Primary Site >> Colorectal Cancer
Gene >> PRKAA1
| 1. | |||||||||||
| Journal: | J Exp Clin Cancer Res. 2004 Jun;23(2):263-8. | ||||||||||
| Title: | Strong association of ARK5 with tumor invasion and metastasis. | ||||||||||
| Author: | Kusakai, G|Suzuki, A|Ogura, T|Kaminishi, M|Esumi, H | ||||||||||
| PMID: | 15354411 | ||||||||||
| 2. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 2005 Jul 1;332(2):433-40. | ||||||||||
| Title: | Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. | ||||||||||
| Author: | Hwang, Jin-Taek|Ha, Joohun|Park, Ock Jin | ||||||||||
| PMID: | 15896711 | ||||||||||
| 3. | |||||||||||
| Journal: | Carcinogenesis. 2010 Jun;31(6):1092-9. | ||||||||||
| Title: | Suppression of mTOR via Akt-dependent and -independent mechanisms in selenium-treated colon cancer cells: involvement of AMPKalpha1. | ||||||||||
| Author: | Lee, Yun-Kyoung|Park, Song Yi|Kim, Young-Min|Kim, Dong Chool|Lee, Won Sup|Surh, Young-Joon|Park, Ock Jin | ||||||||||
| PMID: | 20164123 | ||||||||||
| 4. | |||||||||||
| Journal: | Carcinogenesis. 2010 Sep;31(9):1604-11. | ||||||||||
| Title: | Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. | ||||||||||
| Author: | Slattery, Martha L|Herrick, Jennifer S|Lundgreen, Abbie|Fitzpatrick, Francis A|Curtin, Karen|Wolff, Roger K | ||||||||||
| PMID: | 20622004 | ||||||||||
| 5. | |||||||||||
| Journal: | Br J Cancer. 2010 Sep 28;103(7):1025-33. | ||||||||||
| Title: | Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer. | ||||||||||
| Author: | Baba, Y|Nosho, K|Shima, K|Meyerhardt, J A|Chan, A T|Engelman, J A|Cantley, L C|Loda, M|Giovannucci, E|Fuchs, C S|Ogino, S | ||||||||||
| PMID: | 20808308 | ||||||||||
| 6. | |||||||||||
| Journal: | Oncol Rep. 2010 Dec;24(6):1471-7. | ||||||||||
| Title: | Anthocyanins are novel AMPKalpha1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation. | ||||||||||
| Author: | Lee, Yun-Kyoung|Lee, Won Sup|Kim, Gon Sup|Park, Ock Jin | ||||||||||
| PMID: | 21042741 | ||||||||||
| 7. | |||||||||||
| Journal: | Radiother Oncol. 2011 Jun;99(3):293-9. | ||||||||||
| Title: | AMPK regulates metabolism and survival in response to ionizing radiation. | ||||||||||
| Author: | Zannella, Vanessa E|Cojocari, Dan|Hilgendorf, Susan|Vellanki, Ravi N|Chung, Stephen|Wouters, Bradly G|Koritzinsky, Marianne | ||||||||||
| PMID: | 21715037 | ||||||||||
| 8. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 2012 Oct 5;426(4):461-7. | ||||||||||
| Title: | Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin beta1 signaling. | ||||||||||
| Author: | Park, Jung-Jin|Seo, Seon-Mi|Kim, Eun Ju|Lee, Yoon-Jin|Ko, Young-Gyu|Ha, Joohun|Lee, Minyoung | ||||||||||
| PMID: | 22943849 | ||||||||||
| 9. | |||||||||||
| Journal: | Apoptosis. 2012 Sep;17(9):938-49. | ||||||||||
| Title: | Quercetin enhances hypoxia-mediated apoptosis via direct inhibition of AMPK activity in HCT116 colon cancer. | ||||||||||
| Author: | Kim, Hak-Su|Wannatung, Tirawat|Lee, Sooho|Yang, Woo Kyeom|Chung, Sung Hyun|Lim, Jong-Seok|Choe, Wonchae|Kang, Insug|Kim, Sung-Soo|Ha, Joohun | ||||||||||
| PMID: | 22684842 | ||||||||||
| 10. | |||||||||||
| Journal: | J Surg Oncol. 2012 Nov;106(6):680-8. | ||||||||||
| Title: | AMPK inhibitor compound C suppresses cell proliferation by induction of apoptosis and autophagy in human colorectal cancer cells. | ||||||||||
