Literatures

Primary Site >> Liver Cancer

Gene >> PPARA

1.
Journal:	Carcinogenesis. 1996 Feb;17(2):185-90.
Title:	Convergence of three steroid receptor pathways in the mediation of nongenotoxic hepatocarcinogenesis.
Author:	O'Brien, M L\|Rangwala, S M\|Henry, K W\|Weinberger, C\|Crick, D C\|Waechter, C J\|Feller, D R\|Noonan, D J
PMID:	8625436

2.
Journal:	Carcinogenesis. 1996 Jun;17(6):1337-41.
Title:	Effect on the expression of c-met, c-myc and PPAR-alpha in liver and liver tumors from rats chronically exposed to the hepatocarcinogenic peroxisome proliferator WY-14,643.
Author:	Miller, R T\|Glover, S E\|Stewart, W S\|Corton, J C\|Popp, J A\|Cattley, R C
PMID:	8681452

3.
Journal:	J Endocrinol. 1996 Sep;150 Suppl:S129-47.
Title:	Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator.
Author:	Waxman, D J
PMID:	8943797

4.
Journal:	Biochimie. 1997 Feb-Mar;79(2-3):139-44.
Title:	Recent update on the PPAR alpha-null mouse.
Author:	Gonzalez, F J
PMID:	9209711

5.
Journal:	J Cell Biochem. 1998 May 1;69(2):189-200.
Title:	Inhibition of PPAR alpha/RXR alpha-mediated direct hyperplasia pathways during griseofulvin-induced hepatocarcinogenesis.
Author:	Nagao, Y\|French, B A\|Cai, Y\|French, S W\|Wan, Y J
PMID:	9548566

6.
Journal:	Environ Health Perspect. 1998 Aug;106 Suppl 4:983-8.
Title:	Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids.
Author:	Zhou, Y C\|Waxman, D J
PMID:	9703482

7.
Journal:	J Mol Endocrinol. 1999 Feb;22(1):1-8.
Title:	Peroxisome proliferator-activated receptor alpha: role in rodent liver cancer and species differences.
Author:	Holden, P R\|Tugwood, J D
PMID:	9924174

8.
Journal:	Toxicol Sci. 1999 Jan;47(1):1-8.
Title:	Peroxisome proliferator-activated receptors (PPARS) and carcinogenesis.
Author:	Vanden Heuvel, J P
PMID:	10048147

9.
Journal:	Regul Toxicol Pharmacol. 1999 Jun;29(3):327-57.
Title:	A cancer risk assessment of di(2-ethylhexyl)phthalate: application of the new U.S. EPA Risk Assessment Guidelines.
Author:	Doull, J\|Cattley, R\|Elcombe, C\|Lake, B G\|Swenberg, J\|Wilkinson, C\|Williams, G\|van Gemert, M
PMID:	10388618

10.
Journal:	Mutat Res. 2000 Mar 17;448(2):159-77.
Title:	Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis.
Author:	Yeldandi, A V\|Rao, M S\|Reddy, J K
PMID:	10725470

11.
Journal:	Carcinogenesis. 2000 Apr;21(4):823-6.
Title:	Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis.
Author:	Peters, J M\|Rusyn, I\|Rose, M L\|Gonzalez, F J\|Thurman, R G
PMID:	10753222

12.
Journal:	Environ Health Perspect. 2000 May;108 Suppl 2:241-59.
Title:	Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate.
Author:	Bull, R J
PMID:	10807555

13.
Journal:	Biochem Biophys Res Commun. 2000 Nov 11;278(1):250-7.
Title:	Less extrahepatic induction of fatty acid beta-oxidation enzymes by PPAR alpha.
Author:	Cook, W S\|Yeldandi, A V\|Rao, M S\|Hashimoto, T\|Reddy, J K
PMID:	11071880

14.
Journal:	Antioxid Redox Signal. 2000 Fall;2(3):607-21.
Title:	Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators.
Author:	Rusyn, I\|Rose, M L\|Bojes, H K\|Thurman, R G
PMID:	11229371

15.
Journal:	Toxicology. 2001 Mar 7;160(1-3):219-26.
Title:	Weight-of-evidence versus strength-of-evidence in toxicologic hazard identification: Di(2-ethylhexyl)phthalate (DEHP).
Author:	Willhite, C C
PMID:	11246142

16.
Journal:	J Steroid Biochem Mol Biol. 2001 Apr;77(1):59-71.
Title:	Peroxisome proliferators and fatty acids negatively regulate liver X receptor-mediated activity and sterol biosynthesis.
Author:	Johnson, T E\|Ledwith, B J
PMID:	11358675

17.
Journal:	Annu Rev Nutr. 2001;21:193-230.
Title:	Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system.
Author:	Reddy, J K\|Hashimoto, T
PMID:	11375435

