Primary Site >> Liver Cancer
Gene >> POU5F1
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Ref: Heterogeneous DNA methylation status of the regulatory element of the mouse Oct4 gene in adult somatic cell population. PMID: 15996113 |
Ref: Long-term proliferation of human embryonic stem cell-derived neuroepithelial cells using defined adherent culture conditions. PMID: 16100006 |
Ref: The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines. PMID: 18847459 Ref: Liver stem cells and tgf-Beta in hepatic carcinogenesis. PMID: 19343145 |
Ref: The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. PMID: 19137011 |
Ref: Human liver progenitor cell lines are readily established from non-tumorous tissue adjacent to hepatocellular carcinoma. PMID: 19874130 Ref: The properties of tumor-initiating cells from a hepatocellular carcinoma patient's primary and recurrent tumor. PMID: 19897602 Ref: [OCT4 expression in hepatocellular carcinoma and its clinical significance]. PMID: 20038322 Ref: Expression of Oct4 in HCC and modulation to wnt/beta-catenin and TGF-beta signal pathways. PMID: 20549546 |
Ref: Induced pluripotent stem (iPS) cell research overview. PMID: 20887681 Ref: Role of Sox2 and Oct4 in predicting survival of hepatocellular carcinoma patients after hepatectomy. PMID: 21376027 Ref: Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines. PMID: 21669008 Ref: Granulin-epithelin precursor is an oncofetal protein defining hepatic cancer stem cells. PMID: 22194816 |
Ref: Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145. PMID: 22378186 Ref: p28(GANK) prevents degradation of Oct4 and promotes expansion of tumor-initiating cells in hepatocarcinogenesis. PMID: 22387393 Ref: LIN28 expression and prognostic value in hepatocellular carcinoma patients who meet the Milan criteria and undergo hepatectomy. PMID: 22429493 Ref: Coexpression of stemness factors Oct4 and Nanog predict liver resection. PMID: 22461131 Ref: Exploring stemness gene expression and vasculogenic mimicry capacity in well- and poorly-differentiated hepatocellular carcinoma cell lines. PMID: 22580004 |
Ref: Hepatocellular carcinoma arising in a testicular teratoma: a distinct and unrecognized secondary somatic malignancy. PMID: 22763193 Ref: Inhibition of hepatocyte nuclear factor 1 and 4 alpha (HNF1alpha and HNF4alpha) as a mechanism of arsenic carcinogenesis. PMID: 23052196 Ref: The pan-deacetylase inhibitor panobinostat modulates the expression of epithelial-mesenchymal transition markers in hepatocellular carcinoma models. PMID: 23255907 Ref: OCT4 increases BIRC5 and CCND1 expression and promotes cancer progression in hepatocellular carcinoma. PMID: 23433354 Ref: Positive correlation of Oct4 and ABCG2 to chemotherapeutic resistance in CD90(+)CD133(+) liver cancer stem cells. PMID: 23438193 Ref: The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma. PMID: 23599755 Ref: Pseudogene OCT4-pg4 functions as a natural micro RNA sponge to regulate OCT4 expression by competing for miR-145 in hepatocellular carcinoma. PMID: 23615404 Ref: Epigenetic regulation of pluripotent genes mediates stem cell features in human hepatocellular carcinoma and cancer cell lines. PMID: 24023739 Ref: Single-cell clones of liver cancer stem cells have the potential of differentiating into different types of tumor cells. PMID: 24136221 Ref: Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma. PMID: 24244607 Ref: Cellular reprogramming and hepatocellular carcinoma development. PMID: 24379607 Ref: DNA damage in inflammation-related carcinogenesis and cancer stem cells. PMID: 24382987 Ref: Tumor-initiating stem-like cells and drug resistance: carcinogenesis through Toll-like receptors, environmental factors, and virus. PMID: 25787983 |
Ref: Establishment and identification of induced pluripotent stem cells in liver cancer patients. PMID: 24507670 Ref: The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation. PMID: 24837142 Ref: Influence of adriamycin on changes in Nanog, Oct-4, Sox2, ARID1 and Wnt5b expression in liver cancer stem cells. PMID: 24944491 Ref: MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism. PMID: 25189530 Ref: Digital quantitation of HCC-associated stem cell markers and protein quality control factors using tissue arrays of human liver sections. PMID: 25218810 Ref: Differential expression of drug uptake and efflux transporters in Japanese patients with hepatocellular carcinoma. PMID: 25231932 |
