Primary Site >> Liver Cancer

Gene >> POU5F1

Journal: Cloning Stem Cells. 2005;7(1):8-16.
Title: Heterogeneous DNA methylation status of the regulatory element of the mouse Oct4 gene in adult somatic cell population.
Author: Marikawa, Yusuke|Fujita, Toko C|Alarcon, Vernadeth B
PMID: 15996113
Journal: Stem Cells. 2006 Jan;24(1):125-38.
Title: Long-term proliferation of human embryonic stem cell-derived neuroepithelial cells using defined adherent culture conditions.
Author: Shin, Soojung|Mitalipova, Maisam|Noggle, Scott|Tibbitts, Deanne|Venable, Alison|Rao, Raj|Stice, Steven L
PMID: 16100006
Journal: BMC Med Genomics. 2008 Oct 10;1:49.
Title: The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines.
Author: Regenbrecht, Christian Ra|Jung, Marc|Lehrach, Hans|Adjaye, James
PMID: 18847459
Journal: Gastrointest Cancer Res. 2008 Jul;2(4 Suppl):S27-30.
Title: Liver stem cells and tgf-Beta in hepatic carcinogenesis.
Author: Amin, Rupen|Mishra, Lopa
PMID: 19343145
Journal: Oncogene. 2009 Feb 19;28(7):961-72.
Title: The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling.
Author: Lin, L|Amin, R|Gallicano, G I|Glasgow, E|Jogunoori, W|Jessup, J M|Zasloff, M|Marshall, J L|Shetty, K|Johnson, L|Mishra, L|He, A R
PMID: 19137011
Journal: Stem Cells Dev. 2010 Aug;19(8):1277-84.
Title: Human liver progenitor cell lines are readily established from non-tumorous tissue adjacent to hepatocellular carcinoma.
Author: Zhang, Aibin|London, Roslyn|Schulz, Frederik Michael|Giguere-Simmonds, Philippe Wilfred Roger|Delriviere, Luc|Chandraratana, Harsha|Hardy, Kathy|Zheng, Shusen|Olynyk, John K|Yeoh, George
PMID: 19874130
Journal: Carcinogenesis. 2010 Feb;31(2):167-74.
Title: The properties of tumor-initiating cells from a hepatocellular carcinoma patient's primary and recurrent tumor.
Author: Xu, Xiao-Lan|Xing, Bao-Cai|Han, Hai-Bo|Zhao, Wei|Hu, Mei-Hao|Xu, Zuo-Liang|Li, Ji-You|Xie, Yong|Gu, Jun|Wang, Yu|Zhang, Zhi-Qian
PMID: 19897602
Journal: Chin J Cancer. 2010 Jan;29(1):111-16.
Title: [OCT4 expression in hepatocellular carcinoma and its clinical significance].
Author: Huang, Pin-Zhu|Lu, Can-Liang|Li, Bin-Kui|Hong, Jian|Huang, Liang|Wang, Li|Zhang, Ying|Yuan, Yun-Fei
PMID: 20038322
Journal: Mol Cell Biochem. 2010 Oct;343(1-2):155-62.
Title: Expression of Oct4 in HCC and modulation to wnt/beta-catenin and TGF-beta signal pathways.
Author: Yuan, FangJun|Zhou, Wenbo|Zou, Can|Zhang, Zhiyun|Hu, Hongsheng|Dai, Zongqing|Zhang, YouShun
PMID: 20549546
Journal: Cell Transplant. 2011;20(1):15-9.
Title: Induced pluripotent stem (iPS) cell research overview.
Author: Liu, Shih-Ping|Fu, Ru-Huei|Huang, Yu-Chuen|Chen, Shih-Yin|Chien, Ying-Jiun|Hsu, Chien Yu|Tsai, Chang-Hai|Shyu, Woei-Cherng|Lin, Shinn-Zong
PMID: 20887681
Journal: Clin Biochem. 2011 Jun;44(8-9):582-9.
Title: Role of Sox2 and Oct4 in predicting survival of hepatocellular carcinoma patients after hepatectomy.
Author: Huang, Pinzhu|Qiu, Jiliang|Li, Binkui|Hong, Jian|Lu, Canliang|Wang, Li|Wang, Jianping|Hu, Yezhu|Jia, Weihua|Yuan, Yunfei
PMID: 21376027
Journal: BMC Gastroenterol. 2011 Jun 14;11:71.
Title: Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines.
Author: Cao, Lu|Zhou, Yanming|Zhai, Beibei|Liao, Jian|Xu, Wen|Zhang, Ruixiu|Li, Jing|Zhang, Yu|Chen, Lei|Qian, Haihua|Wu, Mengchao|Yin, Zhengfeng
PMID: 21669008
Journal: PLoS One. 2011;6(12):e28246.
Title: Granulin-epithelin precursor is an oncofetal protein defining hepatic cancer stem cells.
Author: Cheung, Phyllis Fung Yi|Cheng, Christine Kei Chin|Wong, Nicholas Chun Lim|Ho, Jenny Chung Yee|Yip, Chi Wai|Lui, Vincent Chi Hang|Cheung, Annie Nga Yin|Fan, Sheung Tat|Cheung, Siu Tim
PMID: 22194816
Journal: Oncol Rep. 2012 Jun;27(6):1865-72.
Title: Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145.
Author: Jia, Yongsheng|Liu, Honglin|Zhuang, Qianshu|Xu, Shiqing|Yang, Zhihua|Li, Jianzhong|Lou, Jinning|Zhang, Wenjian
PMID: 22378186
Journal: Gastroenterology. 2012 Jun;142(7):1547-58.e14.
Title: p28(GANK) prevents degradation of Oct4 and promotes expansion of tumor-initiating cells in hepatocarcinogenesis.