18.
Journal:	Environ Health Perspect. 2001 May;109(5):437-42.
Title:	Is peroxisome proliferation an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl)phthalate (DEHP)?
Author:	Melnick, R L
PMID:	11401753

19.
Journal:	Exp Cell Res. 2001 Aug 1;268(1):70-6.
Title:	Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice.
Author:	Cook, W S\|Jain, S\|Jia, Y\|Cao, W Q\|Yeldandi, A V\|Reddy, J K\|Rao, M S
PMID:	11461119

20.
Journal:	Toxicol Appl Pharmacol. 2002 Jul 1;182(1):1-10.
Title:	Elevated basal expression of liver peroxisomal beta-oxidation enzymes and CYP4A microsomal fatty acid omega-hydroxylase in STAT5b(-/-) mice: cross-talk in vivo between peroxisome proliferator-activated receptor and signal transducer and activator of trans
Author:	Zhou, Yuan Chun\|Davey, Helen W\|McLachlan, Michael J\|Xie, Tao\|Waxman, David J
PMID:	12127257

21.
Journal:	ScientificWorldJournal. 2002 May 30;2:1491-500.
Title:	Enhanced hepatocarcinogenicity due to agonists of peroxisome proliferator-activated receptors in senescent rats: role of peroxisome proliferation, cell proliferation, and apoptosis.
Author:	Youssef, Jihan\|Badr, Mostafa
PMID:	12805935

22.
Journal:	Toxicol Appl Pharmacol. 2003 May 1;188(3):185-98.
Title:	Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643.
Author:	Vanden Heuvel, John P\|Kreder, Dirk\|Belda, Benjamin\|Hannon, Daniel B\|Nugent, Courtney A\|Burns, Katherine A\|Taylor, Michael J
PMID:	12729718

23.
Journal:	Carcinogenesis. 2003 May;24(5):975-84.
Title:	Molecular profiling of hepatocellular carcinomas developing spontaneously in acyl-CoA oxidase deficient mice: comparison with liver tumors induced in wild-type mice by a peroxisome proliferator and a genotoxic carcinogen.
Author:	Meyer, Kirstin\|Lee, Ju-Seog\|Dyck, Patricia A\|Cao, Wen-Qing\|Rao, M Sambasiva\|Thorgeirsson, Snorri S\|Reddy, Janardan K
PMID:	12771043

24.
Journal:	Toxicology. 2003 Sep 30;191(2-3):211-25.
Title:	Role of the peroxisome proliferator-activated receptor alpha in responses to diisononyl phthalate.
Author:	Valles, Edith G\|Laughter, Ashley R\|Dunn, Corrie S\|Cannelle, Sabine\|Swanson, Cynthia L\|Cattley, Russell C\|Corton, J Christopher
PMID:	12965124

25.
Journal:	Cancer Res. 2003 Sep 15;63(18):5767-80.
Title:	Comprehensive gene expression analysis of peroxisome proliferator-treated immortalized hepatocytes: identification of peroxisome proliferator-activated receptor alpha-dependent growth regulatory genes.
Author:	Tien, Eric S\|Gray, Joshua P\|Peters, Jeffrey M\|Vanden Heuvel, John P
PMID:	14522898

26.
Journal:	Cancer Res. 2004 Jun 1;64(11):3849-54.
Title:	Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha.
Author:	Cheung, Connie\|Akiyama, Taro E\|Ward, Jerrold M\|Nicol, Christopher J\|Feigenbaum, Lionel\|Vinson, Charles\|Gonzalez, Frank J
PMID:	15172993

27.
Journal:	Toxicology. 2004 Oct 15;203(1-3):83-98.
Title:	Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver.
Author:	Laughter, Ashley R\|Dunn, Corrie S\|Swanson, Cynthia L\|Howroyd, Paul\|Cattley, Russell C\|Corton, J Christopher
PMID:	15363585

28.
Journal:	Nihon Rinsho. 2004 Nov;62(11):2137-44.
Title:	[Possible mechanisms of hepatitis C virus-related hepatocarcinogenesis].
Author:	Tanaka, Naoki\|Aoyama, Toshifumi
PMID:	15552900

29.
Journal:	Carcinogenesis. 2005 Jan;26(1):219-27.
Title:	Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis.
Author:	Hays, Thomas\|Rusyn, Ivan\|Burns, Amanda M\|Kennett, Mary J\|Ward, Jerrold M\|Gonzalez, Frank J\|Peters, Jeffrey M
PMID:	15447978

30.
Journal:	J Mol Med (Berl). 2005 Oct;83(10):774-85.
Title:	Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand?
Author:	Peters, Jeffrey M\|Cheung, Connie\|Gonzalez, Frank J
PMID:	15976920

