Primary Site >> Colorectal Cancer

Gene >> PRMT5

Journal: Mol Cancer Ther. 2007 Apr;6(4):1198-211.
Title: Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.
Author: Sharp, Swee Y|Prodromou, Chrisostomos|Boxall, Kathy|Powers, Marissa V|Holmes, Joanna L|Box, Gary|Matthews, Thomas P|Cheung, Kwai-Ming J|Kalusa, Andrew|James, Karen|Hayes, Angela|Hardcastle, Anthea|Dymock, Brian|Brough, Paul A|Barril, Xavier|Cansfield, Jul
PMID: 17431102
Journal: EMBO J. 2012 Apr 4;31(7):1785-97.
Title: Arginine methylation controls growth regulation by E2F-1.
Author: Cho, Er-Chieh|Zheng, Shunsheng|Munro, Shonagh|Liu, Geng|Carr, Simon M|Moehlenbrink, Jutta|Lu, Yi-Chien|Stimson, Lindsay|Khan, Omar|Konietzny, Rebecca|McGouran, Joanna|Coutts, Amanda S|Kessler, Benedikt|Kerr, David J|Thangue, Nicholas B La
PMID: 22327218
Journal: Oncotarget. 2015 Sep 8;6(26):22799-811.
Title: Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3.
Author: Zhang, Baolai|Dong, Shuhong|Zhu, Ruiming|Hu, Chunyan|Hou, Jing|Li, Yan|Zhao, Qian|Shao, Xue|Bu, Qian|Li, Hongyu|Wu, Yongjie|Cen, Xiaobo|Zhao, Yinglan
PMID: 26078354
Journal: Pathol Int. 2015 Oct;65(10):541-8.
Title: High nuclear expression of protein arginine methyltransferase-5 is a potentially useful marker to estimate submucosal invasion in endoscopically resected early colorectal carcinoma.
Author: Pak, Min Gyoung|Lee, Hyoun Wook|Roh, Mee Sook
PMID: 26248553
Journal: BMC Cancer. 2015 Sep 15;15:638.
Title: Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling.
Author: Rastetter, Raphael H|Blomacher, Margit|Drebber, Uta|Marko, Marija|Behrens, Juliane|Solga, Roxana|Hojeili, Sarah|Bhattacharya, Kurchi|Wunderlich, Claudia M|Wunderlich, F Thomas|Odenthal, Margarete|Ziemann, Anja|Eichinger, Ludwig|Clemen, Christoph S
PMID: 26373535
Journal: Chem Biol Drug Des. 2017 Apr;89(4):585-598.
Title: Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations.
Author: Ji, Sen|Ma, Shuang|Wang, Wen-Jing|Huang, Shen-Zhen|Wang, Tian-Qi|Xiang, Rong|Hu, Yi-Guo|Chen, Qiang|Li, Lin-Li|Yang, Sheng-Yong
PMID: 27714957
Journal: Oncotarget. 2017 Jun 20;8(25):39963-39977.
Title: Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers.
Author: Prabhu, Lakshmi|Wei, Han|Chen, Lan|Demir, Ozlem|Sandusky, George|Sun, Emily|Wang, John|Mo, Jessica|Zeng, Lifan|Fishel, Melissa|Safa, Ahmad|Amaro, Rommie|Korc, Murray|Zhang, Zhong-Yin|Lu, Tao
PMID: 28591716
Journal: Mol Biosyst. 2017 Nov 21;13(12):2509-2520.
Title: Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases.
Author: Prabhu, Lakshmi|Chen, Lan|Wei, Han|Demir, Ozlem|Safa, Ahmad|Zeng, Lifan|Amaro, Rommie E|O'Neil, Bert H|Zhang, Zhon-Yin|Lu, Tao
PMID: 29099132
Journal: Oncol Rep. 2018 Jul;40(1):536-544.
Title: Protein arginine methyltransferase 5 is implicated in the aggressiveness of human hepatocellular carcinoma and controls the invasive activity of cancer cells.
Author: Jeon, Ju-Yeon|Lee, Jee San|Park, Eun-Ran|Shen, Yan Nan|Kim, Mi-Yeun|Shin, Hyun-Jin|Joo, Hyun-Yoo|Cho, Eung-Ho|Moon, Sun Mi|Shin, Ui Sup|Park, Sun Hoo|Han, Chul Ju|Choi, Dong Wook|Gu, Man Bock|Kim, Sang-Bum|Lee, Kee-Ho
PMID: 29749478
Journal: J Biol Chem. 2018 Oct 3. pii: RA118.003629.
Title: Sirtuin 7-mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity.
Author: Qi, Hao|Shi, Xiaoyan|Yu, Miao|Liu, Boya|Liu, Minghui|Song, Shi|Chen, Shuaiyi|Zou, Junhua|Zhu, Wei-Guo|Luo, Jianyuan
PMID: 30282801