Primary Site >> Pancreatic Cancer

Gene >> PIK3CD

1.
Journal: J Gastrointest Surg. 2001 Nov-Dec;5(6):603-12; discussion 612-3.
Title: PI-3' kinase and NF-kappaB cross-signaling in human pancreatic cancer cells.
Author: Shah, S A|Potter, M W|Hedeshian, M H|Kim, R D|Chari, R S|Callery, M P
PMID: 12086898
2.
Journal: Mol Cancer Ther. 2002 Oct;1(12):989-97.
Title: Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.
Author: Bondar, Victor M|Sweeney-Gotsch, Bridget|Andreeff, Michael|Mills, Gordon B|McConkey, David J
PMID: 12481421
3.
Journal: J Cell Biochem. 2002;87(4):470-6.
Title: Frequent activation of AKT2 kinase in human pancreatic carcinomas.
Author: Altomare, Deborah A|Tanno, Satoshi|De Rienzo, Assunta|Klein-Szanto, Andres J|Tanno, Sachie|Skele, Kristine L|Hoffman, John P|Testa, Joseph R
PMID: 14735903
4.
Journal: Oncogene. 2003 May 22;22(21):3243-51.
Title: Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death.
Author: Arlt, Alexander|Gehrz, Andre|Muerkoster, Susanne|Vorndamm, Jens|Kruse, Marie-Luise|Folsch, Ulrich R|Schafer, Heiner
PMID: 12761494
5.
Journal: Pancreas. 2004 Apr;28(3):353-8.
Title: Role of the phosphatidylinositol 3'-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines.
Author: Takeda, Ami|Osaki, Mitsuhiko|Adachi, Keiko|Honjo, Soichiro|Ito, Hisao
PMID: 15084985
6.
Journal: Oncogene. 2004 Jul 29;23(34):5729-38.
Title: A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-beta in pancreatic carcinogenesis.
Author: Jonckheere, Nicolas|Perrais, Michael|Mariette, Christophe|Batra, Surinder K|Aubert, Jean-Pierre|Pigny, Pascal|Van Seuningen, Isabelle
PMID: 15184872
7.
Journal: Cancer Res. 2005 Feb 15;65(4):1497-504.
Title: Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenograf
Author: Yau, Cindy Y F|Wheeler, Jeffery J|Sutton, Kymberley L|Hedley, David W
PMID: 15735038
8.
Journal: BMC Gastroenterol. 2005 Mar 31;5:12.
Title: Epidermal growth factor mediates detachment from and invasion through collagen I and Matrigel in Capan-1 pancreatic cancer cells.
Author: Shirk, Andrew J|Kuver, Rahul
PMID: 15801978
9.
Journal: Mol Ther. 2005 May;11(5):724-33.
Title: mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer.
Author: Chada, Sunil|Bocangel, Dora|Ramesh, Rajagopal|Grimm, Elizabeth A|Mumm, John B|Mhashilkar, Abner M|Zheng, Mingzhong
PMID: 15851011
10.
Journal: Carcinogenesis. 2005 Nov;26(11):1956-64.
Title: Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway.
Author: Saleem, Mohammad|Kaur, Satwinderjeet|Kweon, Mee-Hyang|Adhami, Vaqar Mustafa|Afaq, Farrukh|Mukhtar, Hasan
PMID: 15958516
11.
Journal: Oncogene. 2007 Mar 29;26(14):2082-94. Epub 2006 Oct 9.
Title: Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway.
Author: Baril, P|Gangeswaran, R|Mahon, P C|Caulee, K|Kocher, H M|Harada, T|Zhu, M|Kalthoff, H|Crnogorac-Jurcevic, T|Lemoine, N R
PMID: 17043657
12.
Journal: Int J Cancer. 2007 Feb 1;120(3):514-23.
Title: Expression and differential signaling of heregulins in pancreatic cancer cells.
Author: Kolb, Armin|Kleeff, Jorg|Arnold, Nichole|Giese, Nathalia A|Giese, Thomas|Korc, Murray|Friess, Helmut
PMID: 17096356
13.
Journal: Cancer Res. 2007 Mar 1;67(5):2098-106.
Title: K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling.
Author: Campbell, Paul M|Groehler, Angela L|Lee, Kwang M|Ouellette, Michel M|Khazak, Vladimir|Der, Channing J
PMID: 17332339
14.
Journal: J Biol Chem. 2007 May 11;282(19):14048-55. Epub 2007 Mar 12.
Title: Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells.
Author: Ji, Zhenyu|Mei, Fang C|Xie, Jingwu|Cheng, Xiaodong
PMID: 17353198
15.
Journal: Oncol Rep. 2007 Sep;18(3):673-7.
Title: siRNA directed against TrkA sensitizes human pancreatic cancer cells to apoptosis induced by gemcitabine through an inactivation of PI3K/Akt-dependent pathway.
Author: Liu, Dapeng|Zhang, Yong|Dang, Chengxue|Ma, Qingyong|Lee, Woo|Chen, Wuke
PMID: 17671718
16.