Author: Qian, You-Wen|Chen, Yao|Yang, Wen|Fu, Jing|Cao, Jie|Ren, Yi-Bin|Zhu, Jun-Jie|Su, Bo|Luo, Tao|Zhao, Xiao-Fang|Dai, Rong-Yang|Li, Juan-Juan|Sun, Wen|Wu, Meng-Chao|Feng, Gen-Sheng|Wang, Hong-Yang
PMID: 22387393
Journal: Chin J Cancer. 2012 May;31(5):223-32.
Title: LIN28 expression and prognostic value in hepatocellular carcinoma patients who meet the Milan criteria and undergo hepatectomy.
Author: Qiu, Ji-Liang|Huang, Pin-Zhu|You, Jing-Hong|Zou, Ru-Hai|Wang, Li|Hong, Jian|Li, Bin-Kui|Zhou, Kai|Yuan, Yun-Fei
PMID: 22429493
Journal: Ann Surg Oncol. 2012 Sep;19(9):2877-87.
Title: Coexpression of stemness factors Oct4 and Nanog predict liver resection.
Author: Yin, Xin|Li, Yi-Wei|Zhang, Bo-Heng|Ren, Zheng-Gang|Qiu, Shuang-Jian|Yi, Yong|Fan, Jia
PMID: 22461131
Journal: Biochem Biophys Res Commun. 2012 Jun 8;422(3):429-35.
Title: Exploring stemness gene expression and vasculogenic mimicry capacity in well- and poorly-differentiated hepatocellular carcinoma cell lines.
Author: Lirdprapamongkol, Kriengsak|Chiablaem, Khajeelak|Sila-Asna, Monnipha|Surarit, Rudee|Bunyaratvej, Ahnond|Svasti, Jisnuson
PMID: 22580004
Journal: Ann Diagn Pathol. 2013 Aug;17(4):367-71.
Title: Hepatocellular carcinoma arising in a testicular teratoma: a distinct and unrecognized secondary somatic malignancy.
Author: Jain, Deepali|Mittal, Suchi|Gupta, Manu
PMID: 22763193
Journal: Arch Toxicol. 2013 Jun;87(6):1001-12.
Title: Inhibition of hepatocyte nuclear factor 1 and 4 alpha (HNF1alpha and HNF4alpha) as a mechanism of arsenic carcinogenesis.
Author: Pastoret, Anna|Marcos, Ricard|Sampayo-Reyes, Adriana|Saucedo-Cardenas, Odila|Lozano-Garza, Gerardo H|Hernandez, Alba
PMID: 23052196
Journal: Oncol Lett. 2013 Jan;5(1):127-134.
Title: The pan-deacetylase inhibitor panobinostat modulates the expression of epithelial-mesenchymal transition markers in hepatocellular carcinoma models.
Author: DI Fazio, Pietro|Montalbano, Roberta|Quint, Karl|Alinger, Beate|Kemmerling, Ralf|Kiesslich, Tobias|Ocker, Matthias|Neureiter, Daniel
PMID: 23255907
Journal: BMC Cancer. 2013 Feb 22;13:82.
Title: OCT4 increases BIRC5 and CCND1 expression and promotes cancer progression in hepatocellular carcinoma.
Author: Cao, Lu|Li, Chunguang|Shen, Shuwen|Yan, Yan|Ji, Weidan|Wang, Jinghan|Qian, Haihua|Jiang, Xiaoqing|Li, Zhigang|Wu, Mengchao|Zhang, Ying|Su, Changqing
PMID: 23433354
Journal: Cell Reprogram. 2013 Apr;15(2):143-50.
Title: Positive correlation of Oct4 and ABCG2 to chemotherapeutic resistance in CD90(+)CD133(+) liver cancer stem cells.
Author: Jia, Qian|Zhang, Xiaoli|Deng, Tao|Gao, Jian
PMID: 23438193
Journal: Oncol Lett. 2013 Apr;5(4):1155-1162.
Title: The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma.
Author: Yin, Xin|Li, Yi-Wei|Jin, Jian-Jun|Zhou, Yin|Ren, Zheng-Gang|Qiu, Shuang-Jian|Zhang, Bo-Heng
PMID: 23599755
Journal: Carcinogenesis. 2013 Aug;34(8):1773-81.
Title: Pseudogene OCT4-pg4 functions as a natural micro RNA sponge to regulate OCT4 expression by competing for miR-145 in hepatocellular carcinoma.
Author: Wang, Lei|Guo, Zhang-Yan|Zhang, Rui|Xin, Bo|Chen, Rui|Zhao, Jing|Wang, Tao|Wen, Wei-Hong|Jia, Lin-Tao|Yao, Li-Bo|Yang, An-Gang
PMID: 23615404
Journal: PLoS One. 2013 Sep 4;8(9):e72435.
Title: Epigenetic regulation of pluripotent genes mediates stem cell features in human hepatocellular carcinoma and cancer cell lines.
Author: Wang, Xiao Qi|Ng, Ray Kit|Ming, Xiaoyan|Zhang, Wu|Chen, Lin|Chu, Andrew C Y|Pang, Roberta|Lo, Chung Mau|Tsao, Sai Wah|Liu, Xuqing|Poon, Ronnie T P|Fan, Sheung Tat
PMID: 24023739
Journal: Cell Death Dis. 2013 Oct 17;4:e857.
Title: Single-cell clones of liver cancer stem cells have the potential of differentiating into different types of tumor cells.
Author: Liu, H|Zhang, W|Jia, Y|Yu, Q|Grau, G E|Peng, L|Ran, Y|Yang, Z|Deng, H|Lou, J
PMID: 24136221
Journal: PLoS One. 2013 Nov 14;8(11):e80053.
