiya, | ||||||||||
| PMID: | 18422746 | ||||||||||
| 10. | |||||||||||
| Journal: | Mol Cancer Ther. 2008 Sep;7(9):2725-35. | ||||||||||
| Title: | An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer. | ||||||||||
| Author: | Feldmann, Georg|Fendrich, Volker|McGovern, Karen|Bedja, Djahida|Bisht, Savita|Alvarez, Hector|Koorstra, Jan-Bart M|Habbe, Nils|Karikari, Collins|Mullendore, Michael|Gabrielson, Kathleen L|Sharma, Rajni|Matsui, William|Maitra, Anirban | ||||||||||
| PMID: | 18790753 | ||||||||||
| 11. | |||||||||||
| Journal: | Bioorg Med Chem. 2008 Nov 1;16(21):9420-4. | ||||||||||
| Title: | Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana. | ||||||||||
| Author: | Arai, Midori A|Tateno, Chikashi|Hosoya, Takahiro|Koyano, Takashi|Kowithayakorn, Thaworn|Ishibashi, Masami | ||||||||||
| PMID: | 18842418 | ||||||||||
| 12. | |||||||||||
| Journal: | Genes Dev. 2009 Jan 1;23(1):24-36. | ||||||||||
| Title: | GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. | ||||||||||
| Author: | Nolan-Stevaux, Olivier|Lau, Janet|Truitt, Morgan L|Chu, Gerald C|Hebrok, Matthias|Fernandez-Zapico, Martin E|Hanahan, Douglas | ||||||||||
| PMID: | 19136624 | ||||||||||
| 13. | |||||||||||
| Journal: | Cancer Lett. 2009 Oct 8;283(2):119-24. | ||||||||||
| Title: | Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer. | ||||||||||
| Author: | Xu, Fu-Guo|Ma, Qing-Yong|Wang, Zheng | ||||||||||
| PMID: | 19232458 | ||||||||||
| 14. | |||||||||||
| Journal: | Cancer Biol Ther. 2009 Jul;8(14):1328-39. Epub 2009 Jul 6. | ||||||||||
| Title: | Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer. | ||||||||||
| Author: | Chun, Stephen G|Zhou, Weiqiang|Yee, Nelson S | ||||||||||
| PMID: | 19421011 | ||||||||||
| 15. | |||||||||||
| Journal: | Curr Mol Med. 2009 Sep;9(7):873-86. | ||||||||||
| Title: | Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. | ||||||||||
| Author: | Katoh, Y|Katoh, M | ||||||||||
| PMID: | 19860666 | ||||||||||
| 16. | |||||||||||
| Journal: | Mol Biosyst. 2010 Jan;6(1):44-54. | ||||||||||
| Title: | Small-molecule modulators of the Sonic Hedgehog signaling pathway. | ||||||||||
| Author: | Stanton, Benjamin Z|Peng, Lee F | ||||||||||
| PMID: | 20024066 | ||||||||||
| 17. | |||||||||||
| Journal: | Cancer Biol Ther. 2010 Nov 1;10(9):893-902. | ||||||||||
| Title: | Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer. | ||||||||||
| Author: | Steg, Adam|Amm, Hope M|Novak, Zdenek|Frost, Andra R|Johnson, Martin R | ||||||||||
| PMID: | 20814245 | ||||||||||
| 18. | |||||||||||
| Journal: | Pancreatology. 2011;11(6):601-9. | ||||||||||
| Title: | Resveratrol inhibits proliferation and induces apoptosis through the hedgehog signaling pathway in pancreatic cancer cell. | ||||||||||
| Author: | Mo, Wenhui|Xu, Xuanfu|Xu, Ling|Wang, Feng|Ke, Aiwu|Wang, Xingpeng|Guo, Chuanyong | ||||||||||
| PMID: | 22301921 | ||||||||||
| 19. | |||||||||||
| Journal: | Org Biomol Chem. 2011 Feb 21;9(4):1133-9. | ||||||||||
| Title: | New hedgehog/GLI-signaling inhibitors from Adenium obesum. | ||||||||||
| Author: | Arai, Midori A|Tateno, Chikashi|Koyano, Takashi|Kowithayakorn, Thaworn|Kawabe, Seiichiro|Ishibashi, Masami | ||||||||||
| PMID: | 21170436 | ||||||||||
| 20. | |||||||||||
| Journal: | PLoS One. 2011;6(12):e27941. | ||||||||||
| Title: | Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish. | ||||||||||
