Primary Site >> Colorectal Cancer
Gene >> PIK3CG
| 1. | |||||||||||
| Journal: | J Biol Chem. 1998 Nov 27;273(48):32016-22. | ||||||||||
| Title: | A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon. | ||||||||||
| Author: | Graness, A|Adomeit, A|Heinze, R|Wetzker, R|Liebmann, C | ||||||||||
| PMID: | 9822674 | ||||||||||
| 2. | |||||||||||
| Journal: | J Biol Chem. 2000 Jan 14;275(2):992-8. | ||||||||||
| Title: | Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. | ||||||||||
| Author: | Petiot, A|Ogier-Denis, E|Blommaart, E F|Meijer, A J|Codogno, P | ||||||||||
| PMID: | 10625637 | ||||||||||
| 3. | |||||||||||
| Journal: | Nature. 2000 Aug 24;406(6798):897-902. | ||||||||||
| Title: | Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma. | ||||||||||
| Author: | Sasaki, T|Irie-Sasaki, J|Horie, Y|Bachmaier, K|Fata, J E|Li, M|Suzuki, A|Bouchard, D|Ho, A|Redston, M|Gallinger, S|Khokha, R|Mak, T W|Hawkins, P T|Stephens, L|Scherer, S W|Tsao, M|Penninger, J M | ||||||||||
| PMID: | 10972292 | ||||||||||
| 4. | |||||||||||
| Journal: | Oncogene. 2000 Oct 19;19(44):5083-90. | ||||||||||
| Title: | A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells. | ||||||||||
| Author: | Benistant, C|Chapuis, H|Roche, S | ||||||||||
| PMID: | 11042696 | ||||||||||
| 5. | |||||||||||
| Journal: | Blood. 2002 Jan 1;99(1):372-4. | ||||||||||
| Title: | Genomic structure of the PIK3CG gene on chromosome band 7q22 and evaluation as a candidate myeloid tumor suppressor. | ||||||||||
| Author: | Kratz, Christian P|Emerling, Brooke M|Bonifas, Jeannette|Wang, Winfred|Green, Eric D|Le Beau, Michelle M|Shannon, Kevin M | ||||||||||
| PMID: | 11756194 | ||||||||||
| 6. | |||||||||||
| Journal: | Clin Cancer Res. 2002 Dec;8(12):3824-31. | ||||||||||
| Title: | Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma. | ||||||||||
| Author: | Semba, Shuho|Itoh, Nanami|Ito, Masafumi|Youssef, Emile M|Harada, Masaru|Moriya, Toshiyuki|Kimura, Wataru|Yamakawa, Mitsunori | ||||||||||
| PMID: | 12473596 | ||||||||||
| 7. | |||||||||||
| Journal: | J Biol Chem. 2004 Nov 26;279(48):49617-23. Epub 2004 Sep 17. | ||||||||||
| Title: | Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway. | ||||||||||
| Author: | Yamaguchi, Kiyoshi|Lee, Seong-Ho|Eling, Thomas E|Baek, Seung Joon | ||||||||||
| PMID: | 15377673 | ||||||||||
| 8. | |||||||||||
| Journal: | Ann N Y Acad Sci. 2008 Sep;1138:204-13. | ||||||||||
| Title: | The transforming functions of PI3-kinase-gamma are linked to disruption of intercellular adhesion and promotion of cancer cell invasion. | ||||||||||
| Author: | Attoub, Samir|De Wever, Olivier|Bruyneel, Eric|Mareel, Marc|Gespach, Christian | ||||||||||
| PMID: | 18837901 | ||||||||||
| 9. | |||||||||||
| Journal: | Mol Cancer Ther. 2009 Jan;8(1):94-100. | ||||||||||
| Title: | Peroxisome proliferator-activated receptor gamma agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity. | ||||||||||
| Author: | Ihle, Nathan T|Lemos, Robert|Schwartz, David|Oh, Junghwan|Halter, Robert J|Wipf, Peter|Kirkpatrick, Lynn|Powis, Garth | ||||||||||
| PMID: | 19139117 | ||||||||||
| 10. | |||||||||||
| Journal: | Gastroenterology. 2010 Apr;138(4):1374-83. | ||||||||||
| Title: | Phosphatidylinositol 3-kinase gamma inhibition ameliorates inflammation and tumor growth in a model of colitis-associated cancer. | ||||||||||
| Author: | Gonzalez-Garcia, Ana|Sanchez-Ruiz, Jesus|Flores, Juana M|Carrera, Ana C | ||||||||||
| PMID: | 20004201 | ||||||||||
| 11. | |||||||||||
| Journal: | Cell Biochem Biophys. 2012 Jan;62(1):47-54. | ||||||||||
| Title: | Studies on the expression patterns of class I PI3K catalytic subunits and its prognostic significance in colorectal cancer. | ||||||||||