Title: Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma.
Author: Cheng, Shu-Wen|Tsai, Hung-Wen|Lin, Yih-Jyh|Cheng, Pin-Nan|Chang, Yu-Chung|Yen, Chia-Jui|Huang, Hsuan-Pang|Chuang, Yun-Pei|Chang, Ting-Tsung|Lee, Chung-Ta|Chao, Anning|Chou, Cheng-Yang|Chan, Shih-Huang|Chow, Nan-Haw|Ho, Chung-Liang
PMID: 24244607
Journal: World J Gastroenterol. 2013 Dec 21;19(47):8850-60.
Title: Cellular reprogramming and hepatocellular carcinoma development.
Author: Zheng, Yun-Wen|Nie, Yun-Zhong|Taniguchi, Hideki
PMID: 24379607
Journal: Oxid Med Cell Longev. 2013;2013:387014.
Title: DNA damage in inflammation-related carcinogenesis and cancer stem cells.
Author: Ohnishi, Shiho|Ma, Ning|Thanan, Raynoo|Pinlaor, Somchai|Hammam, Olfat|Murata, Mariko|Kawanishi, Shosuke
PMID: 24382987
Journal: Drug Deliv Transl Res. 2013 Apr;3(2):152-64.
Title: Tumor-initiating stem-like cells and drug resistance: carcinogenesis through Toll-like receptors, environmental factors, and virus.
Author: Machida, Keigo
PMID: 25787983
Journal: Asian Pac J Trop Med. 2014 Apr;7(4):253-6.
Title: Establishment and identification of induced pluripotent stem cells in liver cancer patients.
Author: Zhang, Da-Ming|Li, Jian-Jun|Yan, Peng|Hu, Jian-Ting
PMID: 24507670
Journal: Exp Eye Res. 2014 Jul;124:67-73.
Title: The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation.
Author: Brodowska, Katarzyna|Al-Moujahed, Ahmad|Marmalidou, Anna|Meyer Zu Horste, Melissa|Cichy, Joanna|Miller, Joan W|Gragoudas, Evangelos|Vavvas, Demetrios G
PMID: 24837142
Journal: World J Gastroenterol. 2014 Jun 14;20(22):6974-80.
Title: Influence of adriamycin on changes in Nanog, Oct-4, Sox2, ARID1 and Wnt5b expression in liver cancer stem cells.
Author: Sun, Ding|Qin, Lei|Xu, Yang|Liu, Jian-Xia|Tian, Li-Ping|Qian, Hai-Xin
PMID: 24944491
Journal: Cancer Res. 2014 Oct 15;74(20):5903-13.
Title: MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism.
Author: Akita, Hirofumi|Marquardt, Jens U|Durkin, Marian E|Kitade, Mitsuteru|Seo, Daekwan|Conner, Elizabeth A|Andersen, Jesper B|Factor, Valentina M|Thorgeirsson, Snorri S
PMID: 25189530
Journal: Exp Mol Pathol. 2014 Dec;97(3):399-410.
Title: Digital quantitation of HCC-associated stem cell markers and protein quality control factors using tissue arrays of human liver sections.
Author: Buzzanco, A|Gomez, A|Rodriguez, E|French, B A|Tillman, B A|Chang, S|Ganapathy, E|Junrungsee, S|Zarrinpar, A|Agopian, V G|Naini, B V|French, S W Jr|French, S W Sr
PMID: 25218810
Journal: Drug Metab Dispos. 2014 Dec;42(12):2033-40.
Title: Differential expression of drug uptake and efflux transporters in Japanese patients with hepatocellular carcinoma.
Author: Namisaki, Tadashi|Schaeffeler, Elke|Fukui, Hiroshi|Yoshiji, Hitoshi|Nakajima, Yoshiyuki|Fritz, Peter|Schwab, Matthias|Nies, Anne T
PMID: 25231932
Journal: Gut. 2015 Jan;64(1):156-67.
Title: Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4.
Author: Li, Liang|Tang, Jing|Zhang, Baohua|Yang, Wen|LiuGao, Miyang|Wang, Ruoyu|Tan, Yexiong|Fan, Jianling|Chang, Yanxin|Fu, Jing|Jiang, Feng|Chen, Caiyang|Yang, Yingcheng|Gu, Jin|Wu, Dingming|Guo, Linna|Cao, Dan|Li, Hengyu|Cao, Guangwen|Wu, Mengchao|Zhang, Micha
PMID: 24572141
Journal: Hepatology. 2015 Feb;61(2):598-612.
Title: betaII-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin.
Author: Zhi, Xiuling|Lin, Ling|Yang, Shaoxian|Bhuvaneshwar, Krithika|Wang, Hongkun|Gusev, Yuriy|Lee, Mi-Hye|Kallakury, Bhaskar|Shivapurkar, Narayan|Cahn, Katherine|Tian, Xuefei|Marshall, John L|Byers, Stephen W|He, Aiwu R
PMID: 25307947
Journal: Cancer Sci. 2015 Feb;106(2):151-9.
Title: TAZ regulates cell proliferation and epithelial-mesenchymal transition of human hepatocellular carcinoma.
Author: Xiao, Heng|Jiang, Ning|Zhou, Baoyong|Liu, Qiang|Du, Chengyou
PMID: 25495189
Journal: Clin Cancer Res. 2015 Jan 1;21(1):201-10.
Title: Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression.
Author: Chang, Te-Sheng|Wu, Yu-Chih|Chi, Ching-Chi|Su, Wei-Chi|Chang, Pey-Jium|Lee, Kam-Fai|Tung, Tao-Hsin|Wang, Jui|Liu, Jun-Jen|Tung, Shui-Yi|Kuo, Liang-Mou|Ho, Hong-Nerng|Ling, Thai-Yen|Huang, Yen-Hua
PMID: 25564572
Journal: FEBS Lett. 2015 Feb 13;589(4):500-6.