31.
Journal:	Toxicol Sci. 2006 Feb;89(2):535-46.
Title:	The ribosomal protein rpL11 associates with and inhibits the transcriptional activity of peroxisome proliferator-activated receptor-alpha.
Author:	Gray, Joshua P\|Davis, John W 2nd\|Gopinathan, Lakshmi\|Leas, Tara L\|Nugent, Courtney A\|Vanden Heuvel, John P
PMID:	16280383

32.
Journal:	Carcinogenesis. 2006 May;27(5):1074-80.
Title:	Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis.
Author:	Morimura, Keiichirou\|Cheung, Connie\|Ward, Jerrold M\|Reddy, Janardan K\|Gonzalez, Frank J
PMID:	16377806

33.
Journal:	J Pharmacol Exp Ther. 2006 May;317(2):537-45.
Title:	Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alpha.
Author:	Moffit, Jeffrey S\|Aleksunes, Lauren M\|Maher, Jonathan M\|Scheffer, George L\|Klaassen, Curtis D\|Manautou, Jose E
PMID:	16467456

34.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G852-8.
Title:	Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation.
Author:	Reddy, Janardan K\|Rao, M Sambasiva
PMID:	16603729

35.
Journal:	Life Sci. 2006 Aug 8;79(11):1100-7.
Title:	High-fat emulsion-induced rat model of nonalcoholic steatohepatitis.
Author:	Zou, Yuhong\|Li, Jun\|Lu, Chao\|Wang, Jianqing\|Ge, Jinfang\|Huang, Yan\|Zhang, Lei\|Wang, Yuanyuan
PMID:	16624332

36.
Journal:	Toxicol Sci. 2006 Aug;92(2):368-77.
Title:	Activation of peroxisome proliferator-activated receptor alpha enhances apoptosis in the mouse liver.
Author:	Xiao, Shen\|Anderson, Steven P\|Swanson, Cynthia\|Bahnemann, Rainer\|Voss, Kenneth A\|Stauber, Anja J\|Corton, J Christopher
PMID:	16687391

37.
Journal:	Environ Health Perspect. 2006 Sep;114(9):1464-70.
Title:	Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity.
Author:	Keshava, Nagalakshmi\|Caldwell, Jane C
PMID:	16966106

38.
Journal:	BMC Bioinformatics. 2006 Sep 6;7 Suppl 2:S18.
Title:	Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists.
Author:	Guo, Lei\|Fang, Hong\|Collins, Jim\|Fan, Xiao-hui\|Dial, Stacey\|Wong, Alex\|Mehta, Kshama\|Blann, Ernice\|Shi, Leming\|Tong, Weida\|Dragan, Yvonne P
PMID:	17118139

39.
Journal:	Metabolism. 2007 Feb;56(2):267-79.
Title:	Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells.
Author:	Kim, Min Sun\|Sweeney, Trevor R\|Shigenaga, Judy K\|Chui, Lisa G\|Moser, Arthur\|Grunfeld, Carl\|Feingold, Kenneth R
PMID:	17224343

40.
Journal:	Carcinogenesis. 2007 Jun;28(6):1171-7.
Title:	Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis.
Author:	Yang, Qian\|Ito, Shinji\|Gonzalez, Frank J
PMID:	17331954

41.
Journal:	J Biol Chem. 2007 Jun 8;282(23):17053-60.
Title:	Critical role for transcription coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein/TRAP220 in liver regeneration and PPARalpha ligand-induced liver tumor development.
Author:	Matsumoto, Kojiro\|Yu, Songtao\|Jia, Yuzhi\|Ahmed, Mohamed R\|Viswakarma, Navin\|Sarkar, Joy\|Kashireddy, Papreddy V\|Rao, M Sambasiva\|Karpus, William\|Gonzalez, Frank J\|Reddy, Janardan K
PMID:	17438330

42.
Journal:	Gastroenterology. 2007 May;132(5):1955-67.
Title:	Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma.
Author:	Kim, Kook Hwan\|Shin, Hye-Jun\|Kim, Kyeongjin\|Choi, Hyun Mi\|Rhee, Sang Hoon\|Moon, Hyung-Bae\|Kim, Hyeong Hoe\|Yang, Ung Suk\|Yu, Dae-Yeul\|Cheong, Jaehun
PMID:	17484888

43.
Journal:	Cancer Res. 2007 Jul 1;67(13):6512-9.
Title:	Are peroxisome proliferator-activated receptors involved in skeletal muscle wasting during experimental cancer cachexia? Role of beta2-adrenergic agonists.
Author:	Fuster, Gemma\|Busquets, Silvia\|Ametller, Elisabet\|Olivan, Mireia\|Almendro, Vanessa\|de Oliveira, Cibely Cristine Fontes\|Figueras, Maite\|Lopez-Soriano, Francisco J\|Argiles, Josep M
PMID:	17616713