| Author: | Cui, Binbin|Tao, Ji|Yang, Yanmei | ||||||||||
| PMID: | 21910030 | ||||||||||
| 12. | |||||||||||
| Journal: | PLoS One. 2012;7(5):e38033. | ||||||||||
| Title: | KRASness and PIK3CAness in patients with advanced colorectal cancer: outcome after treatment with early-phase trials with targeted pathway inhibitors. | ||||||||||
| Author: | Garrido-Laguna, Ignacio|Hong, David S|Janku, Filip|Nguyen, Ly M|Falchook, Gerald S|Fu, Siqing|Wheler, Jenifer J|Luthra, Rajyalakshmi|Naing, Aung|Wang, Xuemei|Kurzrock, Razelle | ||||||||||
| PMID: | 22675430 | ||||||||||
| 13. | |||||||||||
| Journal: | World J Gastroenterol. 2014 Nov 21;20(43):16258-67. | ||||||||||
| Title: | Phosphatidylinositol 3-kinase CB association with preoperative radiotherapy response in rectal adenocarcinoma. | ||||||||||
| Author: | Yu, Wei-Dong|Peng, Yi-Fan|Pan, Hong-Da|Wang, Lin|Li, Kun|Gu, Jin | ||||||||||
| PMID: | 25473181 | ||||||||||
| 14. | |||||||||||
| Journal: | Oncotarget. 2014 Sep 15;5(17):7936-44. | ||||||||||
| Title: | Mutant NRASQ61 shares signaling similarities across various cancer types--potential implications for future therapies. | ||||||||||
| Author: | Vujic, Igor|Posch, Christian|Sanlorenzo, Martina|Yen, Adam J|Tsumura, Aaron|Kwong, Andrew|Feichtenschlager, Valentin|Lai, Kevin|Arneson, Douglas V|Rappersberger, Klemens|Ortiz-Urda, Susana M | ||||||||||
| PMID: | 25277205 | ||||||||||
| 15. | |||||||||||
| Journal: | Biochem Cell Biol. 2014 Aug;92(4):305-15. | ||||||||||
| Title: | Involvement of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways in the regulation of cell cycle progression by PTHrP in colon adenocarcinoma cells. | ||||||||||
| Author: | Calvo, Natalia|Martin, Maria Julia|de Boland, Ana Russo|Gentili, Claudia | ||||||||||
| PMID: | 25051885 | ||||||||||
| 16. | |||||||||||
| Journal: | BMC Cancer. 2014 Apr 4;14:240. | ||||||||||
| Title: | Met receptor-induced Grb2 or Shc signals both promote transformation of intestinal epithelial cells, albeit they are required for distinct oncogenic functions. | ||||||||||
| Author: | Pomerleau, Veronique|Landry, Melissa|Bernier, Jimmy|Vachon, Pierre H|Saucier, Caroline | ||||||||||
| PMID: | 24708867 | ||||||||||
| 17. | |||||||||||
| Journal: | Oncotarget. 2015 Oct 13;6(31):31272-83. | ||||||||||
| Title: | Phospho-kinase profile of colorectal tumors guides in the selection of multi-kinase inhibitors. | ||||||||||
| Author: | Serrano-Heras, Gemma|Cuenca-Lopez, Maria Dolores|Montero, Juan Carlos|Corrales-Sanchez, Veronica|Morales, Jorge Carlos|Nunez, Luz-Elena|Moris, Francisco|Pandiella, Atanasio|Ocana, Alberto | ||||||||||
| PMID: | 26418718 | ||||||||||
| 18. | |||||||||||
| Journal: | Tumour Biol. 2016 Jul;37(7):9465-72. | ||||||||||
| Title: | B7-H3 increases thymidylate synthase expression via the PI3k-Akt pathway. | ||||||||||
| Author: | Jiang, Bo|Liu, Fen|Liu, ZhiHui|Zhang, Ting|Hua, Dong | ||||||||||
| PMID: | 26787540 | ||||||||||
| 19. | |||||||||||
| Journal: | BMC Cancer. 2016 Jun 13;16:366. | ||||||||||
| Title: | PTEN mRNA expression is less pronounced in left- than right-sided colon cancer: a retrospective observational study. | ||||||||||
| Author: | Kuramochi, Hidekazu|Nakamura, Ayako|Nakajima, Go|Kaneko, Yuka|Araida, Tatsuo|Yamamoto, Masakazu|Hayashi, Kazuhiko | ||||||||||
| PMID: | 27296289 | ||||||||||
| 20. | |||||||||||
| Journal: | Oncotarget. 2017 Jul 25;8(30):48782-48793. | ||||||||||
| Title: | Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis. | ||||||||||
| Author: | Zhao, Yiqing|Scott, Anthony|Zhang, Peng|Hao, Yujun|Feng, Xiujing|Somasundaram, Saigopal|Khalil, Ahmad M|Willis, Joseph|Wang, Zhenghe | ||||||||||
| PMID: | 27447856 | ||||||||||
| 21. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2017 Feb;79(2):389-397. | ||||||||||