Title: MiR-155 targets TP53INP1 to regulate liver cancer stem cell acquisition and self-renewal.
Author: Liu, Fengchao|Kong, Xin|Lv, Lin|Gao, Jian
PMID: 25601564
Journal: Oncol Rep. 2015 Apr;33(4):1621-9.
Title: Aktmediated phosphorylation of Oct4 is associated with the proliferation of stemlike cancer cells.
Author: Zhao, Qing-Wei|Zhou, Yan-Wen|Li, Wen-Xin|Kang, Bo|Zhang, Xiao-Qian|Yang, Ying|Cheng, Jie|Yin, Sheng-Yong|Tong, Ying|He, Jian-Qin|Yao, Hang-Ping|Zheng, Min|Wang, Ying-Jie
PMID: 25625591
Journal: Cancer Lett. 2015 Apr 10;359(2):288-98.
Title: TGF-beta1 acts through miR-155 to down-regulate TP53INP1 in promoting epithelial-mesenchymal transition and cancer stem cell phenotypes.
Author: Liu, Fengchao|Kong, Xin|Lv, Lin|Gao, Jian
PMID: 25633840
Journal: J Hematol Oncol. 2015 Mar 11;8:23.
Title: Coexpression of gene Oct4 and Nanog initiates stem cell characteristics in hepatocellular carcinoma and promotes epithelial-mesenchymal transition through activation of Stat3/Snail signaling.
Author: Yin, Xin|Zhang, Bo-Heng|Zheng, Su-Su|Gao, Dong-Mei|Qiu, Shuang-Jian|Wu, Wei-Zhong|Ren, Zheng-Gang
PMID: 25879771
Journal: Cancer Lett. 2015 Aug 1;364(1):33-43.
Title: MiR-429 increases the metastatic capability of HCC via regulating classic Wnt pathway rather than epithelial-mesenchymal transition.
Author: Tang, Jing|Li, Liang|Huang, Wentao|Sui, Chengjun|Yang, Yingcheng|Lin, Ximeng|Hou, Guojun|Chen, Xin|Fu, Jing|Yuan, Shengxian|Li, Shao|Wen, Wen|Tang, Shanhua|Cao, Dan|Wu, Mengchao|Chen, Lei|Wang, Hongyang
PMID: 25931210
Journal: Int J Clin Exp Pathol. 2015 Feb 1;8(2):1427-34. eCollection 2015.
Title: Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells.
Author: Lin, Rui-Xin|Gong, Lu-Lu|Fan, Li-Mei|Zhao, Zhong-Kai|Yang, Shu-Li
PMID: 25973027
Journal: Stem Cells. 2015 Sep;33(9):2652-63.
Title: SRY and OCT4 Are Required for the Acquisition of Cancer Stem Cell-Like Properties and Are Potential Differentiation Therapy Targets.
Author: Murakami, Shigekazu|Ninomiya, Wataru|Sakamoto, Erina|Shibata, Tatsuhiro|Akiyama, Hirotada|Tashiro, Fumio
PMID: 26013162
Journal: Gastroenterology. 2015 Oct;149(4):1068-81.e5.
Title: Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells.
Author: Song, Yangyang|Pan, Guangjin|Chen, Leilei|Ma, Stephanie|Zeng, Tingting|Man Chan, Tim Hon|Li, Lei|Lian, Qizhou|Chow, Raymond|Cai, Xiujuan|Li, Yan|Li, Yan|Liu, Ming|Li, Yun|Zhu, Yinghui|Wong, Nathalie|Yuan, Yun-Fei|Pei, Duanqing|Guan, Xin-Yuan
PMID: 26099525
Journal: Onco Targets Ther. 2015 Jun 22;8:1543-52.
Title: Roles of dopamine receptors and their antagonist thioridazine in hepatoma metastasis.
Author: Lu, Meiling|Li, Jinghua|Luo, Zaili|Zhang, Shuai|Xue, Shaobo|Wang, Kesheng|Shi, Yan|Zhang, Cunzhen|Chen, Haiyang|Li, Zhong
PMID: 26124671
Journal: Tumour Biol. 2015 Dec;36(12):9711-6.
Title: High expression of OCT4 is frequent and may cause undesirable treatment outcomes in patients with acute myeloid leukemia.
Author: Yin, Jia-Yu|Tang, Qin|Zhai, Ling-Ling|Zhou, Ling-Yu|Qian, Jun|Lin, Jiang|Wen, Xiang-Mei|Zhou, Jing-Dong|Zhang, Ying-Ying|Zhu, Xiao-Wen|Deng, Zhao-Qun
PMID: 26152287
Journal: Oncotarget. 2015 Oct 13;6(31):31927-43.
Title: A novel anti-cancer agent Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/Jak2/Stat3 pathway.
Author: Zhao, Hong|Guo, Yuming|Li, Shu|Han, Ruiqin|Ying, Jianming|Zhu, Hai|Wang, Yuanyuan|Yin, Li|Han, Yuqing|Sun, Lingzhi|Wang, Zhaoyi|Lin, Qingcong|Bi, Xinyu|Jiao, Yuchen|Jia, Hongying|Zhao, Jianjun|Huang, Zhen|Li, Zhiyu|Zhou, Jianguo|Song, Wei|Meng, Kun|Cai, J
PMID: 26376676
Journal: J Clin Invest. 2015 Oct 1;125(10):3795-808.
Title: ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells.