44.
Journal:	Int J Cancer. 2008 Jan 1;122(1):124-31.
Title:	Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
Author:	Tanaka, Naoki\|Moriya, Kyoji\|Kiyosawa, Kendo\|Koike, Kazuhiko\|Aoyama, Toshifumi
PMID:	17764115

45.
Journal:	Toxicology. 2008 Apr 3;246(1):2-8.
Title:	PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators.
Author:	Gonzalez, Frank J\|Shah, Yatrik M
PMID:	18006136

46.
Journal:	World J Gastroenterol. 2008 Jan 7;14(1):22-8.
Title:	Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease.
Author:	Kallwitz, Eric R\|McLachlan, Alan\|Cotler, Scott J
PMID:	18176957

47.
Journal:	J Clin Invest. 2008 Feb;118(2):683-94.
Title:	PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice.
Author:	Tanaka, Naoki\|Moriya, Kyoji\|Kiyosawa, Kendo\|Koike, Kazuhiko\|Gonzalez, Frank J\|Aoyama, Toshifumi
PMID:	18188449

48.
Journal:	Toxicol Sci. 2008 May;103(1):46-56.
Title:	Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR.
Author:	Rosen, Mitchell B\|Lee, Janice S\|Ren, Hongzu\|Vallanat, Beena\|Liu, Jie\|Waalkes, Michael P\|Abbott, Barbara D\|Lau, Christopher\|Corton, J Christopher
PMID:	18281256

49.
Journal:	Adv Exp Med Biol. 2008;617:591-7.
Title:	Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.
Author:	Chung, Chuhan\|Doll, Jennifer A\|Stellmach, Veronica M\|Gonzales, John\|Surapureddi, Sailesh\|Cornwell, Mona\|Reddy, Janardan K\|Crawford, Susan E
PMID:	18497086

50.
Journal:	PPAR Res. 2008;2008:256251.
Title:	Mitochondria, PPARs, and Cancer: Is Receptor-Independent Action of PPAR Agonists a Key?
Author:	Scatena, Roberto\|Bottoni, Patrizia\|Giardina, Bruno
PMID:	18645611

51.
Journal:	Crit Rev Toxicol. 2008;38(10):857-75.
Title:	Evaluation of the role of peroxisome proliferator-activated receptor alpha (PPARalpha) in mouse liver tumor induction by trichloroethylene and metabolites.
Author:	Corton, J Christopher
PMID:	18821149

52.
Journal:	Turk J Gastroenterol. 2008 Dec;19(4):245-9.
Title:	PPAR-alpha L162V polymorphism in human hepatocellular carcinoma.
Author:	Koytak, Elif Sare\|Mizrak, Dilsa\|Bektas, Mehmet\|Verdi, Hasibe\|Arslan Ergul, Ayca\|Idilman, Ramazan\|Cinar, Kubilay\|Yurdaydin, Cihan\|Ersoz, Sadik\|Karayalcin, Kaan\|Uzunalimoglu, Ozden\|Bozkaya, Hakan
PMID:	19119483

53.
Journal:	J Gastroenterol. 2009;44 Suppl 19:82-8.
Title:	Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
Author:	Koike, Kazuhiko
PMID:	19148799

54.
Journal:	J Biol Chem. 2009 Apr 3;284(14):9321-30.
Title:	Mechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis.
Author:	Gyamfi, Maxwell Afari\|Wan, Yu-Jui Yvonne
PMID:	19176532

55.
Journal:	Biochem Pharmacol. 2009 Sep 1;78(5):523-30.
Title:	Identification of a functional peroxisome proliferator-activated receptor (PPAR) response element (PPRE) in the human apolipoprotein A-IV gene.
Author:	Nagasawa, Michiaki\|Hara, Tomoko\|Kashino, Ai\|Akasaka, Yunike\|Ide, Tomohiro\|Murakami, Koji
PMID:	19433068

56.
Journal:	J Toxicol Pathol. 2009 Dec;22(4):255-61.
Title:	No Modifying Effect of Antioxidant N-Acetyl-L-Cysteine on Fenofibrate-induced Hepatocarcinogenesis in Rats.
Author:	Nishimura, Jihei\|Dewa, Yasuaki\|Jin, Meilan\|Saegusa, Yukie\|Kawai, Masaomi\|Kemmochi, Sayaka\|Shimamoto, Keisuke\|Harada, Tomoaki\|Itoh, Tadashi\|Shima, Tomomi\|Shibutani, Makoto\|Mitsumori, Kunitoshi
PMID:	22272000