| Title: | Molecular explorations of substituted 2-(4-phenylquinolin-2-yl) phenols as phosphoinositide 3-kinase inhibitors and anticancer agents. | ||||||||||
| Author: | Alagumuthu, Manikandan|Arumugam, Sivakumar | ||||||||||
| PMID: | 28054203 | ||||||||||
| 22. | |||||||||||
| Journal: | Cancer Prev Res (Phila). 2017 Mar;10(3):208-218. | ||||||||||
| Title: | Aspirin-Induced Chemoprevention and Response Kinetics Are Enhanced by PIK3CA Mutations in Colorectal Cancer Cells. | ||||||||||
| Author: | Zumwalt, Timothy J|Wodarz, Dominik|Komarova, Natalia L|Toden, Shusuke|Turner, Jacob|Cardenas, Jacob|Burn, John|Chan, Andrew T|Boland, C Richard|Goel, Ajay | ||||||||||
| PMID: | 28154202 | ||||||||||
| 23. | |||||||||||
| Journal: | J Nutr Biochem. 2017 May;43:11-17. | ||||||||||
| Title: | A food-based approach that targets interleukin-6, a key regulator of chronic intestinal inflammation and colon carcinogenesis. | ||||||||||
| Author: | Sido, Abigail|Radhakrishnan, Sridhar|Kim, Sung Woo|Eriksson, Elisabeth|Shen, Frank|Li, Qunhua|Bhat, Vadiraja|Reddivari, Lavanya|Vanamala, Jairam K P | ||||||||||
| PMID: | 28193578 | ||||||||||
| 24. | |||||||||||
| Journal: | Int J Mol Sci. 2017 Jul 14;18(7). pii: ijms18071522. | ||||||||||
| Title: | Pharmacogenomics of Targeted Agents for Personalization of Colorectal Cancer Treatment. | ||||||||||
| Author: | Bignucolo, Alessia|De Mattia, Elena|Cecchin, Erika|Roncato, Rossana|Toffoli, Giuseppe | ||||||||||
| PMID: | 28708103 | ||||||||||
| 25. | |||||||||||
| Journal: | Dtsch Med Wochenschr. 2017 Nov;142(22):1652-1659. | ||||||||||
| Title: | [Personalized Treatment for Colorectal Carcinomas]. | ||||||||||
| Author: | Stintzing, Sebastian | ||||||||||
| PMID: | 29078210 | ||||||||||
| 26. | |||||||||||
| Journal: | J Gastrointest Cancer. 2017 Nov 7. pii: 10.1007/s12029-017-0024-9. | ||||||||||
| Title: | A Deregulated PI3K-AKT Signaling Pathway in Patients with Colorectal Cancer. | ||||||||||
| Author: | Zhang, Tao|Ma, Yuanping|Fang, Jiansong|Liu, Chang|Chen, Liangrong | ||||||||||
| PMID: | 29110225 | ||||||||||
| 27. | |||||||||||
| Journal: | Eur J Cancer. 2018 Mar;92:1-10. | ||||||||||
| Title: | Human epidermal receptor family inhibitors in patients with ERBB3 mutated cancers: Entering the back door. | ||||||||||
| Author: | Verlingue, Loic|Hollebecque, Antoine|Lacroix, Ludovic|Postel-Vinay, Sophie|Varga, Andrea|El Dakdouki, Yolla|Baldini, Capucine|Balheda, Rastilav|Gazzah, Anas|Michot, Jean-Marie|Marabelle, Aurelien|Mir, Olivier|Arnedos, Monica|Rouleau, Etienne|Solary, Eric| | ||||||||||
| PMID: | 29413684 | ||||||||||
| 28. | |||||||||||
| Journal: | Clin Colon Rectal Surg. 2018 May;31(3):147-152. | ||||||||||
| Title: | Update on Sporadic Colorectal Cancer Genetics. | ||||||||||
| Author: | Hardiman, Karin M | ||||||||||
| PMID: | 29720900 | ||||||||||
| 29. | |||||||||||
| Journal: | Oncotarget. 2018 Apr 13;9(28):19911-19928. | ||||||||||
| Title: | Over-activation of AKT signaling leading to 5-Fluorouracil resistance in SNU-C5/5-FU cells. | ||||||||||
| Author: | Kim, Eun-Ji|Kang, Gyeoung-Jin|Kang, Jung-Il|Boo, Hye-Jin|Hyun, Jin Won|Koh, Young Sang|Chang, Weon-Young|Kim, Young Ree|Kwon, Jung-Mi|Maeng, Young Hee|Yoo, Eun-Sook|Lee, Chang Hoon|Kang, Hee-Kyoung | ||||||||||
| PMID: | 29731993 | ||||||||||
| 30. | |||||||||||
| Journal: | Cell Death Dis. 2018 Jul 3;9(7):739. | ||||||||||
| Title: | PIK3CA mutations confer resistance to first-line chemotherapy in colorectal cancer. | ||||||||||
| Author: | Wang, Qiang|Shi, Yan-Long|Zhou, Kai|Wang, Li-Li|Yan, Ze-Xuan|Liu, Yu-Lin|Xu, Li-Li|Zhao, Shi-Wei|Chu, Hui-Li|Shi, Ting-Ting|Ma, Qing-Hua|Bi, Jingwang | ||||||||||
| PMID: | 29970892 | ||||||||||