Journal: J Gastrointest Surg. 2008 Feb;12(2):288-96.
Title: Pancreatic cancer cell genetics and signaling response to treatment correlate with efficacy of gemcitabine-based molecular targeting strategies.
Author: Holcomb, Bryan|Yip-Schneider, Michele T|Matos, Jesus M|Dixon, Jennifer|Kennard, Jason|Mahomed, Julie|Shanmugam, Rajasubramaniam|Sebolt-Leopold, Judith|Schmidt, C Max
PMID: 18049840
17.
Journal: Curr Med Chem. 2008;15(10):978-90.
Title: ANTI-ADHESION evolves to a promising therapeutic concept in oncology.
Author: Schmidmaier, R|Baumann, P
PMID: 18393855
18.
Journal: Curr Opin Oncol. 2008 Jul;20(4):454-8.
Title: Lessons from Tarceva in pancreatic cancer: where are we now, and how should future trials be designed in pancreatic cancer?
Author: Laurent-Puig, Pierre|Taieb, Julien
PMID: 18525343
19.
Journal: Cell Mol Life Sci. 2008 Oct;65(19):3110-7.
Title: Phosphatidylinositol 3-kinase-dependent transcriptional silencing of the translational repressor 4E-BP1.
Author: Azar, R|Najib, S|Lahlou, H|Susini, C|Pyronnet, S
PMID: 18810319
20.
Journal: Pancreas. 2008 Nov;37(4):426-31.
Title: Apigenin inhibits the GLUT-1 glucose transporter and the phosphoinositide 3-kinase/Akt pathway in human pancreatic cancer cells.
Author: Melstrom, Laleh G|Salabat, Mohammad R|Ding, Xian-Zhong|Milam, Benjamin M|Strouch, Matthew|Pelling, Jill C|Bentrem, David J
PMID: 18953257
21.
Journal: J Exp Clin Cancer Res. 2008 Nov 25;27:76.
Title: Modulating effect of the PI3-kinase inhibitor LY294002 on cisplatin in human pancreatic cancer cells.
Author: Fujiwara, Masao|Izuishi, Kunihiko|Sano, Takanori|Hossain, Mohammad Akram|Kimura, Shoji|Masaki, Tsutomu|Suzuki, Yasuyuki
PMID: 19032736
22.
Journal: Zhonghua Yi Xue Za Zhi. 2008 Nov 18;88(42):2994-8.
Title: [Phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway is critical for survival and proliferation of pancreatic cancer stem-like side population cells].
Author: Zhou, Jing|Wang, Chun-you|Liu, Tao|Wu, He-shui|Zhou, Feng|Xiong, Jiong-xin|Zhao, Gang|Yang, Ming|Yin, Tao|Zhou, Meng-tao
PMID: 19080079
23.
Journal: Cancer Gene Ther. 2009 Mar;16(3):227-36.
Title: Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo.
Author: Shi, X H|Liang, Z Y|Ren, X Y|Liu, T H
PMID: 18949011
24.
Journal: JOP. 2009 Mar 9;10(2):98-103.
Title: Pancreatic cancer: translating lessons from mouse models.
Author: Strimpakos, Alexios S|Hoimes, Christopher|Saif, Muhammad Wasif
PMID: 19287100
25.
Journal: Br J Cancer. 2009 Apr 21;100(8):1267-76.
Title: Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts.
Author: Cao, P|Maira, S-M|Garcia-Echeverria, C|Hedley, D W
PMID: 19319133
26.
Journal: Mol Cell Biochem. 2009 Nov;331(1-2):161-71.
Title: PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells.
Author: Ma, Jiachi|Sawai, Hirozumi|Ochi, Nobuo|Matsuo, Yoichi|Xu, Donghui|Yasuda, Akira|Takahashi, Hiroki|Wakasugi, Takehiro|Takeyama, Hiromitsu
PMID: 19437103
27.
Journal: Cancer Sci. 2009 Apr;100(4):770-7.
Title: Phosphoinositide 3-kinase inhibitor (wortmannin) inhibits pancreatic cancer cell motility and migration induced by hyaluronan in vitro and peritoneal metastasis in vivo.
Author: Teranishi, Futoshi|Takahashi, Naoko|Gao, Nan|Akamo, Yoshimi|Takeyama, Hiromitsu|Manabe, Tadao|Okamoto, Takashi
PMID: 19469020
28.
Journal: Mol Carcinog. 2009 Dec;48(12):1149-58.
Title: PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells.
Author: Schild, Carolin|Wirth, Matthias|Reichert, Maximilian|Schmid, Roland M|Saur, Dieter|Schneider, Gunter
PMID: 19603422
29.
Journal: World J Gastroenterol. 2009 Jul 21;15(27):3355-66.
Title: Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth.
Author: Johnson, Sarah K|Haun, Randy S
PMID: 19610136
30.
Journal: J Surg Res. 2010 May 1;160(1):90-101.
Title: IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells.
Author: Ma, Jiachi|Sawai, Hirozumi|Matsuo, Yoichi|Ochi, Nobuo|Yasuda, Akira|Takahashi, Hiroki|Wakasugi, Takehiro|Funahashi, Hitoshi|Sato, Mikinori|Takeyama, Hiromitsu
PMID: 19560785
31.
