Primary Site >> Colorectal Cancer
Gene >> PRKG1
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Mapping of DNA alkylation sites induced by adozelesin and bizelesin in human cells by ligation-mediated polymerase chain reaction. PMID: 8180230 |
Ref: Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1. PMID: 11278263 Ref: Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells. PMID: 11602670 |
Ref: [Action of apoptosis-induced ligand gene in relation to tumor necrosis factor on human colon cancer cell line HT29]. PMID: 12015033 Ref: Vasodilator-stimulated phosphoprotein (VASP) phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein kinase G. PMID: 12492113 Ref: beta-Catenin signaling: therapeutic strategies in oncology. PMID: 12642683 |
Ref: Tumor necrosis factor-related apoptosis-inducing ligand gene on human colorectal cancer cell line HT29. PMID: 12717839 |
Ref: Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells. PMID: 15173009 |
Ref: Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells. PMID: 15526282 Ref: Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment. PMID: 16091733 Ref: Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells. PMID: 16166323 Ref: Gene targeting approach to selectively kill colon cancer cells, with hyperactive K-Ras pathway. PMID: 16507412 |
Ref: A role for cyclic-GMP dependent protein kinase in anoikis. PMID: 16139477 Ref: An anti-tumor role for cGMP-dependent protein kinase. PMID: 16256267 Ref: Sulindac independently modulates extracellular signal-regulated kinase 1/2 and cyclic GMP-dependent protein kinase signaling pathways. PMID: 16546990 |
Ref: Downregulation of human colon carcinoma cell (COLO-205) proliferation through PKG-MAP kinase mediated signaling cascade by E. coli heat stable enterotoxin (STa), a potent anti-angiogenic and anti-metastatic molecule. PMID: 17828804 Ref: Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G. PMID: 18163459 Ref: Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis. PMID: 18260092 Ref: Protein kinase G as a therapeutic target for the treatment of metastatic colorectal cancer. PMID: 18269345 Ref: Activation of protein kinase G Increases the expression of p21CIP1, p27KIP1, and histidine triad protein 1 through Sp1. PMID: 18593937 |
Ref: PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4. PMID: 20348951 Ref: cGMP-dependent protein kinases as potential targets for colon cancer prevention and treatment. PMID: 21426046 |
Ref: Phosphorylation of vasodilator-stimulated phosphoprotein Ser239 suppresses filopodia and invadopodia in colon cancer. PMID: 21702043 Ref: A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and beta-catenin transcriptional activity. PMID: 22556201 |
Ref: Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/beta-catenin signaling. PMID: 23804703 |
Ref: beta-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG. PMID: 26713600 |
Ref: The interaction between the Wnt/beta-catenin signaling cascade and PKG activation in cancer. PMID: 28808213 Ref: New dimeric cGMP analogues reduce proliferation in three colon cancer cell lines. PMID: 29028532 |