| Author: | Yang, Weng-Lang|Perillo, William|Liou, Deanna|Marambaud, Philippe|Wang, Ping | ||||||||||
| PMID: | 22674626 | ||||||||||
| 11. | |||||||||||
| Journal: | BMC Cancer. 2012 Mar 26;12:118. | ||||||||||
| Title: | Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial. | ||||||||||
| Author: | Higurashi, Takuma|Takahashi, Hirokazu|Endo, Hiroki|Hosono, Kunihiro|Yamada, Eiji|Ohkubo, Hidenori|Sakai, Eiji|Uchiyama, Takashi|Hata, Yasuo|Fujisawa, Nobutaka|Uchiyama, Shiori|Ezuka, Akiko|Nagase, Hajime|Kessoku, Takaomi|Matsuhashi, Nobuyuki|Yamanaka, Sho | ||||||||||
| PMID: | 22443173 | ||||||||||
| 12. | |||||||||||
| Journal: | J Cancer Res Clin Oncol. 2013 Jan;139(1):131-8. | ||||||||||
| Title: | Significant correlation between LKB1 and LGR5 gene expression and the association with poor recurrence-free survival in rectal cancer after preoperative chemoradiotherapy. | ||||||||||
| Author: | Saigusa, Susumu|Inoue, Yasuhiro|Tanaka, Koji|Toiyama, Yuji|Kawamura, Mikio|Okugawa, Yoshinaga|Okigami, Masato|Hiro, Junichiro|Uchida, Keiichi|Mohri, Yasuhiko|Kusunoki, Masato | ||||||||||
| PMID: | 22986809 | ||||||||||
| 13. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 2013 Jan 11;430(2):653-8. | ||||||||||
| Title: | p21(WAF(1)/C(1)P(1)) deficiency induces mitochondrial dysfunction in HCT116 colon cancer cells. | ||||||||||
| Author: | Kim, Ae Jeong|Jee, Hye Jin|Song, Naree|Kim, Minjee|Jeong, Seon-Young|Yun, Jeanho | ||||||||||
| PMID: | 23211592 | ||||||||||
| 14. | |||||||||||
| Journal: | Asian Pac J Cancer Prev. 2013;14(6):3631-4. | ||||||||||
| Title: | MicroRNA-451 inhibits growth of human colorectal carcinoma cells via downregulation of Pi3k/Akt pathway. | ||||||||||
| Author: | Li, Hong-Yan|Zhang, Yan|Cai, Jian-Hui|Bian, Hong-Lei | ||||||||||
| PMID: | 23886157 | ||||||||||
| 15. | |||||||||||
| Journal: | Rev Med Liege. 2013 Sep;68(9):444-9. | ||||||||||
| Title: | [Metformin, an antidiabetic molecule with anti-cancer properties]. | ||||||||||
| Author: | Beck, E|Scheen, A J | ||||||||||
| PMID: | 24180199 | ||||||||||
| 16. | |||||||||||
| Journal: | J Cancer Prev. 2013 Sep;18(3):264-70. | ||||||||||
| Title: | Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells. | ||||||||||
| Author: | Kim, Guen Tae|Lee, Se Hee|Kim, Young Min | ||||||||||
| PMID: | 25337554 | ||||||||||
| 17. | |||||||||||
| Journal: | Autophagy. 2014 Sep;10(9):1495-508. | ||||||||||
| Title: | Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells. | ||||||||||
| Author: | Xie, Chuan-Ming|Liu, Xiao-Yu|Sham, Kathy W Y|Lai, Josie M Y|Cheng, Christopher H K | ||||||||||
| PMID: | 24955726 | ||||||||||
| 18. | |||||||||||
| Journal: | Exp Mol Med. 2014 Dec 5;46:e124. | ||||||||||
| Title: | Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells. | ||||||||||
| Author: | Hwang, Won Chan|Kim, Mi Kyoung|Song, Ju Hyun|Choi, Kang-Yell|Min, Do Sik | ||||||||||
| PMID: | 25475140 | ||||||||||
| 19. | |||||||||||
| Journal: | Br J Cancer. 2014 Jul 8;111(1):25-32. | ||||||||||
| Title: | Prognostic significance of AMPK activation in advanced stage colorectal cancer treated with chemotherapy plus bevacizumab. | ||||||||||
| Author: | Zulato, E|Bergamo, F|De Paoli, A|Griguolo, G|Esposito, G|De Salvo, G L|Mescoli, C|Rugge, M|Nardin, M|Di Grazia, L|Lonardi, S|Indraccolo, S|Zagonel, V | ||||||||||