Author: Zhu, Pingping|Wang, Yanying|He, Lei|Huang, Guanling|Du, Ying|Zhang, Geng|Yan, Xinlong|Xia, Pengyan|Ye, Buqing|Wang, Shuo|Hao, Lu|Wu, Jiayi|Fan, Zusen
PMID: 26426078
Journal: Oncotarget. 2015 Nov 10;6(35):37200-15.
Title: Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism.
Author: Sureban, Sripathi M|Madhoun, Mohammad F|May, Randal|Qu, Dongfeng|Ali, Naushad|Fazili, Javid|Weygant, Nathaniel|Chandrakesan, Parthasarathy|Ding, Kai|Lightfoot, Stanley A|Houchen, Courtney W
PMID: 26468984
Journal: Cell Mol Biol (Noisy-le-grand). 2015 Oct 30;61(6):85-91.
Title: Saturated fatty acid induces cancer stem cell-like properties in human hepatoma cells.
Author: Chong, L-W|Chou, R-H|Liao, C-C|Lee, T-F|Lin, Y|Yang, K-C|Hsu, Y-C
PMID: 26518899
Journal: Oncotarget. 2015 Dec 29;6(42):44452-65.
Title: Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation.
Author: Han, Shuo|Guo, Jinhai|Liu, Yinan|Zhang, Zhi|He, Qihua|Li, Peng|Zhang, Mingzhi|Sun, Haojie|Li, Ruizhi|Li, Yang|Zeng, Wotan|Liu, Jinwen|Lian, Lejian|Gao, Yi|Shen, Li
PMID: 26540347
Journal: Discov Med. 2015 Oct;20(110):219-29.
Title: Oct4 is a reliable marker of liver tumor propagating cells in hepatocellular carcinoma.
Author: Wu, Guang|Wilson, George|Zhou, Gang|Hebbard, Lionel|George, Jacob|Qiao, Liang
PMID: 26562475
Journal: Cancer Lett. 2016 Sep 1;379(2):184-90.
Title: Survivin in survival of hepatocellular carcinoma.
Author: Su, Changqing
PMID: 26118774
Journal: Neoplasma. 2016;63(2):288-98.
Title: The prognostic value of combination of CD90 and OCT4 for hepatocellular carcinoma after curative resection.
Author: Zhao, R C|Zhou, J|Chen, K F|Gong, J|Liu, J|He, J Y|Guan, P|Li, B|Qin, Y
PMID: 26674131
Journal: Oncol Rep. 2016 Mar;35(3):1657-63.
Title: TALEN-induced disruption of Nanog expression results in reduced proliferation, invasiveness and migration, increased chemosensitivity and reversal of EMT in HepG2 cells.
Author: Yu, Ai Qing|Ding, Yan|Li, Cheng Lin|Yang, Yi|Yan, Shi Rong|Li, Dong Sheng
PMID: 26676719
Journal: J Transl Med. 2016 Feb 12;14:49.
Title: Detection of ALDH1 activity in rabbit hepatic VX2 tumors and isolation of ALDH1 positive cancer stem cells.
Author: Gehlot, Prashasnika|Shukla, Vivek|Gupta, Sanjay|Makidon, Paul E
PMID: 26873175
Journal: PLoS One. 2016 Feb 26;11(2):e0149897.
Title: Inflammation Promotes Expression of Stemness-Related Properties in HBV-Related Hepatocellular Carcinoma.
Author: Chang, Te-Sheng|Chen, Chi-Long|Wu, Yu-Chih|Liu, Jun-Jen|Kuo, Yung Che|Lee, Kam-Fai|Lin, Sin-Yi|Lin, Sey-En|Tung, Shui-Yi|Kuo, Liang-Mou|Tsai, Ying-Huang|Huang, Yen-Hua
PMID: 26919045
Journal: Oncotarget. 2016 Apr 19;7(16):21644-57.
Title: Hepatic cancer stem cell marker granulin-epithelin precursor and beta-catenin expression associate with recurrence in hepatocellular carcinoma.
Author: Cheung, Phyllis F Y|Cheung, Tan To|Yip, Chi Wai|Ng, Linda W C|Fung, Sze Wai|Lo, Chung Mau|Fan, Sheung Tat|Cheung, Siu Tim
PMID: 26942873
Journal: Oncotarget. 2016 May 31;7(22):33246-56.
Title: Folate deficient tumor microenvironment promotes epithelial-to-mesenchymal transition and cancer stem-like phenotypes.
Author: Su, Yen-Hao|Huang, Wen-Chien|Huang, Tse-Hung|Huang, Yan-Jiun|Sue, Yu-Kai|Huynh, Thanh-Tuan|Hsiao, Michael|Liu, Tsan-Zon|Wu, Alexander Th|Lin, Chien-Min
PMID: 27119349
Journal: Oncol Rep. 2016 Jul;36(1):582-8.
Title: Hepatitis C virus core protein regulates OCT4 expression and promotes cell cycle progression in hepatocellular carcinoma.
Author: Zhou, Jia-Jia|Meng, Zhe|Zhou, Yu|Cheng, Di|Ye, Hui-Lin|Zhou, Quan-Bo|Deng, Xiao-Geng|Chen, Ru-Fu
PMID: 27121765
Journal: Oncol Lett. 2016 May;11(5):3145-3151.
Title: Side population in hepatocellular carcinoma HCCLM3 cells is enriched with stem-like cancer cells.
Author: Guo, Zhe|Jiang, Jing-Hang|Zhang, Jun|Yang, Hao-Jie|Zhong, Yan-Ping|Su, Jie|Yang, Ri-Rong|Li, LE-Qun|Xiang, Bang-DE
PMID: 27123080
Journal: Am J Physiol Gastrointest Liver Physiol. 2016 Jul 1;311(1):G91-G104.
Title: Bile acids promote diethylnitrosamine-induced hepatocellular carcinoma via increased inflammatory signaling.
