Primary Site >> Liver Cancer
Gene >> PPARA
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Convergence of three steroid receptor pathways in the mediation of nongenotoxic hepatocarcinogenesis. PMID: 8625436 Ref: Effect on the expression of c-met, c-myc and PPAR-alpha in liver and liver tumors from rats chronically exposed to the hepatocarcinogenic peroxisome proliferator WY-14,643. PMID: 8681452 Ref: Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator. PMID: 8943797 |
Ref: Recent update on the PPAR alpha-null mouse. PMID: 9209711 |
Ref: Inhibition of PPAR alpha/RXR alpha-mediated direct hyperplasia pathways during griseofulvin-induced hepatocarcinogenesis. PMID: 9548566 Ref: Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids. PMID: 9703482 |
Ref: Peroxisome proliferator-activated receptor alpha: role in rodent liver cancer and species differences. PMID: 9924174 Ref: Peroxisome proliferator-activated receptors (PPARS) and carcinogenesis. PMID: 10048147 Ref: A cancer risk assessment of di(2-ethylhexyl)phthalate: application of the new U.S. EPA Risk Assessment Guidelines. PMID: 10388618 |
Ref: Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis. PMID: 10725470 Ref: Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis. PMID: 10753222 Ref: Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate. PMID: 10807555 Ref: Less extrahepatic induction of fatty acid beta-oxidation enzymes by PPAR alpha. PMID: 11071880 Ref: Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators. PMID: 11229371 |
Ref: Weight-of-evidence versus strength-of-evidence in toxicologic hazard identification: Di(2-ethylhexyl)phthalate (DEHP). PMID: 11246142 Ref: Peroxisome proliferators and fatty acids negatively regulate liver X receptor-mediated activity and sterol biosynthesis. PMID: 11358675 Ref: Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system. PMID: 11375435 Ref: Is peroxisome proliferation an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl)phthalate (DEHP)? PMID: 11401753 Ref: Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice. PMID: 11461119 |
Ref: Elevated basal expression of liver peroxisomal beta-oxidation enzymes and CYP4A microsomal fatty acid omega-hydroxylase in STAT5b(-/-) mice: cross-talk in vivo between peroxisome proliferator-activated receptor and signal transducer and activator of trans PMID: 12127257 Ref: Enhanced hepatocarcinogenicity due to agonists of peroxisome proliferator-activated receptors in senescent rats: role of peroxisome proliferation, cell proliferation, and apoptosis. PMID: 12805935 |
Ref: Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643. PMID: 12729718 Ref: Molecular profiling of hepatocellular carcinomas developing spontaneously in acyl-CoA oxidase deficient mice: comparison with liver tumors induced in wild-type mice by a peroxisome proliferator and a genotoxic carcinogen. PMID: 12771043 Ref: Role of the peroxisome proliferator-activated receptor alpha in responses to diisononyl phthalate. PMID: 12965124 Ref: Comprehensive gene expression analysis of peroxisome proliferator-treated immortalized hepatocytes: identification of peroxisome proliferator-activated receptor alpha-dependent growth regulatory genes. PMID: 14522898 |
Ref: Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha. PMID: 15172993 Ref: Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver. PMID: 15363585 Ref: [Possible mechanisms of hepatitis C virus-related hepatocarcinogenesis]. PMID: 15552900 |
Ref: Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis. PMID: 15447978 Ref: Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand? PMID: 15976920 |
Ref: The ribosomal protein rpL11 associates with and inhibits the transcriptional activity of peroxisome proliferator-activated receptor-alpha. PMID: 16280383 Ref: Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis. PMID: 16377806 Ref: Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alpha. PMID: 16467456 Ref: Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. PMID: 16603729 Ref: High-fat emulsion-induced rat model of nonalcoholic steatohepatitis. PMID: 16624332 Ref: Activation of peroxisome proliferator-activated receptor alpha enhances apoptosis in the mouse liver. PMID: 16687391 Ref: Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity. PMID: 16966106 Ref: Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists. PMID: 17118139 |