| PMID: | 24892446 | ||||||||||
| 20. | |||||||||||
| Journal: | PLoS One. 2014 May 21;9(5):e97781. | ||||||||||
| Title: | Use of metformin alone is not associated with survival outcomes of colorectal cancer cell but AMPK activator AICAR sensitizes anticancer effect of 5-fluorouracil through AMPK activation. | ||||||||||
| Author: | Sui, Xinbing|Xu, Yinghua|Yang, Jie|Fang, Yong|Lou, Haizhou|Han, Weidong|Zhang, Maolin|Chen, Wei|Wang, Kaifeng|Li, Da|Jin, Wei|Lou, Fang|Zheng, Yu|Hu, Hong|Gong, Liu|Zhou, Xiaoyun|Pan, Qin|Pan, Hongming|Wang, Xian|He, Chao | ||||||||||
| PMID: | 24849329 | ||||||||||
| 21. | |||||||||||
| Journal: | Mediators Inflamm. 2014;2014:287381. | ||||||||||
| Title: | Astrocyte elevated gene-1 mediates glycolysis and tumorigenesis in colorectal carcinoma cells via AMPK signaling. | ||||||||||
| Author: | Song, Hong-tao|Qin, Yu|Yao, Guo-dong|Tian, Zhen-nan|Fu, Song-bin|Geng, Jing-shu | ||||||||||
| PMID: | 24829520 | ||||||||||
| 22. | |||||||||||
| Journal: | Ann Surg Oncol. 2014 Dec;21 Suppl 4:S634-9. | ||||||||||
| Title: | Genetic variations in STK11, PRKAA1, and TSC1 associated with prognosis for patients with colorectal cancer. | ||||||||||
| Author: | Lee, Soo Jung|Kang, Byung Woog|Chae, Yee Soo|Kim, Hye Jin|Park, Su Yeon|Park, Jun Seok|Choi, Gyu Seog|Jeon, Hyo-Sung|Lee, Won Kee|Kim, Jong Gwang | ||||||||||
| PMID: | 24770722 | ||||||||||
| 23. | |||||||||||
| Journal: | Cell Signal. 2014 Jan;26(1):102-9. | ||||||||||
| Title: | MicroRNA-451 regulates AMPK/mTORC1 signaling and fascin1 expression in HT-29 colorectal cancer. | ||||||||||
| Author: | Chen, Min-Bin|Wei, Mu-Xin|Han, Jun-Yi|Wu, Xiao-Yang|Li, Chen|Wang, Jian|Shen, Wei|Lu, Pei-Hua | ||||||||||
| PMID: | 23899558 | ||||||||||
| 24. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2014 Jul;74(1):167-76. | ||||||||||
| Title: | Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells. | ||||||||||
| Author: | Min, Han|Xu, Min|Chen, Zhi-Rong|Zhou, Jun-Dong|Huang, Min|Zheng, Kai|Zou, Xiao-Ping | ||||||||||
| PMID: | 24842158 | ||||||||||
| 25. | |||||||||||
| Journal: | Biochem J. 2015 Jul 15;469(2):177-87. | ||||||||||
| Title: | Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis. | ||||||||||
| Author: | O'Brien, Andrew J|Villani, Linda A|Broadfield, Lindsay A|Houde, Vanessa P|Galic, Sandra|Blandino, Giovanni|Kemp, Bruce E|Tsakiridis, Theodoros|Muti, Paola|Steinberg, Gregory R | ||||||||||
| PMID: | 25940306 | ||||||||||
| 26. | |||||||||||
| Journal: | Nat Genet. 2015 Aug;47(8):906-10. | ||||||||||
| Title: | Loss-of-function variants in ATM confer risk of gastric cancer. | ||||||||||
| Author: | Helgason, Hannes|Rafnar, Thorunn|Olafsdottir, Halla S|Jonasson, Jon G|Sigurdsson, Asgeir|Stacey, Simon N|Jonasdottir, Adalbjorg|Tryggvadottir, Laufey|Alexiusdottir, Kristin|Haraldsson, Asgeir|le Roux, Louise|Gudmundsson, Julius|Johannsdottir, Hrefna|Oddss | ||||||||||
| PMID: | 26098866 | ||||||||||
| 27. | |||||||||||
| Journal: | Mol Cancer. 2015 Jun 27;14:123. | ||||||||||
| Title: | NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7. | ||||||||||
| Author: | Banskota, Suhrid|Regmi, Sushil C|Kim, Jung-Ae | ||||||||||
| PMID: | 26116564 | ||||||||||
| 28. | |||||||||||