Journal: Med Oncol. 2010 Sep;27(3):1017-22.
Title: Inhibition of Notch3 enhances sensitivity to gemcitabine in pancreatic cancer through an inactivation of PI3K/Akt-dependent pathway.
Author: Yao, Jun|Qian, Cuijuan
PMID: 19816816
32.
Journal: Biochem Biophys Res Commun. 2010 Mar 12;393(3):371-6.
Title: Hypoxia-reoxygenation increase invasiveness of PANC-1 cells through Rac1/MMP-2.
Author: Binker, Marcelo G|Binker-Cosen, Andres A|Richards, Daniel|Gaisano, Herbert Y|de Cosen, Rodica H|Cosen-Binker, Laura I
PMID: 20153729
33.
Journal: Zhonghua Yi Xue Za Zhi. 2010 Jan 12;90(2):123-7.
Title: [Effect of anti-cancer drugs on the expression of BIC/miR-155 in human pancreatic cancer PANC-1 cells].
Author: Xia, Qi-sheng|Ishigaki, Yasuhito|Sun, Li|Chen, Rui|Motoo, Yoshiharu
PMID: 20356498
34.
Journal: World J Gastroenterol. 2010 Apr 21;16(15):1854-8.
Title: Insulin-like growth factor-I receptor in proliferation and motility of pancreatic cancer.
Author: Tomizawa, Minoru|Shinozaki, Fuminobu|Sugiyama, Takao|Yamamoto, Shigenori|Sueishi, Makoto|Yoshida, Takanobu
PMID: 20397262
35.
Journal: BMC Cancer. 2010 Apr 27;10:161.
Title: Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells.
Author: Xu, Zekuan|Zhang, Yi|Jiang, Jiakai|Yang, Yang|Shi, Ruihua|Hao, Bo|Zhang, Zhihong|Huang, Zuhu|Kim, Jin W|Zhang, Guoxin
PMID: 20423485
36.
Journal: BMC Cancer. 2010 Jul 14;10:368.
Title: Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies.
Author: Javle, Milind M|Shroff, Rachna T|Xiong, Henry|Varadhachary, Gauri A|Fogelman, David|Reddy, Shrikanth A|Davis, Darren|Zhang, Yujian|Wolff, Robert A|Abbruzzese, James L
PMID: 20630061
37.
Journal: Clin Cancer Res. 2010 Oct 15;16(20):4928-37.
Title: Key role of phosphoinositide 3-kinase class IB in pancreatic cancer.
Author: Edling, Charlotte E|Selvaggi, Federico|Buus, Richard|Maffucci, Tania|Di Sebastiano, Pierluigi|Friess, Helmut|Innocenti, Paolo|Kocher, Hemant M|Falasca, Marco
PMID: 20876794
38.
Journal: Invest New Drugs. 2011 Feb;29(1):144-53.
Title: Gemcitabine plus enzastaurin or single-agent gemcitabine in locally advanced or metastatic pancreatic cancer: results of a phase II, randomized, noncomparative study.
Author: Richards, Donald A|Kuefler, Paul R|Becerra, Carlos|Wilfong, Lalan S|Gersh, Robert H|Boehm, Kristi A|Zhan, Feng|Asmar, Lina|Myrand, Scott P|Hozak, Rebecca R|Zhao, Luping|Gill, John F|Mullaney, Brian P|Obasaju, Coleman K|Nicol, Steven J
PMID: 19714296
39.
Journal: Pathol Oncol Res. 2011 Jun;17(2):257-61.
Title: Activation of the PI3K/Akt pathway mediates bone morphogenetic protein 2-induced invasion of pancreatic cancer cells Panc-1.
Author: Chen, Xiong|Liao, Jie|Lu, YeBin|Duan, XiaoHui|Sun, WeiJia
PMID: 20848249
40.
Journal: Clin Cancer Res. 2011 Apr 1;17(7):1784-95.
Title: Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway.
Author: Boreddy, Srinivas Reddy|Pramanik, Kartick C|Srivastava, Sanjay K
PMID: 21350002
41.
Journal: Anticancer Agents Med Chem. 2011 Jun;11(5):455-63.
Title: Targeting phosphoinositide 3-kinase pathways in pancreatic cancer--from molecular signalling to clinical trials.
Author: Falasca, Marco|Selvaggi, Federico|Buus, Richard|Sulpizio, Sara|Edling, Charlotte E
PMID: 21521159
42.
Journal: Pancreatology. 2011;11(2):252-60.
Title: The role of phosphatidylinositol 3-kinase signaling pathways in pancreatic cancer.
Author: Sun, Chen|Rosendahl, Ann H|Andersson, Roland|Wu, DeQuan|Wang, Xiangdong
PMID: 21625196
43.
Journal: Mol Cancer. 2011 Aug 31;10:106.
Title: Mesothelin confers pancreatic cancer cell resistance to TNF-alpha-induced apoptosis through Akt/PI3K/NF-kappaB activation and IL-6/Mcl-1 overexpression.