57.
Journal:	Nucl Recept Signal. 2010 Apr 16;8:e002.
Title:	PPARalpha: energy combustion, hypolipidemia, inflammation and cancer.
Author:	Pyper, Sean R\|Viswakarma, Navin\|Yu, Songtao\|Reddy, Janardan K
PMID:	20414453

58.
Journal:	Toxicol Sci. 2010 Dec;118(2):404-10.
Title:	PPARalpha-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells.
Author:	Qu, Aijuan\|Shah, Yatrik M\|Matsubara, Tsutomu\|Yang, Qian\|Gonzalez, Frank J
PMID:	20813756

59.
Journal:	Biomed Khim. 2010 Jul-Aug;56(4):480-9.
Title:	[Expression of nuclear hormone receptors PPAR, LXR and RXR in the liver and lipid and glucose levels in blood in susceptible and resistant to hepatocarcinogenesis mice strains].
Author:	Pivovarova, E N\|Baginskaia, N V\|Perepechaeva, M L\|Il'nitskaia, S I\|Dushkin, M I
PMID:	21032898

60.
Journal:	World J Surg Oncol. 2011 Dec 15;9:167.
Title:	Peroxisome proliferator-activated receptor alpha (PPARalpha) mRNA expression in human hepatocellular carcinoma tissue and non-cancerous liver tissue.
Author:	Kurokawa, Tsuyoshi\|Shimomura, Yoshiharu\|Bajotto, Gustavo\|Kotake, Katsuhiro\|Arikawa, Takashi\|Ito, Nobuhiro\|Yasuda, Akira\|Nagata, Hiroshi\|Nonami, Toshiaki\|Masuko, Kazuo
PMID:	22168458

61.
Journal:	FASEB J. 2012 Feb;26(2):628-38.
Title:	Sustained activation of PPARalpha by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice.
Author:	Huang, Jiansheng\|Jia, Yuzhi\|Fu, Tao\|Viswakarma, Navin\|Bai, Liang\|Rao, M Sambasiva\|Zhu, Yijun\|Borensztajn, Jayme\|Reddy, Janardan K
PMID:	22009939

62.
Journal:	Biochim Biophys Acta. 2012 May;1821(5):809-18.
Title:	Roles of PPARs in NAFLD: potential therapeutic targets.
Author:	Tailleux, Anne\|Wouters, Kristiaan\|Staels, Bart
PMID:	22056763

63.
Journal:	Toxicol Pathol. 2012;40(1):18-32.
Title:	Tesaglitazar, a dual PPAR-alpha/gamma agonist, hamster carcinogenicity, investigative animal and clinical studies.
Author:	Lindblom, Per\|Berg, Anna-Lena\|Zhang, Hui\|Westerberg, Rolf\|Tugwood, Jonathan\|Lundgren, Hanna\|Marcusson-Stahl, Maritha\|Sjogren, Niclas\|Blomgren, Bo\|Ohman, Peter\|Skanberg, Inger\|Evans, John\|Hellmold, Heike
PMID:	22131108

64.
Journal:	Biotechnol J. 2012 Nov;7(11):1395-404.
Title:	Gene network analysis leads to functional validation of pathways linked to cancer cell growth and survival.
Author:	Berger, Emmanuelle\|Vega, Nathalie\|Vidal, Hubert\|Geloen, Alain
PMID:	22930530

65.
Journal:	PPAR Res. 2012;2012:757803.
Title:	PPARs in Liver Diseases and Cancer: Epigenetic Regulation by MicroRNAs.
Author:	Peyrou, Marion\|Ramadori, Pierluigi\|Bourgoin, Lucie\|Foti, Michelangelo
PMID:	23024649

66.
Journal:	PPAR Res. 2012;2012:574180.
Title:	PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma.
Author:	Kimura, Osamu\|Kondo, Yasuteru\|Shimosegawa, Tooru
PMID:	23316217

67.
Journal:	J Biol Chem. 2013 Jan 18;288(3):1726-38.
Title:	Peroxisome proliferator-activated receptor alpha positively regulates complement C3 expression but inhibits tumor necrosis factor alpha-mediated activation of C3 gene in mammalian hepatic-derived cells.
Author:	Mogilenko, Denis A\|Kudriavtsev, Igor V\|Shavva, Vladimir S\|Dizhe, Ella B\|Vilenskaya, Ekaterina G\|Efremov, Alexander M\|Perevozchikov, Andrej P\|Orlov, Sergey V
PMID:	23168409

68.
Journal:	J Steroid Biochem Mol Biol. 2013 Nov;138:236-47.
Title:	PPARalpha-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons.
Author:	Kim, S\|Kiyosawa, N\|Burgoon, L D\|Chang, C C\|Zacharewski, T R
PMID:	23811191