| Journal: | Eur J Pharmacol. 2015 Oct 5;764:124-33. | ||||||||||
| Title: | Physcion induces mitochondria-driven apoptosis in colorectal cancer cells via downregulating EMMPRIN. | ||||||||||
| Author: | Chen, Xuehong|Gao, Hui|Han, Yantao|Ye, Junli|Xie, Jing|Wang, Chunbo | ||||||||||
| PMID: | 26144377 | ||||||||||
| 29. | |||||||||||
| Journal: | Mol Pharmacol. 2015 Oct;88(4):708-19. | ||||||||||
| Title: | Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells. | ||||||||||
| Author: | Jung, Yu Ri|Kim, Eun Ju|Choi, Hyeong Jwa|Park, Jung-Jin|Kim, Hak-Su|Lee, Yoon-Jin|Park, Myung-Jin|Lee, Minyoung | ||||||||||
| PMID: | 26219912 | ||||||||||
| 30. | |||||||||||
| Journal: | Radiother Oncol. 2015 Sep;116(3):409-16. | ||||||||||
| Title: | AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro. | ||||||||||
| Author: | Chaachouay, Hassan|Fehrenbacher, Birgit|Toulany, Mahmoud|Schaller, Martin|Multhoff, Gabriele|Rodemann, H Peter | ||||||||||
| PMID: | 26318663 | ||||||||||
| 31. | |||||||||||
| Journal: | Sci Rep. 2015 Oct 29;5:15900. | ||||||||||
| Title: | The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death. | ||||||||||
| Author: | Huang, Yu-Han|Huang, Shiu-Wen|Hsu, Ya-Fen|Ou, George|Huang, Wei-Jan|Hsu, Ming-Jen | ||||||||||
| PMID: | 26510776 | ||||||||||
| 32. | |||||||||||
| Journal: | Oncotarget. 2016 Jul 19;7(29):45889-45900. | ||||||||||
| Title: | Aqueous Oldenlandia diffusa extracts inhibits colorectal cancer cells via activating AMP-activated protein kinase signalings. | ||||||||||
| Author: | Lu, Pei-Hua|Chen, Min-Bin|Ji, Chao|Li, Wen-Ting|Wei, Mu-Xin|Wu, Mian-Hua | ||||||||||
| PMID: | 27322552 | ||||||||||
| 33. | |||||||||||
| Journal: | Sci Rep. 2016 Jan 11;6:18949. | ||||||||||
| Title: | BRAF V600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells. | ||||||||||
| Author: | Sueda, Toshinori|Sakai, Daisuke|Kawamoto, Koichi|Konno, Masamitsu|Nishida, Naohiro|Koseki, Jun|Colvin, Hugh|Takahashi, Hidekazu|Haraguchi, Naotsugu|Nishimura, Junichi|Hata, Taishi|Takemasa, Ichiro|Mizushima, Tsunekazu|Yamamoto, Hirofumi|Satoh, Taroh|Doki, | ||||||||||
| PMID: | 26750638 | ||||||||||
| 34. | |||||||||||
| Journal: | Int J Oncol. 2017 Jan;50(1):161-172. | ||||||||||
| Title: | Metabolic reprogramming and AMPKalpha1 pathway activation by caulerpin in colorectal cancer cells. | ||||||||||
| Author: | Yu, Hua|Zhang, Huiqin|Dong, Mingjun|Wu, Zhou|Shen, Zhonglei|Xie, Yangyang|Kong, Zhenfang|Dai, Xiaoyu|Xu, Binbin | ||||||||||
| PMID: | 27922662 | ||||||||||
| 35. | |||||||||||
| Journal: | Oncotarget. 2017 Jan 24;8(4):6419-6432. | ||||||||||
| Title: | Autophagy inhibition enhances photocytotoxicity of Photosan-II in human colorectal cancer cells. | ||||||||||
| Author: | Xiong, Li|Liu, Zhipeng|Ouyang, Guoqing|Lin, Liangwu|Huang, He|Kang, Hongxiang|Chen, Wei|Miao, Xiongying|Wen, Yu | ||||||||||
| PMID: | 28031534 | ||||||||||
| 36. | |||||||||||
| Journal: | Oncotarget. 2017 Feb 28;8(9):14736-14747. | ||||||||||
| Title: | AMPK-autophagy inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity. | ||||||||||
| Author: | Zhou, Chunxian|Gu, Jun|Zhang, Gang|Dong, Da|Yang, Qunying|Chen, Min-Bin|Xu, Dongfeng | ||||||||||
| PMID: | 28103582 | ||||||||||
| 37. | |||||||||||
| Journal: | Oncotarget. 2017 Mar 14;8(11):18312-18321. | ||||||||||