| Author: | Jung, In Hye|Jung, Dawoon E|Park, Young Nyun|Song, Si Young|Park, Seung Woo | ||||||||||
| PMID: | 22164219 | ||||||||||
| 21. | |||||||||||
| Journal: | Pancreas. 2012 Mar;41(2):222-9. | ||||||||||
| Title: | Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas. | ||||||||||
| Author: | Bahra, Marcus|Kamphues, Carsten|Boas-Knoop, Sabine|Lippert, Steffen|Esendik, Ulrike|Schuller, Ulrich|Hartmann, Wolfgang|Waha, Andreas|Neuhaus, Peter|Heppner, Frank|Pietsch, Torsten|Koch, Arend | ||||||||||
| PMID: | 22076568 | ||||||||||
| 22. | |||||||||||
| Journal: | J Gastroenterol. 2012 Apr;47(4):452-60. | ||||||||||
| Title: | Targeting the hedgehog signaling pathway with interacting peptides to Patched-1. | ||||||||||
| Author: | Nakamura, Masafumi|Tanaka, Haruo|Nagayoshi, Yousuke|Nakashima, Hiroshi|Tsutsumi, Kosuke|Ohtsuka, Takao|Takahata, Shunichi|Tanaka, Masao|Okada, Hidechika | ||||||||||
| PMID: | 22170414 | ||||||||||
| 23. | |||||||||||
| Journal: | Zhong Xi Yi Jie He Xue Bao. 2012 Mar;10(3):256-63. | ||||||||||
| Title: | Advances in Smoothened-targeting therapies for pancreatic cancer: implication for drug discovery from herbal medicines. | ||||||||||
| Author: | Han, Jin-bin|Hua, Yong-qiang|Chen, Lian-yu|Liu, Lu-ming | ||||||||||
| PMID: | 22409914 | ||||||||||
| 24. | |||||||||||
| Journal: | J Pharmacol Pharmacother. 2013 Jan;4(1):4-7. | ||||||||||
| Title: | The dawn of hedgehog inhibitors: Vismodegib. | ||||||||||
| Author: | Sandhiya, Selvarajan|Melvin, George|Kumar, Srinivasamurthy Suresh|Dkhar, Steven Aibor | ||||||||||
| PMID: | 23662017 | ||||||||||
| 25. | |||||||||||
| Journal: | Mol Cancer. 2013 Jun 20;12:66. | ||||||||||
| Title: | Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner. | ||||||||||
| Author: | Lei, Jianjun|Ma, Jiguang|Ma, Qingyong|Li, Xuqi|Liu, Han|Xu, Qinhong|Duan, Wanxing|Sun, Qing|Xu, Jun|Wu, Zheng|Wu, Erxi | ||||||||||
| PMID: | 23786654 | ||||||||||
| 26. | |||||||||||
| Journal: | Cancer Lett. 2013 Oct 10;339(2):185-94. | ||||||||||
| Title: | Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo. | ||||||||||
| Author: | Guo, Jiefang|Gao, Jun|Li, Zhaoshen|Gong, Yanfang|Man, Xiaohua|Jin, Jing|Wu, Hongyu | ||||||||||
| PMID: | 23791879 | ||||||||||
| 27. | |||||||||||
| Journal: | J Exp Clin Cancer Res. 2014 Jun 25;33:54. | ||||||||||
| Title: | miR-212 promotes pancreatic cancer cell growth and invasion by targeting the hedgehog signaling pathway receptor patched-1. | ||||||||||
| Author: | Ma, Chenchao|Nong, Kate|Wu, Bo|Dong, Bo|Bai, Yueqing|Zhu, Hongda|Wang, Weiwei|Huang, Xinyu|Yuan, Zhou|Ai, Kaixing | ||||||||||
| PMID: | 24961235 | ||||||||||
| 28. | |||||||||||
| Journal: | Clin Cancer Res. 2014 Dec 1;20(23):5937-5945. | ||||||||||
| Title: | Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma. | ||||||||||
| Author: | Kim, Edward J|Sahai, Vaibhav|Abel, Ethan V|Griffith, Kent A|Greenson, Joel K|Takebe, Naoko|Khan, Gazala N|Blau, John L|Craig, Ronald|Balis, Ulysses G|Zalupski, Mark M|Simeone, Diane M | ||||||||||
| PMID: | 25278454 | ||||||||||
| 29. | |||||||||||
| Journal: | Mol Med Rep. 2014 Nov;10(5):2563-7. | ||||||||||
| Title: | Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway. | ||||||||||
| Author: | Qin, Yong|Ma, Zhenhua|Dang, Xiaoyan|Li, Wei|Ma, Qingyong | ||||||||||
| PMID: | 25190613 | ||||||||||
| 30. | |||||||||||
| Journal: | World J Gastroenterol. 2014 Apr 28;20(16):4712-7. | ||||||||||
