Primary Site >> Colorectal Cancer
Gene >> PIK3CG
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Ref: A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon. PMID: 9822674 |
Ref: Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. PMID: 10625637 Ref: Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma. PMID: 10972292 Ref: A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells. PMID: 11042696 |
Ref: Genomic structure of the PIK3CG gene on chromosome band 7q22 and evaluation as a candidate myeloid tumor suppressor. PMID: 11756194 Ref: Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma. PMID: 12473596 |
Ref: Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway. PMID: 15377673 |
Ref: The transforming functions of PI3-kinase-gamma are linked to disruption of intercellular adhesion and promotion of cancer cell invasion. PMID: 18837901 |
Ref: Peroxisome proliferator-activated receptor gamma agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity. PMID: 19139117 |
Ref: Phosphatidylinositol 3-kinase gamma inhibition ameliorates inflammation and tumor growth in a model of colitis-associated cancer. PMID: 20004201 |
Ref: Studies on the expression patterns of class I PI3K catalytic subunits and its prognostic significance in colorectal cancer. PMID: 21910030 Ref: KRASness and PIK3CAness in patients with advanced colorectal cancer: outcome after treatment with early-phase trials with targeted pathway inhibitors. PMID: 22675430 |
Ref: Met receptor-induced Grb2 or Shc signals both promote transformation of intestinal epithelial cells, albeit they are required for distinct oncogenic functions. PMID: 24708867 Ref: Involvement of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways in the regulation of cell cycle progression by PTHrP in colon adenocarcinoma cells. PMID: 25051885 Ref: Mutant NRASQ61 shares signaling similarities across various cancer types--potential implications for future therapies. PMID: 25277205 Ref: Phosphatidylinositol 3-kinase CB association with preoperative radiotherapy response in rectal adenocarcinoma. PMID: 25473181 |
Ref: Phospho-kinase profile of colorectal tumors guides in the selection of multi-kinase inhibitors. PMID: 26418718 |
Ref: B7-H3 increases thymidylate synthase expression via the PI3k-Akt pathway. PMID: 26787540 Ref: PTEN mRNA expression is less pronounced in left- than right-sided colon cancer: a retrospective observational study. PMID: 27296289 |
Ref: Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis. PMID: 27447856 Ref: Molecular explorations of substituted 2-(4-phenylquinolin-2-yl) phenols as phosphoinositide 3-kinase inhibitors and anticancer agents. PMID: 28054203 Ref: Aspirin-Induced Chemoprevention and Response Kinetics Are Enhanced by PIK3CA Mutations in Colorectal Cancer Cells. PMID: 28154202 Ref: A food-based approach that targets interleukin-6, a key regulator of chronic intestinal inflammation and colon carcinogenesis. PMID: 28193578 Ref: Pharmacogenomics of Targeted Agents for Personalization of Colorectal Cancer Treatment. PMID: 28708103 Ref: [Personalized Treatment for Colorectal Carcinomas]. PMID: 29078210 Ref: A Deregulated PI3K-AKT Signaling Pathway in Patients with Colorectal Cancer. PMID: 29110225 |
Ref: Human epidermal receptor family inhibitors in patients with ERBB3 mutated cancers: Entering the back door. PMID: 29413684 Ref: Update on Sporadic Colorectal Cancer Genetics. PMID: 29720900 Ref: Over-activation of AKT signaling leading to 5-Fluorouracil resistance in SNU-C5/5-FU cells. PMID: 29731993 Ref: PIK3CA mutations confer resistance to first-line chemotherapy in colorectal cancer. PMID: 29970892 |