69.
Journal:	Tumour Biol. 2013 Dec;34(6):3853-7.
Title:	Regulation of URG4/URGCP and PPARalpha gene expressions after retinoic acid treatment in neuroblastoma cells.
Author:	Avci, Cigir Biray\|Dodurga, Yavuz\|Gundogdu, Gulsah\|Caglar, Hasan Onur\|Kucukatay, Vural\|Gunduz, Cumhur\|Satiroglu-Tufan, N Lale
PMID:	23821302

70.
Journal:	Korean J Hepatobiliary Pancreat Surg. 2013 Aug;17(3):89-108.
Title:	Fenofibrate, a peroxisome proliferator-activated receptor alpha-agonist, blocks lipopolysaccharide-induced inflammatory pathways in mouse liver.
Author:	Won, Tae Wan
PMID:	26155222

71.
Journal:	J Hepatol. 2014 Feb;60(2):331-8.
Title:	Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.
Author:	Qu, Aijuan\|Jiang, Changtao\|Cai, Yan\|Kim, Jung-Hwan\|Tanaka, Naoki\|Ward, Jerrold M\|Shah, Yatrik M\|Gonzalez, Frank J
PMID:	24096051

72.
Journal:	Anal Bioanal Chem. 2014 Jan;406(3):705-13.
Title:	Bioactivity screening and mass spectrometric confirmation for the detection of PPARdelta agonists that increase type 1 muscle fibres.
Author:	Bovee, Toine F H\|Blokland, Marco\|Kersten, Sander\|Hamers, Astrid R M\|Heskamp, Henri H\|Essers, Martien L\|Nielen, Michel W F\|van Ginkel, Leendert A
PMID:	24287635

73.
Journal:	Biochimie. 2014 Mar;98:63-74.
Title:	Peroxisome proliferator-activated receptor-alpha activation and excess energy burning in hepatocarcinogenesis.
Author:	Misra, Parimal\|Reddy, Janardan K
PMID:	24291192

74.
Journal:	Crit Rev Toxicol. 2014 May;44 Suppl 2:15-24.
Title:	Human relevance framework for rodent liver tumors induced by the insecticide sulfoxaflor.
Author:	LeBaron, Matthew J\|Gollapudi, B Bhaskar\|Terry, Claire\|Billington, Richard\|Rasoulpour, Reza J
PMID:	24832551

75.
Journal:	World J Gastroenterol. 2014 Jul 7;20(25):8055-60.
Title:	Peroxisome proliferator-activated receptor alpha, a potential therapeutic target for alcoholic liver disease.
Author:	Nan, Yue-Min\|Wang, Rong-Qi\|Fu, Na
PMID:	25009377

76.
Journal:	PLoS One. 2014 Dec 30;9(12):e116179.
Title:	Trichloroethylene-induced gene expression and DNA methylation changes in B6C3F1 mouse liver.
Author:	Jiang, Yan\|Chen, Jiahong\|Tong, Jian\|Chen, Tao
PMID:	25549359

77.
Journal:	Cancer Res. 2015 Mar 1;75(5):846-57.
Title:	Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
Author:	Cui, Ming\|Xiao, Zelin\|Wang, Yue\|Zheng, Minying\|Song, Tianqiang\|Cai, Xiaoli\|Sun, Baodi\|Ye, Lihong\|Zhang, Xiaodong
PMID:	25592151

78.
Journal:	PLoS One. 2015 Feb 17;10(2):e0112655.
Title:	Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) in a mouse liver gene expression compendium.
Author:	Oshida, Keiyu\|Vasani, Naresh\|Thomas, Russell S\|Applegate, Dawn\|Rosen, Mitch\|Abbott, Barbara\|Lau, Christopher\|Guo, Grace\|Aleksunes, Lauren M\|Klaassen, Curtis\|Corton, J Christopher
PMID:	25689681

79.
Journal:	Oncotarget. 2015;6(12):9686-700.
Title:	Forced expression of fibroblast growth factor 21 reverses the sustained impairment of liver regeneration in hPPARalpha(PAC) mice due to dysregulated bile acid synthesis.
Author:	Liu, Hui-Xin\|Hu, Ying\|French, Samuel W\|Gonzalez, Frank J\|Wan, Yu-Jui Yvonne
PMID:	25991671

80.
Journal:	J Med Food. 2015 Oct;18(10):1081-7.
Title:	Maltitol Prevents the Progression of Fatty Liver Degeneration in Mice Fed High-Fat Diets.
Author:	Urushima, Hayato\|Sanada, Yasuaki\|Sakaue, Miki\|Matsuzawa, Yuji\|Ito, Toshinori\|Maeda, Kazuhisa
PMID:	26061453