Author: Bharadwaj, Uddalak|Marin-Muller, Christian|Li, Min|Chen, Changyi|Yao, Qizhi
PMID: 21880146
44.
Journal: Eur J Cancer. 2011 Nov;47(17):2654-64.
Title: Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phosphatase 2A inhibitors through overactivation of the c-Jun N-terminal kinase pathway.
Author: Li, Wei|Chen, Zheng|Gong, Fei-Ran|Zong, Yang|Chen, Kai|Li, Dao-Ming|Yin, Hong|Duan, Wei-Ming|Miao, Yi|Tao, Min|Han, Xiao|Xu, Ze-Kuan
PMID: 21958460
45.
Journal: BMC Cancer. 2011 Oct 2;11:421.
Title: Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells.
Author: Muller, Kristin M|Tveteraas, Ingun H|Aasrum, Monica|Odegard, John|Dawood, Mona|Dajani, Olav|Christoffersen, Thoralf|Sandnes, Dagny L
PMID: 21961726
46.
Journal: Small GTPases. 2011 Sep;2(5):264-267.
Title: Ras, PI3K/Akt and senescence: Paradoxes provide clues for pancreatic cancer therapy.
Author: Kennedy, Alyssa L|Adams, Peter D|Morton, Jennifer P
PMID: 22292129
47.
Journal: J Gastrointest Oncol. 2011 Jun;2(2):93-103.
Title: Emerging therapies in pancreas cancer.
Author: Kotowski, Adam|Ma, Wen W
PMID: 22811835
48.
Journal: Oncol Rep. 2012 Jan;27(1):182-8.
Title: ZSTK474, a PI3K inhibitor, suppresses proliferation and sensitizes human pancreatic adenocarcinoma cells to gemcitabine.
Author: Duong, Hong-Quan|Kim, Hee Jeong|Kang, Hyo Jin|Seong, Yeon-Sun|Bae, Insoo
PMID: 21993922
49.
Journal: J Cell Biochem. 2012 Mar;113(3):784-91.
Title: The efficacy of a novel, dual PI3K/mTOR inhibitor NVP-BEZ235 to enhance chemotherapy and antiangiogenic response in pancreatic cancer.
Author: Awasthi, Niranjan|Yen, Peter L|Schwarz, Margaret A|Schwarz, Roderich E
PMID: 22020918
50.
Journal: Tumour Biol. 2012 Jun;33(3):757-65.
Title: The dual PI3K/mTOR inhibitor NVP-BGT226 induces cell cycle arrest and regulates Survivin gene expression in human pancreatic cancer cell lines.
Author: Glienke, Wolfgang|Maute, Luise|Wicht, Johannes|Bergmann, Lothar
PMID: 22170433
51.
Journal: Ann Surg Oncol. 2012 Aug;19(8):2733-43.
Title: VEGF-A/VEGFR-2 signaling plays an important role for the motility of pancreas cancer cells.
Author: Doi, Yosuke|Yashiro, Masakazu|Yamada, Nobuya|Amano, Ryosuke|Noda, Satoru|Hirakawa, Kosei
PMID: 22207048
52.
Journal: Clin Cancer Res. 2012 Apr 1;18(7):2048-55.
Title: Phase I study of Rigosertib, an inhibitor of the phosphatidylinositol 3-kinase and Polo-like kinase 1 pathways, combined with gemcitabine in patients with solid tumors and pancreatic cancer.
Author: Ma, Wen Wee|Messersmith, Wells A|Dy, Grace K|Weekes, Colin D|Whitworth, Amy|Ren, Chen|Maniar, Manoj|Wilhelm, Francois|Eckhardt, S Gail|Adjei, Alex A|Jimeno, Antonio
PMID: 22338014
53.
Journal: Mol Cancer Ther. 2012 May;11(5):1193-202.
Title: Cotargeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancer.
Author: Williams, Terence M|Flecha, Athena R|Keller, Paul|Ram, Ashwin|Karnak, David|Galban, Stefanie|Galban, Craig J|Ross, Brian D|Lawrence, Theodore S|Rehemtulla, Alnawaz|Sebolt-Leopold, Judith
PMID: 22411900
54.
Journal: PLoS One. 2012;7(4):e33214.
Title: Inhibition of mesothelin as a novel strategy for targeting cancer cells.
Author: Wang, Kun|Bodempudi, Vidya|Liu, Zhengian|Borrego-Diaz, Emma|Yamoutpoor, Farnaz|Meyer, Anna|Woo, Richard A|Pan, Weihong|Dudek, Arkadiusz Z|Olyaee, Mojtaba S|Esfandyari, Tuba|Farassati, Faris
PMID: 22485139
55.
Journal: Genome Med. 2012 Jul 4;4(7):56.
Title: Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability.
Author: Demeure, Michael J|Craig, David W|Sinari, Shripad|Moses, Tracy M|Christoforides, Alexis|Dinh, Jennifer|Izatt, Tyler|Aldrich, Jessica|Decker, Ardis|Baker, Angela|Cherni, Irene|Watanabe, April|Koep, Lawrence|Lake, Douglas|Hostetter, Galen|Trent, Jeffrey M|V
PMID: 22762308
56.