Author: Sun, Lina|Beggs, Kevin|Borude, Prachi|Edwards, Genea|Bhushan, Bharat|Walesky, Chad|Roy, Nairita|Manley, Michael W Jr|Gunewardena, Sumedha|O'Neil, Maura|Li, Hua|Apte, Udayan
PMID: 27151938
Journal: J Hepatol. 2016 Nov;65(5):888-898.
Title: EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes.
Author: Mani, Saravana Kumar Kailasam|Zhang, Hao|Diab, Ahmed|Pascuzzi, Pete E|Lefrancois, Lydie|Fares, Nadim|Bancel, Brigitte|Merle, Philippe|Andrisani, Ourania
PMID: 27238755
Journal: Oncotarget. 2016 Jul 26;7(30):47431-47443.
Title: Prognostic value of the expression of cancer stem cell-related markers CD133 and CD44 in hepatocellular carcinoma: From patients to patient-derived tumor xenograft models.
Author: Zhao, Qihong|Zhou, Heng|Liu, Qifei|Cao, Ye|Wang, Gang|Hu, Anla|Ruan, Liang|Wang, Sufang|Bo, Qingli|Chen, Wenjun|Hu, Chuanlai|Xu, Dexiang|Tao, Fangbiao|Cao, Jiyu|Ge, Yongsheng|Yu, Zongfan|Li, Li|Wang, Hua
PMID: 27329727
Journal: Stem Cells. 2016 Nov;34(11):2613-2624.
Title: Positive Feedback Loop of OCT4 and c-JUN Expedites Cancer Stemness in Liver Cancer.
Author: Kuo, Kung-Kai|Lee, King-Teh|Chen, Ker-Kong|Yang, Ya-Han|Lin, Ying-Chu|Tsai, Ming-Ho|Wuputra, Kenly|Lee, Yen-Liang|Ku, Chia-Chen|Miyoshi, Hiroyuki|Nakamura, Yukio|Saito, Shigeo|Wu, Chun-Chieh|Chai, Chee-Yin|Eckner, Richard|Steve Lin, Chen-Lung|Wang, Sophie
PMID: 27341307
Journal: Tumour Biol. 2016 Oct;37(10):14103-14115.
Title: Arsenite inhibits the function of CD133(+) CD13(+) liver cancer stem cells by reducing PML and Oct4 protein expression.
Author: Tang, Huaming|Jin, Yukai|Jin, Shilong|Tan, Zhiming|Peng, Zhang|Kuang, Yuanli
PMID: 27517564
Journal: Mol Med. 2016 Oct;22:653-663.
Title: Stemness-related transcriptional factors and homing gene expression profiles in hepatic differentiation and cancer.
Author: Toraih, Eman A|Fawzy, Manal S|El-Falouji, Abdullah I|Hamed, Elham O|Nemr, Nader A|Hussein, Mohammad H|Abd El Fadeal, Noha M
PMID: 27623812
Journal: Cancer Res. 2016 Dec 1;76(23):7059-7071.
Title: NRBP2 Overexpression Increases the Chemosensitivity of Hepatocellular Carcinoma Cells via Akt Signaling.
Author: Zhang, Lixing|Ge, Chao|Zhao, Fangyu|Zhang, Yang|Wang, Xin|Yao, Ming|Li, Jinjun
PMID: 27634758
Journal: World J Surg Oncol. 2016 Oct 28;14(1):278.
Title: Overexpression of microRNA-21 strengthens stem cell-like characteristics in a hepatocellular carcinoma cell line.
Author: Jiang, Jinghang|Yang, Peipei|Guo, Zhe|Yang, Rirong|Yang, Haojie|Yang, Fuquan|Li, Lequn|Xiang, Bangde
PMID: 27793160
Journal: J Exp Clin Cancer Res. 2016 Nov 11;35(1):176.
Title: miR-589-5p inhibits MAP3K8 and suppresses CD90(+) cancer stem cells in hepatocellular carcinoma.
Author: Zhang, Xi|Jiang, Peng|Shuai, Ling|Chen, Kai|Li, Zhonghu|Zhang, Yujun|Jiang, Yan|Li, Xiaowu
PMID: 27835990
Journal: Cell Physiol Biochem. 2016;40(1-2):219-229.
Title: The Emerging Roles of Long Noncoding RNA ROR (lincRNA-ROR) and its Possible Mechanisms in Human Cancers.
Author: Pan, Yan|Li, Chen|Chen, Jing|Zhang, Kai|Chu, Xiaoyuan|Wang, Rui|Chen, Longbang
PMID: 27855392
Journal: Clin Cancer Res. 2016 Dec 15;22(24):6303.
Title: Correction: Activation of IL6/IGFIR Confers Poor Prognosis of HBV-Related Hepatocellular Carcinoma through Induction of OCT4/NANOG Expression.
Author:
PMID: 27980027
Journal: Genes Environ. 2017 Jan 1;38:26.
Title: Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells.
Author: Kawanishi, Shosuke|Ohnishi, Shiho|Ma, Ning|Hiraku, Yusuke|Oikawa, Shinji|Murata, Mariko
PMID: 28050219
Journal: Liver Int. 2017 Mar;37(3):354-361.
Title: Identification of novel OCT4 genetic variant associated with the risk of chronic hepatitis B in a Korean population.
Author: Shin, Joong-Gon|Cheong, Hyun Sub|Lee, Kwanghyun|Ju, Bong-Gun|Lee, Jeong-Hoon|Yu, Su Jong|Yoon, Jung-Hwan|Cheong, Jae Youn|Cho, Sung Won|Park, Neung Hwa|Namgoong, Suhg|Kim, Lyoung Hyo|Kim, Yoon Jun|Shin, Hyoung Doo
PMID: 27596359
Journal: Gut Liver. 2017 Mar 15;11(2):261-269.