81.
Journal:	BMC Cancer. 2015 Jul 24;15:542.
Title:	Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway.
Author:	Drakaki, Alexandra\|Hatziapostolou, Maria\|Polytarchou, Christos\|Vorvis, Christina\|Poultsides, George A\|Souglakos, John\|Georgoulias, Vassilis\|Iliopoulos, Dimitrios
PMID:	26206264

82.
Journal:	Bioorg Med Chem Lett. 2015 Sep 15;25(18):3897-9.
Title:	N-Aryl benzenesulfonamide inhibitors of [3H]-thymidine incorporation and beta-catenin signaling in human hepatocyte-derived Huh-7 carcinoma cells.
Author:	Kril, Liliia M\|Vilchez, Valery\|Jiang, Jieyun\|Turcios, Lilia\|Chen, Changguo\|Sviripa, Vitaliy M\|Zhang, Wen\|Liu, Chunming\|Spear, Brett\|Watt, David S\|Gedaly, Roberto
PMID:	26243371

83.
Journal:	Biomed Res Int. 2015;2015:821761.
Title:	Gene Network Analysis of Glucose Linked Signaling Pathways and Their Role in Human Hepatocellular Carcinoma Cell Growth and Survival in HuH7 and HepG2 Cell Lines.
Author:	Berger, Emmanuelle\|Vega, Nathalie\|Weiss-Gayet, Michele\|Geloen, Alain
PMID:	26380295

84.
Journal:	Am J Transl Res. 2015 Dec 15;7(12):2752-63. eCollection 2015.
Title:	c9, t11- conjugated linoleic acid induces HCC cell apoptosis and correlation with PPAR-gamma signaling pathway.
Author:	Lu, Guozhong\|Zhang, Guoqing\|Zheng, Xing\|Zeng, Yan\|Xu, Ziqi\|Zeng, Weichi\|Wang, Kebing
PMID:	26885272

85.
Journal:	Toxicol Sci. 2016 Feb;149(2):312-25.
Title:	Dose and Effect Thresholds for Early Key Events in a PPARalpha-Mediated Mode of Action.
Author:	Lake, April D\|Wood, Charles E\|Bhat, Virunya S\|Chorley, Brian N\|Carswell, Gleta K\|Sey, Yusupha M\|Kenyon, Elaina M\|Padnos, Beth\|Moore, Tanya M\|Tennant, Alan H\|Schmid, Judith E\|George, Barbara Jane\|Ross, David G\|Hughes, Michael F\|Corton, J Christopher\|Simmon
PMID:	26519955

86.
Journal:	Food Chem Toxicol. 2016 Feb;88:75-86.
Title:	Constitutive active/androstane receptor, peroxisome proliferator-activated receptor alpha, and cytotoxicity are involved in oxadiazon-induced liver tumor development in mice.
Author:	Kuwata, Kazunori\|Inoue, Kaoru\|Ichimura, Ryohei\|Takahashi, Miwa\|Kodama, Yukio\|Yoshida, Midori
PMID:	26710982

87.
Journal:	Pediatr Res. 2016 May;79(5):754-8.
Title:	Role of PPARalpha in the attenuation of bile acid-induced apoptosis by omega-3 long-chain polyunsaturated fatty acids in cultured hepatocytes.
Author:	Tillman, Emma M\|Guan, Peihong\|Howze, Timothy J\|Helms, Richard A\|Black, Dennis D
PMID:	26756785

88.
Journal:	Exp Ther Med. 2016 Feb;11(2):387-396.
Title:	PPARgamma activation reduces ischemia/reperfusion-induced metastasis in a murine model of hepatocellular carcinoma.
Author:	Liu, Y I\|Liu, Zhao\|Chen, Yuxin\|Xu, Kesen\|Dong, Jiahong
PMID:	26893620

89.
Journal:	Pharmacogn Mag. 2016 Jan-Mar;12(45):31-5.
Title:	Nuclear Factor Kappa B Activation and Peroxisome Proliferator-activated Receptor Transactivational Effects of Chemical Components of the Roots of Polygonum multiflorum.
Author:	Sun, Ya Nan\|Li, Wei\|Song, Seok Bean\|Yan, Xi Tao\|Yang, Seo Young\|Kim, Young Ho
PMID:	27019559

90.
Journal:	Glycoconj J. 2016 Dec;33(6):927-936.
Title:	Age-dependent PPARalpha activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene.
Author:	Tian, Yangyang\|Yang, Yang\|Zhang, Xiaowei\|Nakajima, Takero\|Tanaka, Naoki\|Sugiyama, Eiko\|Kamijo, Yuji\|Lu, Yu\|Moriya, Kyoji\|Koike, Kazuhiko\|Gonzalez, Frank J\|Aoyama, Toshifumi
PMID:	27318478

