Primary Site >> Colorectal Cancer

Gene >> PRKG1

Journal: Biochemistry. 1994 May 17;33(19):6024-30.
Title: Mapping of DNA alkylation sites induced by adozelesin and bizelesin in human cells by ligation-mediated polymerase chain reaction.
Author: Lee, C S|Pfeifer, G P|Gibson, N W
PMID: 8180230
Journal: J Biol Chem. 2001 May 11;276(19):16406-10. Epub 2001 Mar 14.
Title: Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1.
Author: Soh, J W|Mao, Y|Liu, L|Thompson, W J|Pamukcu, R|Weinstein, I B
PMID: 11278263
Journal: J Pharmacol Exp Ther. 2001 Nov;299(2):583-92.
Title: Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells.
Author: Liu, L|Li, H|Underwood, T|Lloyd, M|David, M|Sperl, G|Pamukcu, R|Thompson, W J
PMID: 11602670
Journal: Zhonghua Zhong Liu Za Zhi. 2002 Mar;24(2):133-6.
Title: [Action of apoptosis-induced ligand gene in relation to tumor necrosis factor on human colon cancer cell line HT29].
Author: He, Chao|Hu, Xiaotong|Xu, Xiangming|Fang, Bingliang
PMID: 12015033
Journal: Mol Cancer Ther. 2002 Aug;1(10):803-9.
Title: Vasodilator-stimulated phosphoprotein (VASP) phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein kinase G.
Author: Deguchi, Atsuko|Soh, Jae-Won|Li, Han|Pamukcu, Rifat|Thompson, W Joseph|Weinstein, I Bernard
PMID: 12492113
Journal: Cancer Biol Ther. 2002 Nov-Dec;1(6):621-5.
Title: beta-Catenin signaling: therapeutic strategies in oncology.
Author: Li, Han|Pamukcu, Rifat|Thompson, W Joseph
PMID: 12642683
Journal: World J Gastroenterol. 2003 May;9(5):965-9.
Title: Tumor necrosis factor-related apoptosis-inducing ligand gene on human colorectal cancer cell line HT29.
Author: Xu, Xiang-Ming|He, Chao|Hu, Xiao-Tong|Fang, Bing-Liang
PMID: 12717839
Journal: Cancer Res. 2004 Jun 1;64(11):3966-73.
Title: Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells.
Author: Deguchi, Atsuko|Thompson, W Joseph|Weinstein, I Bernard
PMID: 15173009
Journal: J Cell Biochem. 2005 Feb 1;94(2):336-50.
Title: Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells.
Author: Zhu, Bing|Vemavarapu, Lakshmi|Thompson, W Joseph|Strada, Samuel J
PMID: 15526282
Journal: Oncogene. 2005 Dec 15;24(56):8240-51.
Title: Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment.
Author: Nguyen, Quang-De|De Wever, Olivier|Bruyneel, Erik|Hendrix, An|Xie, Wan-Zhuo|Lombet, Alain|Leibl, Martin|Mareel, Marc|Gieseler, Frank|Bracke, Marc|Gespach, Christian
PMID: 16091733
Journal: Cancer Res. 2005 Sep 15;65(18):8442-7.
Title: Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells.
Author: Deguchi, Atsuko|Xing, Steven W|Shureiqi, Imad|Yang, Peiying|Newman, Robert A|Lippman, Scott M|Feinmark, Steven J|Oehlen, Bert|Weinstein, I Bernard
PMID: 16166323
Journal: Biomed Pharmacother. 2005 Oct;59 Suppl 2:S370-4.
Title: Gene targeting approach to selectively kill colon cancer cells, with hyperactive K-Ras pathway.
Author: Dvory-Sobol, H|Kazanov, D|Arber, N
PMID: 16507412
Journal: Mol Cancer Ther. 2006 Mar;5(3):746-54.
Title: Sulindac independently modulates extracellular signal-regulated kinase 1/2 and cyclic GMP-dependent protein kinase signaling pathways.
Author: Rice, Pamela L|Peters, Stevany L|Beard, K Scott|Ahnen, Dennis J
PMID: 16546990
Journal: Cancer Lett. 2006 Aug 18;240(1):60-8.
Title: An anti-tumor role for cGMP-dependent protein kinase.
Author: Hou, Yali|Gupta, Naren|Schoenlein, Patricia|Wong, Elsie|Martindale, Robert|Ganapathy, Vadivel|Browning, Darren
PMID: 16256267
Journal: Cell Signal. 2006 Jun;18(6):882-8.
Title: A role for cyclic-GMP dependent protein kinase in anoikis.