Title: Establishment of Hepatocellular Cancer Induced Pluripotent Stem Cells Using a Reprogramming Technique.
Author: Kim, Han Joon|Jeong, Jaemin|Park, Sunhoo|Jin, Young-Woo|Lee, Seung-Sook|Lee, Seung Bum|Choi, Dongho
PMID: 27728962
Journal: Oncogene. 2017 Apr 27;36(17):2435-2445.
Title: DNA demethylation induces SALL4 gene re-expression in subgroups of hepatocellular carcinoma associated with Hepatitis B or C virus infection.
Author: Fan, H|Cui, Z|Zhang, H|Mani, S K|Diab, A|Lefrancois, L|Fares, N|Merle, P|Andrisani, O
PMID: 27797380
Journal: Oncotarget. 2017 Jan 24;8(4):6067-6078.
Title: MBD3 inhibits formation of liver cancer stem cells.
Author: Li, Ruizhi|He, Qihua|Han, Shuo|Zhang, Mingzhi|Liu, Jinwen|Su, Ming|Wei, Shiruo|Wang, Xuan|Shen, Li
PMID: 27894081
Journal: Drug Metab Dispos. 2017 Feb;45(2):166-173.
Title: Impact of Organic Cation Transporters (OCT-SLC22A) on Differential Diagnosis of Intrahepatic Lesions.
Author: Visentin, Michele|van Rosmalen, Belle V|Hiller, Christian|Bieze, Matthanja|Hofstetter, Lia|Verheij, Joanne|Kullak-Ublick, Gerd A|Koepsell, Hermann|Phoa, Saffire S K S|Tamai, Ikumi|Bennink, Roelof J|van Gulik, Thomas M|Stieger, Bruno
PMID: 27903597
Journal: Int J Cancer. 2017 Mar 15;140(6):1346-1355.
Title: HBx drives alpha fetoprotein expression to promote initiation of liver cancer stem cells through activating PI3K/AKT signal pathway.
Author: Zhu, Mingyue|Li, Wei|Lu, Yan|Dong, Xu|Lin, Bo|Chen, Yi|Zhang, Xueer|Guo, Junli|Li, Mengsen
PMID: 27925189
Journal: PLoS One. 2017 Jan 23;12(1):e0170465.
Title: Progressive Enrichment of Stemness Features and Tumor Stromal Alterations in Multistep Hepatocarcinogenesis.
Author: Yoo, Jeong Eun|Kim, Young-Joo|Rhee, Hyungjin|Kim, Haeryoung|Ahn, Ei Yong|Choi, Jin Sub|Roncalli, Massimo|Park, Young Nyun
PMID: 28114366
Journal: Cancer Lett. 2017 Aug 1;400:149-160.
Title: Hepatitis B virus PreS1 facilitates hepatocellular carcinoma development by promoting appearance and self-renewal of liver cancer stem cells.
Author: Liu, Zhixin|Dai, Xuechen|Wang, Tianci|Zhang, Chengcheng|Zhang, Wenjun|Zhang, Wei|Zhang, Qi|Wu, Kailang|Liu, Fang|Liu, Yingle|Wu, Jianguo
PMID: 28455240
Journal: Oncogene. 2017 Oct 12;36(41):5709-5721.
Title: Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3.
Author: Sengupta, S|Nagalingam, A|Muniraj, N|Bonner, M Y|Mistriotis, P|Afthinos, A|Kuppusamy, P|Lanoue, D|Cho, S|Korangath, P|Shriver, M|Begum, A|Merino, V F|Huang, C-Y|Arbiser, J L|Matsui, W|Gyorffy, B|Konstantopoulos, K|Sukumar, S|Marignani, P A|Saxena, N K|Sha
PMID: 28581518
Journal: Cancer Lett. 2017 Sep 10;403:165-174.
Title: BORIS up-regulates OCT4 via histone methylation to promote cancer stem cell-like properties in human liver cancer cells.
Author: Liu, Qiuying|Chen, Kefei|Liu, Zhongjian|Huang, Yuan|Zhao, Rongce|Wei, Ling|Yu, Xiaoqin|He, Jingyang|Liu, Jun|Qi, Jianguo|Qin, Yang|Li, Bo
PMID: 28645561
Journal: Oncogenesis. 2017 Jul 24;6(7):e363.
Title: Overexpression of zinc finger protein 687 enhances tumorigenic capability and promotes recurrence of hepatocellular carcinoma.
Author: Zhang, T|Huang, Y|Liu, W|Meng, W|Zhao, H|Yang, Q|Gu, S-J|Xiao, C-C|Jia, C-C|Zhang, B|Zou, Y|Li, H-P|Fu, B-S
PMID: 28737756
Journal: Tumour Biol. 2017 Oct;39(10):1010428317719272.
Title: Dopamine-induced SULT1A3/4 promotes EMT and cancer stemness in hepatocellular carcinoma.
Author: Zou, Juan|Li, Hong|Huang, Qianling|Liu, Xiaomin|Qi, Xiaoxiao|Wang, Ying|Lu, Linlin|Liu, Zhongqiu
PMID: 29025375
Journal: Mol Cell. 2017 Oct 19;68(2):281-292.e5.
Title: Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells.
Author: Liu, Kai|Lee, Jiyoung|Kim, Ja Yeon|Wang, Linya|Tian, Yongjun|Chan, Stephanie T|Cho, Cecilia|Machida, Keigo|Chen, Dexi|Ou, Jing-Hsiung James
PMID: 29033320
Journal: Hepatol Commun. 2017 Oct;1(8):816-830.