Ref: Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells. PMID: 17224343 Ref: Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis. PMID: 17331954 Ref: Critical role for transcription coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein/TRAP220 in liver regeneration and PPARalpha ligand-induced liver tumor development. PMID: 17438330 Ref: Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma. PMID: 17484888 Ref: Are peroxisome proliferator-activated receptors involved in skeletal muscle wasting during experimental cancer cachexia? Role of beta2-adrenergic agonists. PMID: 17616713 |
Ref: Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis. PMID: 17764115 Ref: PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators. PMID: 18006136 Ref: Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease. PMID: 18176957 Ref: PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice. PMID: 18188449 Ref: Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR. PMID: 18281256 Ref: Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha. PMID: 18497086 Ref: Mitochondria, PPARs, and Cancer: Is Receptor-Independent Action of PPAR Agonists a Key? PMID: 18645611 Ref: Evaluation of the role of peroxisome proliferator-activated receptor alpha (PPARalpha) in mouse liver tumor induction by trichloroethylene and metabolites. PMID: 18821149 Ref: PPAR-alpha L162V polymorphism in human hepatocellular carcinoma. PMID: 19119483 |
Ref: Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection. PMID: 19148799 Ref: Mechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis. PMID: 19176532 Ref: Identification of a functional peroxisome proliferator-activated receptor (PPAR) response element (PPRE) in the human apolipoprotein A-IV gene. PMID: 19433068 Ref: No Modifying Effect of Antioxidant N-Acetyl-L-Cysteine on Fenofibrate-induced Hepatocarcinogenesis in Rats. PMID: 22272000 |
Ref: PPARalpha: energy combustion, hypolipidemia, inflammation and cancer. PMID: 20414453 Ref: PPARalpha-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells. PMID: 20813756 Ref: [Expression of nuclear hormone receptors PPAR, LXR and RXR in the liver and lipid and glucose levels in blood in susceptible and resistant to hepatocarcinogenesis mice strains]. PMID: 21032898 |
Ref: Peroxisome proliferator-activated receptor alpha (PPARalpha) mRNA expression in human hepatocellular carcinoma tissue and non-cancerous liver tissue. PMID: 22168458 |
Ref: Sustained activation of PPARalpha by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice. PMID: 22009939 Ref: Roles of PPARs in NAFLD: potential therapeutic targets. PMID: 22056763 Ref: Tesaglitazar, a dual PPAR-alpha/gamma agonist, hamster carcinogenicity, investigative animal and clinical studies. PMID: 22131108 Ref: Gene network analysis leads to functional validation of pathways linked to cancer cell growth and survival. PMID: 22930530 Ref: PPARs in Liver Diseases and Cancer: Epigenetic Regulation by MicroRNAs. PMID: 23024649 Ref: PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma. PMID: 23316217 |
Ref: Peroxisome proliferator-activated receptor alpha positively regulates complement C3 expression but inhibits tumor necrosis factor alpha-mediated activation of C3 gene in mammalian hepatic-derived cells. PMID: 23168409 Ref: PPARalpha-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons. PMID: 23811191 Ref: Regulation of URG4/URGCP and PPARalpha gene expressions after retinoic acid treatment in neuroblastoma cells. PMID: 23821302 Ref: Fenofibrate, a peroxisome proliferator-activated receptor alpha-agonist, blocks lipopolysaccharide-induced inflammatory pathways in mouse liver. PMID: 26155222 |