Journal: PLoS One. 2012;7(8):e43064.
Title: Grape proanthocyanidin inhibit pancreatic cancer cell growth in vitro and in vivo through induction of apoptosis and by targeting the PI3K/Akt pathway.
Author: Prasad, Ram|Vaid, Mudit|Katiyar, Santosh K
PMID: 22905202
57.
Journal: PLoS One. 2012;7(8):e44146.
Title: K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo.
Author: Hofmann, Irmgard|Weiss, Andreas|Elain, Gaelle|Schwaederle, Maria|Sterker, Dario|Romanet, Vincent|Schmelzle, Tobias|Lai, Albert|Brachmann, Saskia M|Bentires-Alj, Mohamed|Roberts, Thomas M|Sellers, William R|Hofmann, Francesco|Maira, Sauveur-Michel
PMID: 22952903
58.
Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 Sep;37(9):883-8.
Title: [Simultaneous inhibition of XIAP and survivin expression on EMT and invasion of human pancreatic cancer cells].
Author: Zai, Hongyan|Yi, Xiaoping|Li, Yixiong|Jiang, Chun|Lu, Xinsheng
PMID: 23000761
59.
Journal: Carcinogenesis. 2012 Dec;33(12):2467-76.
Title: Transcriptional regulation of the interleukin-11 gene by oncogenic Ras.
Author: Shin, Soon Young|Choi, Chan|Lee, Hong Ghi|Lim, Yoongho|Lee, Young Han
PMID: 23027619
60.
Journal: Oncotarget. 2012 Nov;3(11):1416-27.
Title: Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer.
Author: Venkannagari, Sreedhar|Fiskus, Warren|Peth, Karissa|Atadja, Peter|Hidalgo, Manuel|Maitra, Anirban|Bhalla, Kapil N
PMID: 23232026
61.
Journal: Mol Cell Biochem. 2013 Jan;372(1-2):83-94.
Title: EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin.
Author: Shankar, Sharmila|Marsh, Luke|Srivastava, Rakesh K
PMID: 22971992
62.
Journal: Anticancer Agents Med Chem. 2013 Mar;13(3):382-8.
Title: Advances in the systemic treatment of neuroendocrine tumors in the era of molecular therapy.
Author: Leung, Roland|Lang, Brian|Wong, Hilda|Chiu, Joanne|Yat, Wan K|Shek, Tony|Cho, Woo Y|Yau, Lo C|Yau, Thomas
PMID: 23092266
63.
Journal: Anticancer Agents Med Chem. 2013 Jul 1;13(6):952-6.
Title: Cucurmosin kills human pancreatic cancer SW-1990 cells in vitro and in vivo.
Author: Xie, Jieming|Wang, Congfei|Yang, Aiqin|Zhang, Baoming|Yin, Qiang|Huang, Heguang|Chen, Minghuang
PMID: 23157594
64.
Journal: Cancer Lett. 2013 May 1;331(2):250-61.
Title: Synergistic anticancer activity of HS-173, a novel PI3K inhibitor in combination with Sorafenib against pancreatic cancer cells.
Author: Yun, Sun-Mi|Jung, Kyung Hee|Lee, Hyunseung|Son, Mi Kwon|Seo, Ju-Hyeon|Yan, Hong Hua|Park, Byung Hee|Hong, Sungwoo|Hong, Soon-Sun
PMID: 23340175
65.
Journal: Biotech Histochem. 2013 Oct;88(7):397-402.
Title: MicroRNA-100 regulates IGF1-receptor expression in metastatic pancreatic cancer cells.
Author: Huang, J S|Egger, M E|Grizzle, W E|McNally, L R
PMID: 23373509
66.
Journal: J Huazhong Univ Sci Technolog Med Sci. 2013 Feb;33(1):57-62.
Title: LY294002 enhances inhibitory effect of gemcitabine on proliferation of human pancreatic carcinoma PANC-1 cells.
Author: Ke, Xiao-Yu|Wang, Yu|Xie, Zuo-Qi|Liu, Zhi-Qing|Zhang, Cui-Fang|Zhao, Qiu|Yang, Dong-Liang
PMID: 23392708
67.
Journal: Onco Targets Ther. 2013;6:95-7.
Title: Molecular guided therapy for advanced pancreatic cancer patients with PI3K activated mutation: vision or illusion?
Author: Gazzah, Anas|Gonzales, Daniel Barrios|Levy, Antonin|Bahleda, Rastislav|Ducreux, Michel|Lacroix, Ludovic|Soria, Jean Charles
PMID: 23450148
68.
Journal: PLoS One. 2013;8(3):e58055.
Title: Cytotoxic activity and apoptosis-inducing potential of di-spiropyrrolidino and di-spiropyrrolizidino oxindole andrographolide derivatives.
