Primary Site >> Colorectal Cancer
Gene >> PRMT5
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Ref: Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. PMID: 17431102 |
Ref: Arginine methylation controls growth regulation by E2F-1. PMID: 22327218 |
Ref: Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3. PMID: 26078354 Ref: High nuclear expression of protein arginine methyltransferase-5 is a potentially useful marker to estimate submucosal invasion in endoscopically resected early colorectal carcinoma. PMID: 26248553 Ref: Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling. PMID: 26373535 |
Ref: Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations. PMID: 27714957 Ref: Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers. PMID: 28591716 Ref: Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases. PMID: 29099132 |
Ref: Protein arginine methyltransferase 5 is implicated in the aggressiveness of human hepatocellular carcinoma and controls the invasive activity of cancer cells. PMID: 29749478 Ref: Sirtuin 7-mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity. PMID: 30282801 |