Primary Site >> Pancreatic Cancer
Gene >> PTCH1
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Ref: KIF27 is one of orthologs for Drosophila Costal-2. PMID: 15547729 |
Ref: Identification and characterization of rat Desert hedgehog and Indian hedgehog genes in silico. PMID: 15645142 Ref: Hedgehog signaling pathway and gastric cancer. PMID: 16258256 |
Ref: Aberrant expression of PTCH (patched gene) and Smo (smoothened gene) in human pancreatic cancerous tissues and its association with hyperglycemia. PMID: 16804411 Ref: Antisense Smo under the control of the PTCH1 promoter delivered by an adenoviral vector inhibits the growth of human pancreatic cancer. PMID: 16826192 Ref: Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). PMID: 17089004 |
Ref: Sonic hedgehog signaling pathway in pancreatic cystic neoplasms and ductal adenocarcinoma. PMID: 17414057 Ref: Anti-patched-1 antibodies suppress hedgehog signaling pathway and pancreatic cancer proliferation. PMID: 17970037 |
Ref: Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells. PMID: 18422746 Ref: An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer. PMID: 18790753 Ref: Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana. PMID: 18842418 |
Ref: GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. PMID: 19136624 Ref: Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer. PMID: 19232458 Ref: Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer. PMID: 19421011 Ref: Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. PMID: 19860666 |
Ref: Small-molecule modulators of the Sonic Hedgehog signaling pathway. PMID: 20024066 Ref: Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer. PMID: 20814245 |
Ref: New hedgehog/GLI-signaling inhibitors from Adenium obesum. PMID: 21170436 Ref: Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish. PMID: 22164219 Ref: Resveratrol inhibits proliferation and induces apoptosis through the hedgehog signaling pathway in pancreatic cancer cell. PMID: 22301921 |
Ref: Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas. PMID: 22076568 Ref: Targeting the hedgehog signaling pathway with interacting peptides to Patched-1. PMID: 22170414 Ref: Advances in Smoothened-targeting therapies for pancreatic cancer: implication for drug discovery from herbal medicines. PMID: 22409914 |
Ref: The dawn of hedgehog inhibitors: Vismodegib. PMID: 23662017 Ref: Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner. PMID: 23786654 Ref: Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo. PMID: 23791879 |
Ref: Perifosine inhibits S6K1-Gli1 signaling and enhances gemcitabine-induced anti-pancreatic cancer efficiency. PMID: 24519751 Ref: Sonic hedgehog expression in a rat model of chronic pancreatitis. PMID: 24782623 Ref: miR-212 promotes pancreatic cancer cell growth and invasion by targeting the hedgehog signaling pathway receptor patched-1. PMID: 24961235 Ref: Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway. PMID: 25190613 Ref: Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma. PMID: 25278454 |
Ref: PTCH 1 staining of pancreatic neuroendocrine tumor (PNET) samples from patients with and without multiple endocrine neoplasia (MEN-1) syndrome reveals a potential therapeutic target. PMID: 25482929 Ref: Ormeloxifene suppresses desmoplasia and enhances sensitivity of gemcitabine in pancreatic cancer. PMID: 25840985 |
Ref: Synthesis, Molecular Mechanism and Pharmacokinetic Studies of New Epoxy Lignan-Based Derivatives. PMID: 27699826 Ref: Ski modulate the characteristics of pancreatic cancer stem cells via regulating sonic hedgehog signaling pathway. PMID: 27734340 Ref: Epithelial to Stromal Re-Distribution of Primary Cilia during Pancreatic Carcinogenesis. PMID: 27783689 |
Ref: Hedgehog pathway overexpression in pancreatic cancer is abrogated by new-generation taxoid SB-T-1216. PMID: 27573236 Ref: Silencing IGFBP-2 decreases pancreatic cancer metastasis and enhances chemotherapeutic sensitivity. PMID: 28977895 |