Ref: Role of Myc in hepatocellular proliferation and hepatocarcinogenesis. PMID: 24096051 Ref: Bioactivity screening and mass spectrometric confirmation for the detection of PPARdelta agonists that increase type 1 muscle fibres. PMID: 24287635 Ref: Peroxisome proliferator-activated receptor-alpha activation and excess energy burning in hepatocarcinogenesis. PMID: 24291192 Ref: Human relevance framework for rodent liver tumors induced by the insecticide sulfoxaflor. PMID: 24832551 Ref: Peroxisome proliferator-activated receptor alpha, a potential therapeutic target for alcoholic liver disease. PMID: 25009377 Ref: Trichloroethylene-induced gene expression and DNA methylation changes in B6C3F1 mouse liver. PMID: 25549359 |
Ref: Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway. PMID: 25592151 Ref: Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) in a mouse liver gene expression compendium. PMID: 25689681 Ref: Forced expression of fibroblast growth factor 21 reverses the sustained impairment of liver regeneration in hPPARalpha(PAC) mice due to dysregulated bile acid synthesis. PMID: 25991671 Ref: Maltitol Prevents the Progression of Fatty Liver Degeneration in Mice Fed High-Fat Diets. PMID: 26061453 Ref: Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway. PMID: 26206264 Ref: N-Aryl benzenesulfonamide inhibitors of [3H]-thymidine incorporation and beta-catenin signaling in human hepatocyte-derived Huh-7 carcinoma cells. PMID: 26243371 Ref: Gene Network Analysis of Glucose Linked Signaling Pathways and Their Role in Human Hepatocellular Carcinoma Cell Growth and Survival in HuH7 and HepG2 Cell Lines. PMID: 26380295 Ref: c9, t11- conjugated linoleic acid induces HCC cell apoptosis and correlation with PPAR-gamma signaling pathway. PMID: 26885272 |
Ref: Dose and Effect Thresholds for Early Key Events in a PPARalpha-Mediated Mode of Action. PMID: 26519955 Ref: Constitutive active/androstane receptor, peroxisome proliferator-activated receptor alpha, and cytotoxicity are involved in oxadiazon-induced liver tumor development in mice. PMID: 26710982 Ref: Role of PPARalpha in the attenuation of bile acid-induced apoptosis by omega-3 long-chain polyunsaturated fatty acids in cultured hepatocytes. PMID: 26756785 Ref: PPARgamma activation reduces ischemia/reperfusion-induced metastasis in a murine model of hepatocellular carcinoma. PMID: 26893620 Ref: Nuclear Factor Kappa B Activation and Peroxisome Proliferator-activated Receptor Transactivational Effects of Chemical Components of the Roots of Polygonum multiflorum. PMID: 27019559 Ref: Age-dependent PPARalpha activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene. PMID: 27318478 |
Ref: C/EBP-beta Is Differentially Affected by PPARalpha Agonists Fenofibric Acid and GW7647, But Does Not Change Apolipoprotein A-I Production During ER-Stress and Inflammation. PMID: 27618583 Ref: E2/ERbeta Inhibits PPARalpha to Regulate Cell-Proliferation and Enhance Apoptosis in Hep3B-Hepatocellular Carcinoma. PMID: 27757837 Ref: PPARs and nonalcoholic fatty liver disease. PMID: 27916647 Ref: Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells. PMID: 28082284 Ref: Investigation of the mechanism of triclosan induced mouse liver tumors. PMID: 28267557 Ref: MicroRNA-33a promotes cell proliferation and inhibits apoptosis by targeting PPARalpha in human hepatocellular carcinoma. PMID: 28565872 Ref: circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis. PMID: 29018509 |
Ref: Fenofibrate induced PPAR alpha expression was attenuated by oestrogen receptor alpha overexpression in Hep3B cells. PMID: 29134746 Ref: Up-regulation of CTD-2547G23.4 in hepatocellular carcinoma tissues and its prospective molecular regulatory mechanism: a novel qRT-PCR and bioinformatics analysis study. PMID: 29780284 Ref: Decreased expression of peroxisome proliferator-activated receptor alpha indicates unfavorable outcomes in hepatocellular carcinoma. PMID: 29983595 Ref: Hepatitis B Virus Deregulates the Cell Cycle To Promote Viral Replication and a Premalignant Phenotype. PMID: 30021897 |