| Title: | NPC-26 kills human colorectal cancer cells via activating AMPK signaling. | ||||||||||
| Author: | Zhao, Zhen|Feng, Li|Wang, Jiqin|Cheng, Deshan|Liu, Mei|Ling, Meirong|Xu, Weiping|Sun, Keyu | ||||||||||
| PMID: | 28407688 | ||||||||||
| 38. | |||||||||||
| Journal: | Oncotarget. 2017 Jun 27;8(39):65329-65338. | ||||||||||
| Title: | Silencing protein kinase C zeta by microRNA-25-5p activates AMPK signaling and inhibits colorectal cancer cell proliferation. | ||||||||||
| Author: | Zhang, Shihu|Zhang, Yiyang|Cheng, Qing|Ma, Zhaoqun|Gong, Guanwen|Deng, Zhengming|Xu, Kun|Wang, Gaoyuan|Wei, Yousong|Zou, Xiaoping | ||||||||||
| PMID: | 29029434 | ||||||||||
| 39. | |||||||||||
| Journal: | Oncotarget. 2017 Sep 28;8(56):95810-95823. | ||||||||||
| Title: | Targeting PP2A activates AMPK signaling to inhibit colorectal cancer cells. | ||||||||||
| Author: | Dai, Cuiping|Zhang, Xuning|Xie, Da|Tang, Peipei|Li, Chunmei|Zuo, Yi|Jiang, Baofei|Xue, Caiping | ||||||||||
| PMID: | 29221169 | ||||||||||
| 40. | |||||||||||
| Journal: | Sci Rep. 2018 Feb 28;8(1):3770. | ||||||||||
| Title: | A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells. | ||||||||||
| Author: | Das, Binita|Neilsen, Beth K|Fisher, Kurt W|Gehring, Drew|Hu, Youcai|Volle, Deanna J|Kim, Hyun Seok|McCall, Jamie L|Kelly, David L|MacMillan, John B|White, Michael A|Lewis, Robert E | ||||||||||
| PMID: | 29491475 | ||||||||||
| 41. | |||||||||||
| Journal: | Oncotarget. 2018 Jan 31;9(12):10650-10664. | ||||||||||
| Title: | Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. | ||||||||||
| Author: | Yagi, Takashi|Kubota, Eiji|Koyama, Hiroyuki|Tanaka, Tomohiro|Kataoka, Hiromi|Imaeda, Kenro|Joh, Takashi | ||||||||||
| PMID: | 29535833 | ||||||||||
| 42. | |||||||||||
| Journal: | Oncotarget. 2018 May 15;9(37):24787-24800. | ||||||||||
| Title: | Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. | ||||||||||
| Author: | Zaytseva, Yekaterina Y|Rychahou, Piotr G|Le, Anh-Thu|Scott, Timothy L|Flight, Robert M|Kim, Ji Tae|Harris, Jennifer|Liu, Jinpeng|Wang, Chi|Morris, Andrew J|Sivakumaran, Theru A|Fan, Teresa|Moseley, Hunter|Gao, Tianyan|Lee, Eun Y|Weiss, Heidi L|Heuer, Timo | ||||||||||
| PMID: | 29872506 | ||||||||||
| 43. | |||||||||||
| Journal: | Acta Pharmacol Sin. 2018 Jun 19. pii: 10.1038/s41401-018-0047-1. | ||||||||||
| Title: | Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy. | ||||||||||
| Author: | Li, Bin|Wu, Guo-Liang|Dai, Wei|Wang, Gang|Su, Hao-Yuan|Shen, Xue-Ping|Zhan, Rui|Xie, Jia-Ming|Wang, Zhong|Qin, Zheng-Hong|Gao, Quan-Gen|Shen, Gen-Hai | ||||||||||
| PMID: | 29921885 | ||||||||||
| 44. | |||||||||||
| Journal: | Cancer Lett. 2018 Oct 28;435:1-9. | ||||||||||
| Title: | miR-1273g silences MAGEA3/6 to inhibit human colorectal cancer cell growth via activation of AMPK signaling. | ||||||||||
| Author: | Wu, Fang|Liu, Fang|Dong, Lemei|Yang, Han|He, Xixi|Li, Lili|Zhao, Lihao|Jin, Sisi|Li, Gang | ||||||||||
| PMID: | 30056111 | ||||||||||
| 45. | |||||||||||
| Journal: | J Physiol Biochem. 2018 Oct 25. pii: 10.1007/s13105-018-0651-z. | ||||||||||
| Title: | Sodium butyrate induces autophagy in colorectal cancer cells through LKB1/AMPK signaling. | ||||||||||
| Author: | Luo, Shunli|Li, Ziyin|Mao, Lianzhi|Chen, Siqiang|Sun, Suxia | ||||||||||
| PMID: | 30362049 | ||||||||||