| Title: | Sonic hedgehog expression in a rat model of chronic pancreatitis. | ||||||||||
| Author: | Wang, Luo-Wei|Lin, Han|Lu, Yi|Xia, Wei|Gao, Jun|Li, Zhao-Shen | ||||||||||
| PMID: | 24782623 | ||||||||||
| 31. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2014 Apr;73(4):711-9. | ||||||||||
| Title: | Perifosine inhibits S6K1-Gli1 signaling and enhances gemcitabine-induced anti-pancreatic cancer efficiency. | ||||||||||
| Author: | Xin, Ying|Shen, Xiang-di|Cheng, Long|Hong, De-fei|Chen, Bin | ||||||||||
| PMID: | 24519751 | ||||||||||
| 32. | |||||||||||
| Journal: | Cancer Biol Ther. 2015;16(2):219-24. | ||||||||||
| Title: | PTCH 1 staining of pancreatic neuroendocrine tumor (PNET) samples from patients with and without multiple endocrine neoplasia (MEN-1) syndrome reveals a potential therapeutic target. | ||||||||||
| Author: | Gurung, Buddha|Hua, Xianxin|Runske, Melissa|Bennett, Bonita|LiVolsi, Virginia|Roses, Robert|Fraker, Douglas A|Metz, David C | ||||||||||
| PMID: | 25482929 | ||||||||||
| 33. | |||||||||||
| Journal: | Cancer Res. 2015 Jun 1;75(11):2292-304. | ||||||||||
| Title: | Ormeloxifene suppresses desmoplasia and enhances sensitivity of gemcitabine in pancreatic cancer. | ||||||||||
| Author: | Khan, Sheema|Ebeling, Mara C|Chauhan, Neeraj|Thompson, Paul A|Gara, Rishi K|Ganju, Aditya|Yallapu, Murali M|Behrman, Stephen W|Zhao, Haotian|Zafar, Nadeem|Singh, Man Mohan|Jaggi, Meena|Chauhan, Subhash C | ||||||||||
| PMID: | 25840985 | ||||||||||
| 34. | |||||||||||
| Journal: | Arch Pharm (Weinheim). 2016 Nov;349(11):848-852. | ||||||||||
| Title: | Synthesis, Molecular Mechanism and Pharmacokinetic Studies of New Epoxy Lignan-Based Derivatives. | ||||||||||
| Author: | Rifai, Yusnita|Tani, Harold B|Nur, Muhammad|Aswad, Muhammad|Lallo, Subehan|Wahyudin, Elly | ||||||||||
| PMID: | 27699826 | ||||||||||
| 35. | |||||||||||
| Journal: | Tumour Biol. 2016 Oct 12. pii: 10.1007/s13277-016-5461-8. | ||||||||||
| Title: | Ski modulate the characteristics of pancreatic cancer stem cells via regulating sonic hedgehog signaling pathway. | ||||||||||
| Author: | Song, Libin|Chen, Xiangyuan|Gao, Song|Zhang, Chenyue|Qu, Chao|Wang, Peng|Liu, Luming | ||||||||||
| PMID: | 27734340 | ||||||||||
| 36. | |||||||||||
| Journal: | PLoS One. 2016 Oct 26;11(10):e0164231. | ||||||||||
| Title: | Epithelial to Stromal Re-Distribution of Primary Cilia during Pancreatic Carcinogenesis. | ||||||||||
| Author: | Schimmack, Simon|Kneller, Sarah|Dadabaeva, Nigora|Bergmann, Frank|Taylor, Andrew|Hackert, Thilo|Werner, Jens|Strobel, Oliver | ||||||||||
| PMID: | 27783689 | ||||||||||
| 37. | |||||||||||
| Journal: | Pharmacogenomics J. 2017 Oct;17(5):452-460. | ||||||||||
| Title: | Hedgehog pathway overexpression in pancreatic cancer is abrogated by new-generation taxoid SB-T-1216. | ||||||||||
| Author: | Mohelnikova-Duchonova, B|Kocik, M|Duchonova, B|Brynychova, V|Oliverius, M|Hlavsa, J|Honsova, E|Mazanec, J|Kala, Z|Ojima, I|Hughes, D J|Doherty, J E|Murray, H A|Crockard, M A|Lemstrova, R|Soucek, P | ||||||||||
| PMID: | 27573236 | ||||||||||
| 38. | |||||||||||
| Journal: | Oncotarget. 2017 Jun 27;8(37):61674-61686. | ||||||||||
| Title: | Silencing IGFBP-2 decreases pancreatic cancer metastasis and enhances chemotherapeutic sensitivity. | ||||||||||
| Author: | Liu, Huan|Li, Le|Chen, Hua|Kong, Rui|Pan, Shangha|Hu, Jisheng|Wang, Yongwei|Li, Yilong|Sun, Bei | ||||||||||
| PMID: | 28977895 | ||||||||||