Ref: Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4. PMID: 24572141 Ref: betaII-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin. PMID: 25307947 Ref: TAZ regulates cell proliferation and epithelial-mesenchymal transition of human hepatocellular carcinoma. PMID: 25495189 Ref: Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression. PMID: 25564572 Ref: MiR-155 targets TP53INP1 to regulate liver cancer stem cell acquisition and self-renewal. PMID: 25601564 Ref: Aktmediated phosphorylation of Oct4 is associated with the proliferation of stemlike cancer cells. PMID: 25625591 Ref: TGF-beta1 acts through miR-155 to down-regulate TP53INP1 in promoting epithelial-mesenchymal transition and cancer stem cell phenotypes. PMID: 25633840 Ref: Coexpression of gene Oct4 and Nanog initiates stem cell characteristics in hepatocellular carcinoma and promotes epithelial-mesenchymal transition through activation of Stat3/Snail signaling. PMID: 25879771 Ref: MiR-429 increases the metastatic capability of HCC via regulating classic Wnt pathway rather than epithelial-mesenchymal transition. PMID: 25931210 Ref: Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells. PMID: 25973027 Ref: SRY and OCT4 Are Required for the Acquisition of Cancer Stem Cell-Like Properties and Are Potential Differentiation Therapy Targets. PMID: 26013162 Ref: Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells. PMID: 26099525 Ref: Roles of dopamine receptors and their antagonist thioridazine in hepatoma metastasis. PMID: 26124671 Ref: High expression of OCT4 is frequent and may cause undesirable treatment outcomes in patients with acute myeloid leukemia. PMID: 26152287 Ref: A novel anti-cancer agent Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/Jak2/Stat3 pathway. PMID: 26376676 Ref: ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells. PMID: 26426078 Ref: Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism. PMID: 26468984 Ref: Saturated fatty acid induces cancer stem cell-like properties in human hepatoma cells. PMID: 26518899 Ref: Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation. PMID: 26540347 Ref: Oct4 is a reliable marker of liver tumor propagating cells in hepatocellular carcinoma. PMID: 26562475 |
Ref: Survivin in survival of hepatocellular carcinoma. PMID: 26118774 Ref: The prognostic value of combination of CD90 and OCT4 for hepatocellular carcinoma after curative resection. PMID: 26674131 Ref: TALEN-induced disruption of Nanog expression results in reduced proliferation, invasiveness and migration, increased chemosensitivity and reversal of EMT in HepG2 cells. PMID: 26676719 Ref: Detection of ALDH1 activity in rabbit hepatic VX2 tumors and isolation of ALDH1 positive cancer stem cells. PMID: 26873175 Ref: Inflammation Promotes Expression of Stemness-Related Properties in HBV-Related Hepatocellular Carcinoma. PMID: 26919045 Ref: Hepatic cancer stem cell marker granulin-epithelin precursor and beta-catenin expression associate with recurrence in hepatocellular carcinoma. PMID: 26942873 Ref: Folate deficient tumor microenvironment promotes epithelial-to-mesenchymal transition and cancer stem-like phenotypes. PMID: 27119349 Ref: Hepatitis C virus core protein regulates OCT4 expression and promotes cell cycle progression in hepatocellular carcinoma. PMID: 27121765 Ref: Side population in hepatocellular carcinoma HCCLM3 cells is enriched with stem-like cancer cells. PMID: 27123080 Ref: Bile acids promote diethylnitrosamine-induced hepatocellular carcinoma via increased inflammatory signaling. PMID: 27151938 Ref: EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes. PMID: 27238755 Ref: Prognostic value of the expression of cancer stem cell-related markers CD133 and CD44 in hepatocellular carcinoma: From patients to patient-derived tumor xenograft models. PMID: 27329727 Ref: Positive Feedback Loop of OCT4 and c-JUN Expedites Cancer Stemness in Liver Cancer. PMID: 27341307 Ref: Arsenite inhibits the function of CD133(+) CD13(+) liver cancer stem cells by reducing PML and Oct4 protein expression. PMID: 27517564 Ref: Stemness-related transcriptional factors and homing gene expression profiles in hepatic differentiation and cancer. PMID: 27623812 