Author: Dey, Sumit Kumar|Bose, Dipayan|Hazra, Abhijit|Naskar, Subhendu|Nandy, Abhishek|Munda, Rudra Narayan|Das, Subhadip|Chatterjee, Nabanita|Mondal, Nirup Bikash|Banerjee, Sukdeb|Saha, Krishna Das
PMID: 23472133
69.
Journal: Am J Chin Med. 2013;41(3):629-42.
Title: PI3K/AKT/mTOR signaling is involved in (-)-epigallocatechin-3-gallate-induced apoptosis of human pancreatic carcinoma cells.
Author: Liu, Shi|Wang, Xiao-Jie|Liu, Ying|Cui, Yun-Fu
PMID: 23711146
70.
Journal: Curr Drug Targets. 2013 Sep;14(10):1110-7.
Title: miRNAs in insulin resistance and diabetes-associated pancreatic cancer: the 'minute and miracle' molecule moving as a monitor in the 'genomic galaxy'.
Author: Chakraborty, Chiranjib|George Priya Doss, C|Bandyopadhyay, Sanghamitra
PMID: 23834149
71.
Journal: J Natl Cancer Inst. 2013 Jul 17;105(14):1005-17.
Title: Current understanding of the molecular biology of pancreatic neuroendocrine tumors.
Author: Zhang, Jianliang|Francois, Rony|Iyer, Renuka|Seshadri, Mukund|Zajac-Kaye, Maria|Hochwald, Steven N
PMID: 23840053
72.
Journal: J Cell Biochem. 2013 Nov;114(11):2603-11.
Title: The CX3CL1/CX3CR1 reprograms glucose metabolism through HIF-1 pathway in pancreatic adenocarcinoma.
Author: Ren, He|Zhao, Tiansuo|Sun, Junwei|Wang, Xiuchao|Liu, Jingcheng|Gao, Song|Yu, Ming|Hao, Jihui
PMID: 23857671
73.
Journal: PLoS One. 2013 Aug 14;8(8):e70594.
Title: Oncosuppressive suicide gene virotherapy "PVH1-yCD/5-FC" for pancreatic peritoneal carcinomatosis treatment: NFkappaB and Akt/PI3K involvement.
Author: Rejiba, Soukaina|Bigand, Christelle|Parmentier, Celine|Masmoudi, Ahmed|Hajri, Amor
PMID: 23967078
74.
Journal: PLoS One. 2013 Oct 9;8(10):e77243.
Title: Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models.
Author: Zhong, Hua|Sanchez, Cesar|Spitzer, Dirk|Plambeck-Suess, Stacy|Gibbs, Jesse|Hawkins, Williams G|Denardo, David|Gao, Feng|Pufahl, Robert A|Lockhart, Albert C|Xu, Mai|Linehan, David|Weber, Jason|Wang-Gillam, Andrea
PMID: 24130864
75.
Journal: Hepatogastroenterology. 2013 Oct;60(127):1766-72.
Title: PTEN/PI3K/mTOR/B7-H1 signaling pathway regulates cell progression and immuno-resistance in pancreatic cancer.
Author: Zhang, Yingfei|Zhang, Jianlong|Xu, Kang|Xiao, Zhiyu|Sun, Jian|Xu, Junyao|Wang, Jie|Tang, Qibing
PMID: 24624456
76.
Journal: Toxicol Lett. 2014 Jan 3;224(1):7-15.
Title: Par-4 downregulation confers cisplatin resistance in pancreatic cancer cells via PI3K/Akt pathway-dependent EMT.
Author: Tan, Jiaxin|You, Yu|Xu, Tubin|Yu, Peng|Wu, Dingguo|Deng, Hao|Zhang, Yujun|Bie, Ping
PMID: 24144893
77.
Journal: J Clin Invest. 2014 Jan;124(1):338-52.
Title: Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-beta to promote proliferation.
Author: Gore, A Jesse|Deitz, Samantha L|Palam, Lakshmi Reddy|Craven, Kelly E|Korc, Murray
PMID: 24334458
78.
Journal: Biomed Rep. 2014 Mar;2(2):188-192.
Title: High glucose-induced resistance to 5-fluorouracil in pancreatic cancer cells alleviated by 2-deoxy-D-glucose.
Author: Cheng, Yao|Diao, Dongmei|Zhang, Hao|Guo, Qi|Wu, Xuandi|Song, Yongchun|Dang, Chengxue
PMID: 24649094
79.
Journal: Int J Clin Exp Pathol. 2014 Feb 15;7(3):923-31. eCollection 2014.
Title: Downregulation of mTOR by lentivirus inhibits prostate cancer cell growth.
Author: Du, Yue-Feng|Long, Qing-Zhi|Shi, Ying|Liu, Xiao-Gang|Li, Xu-Dong|Zeng, Jin|Gong, Yong-Guang|Wang, Xin-Yang|He, Da-Lin
PMID: 24695460
80.
Journal: Biomed Res Int. 2014;2014:546353.
Title: alpha-Mangostin suppresses the viability and epithelial-mesenchymal transition of pancreatic cancer cells by downregulating the PI3K/Akt pathway.