91.
Journal:	J Cell Biochem. 2017 Apr;118(4):754-763.
Title:	C/EBP-beta Is Differentially Affected by PPARalpha Agonists Fenofibric Acid and GW7647, But Does Not Change Apolipoprotein A-I Production During ER-Stress and Inflammation.
Author:	van der Krieken, Sophie E\|Popeijus, Herman E\|Konings, Maurice\|Dullens, Stefan P J\|Mensink, Ronald P\|Plat, Jogchum
PMID:	27618583

92.
Journal:	Pathol Oncol Res. 2017 Jul;23(3):477-485.
Title:	E2/ERbeta Inhibits PPARalpha to Regulate Cell-Proliferation and Enhance Apoptosis in Hep3B-Hepatocellular Carcinoma.
Author:	Chang-Lee, Shu Nu\|Hsu, Hsi-Hsien\|Shibu, Marthandam Asokan\|Ho, Tsung-Jung\|Tsai, Chih-Hao\|Chen, Ming-Cheng\|Tu, Chuan-Chou\|Viswanadha, Vijaya Padma\|Kuo, Wei- Wen\|Huang, Chih-Yang
PMID:	27757837

93.
Journal:	Biochimie. 2017 May;136:65-74.
Title:	PPARs and nonalcoholic fatty liver disease.
Author:	Liss, Kim H H\|Finck, Brian N
PMID:	27916647

94.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1;312(3):G283-G299.
Title:	Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells.
Author:	Brocker, Chad N\|Yue, Jiang\|Kim, Donghwan\|Qu, Aijuan\|Bonzo, Jessica A\|Gonzalez, Frank J
PMID:	28082284

95.
Journal:	Regul Toxicol Pharmacol. 2017 Jun;86:137-147.
Title:	Investigation of the mechanism of triclosan induced mouse liver tumors.
Author:	Wang, Zemin\|Li, Xilin\|Klaunig, James E
PMID:	28267557

96.
Journal:	Exp Ther Med. 2017 May;13(5):2507-2514.
Title:	MicroRNA-33a promotes cell proliferation and inhibits apoptosis by targeting PPARalpha in human hepatocellular carcinoma.
Author:	Chang, Weiping\|Zhang, Lei\|Xian, Yao\|Yu, Zhaoxiang
PMID:	28565872

97.
Journal:	Oxid Med Cell Longev. 2017;2017:3960197.
Title:	circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis.
Author:	Guo, Xing-Ya\|Chen, Jian-Neng\|Sun, Fang\|Wang, Yu-Qin\|Pan, Qin\|Fan, Jian-Gao
PMID:	29018509

98.
Journal:	Environ Toxicol. 2018 Feb;33(2):234-247.
Title:	Fenofibrate induced PPAR alpha expression was attenuated by oestrogen receptor alpha overexpression in Hep3B cells.
Author:	Jeng, Long-Bin\|Velmurugan, Bharath Kumar\|Hsu, Hsi-Hsien\|Wen, Su-Ying\|Shen, Chia-Yao\|Lin, Chih-Hao\|Lin, Yueh-Min\|Chen, Ray-Jade\|Kuo, Wei-Wen\|Huang, Chih-Yang
PMID:	29134746

99.
Journal:	Cancer Cell Int. 2018 May 11;18:74.
Title:	Up-regulation of CTD-2547G23.4 in hepatocellular carcinoma tissues and its prospective molecular regulatory mechanism: a novel qRT-PCR and bioinformatics analysis study.
Author:	Wen, Dong-Yue\|Lin, Peng\|Liang, Hai-Wei\|Yang, Xia\|Li, Hai-Yuan\|He, Yun\|Yang, Hong\|Chen, Gang
PMID:	29780284

100.
Journal:	Cancer Manag Res. 2018 Jun 26;10:1781-1789.
Title:	Decreased expression of peroxisome proliferator-activated receptor alpha indicates unfavorable outcomes in hepatocellular carcinoma.
Author:	Xiao, Yong-Bo\|Cai, Shao-Hang\|Liu, Li-Li\|Yang, Xia\|Yun, Jing-Ping
PMID:	29983595

101.
Journal:	J Virol. 2018 Sep 12;92(19). pii: JVI.00722-18.
Title:	Hepatitis B Virus Deregulates the Cell Cycle To Promote Viral Replication and a Premalignant Phenotype.
Author:	Xia, Yuchen\|Cheng, Xiaoming\|Li, Yao\|Valdez, Kristin\|Chen, Weiping\|Liang, T Jake
PMID:	30021897