Ref: NRBP2 Overexpression Increases the Chemosensitivity of Hepatocellular Carcinoma Cells via Akt Signaling. PMID: 27634758 Ref: Overexpression of microRNA-21 strengthens stem cell-like characteristics in a hepatocellular carcinoma cell line. PMID: 27793160 Ref: miR-589-5p inhibits MAP3K8 and suppresses CD90(+) cancer stem cells in hepatocellular carcinoma. PMID: 27835990 Ref: The Emerging Roles of Long Noncoding RNA ROR (lincRNA-ROR) and its Possible Mechanisms in Human Cancers. PMID: 27855392 Ref: Correction: Activation of IL6/IGFIR Confers Poor Prognosis of HBV-Related Hepatocellular Carcinoma through Induction of OCT4/NANOG Expression. PMID: 27980027 Ref: Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells. PMID: 28050219 |
Ref: Identification of novel OCT4 genetic variant associated with the risk of chronic hepatitis B in a Korean population. PMID: 27596359 Ref: Establishment of Hepatocellular Cancer Induced Pluripotent Stem Cells Using a Reprogramming Technique. PMID: 27728962 Ref: DNA demethylation induces SALL4 gene re-expression in subgroups of hepatocellular carcinoma associated with Hepatitis B or C virus infection. PMID: 27797380 Ref: MBD3 inhibits formation of liver cancer stem cells. PMID: 27894081 Ref: Impact of Organic Cation Transporters (OCT-SLC22A) on Differential Diagnosis of Intrahepatic Lesions. PMID: 27903597 Ref: HBx drives alpha fetoprotein expression to promote initiation of liver cancer stem cells through activating PI3K/AKT signal pathway. PMID: 27925189 Ref: Progressive Enrichment of Stemness Features and Tumor Stromal Alterations in Multistep Hepatocarcinogenesis. PMID: 28114366 Ref: Hepatitis B virus PreS1 facilitates hepatocellular carcinoma development by promoting appearance and self-renewal of liver cancer stem cells. PMID: 28455240 Ref: Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3. PMID: 28581518 Ref: BORIS up-regulates OCT4 via histone methylation to promote cancer stem cell-like properties in human liver cancer cells. PMID: 28645561 Ref: Overexpression of zinc finger protein 687 enhances tumorigenic capability and promotes recurrence of hepatocellular carcinoma. PMID: 28737756 Ref: Dopamine-induced SULT1A3/4 promotes EMT and cancer stemness in hepatocellular carcinoma. PMID: 29025375 Ref: Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells. PMID: 29033320 Ref: High-mobility-group protein 2 regulated by microRNA-127 and small heterodimer partner modulates pluripotency of mouse embryonic stem cells and liver tumor initiating cells. PMID: 29218329 Ref: [Effects of aqueous extracts of gecko on stemness of hepatocellular carcinoma]. PMID: 29243438 Ref: Pluripotency transcription factors and Metabolic reprogramming of mitochondria in tumor-initiating stem-like cells. PMID: 29256636 Ref: Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis. PMID: 29383190 |
Ref: NF-kappaB-regulated miR-155, via repression of QKI, contributes to the acquisition of CSC-like phenotype during the neoplastic transformation of hepatic cells induced by arsenite. PMID: 29240254 Ref: Clinicopathological and prognostic significance of OCT4 in patients with hepatocellular carcinoma: a meta-analysis. PMID: 29317833 Ref: POU5F1B promotes hepatocellular carcinoma proliferation by activating AKT. PMID: 29454285 Ref: Ovatodiolide suppresses yes-associated protein 1-modulated cancer stem cell phenotypes in highly malignant hepatocellular carcinoma and sensitizes cancer cells to chemotherapy in vitro. PMID: 29698666 Ref: Downregulation of Cancer Stemness by Novel Diterpenoid Ovatodiolide Inhibits Hepatic Cancer Stem Cell-Like Traits by Repressing Wnt/[Formula: see text]-Catenin Signaling. PMID: 29792038 Ref: Effect of Bmi-1-mediated NF-kappaB signaling pathway on the stem-like properties of CD133+ human liver cancer cells. PMID: 29843222 Ref: Blocking CDK1/PDK1/beta-Catenin signaling by CDK1 inhibitor RO3306 increased the efficacy of sorafenib treatment by targeting cancer stem cells in a preclinical model of hepatocellular carcinoma. PMID: 30083256 Ref: Oct3/4 is potentially useful for the suppression of the proliferation and motility of hepatocellular carcinoma cells. PMID: 30250594 Ref: Microporous cellulosic scaffold as a spheroid culture system modulates chemotherapeutic responses and stemness in hepatocellular carcinoma. PMID: 30302811 |