Author: Xu, Qinhong|Ma, Jiguang|Lei, Jianjun|Duan, Wanxing|Sheng, Liang|Chen, Xin|Hu, Ang|Wang, Zheng|Wu, Zheng|Wu, Erxi|Ma, Qingyong|Li, Xuqi
PMID: 24812621
81.
Journal: Int J Oncol. 2014 Jul;45(1):311-21.
Title: HS-104, a PI3K inhibitor, enhances the anticancer efficacy of gemcitabine in pancreatic cancer.
Author: Jung, Kyung Hee|Yan, Hong Hua|Fang, Zhenghuan|Son, Mi Kwon|Lee, Hyunseung|Hong, Sungwoo|Hong, Soon-Sun
PMID: 24819705
82.
Journal: J Biol Chem. 2014 Aug 1;289(31):21694-705.
Title: The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT.
Author: Duan, Lei|Ying, Guoguang|Danzer, Brian|Perez, Ricardo E|Shariat-Madar, Zia|Levenson, Victor V|Maki, Carl G
PMID: 24936056
83.
Journal: Cancer Lett. 2014 Oct 10;353(1):68-77.
Title: Anticancer activity of HS-527, a novel inhibitor targeting PI3-kinase in human pancreatic cancer cells.
Author: Ryu, Ye-Lim|Jung, Kyung Hee|Son, Mi Kwon|Yan, Hong Hua|Kim, Soo Jung|Shin, Sanghye|Hong, Sungwoo|Hong, Soon-Sun
PMID: 25016056
84.
Journal: FEBS Lett. 2014 Aug 25;588(17):3240-50.
Title: Nitric oxide increases the invasion of pancreatic cancer cells via activation of the PI3K-AKT and RhoA pathways after carbon ion irradiation.
Author: Fujita, Mayumi|Imadome, Kaori|Endo, Satoshi|Shoji, Yoshimi|Yamada, Shigeru|Imai, Takashi
PMID: 25019574
85.
Journal: Pancreas. 2014 Oct;43(7):1093-100.
Title: Expression of Akt kinase-interacting protein 1, a scaffold protein of the PI3K/PDK1/Akt pathway, in pancreatic cancer.
Author: Ohtsubo, Koushiro|Yamada, Tadaaki|Zhao, Lu|Jin, Tie-Feng|Takeuchi, Shinji|Mouri, Hisatsugu|Yamashita, Kaname|Yasumoto, Kazuo|Fujita, Naoya|Kitagawa, Hirohisa|Ohta, Tetsuo|Ikeda, Hiroko|Yano, Seiji
PMID: 25036909
86.
Journal: Adv Biol Regul. 2014 Sep;56:66-80.
Title: PTEN expression and function in adult cancer stem cells and prospects for therapeutic targeting.
Author: Ciuffreda, Ludovica|Falcone, Italia|Incani, Ursula Cesta|Del Curatolo, Anais|Conciatori, Fabiana|Matteoni, Silvia|Vari, Sabrina|Vaccaro, Vanja|Cognetti, Francesco|Milella, Michele
PMID: 25088603
87.
Journal: Oncol Lett. 2014 Sep;8(3):1087-1089.
Title: Shikonin promotes autophagy in BXPC-3 human pancreatic cancer cells through the PI3K/Akt signaling pathway.
Author: Shi, Shuqing|Cao, Haimei
PMID: 25120662
88.
Journal: World J Gastroenterol. 2014 Aug 21;20(31):10752-7.
Title: Emerging role of the KRAS-PDK1 axis in pancreatic cancer.
Author: Ferro, Riccardo|Falasca, Marco
PMID: 25152578
89.
Journal: Oncotarget. 2014 Aug 15;5(15):6512-25.
Title: CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer.
Author: Franco, Jorge|Witkiewicz, Agnieszka K|Knudsen, Erik S
PMID: 25156567
90.
Journal: Front Physiol. 2014 Oct 15;5:391.
Title: Targeting p110gamma in gastrointestinal cancers: attack on multiple fronts.
Author: Falasca, Marco|Maffucci, Tania
PMID: 25360116
91.
Journal: Front Physiol. 2014 Dec 16;5:478.
Title: Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities.
Author: Hubbard, Paul A|Moody, Colleen L|Murali, Ramachandran
PMID: 25566081
92.
Journal: Dig Dis Sci. 2015 Apr;60(4):1067-80.
Title: Thymoquinone Pretreatment Overcomes the Insensitivity and Potentiates the Antitumor Effect of Gemcitabine Through Abrogation of Notch1, PI3K/Akt/mTOR Regulated Signaling Pathways in Pancreatic Cancer.
Author: Mu, Gang-Gang|Zhang, Ling-Li|Li, Hong-Yan|Liao, Yan|Yu, Hong-Gang
PMID: 25344906
93.
Journal: Clin Cancer Res. 2015 Jan 15;21(2):396-404.
Title: Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer.
Author: Alagesan, Brinda|Contino, Gianmarco|Guimaraes, Alex R|Corcoran, Ryan B|Deshpande, Vikram|Wojtkiewicz, Gregory R|Hezel, Aram F|Wong, Kwok-Kin|Loda, Massimo|Weissleder, Ralph|Benes, Cyril H|Engelman, Jeffrey|Bardeesy, Nabeel
PMID: 25348516
94.
