Primary Site >> Colorectal Cancer
Gene >> PRKAA1
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Strong association of ARK5 with tumor invasion and metastasis. PMID: 15354411 |
Ref: Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. PMID: 15896711 |
Ref: Suppression of mTOR via Akt-dependent and -independent mechanisms in selenium-treated colon cancer cells: involvement of AMPKalpha1. PMID: 20164123 Ref: Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. PMID: 20622004 Ref: Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer. PMID: 20808308 Ref: Anthocyanins are novel AMPKalpha1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation. PMID: 21042741 |
Ref: AMPK regulates metabolism and survival in response to ionizing radiation. PMID: 21715037 |
Ref: Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial. PMID: 22443173 Ref: AMPK inhibitor compound C suppresses cell proliferation by induction of apoptosis and autophagy in human colorectal cancer cells. PMID: 22674626 Ref: Quercetin enhances hypoxia-mediated apoptosis via direct inhibition of AMPK activity in HCT116 colon cancer. PMID: 22684842 Ref: Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin beta1 signaling. PMID: 22943849 |
Ref: Significant correlation between LKB1 and LGR5 gene expression and the association with poor recurrence-free survival in rectal cancer after preoperative chemoradiotherapy. PMID: 22986809 Ref: p21(WAF(1)/C(1)P(1)) deficiency induces mitochondrial dysfunction in HCT116 colon cancer cells. PMID: 23211592 Ref: MicroRNA-451 inhibits growth of human colorectal carcinoma cells via downregulation of Pi3k/Akt pathway. PMID: 23886157 Ref: [Metformin, an antidiabetic molecule with anti-cancer properties]. PMID: 24180199 Ref: Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells. PMID: 25337554 |
Ref: MicroRNA-451 regulates AMPK/mTORC1 signaling and fascin1 expression in HT-29 colorectal cancer. PMID: 23899558 Ref: Genetic variations in STK11, PRKAA1, and TSC1 associated with prognosis for patients with colorectal cancer. PMID: 24770722 Ref: Astrocyte elevated gene-1 mediates glycolysis and tumorigenesis in colorectal carcinoma cells via AMPK signaling. PMID: 24829520 Ref: Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells. PMID: 24842158 Ref: Use of metformin alone is not associated with survival outcomes of colorectal cancer cell but AMPK activator AICAR sensitizes anticancer effect of 5-fluorouracil through AMPK activation. PMID: 24849329 Ref: Prognostic significance of AMPK activation in advanced stage colorectal cancer treated with chemotherapy plus bevacizumab. PMID: 24892446 Ref: Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells. PMID: 24955726 Ref: Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells. PMID: 25475140 |
Ref: Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis. PMID: 25940306 Ref: Loss-of-function variants in ATM confer risk of gastric cancer. PMID: 26098866 Ref: NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7. PMID: 26116564 Ref: Physcion induces mitochondria-driven apoptosis in colorectal cancer cells via downregulating EMMPRIN. PMID: 26144377 Ref: Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells. PMID: 26219912 Ref: AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro. PMID: 26318663 Ref: The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death. PMID: 26510776 |
Ref: BRAF V600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells. PMID: 26750638 Ref: Aqueous Oldenlandia diffusa extracts inhibits colorectal cancer cells via activating AMP-activated protein kinase signalings. PMID: 27322552 |
Ref: Metabolic reprogramming and AMPKalpha1 pathway activation by caulerpin in colorectal cancer cells. PMID: 27922662 Ref: Autophagy inhibition enhances photocytotoxicity of Photosan-II in human colorectal cancer cells. PMID: 28031534 Ref: AMPK-autophagy inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity. PMID: 28103582 Ref: NPC-26 kills human colorectal cancer cells via activating AMPK signaling. PMID: 28407688 Ref: Silencing protein kinase C zeta by microRNA-25-5p activates AMPK signaling and inhibits colorectal cancer cell proliferation. PMID: 29029434 Ref: Targeting PP2A activates AMPK signaling to inhibit colorectal cancer cells. PMID: 29221169 |
Ref: A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells. PMID: 29491475 Ref: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. PMID: 29535833 Ref: Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. PMID: 29872506 Ref: Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy. PMID: 29921885 Ref: miR-1273g silences MAGEA3/6 to inhibit human colorectal cancer cell growth via activation of AMPK signaling. PMID: 30056111 Ref: Sodium butyrate induces autophagy in colorectal cancer cells through LKB1/AMPK signaling. PMID: 30362049 |