Title: High-mobility-group protein 2 regulated by microRNA-127 and small heterodimer partner modulates pluripotency of mouse embryonic stem cells and liver tumor initiating cells.
Author: Zhao, Yulan|Yang, Zhihong|Wu, Jianguo|Wu, Raymond|Keshipeddy, Santosh K|Wright, Dennis|Wang, Li
PMID: 29218329
Journal: Zhongguo Zhong Yao Za Zhi. 2017 Oct;42(20):3990-3995.
Title: [Effects of aqueous extracts of gecko on stemness of hepatocellular carcinoma].
Author: Huang, Hui-Ling|Zhang, Ya-Lan|Chen, Wen-Fa|Wu, Chun-Ling
PMID: 29243438
Journal: Antioxid Redox Signal. 2017 Dec 19.
Title: Pluripotency transcription factors and Metabolic reprogramming of mitochondria in tumor-initiating stem-like cells.
Author: Machida, Keigo
PMID: 29256636
Journal: Oncotarget. 2017 Dec 18;8(70):115667-115680.
Title: Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis.
Author: Vollmar, Johanna|Lautem, Anja|Closs, Ellen|Schuppan, Detlef|Kim, Yong Ook|Grimm, Daniel|Marquardt, Jens U|Fuchs, Peter|Straub, Beate K|Schad, Arno|Grundemann, Dirk|Schattenberg, Jorn M|Gehrke, Nadine|Worns, Marcus A|Baumgart, Jan|Galle, Peter R|Zimmermann
PMID: 29383190
Journal: Mol Carcinog. 2018 Apr;57(4):483-493.
Title: NF-kappaB-regulated miR-155, via repression of QKI, contributes to the acquisition of CSC-like phenotype during the neoplastic transformation of hepatic cells induced by arsenite.
Author: Chen, Chao|Luo, Fei|Yang, Qianlei|Wang, Dapeng|Yang, Ping|Xue, Junchao|Dai, Xiangyu|Liu, Xinlu|Xu, Hui|Lu, Jiachun|Zhang, Aihua|Liu, Qizhan
PMID: 29240254
Journal: Onco Targets Ther. 2017 Dec 21;11:47-57.
Title: Clinicopathological and prognostic significance of OCT4 in patients with hepatocellular carcinoma: a meta-analysis.
Author: Liang, Chaojie|Xu, Yingchen|Ge, Hua|Li, Guangming|Wu, Jixiang
PMID: 29317833
Journal: Biomed Pharmacother. 2018 Apr;100:374-380.
Title: POU5F1B promotes hepatocellular carcinoma proliferation by activating AKT.
Author: Pan, Yaozhen|Zhan, Lei|Chen, Ling|Zhang, Hong|Sun, Chengyi|Xing, Chungen
PMID: 29454285
Journal: Toxicol In Vitro. 2018 Sep;51:74-82.
Title: Ovatodiolide suppresses yes-associated protein 1-modulated cancer stem cell phenotypes in highly malignant hepatocellular carcinoma and sensitizes cancer cells to chemotherapy in vitro.
Author: Chang, Hang-Lung|Chen, Hsin-An|Bamodu, Oluwaseun Adebayo|Lee, Kwai-Fong|Tzeng, Yew-Min|Lee, Wei-Hwa|Tsai, Jo-Ting
PMID: 29698666
Journal: Am J Chin Med. 2018;46(4):891-910.
Title: Downregulation of Cancer Stemness by Novel Diterpenoid Ovatodiolide Inhibits Hepatic Cancer Stem Cell-Like Traits by Repressing Wnt/[Formula: see text]-Catenin Signaling.
Author: Liu, Mingche|Bamodu, Oluwaseun Adebayo|Kuo, Kuang-Tai|Lee, Wei-Hwa|Lin, Yen-Kuang|Wu, Alexander T H|M, Hsiao|Tzeng, Yew-Min|Yeh, Chi-Tai|Tsai, Jo-Ting
PMID: 29792038
Journal: Cancer Biomark. 2018;22(3):575-585.
Title: Effect of Bmi-1-mediated NF-kappaB signaling pathway on the stem-like properties of CD133+ human liver cancer cells.
Author: Ma, De-Qiang|Zhang, Yin-Hua|Ding, De-Ping|Li, Juan|Chen, Lin-Li|Tian, You-You|Ao, Kang-Jian
PMID: 29843222
Journal: Theranostics. 2018 Jun 13;8(14):3737-3750.
Title: Blocking CDK1/PDK1/beta-Catenin signaling by CDK1 inhibitor RO3306 increased the efficacy of sorafenib treatment by targeting cancer stem cells in a preclinical model of hepatocellular carcinoma.
Author: Wu, Chuan Xing|Wang, Xiao Qi|Chok, Siu Ho|Man, Kwan|Tsang, Simon Hing Yin|Chan, Albert Chi Yan|Ma, Ka Wing|Xia, Wei|Cheung, Tan To
PMID: 30083256
Journal: Oncol Lett. 2018 Oct;16(4):5243-5248.
Title: Oct3/4 is potentially useful for the suppression of the proliferation and motility of hepatocellular carcinoma cells.
Author: Tomizawa, Minoru|Shinozaki, Fuminobu|Motoyoshi, Yasufumi|Sugiyama, Takao|Yamamoto, Shigenori|Ishige, Naoki
PMID: 30250594
Journal: J Cell Biochem. 2018 Oct 9.
Title: Microporous cellulosic scaffold as a spheroid culture system modulates chemotherapeutic responses and stemness in hepatocellular carcinoma.
Author: Wu, Guoyi|Zhan, Shanshan|Rui, Chen|Sho, Eiketsu|Shi, Xiaolei|Ding, Yitao
PMID: 30302811