Author: Hou, Yali|Wong, Elsie|Martin, Jessica|Schoenlein, Patricia V|Dostmann, Wolfgang R|Browning, Darren D
PMID: 16139477
Journal: J Appl Toxicol. 2008 May;28(4):475-83.
Title: Downregulation of human colon carcinoma cell (COLO-205) proliferation through PKG-MAP kinase mediated signaling cascade by E. coli heat stable enterotoxin (STa), a potent anti-angiogenic and anti-metastatic molecule.
Author: Saha, Subhrajit|Chowdhury, Pinki|Pal, Amit|Chakrabarti, Manoj K
PMID: 17828804
Journal: Mol Carcinog. 2008 Jul;47(7):519-25.
Title: Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G.
Author: Soh, Jae-Won|Kazi, Julhash U|Li, Han|Thompson, W Joseph|Weinstein, I Bernard
PMID: 18163459
Journal: Cancer. 2008 Apr 1;112(7):1462-70.
Title: Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis.
Author: Kwon, In-Kiu|Schoenlein, Patricia V|Delk, Jennifer|Liu, Kebin|Thangaraju, Muthusmy|Dulin, Nickolai O|Ganapathy, Vadivel|Berger, Franklin G|Browning, Darren D
PMID: 18260092
Journal: Expert Opin Ther Targets. 2008 Mar;12(3):367-76.
Title: Protein kinase G as a therapeutic target for the treatment of metastatic colorectal cancer.
Author: Browning, Darren D
PMID: 18269345
Journal: Cancer Res. 2008 Jul 1;68(13):5355-62.
Title: Activation of protein kinase G Increases the expression of p21CIP1, p27KIP1, and histidine triad protein 1 through Sp1.
Author: Cen, Bo|Deguchi, Atsuko|Weinstein, I Bernard
PMID: 18593937
Journal: Oncogene. 2010 Jun 10;29(23):3423-34.
Title: PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4.
Author: Kwon, I-K|Wang, R|Thangaraju, M|Shuang, H|Liu, K|Dashwood, R|Dulin, N|Ganapathy, V|Browning, D D
PMID: 20348951
Journal: Future Med Chem. 2010 Jan;2(1):65-80.
Title: cGMP-dependent protein kinases as potential targets for colon cancer prevention and treatment.
Author: Browning, Darren D|Kwon, In-Kiu|Wang, Rui
PMID: 21426046
Journal: Int J Cancer. 2012 Jun 1;130(11):2539-48.
Title: Phosphorylation of vasodilator-stimulated phosphoprotein Ser239 suppresses filopodia and invadopodia in colon cancer.
Author: Zuzga, David S|Pelta-Heller, Joshua|Li, Peng|Bombonati, Alessandro|Waldman, Scott A|Pitari, Giovanni M
PMID: 21702043
Journal: Cancer Prev Res (Phila). 2012 Jun;5(6):822-33.
Title: A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and beta-catenin transcriptional activity.
Author: Whitt, Jason D|Li, Nan|Tinsley, Heather N|Chen, Xi|Zhang, Wei|Li, Yonghe|Gary, Bernard D|Keeton, Adam B|Xi, Yaguang|Abadi, Ashraf H|Grizzle, William E|Piazza, Gary A
PMID: 22556201
Journal: Mol Cancer Ther. 2013 Sep;12(9):1848-59.
Title: Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/beta-catenin signaling.
Author: Li, Nan|Xi, Yaguang|Tinsley, Heather N|Gurpinar, Evrim|Gary, Bernard D|Zhu, Bing|Li, Yonghe|Chen, Xi|Keeton, Adam B|Abadi, Ashraf H|Moyer, Mary P|Grizzle, William E|Chang, Wen-Chi|Clapper, Margie L|Piazza, Gary A
PMID: 23804703
Journal: Oncotarget. 2016 Feb 2;7(5):5353-65.
Title: beta-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG.
Author: Lee, Kevin|Lindsey, Ashley S|Li, Nan|Gary, Bernard|Andrews, Joel|Keeton, Adam B|Piazza, Gary A
PMID: 26713600
Journal: J Biomed Res. 2017 Jan 19;31(3):189-196.
Title: The interaction between the Wnt/beta-catenin signaling cascade and PKG activation in cancer.
Author: Lee, Kevin|A Piazza, Gary
PMID: 28808213
Journal: Eur J Med Chem. 2017 Dec 1;141:61-72.
Title: New dimeric cGMP analogues reduce proliferation in three colon cancer cell lines.
Author: Hoffmann, Dorit|Rentsch, Andreas|Vighi, Eleonora|Bertolotti, Evelina|Comitato, Antonella|Schwede, Frank|Genieser, Hans-Gottfried|Marigo, Valeria
PMID: 29028532