Journal: Mol Cancer Ther. 2015 Jan;14(1):40-7.
Title: Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer.
Author: Junttila, Melissa R|Devasthali, Vidusha|Cheng, Jason H|Castillo, Joseph|Metcalfe, Ciara|Clermont, Anne C|Otter, Douglas Den|Chan, Emily|Bou-Reslan, Hani|Cao, Tim|Forrest, William|Nannini, Michelle A|French, Dorothy|Carano, Richard|Merchant, Mark|Hoeflich,
PMID: 25376606
95.
Journal: Cancer Lett. 2015 Feb 1;357(1):219-230.
Title: Synergistic antitumor activity of withaferin A combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the PI3K/AKT pathway in human pancreatic cancer cells.
Author: Li, Xu|Zhu, Feng|Jiang, Jianxin|Sun, Chengyi|Wang, Xin|Shen, Ming|Tian, Rui|Shi, Chengjian|Xu, Meng|Peng, Feng|Guo, Xingjun|Wang, Min|Qin, Renyi
PMID: 25444914
96.
Journal: Invest New Drugs. 2015 Apr;33(2):271-9.
Title: PBI-05204, a supercritical CO(2) extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway.
Author: Pan, Yong|Rhea, Patrea|Tan, Lin|Cartwright, Carrie|Lee, Ho-Jeong|Ravoori, Murali K|Addington, Crandell|Gagea, Mihai|Kundra, Vikas|Kim, Sun-Jin|Newman, Robert A|Yang, Peiying
PMID: 25476893
97.
Journal: Clin Cancer Res. 2015 Feb 15;21(4):730-8.
Title: A phase Ib dose-escalation study of the oral pan-PI3K inhibitor buparlisib (BKM120) in combination with the oral MEK1/2 inhibitor trametinib (GSK1120212) in patients with selected advanced solid tumors.
Author: Bedard, Philippe L|Tabernero, Josep|Janku, Filip|Wainberg, Zev A|Paz-Ares, Luis|Vansteenkiste, Johan|Van Cutsem, Eric|Perez-Garcia, Jose|Stathis, Anastasios|Britten, Carolyn D|Le, Ngocdiep|Carter, Kirsten|Demanse, David|Csonka, Denes|Peters, Malte|Zubel,
PMID: 25500057
98.
Journal: Cancer Lett. 2015 Mar 1;358(1):59-66.
Title: Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer.
Author: Awasthi, Niranjan|Hinz, Stefan|Brekken, Rolf A|Schwarz, Margaret A|Schwarz, Roderich E
PMID: 25527450
99.
Journal: Drug Des Devel Ther. 2015 Jan 17;9:537-60.
Title: Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells.
Author: Wang, Feng|Wang, Qi|Zhou, Zhi-Wei|Yu, Song-Ning|Pan, Shu-Ting|He, Zhi-Xu|Zhang, Xueji|Wang, Dong|Yang, Yin-Xue|Yang, Tianxing|Sun, Tao|Li, Min|Qiu, Jia-Xuan|Zhou, Shu-Feng
PMID: 25632222
100.
Journal: Drug Des Devel Ther. 2015 Jan 17;9:575-601.
Title: Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells.
Author: Wang, Feng|Li, Hai|Yan, Xiao-Gang|Zhou, Zhi-Wei|Yi, Zhi-Gang|He, Zhi-Xu|Pan, Shu-Ting|Yang, Yin-Xue|Wang, Zuo-Zheng|Zhang, Xueji|Yang, Tianxing|Qiu, Jia-Xuan|Zhou, Shu-Feng
PMID: 25632225
101.
Journal: Mol Cancer Ther. 2015 Apr;14(4):1014-23.
Title: Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2.
Author: Soares, Heloisa P|Ming, Ming|Mellon, Michelle|Young, Steven H|Han, Liang|Sinnet-Smith, James|Rozengurt, Enrique
PMID: 25673820
102.
Journal: Sci Rep. 2015 Feb 16;5:8473.
Title: Genetic variants in the inositol phosphate metabolism pathway and risk of different types of cancer.
Author: Tan, Juan|Yu, Chen-Yang|Wang, Zhen-Hua|Chen, Hao-Yan|Guan, Jian|Chen, Ying-Xuan|Fang, Jing-Yuan
PMID: 25683757
103.
Journal: Mol Med Rep. 2015 Jul;12(1):601-8.
Title: Simultaneous silencing of XIAP and survivin causes partial mesenchymal-epithelial transition of human pancreatic cancer cells via the PTEN/PI3K/Akt pathway.
Author: Yi, Xiao-Ping|Han, Tong|Li, Yi-Xiong|Long, Xue-Ying|Li, Wen-Zheng
PMID: 25707849
104.
Journal: Cancer Sci. 2015 May;106(5):576-83.
Title: Catechol-O-methyltransferase, a new target for pancreatic cancer therapy.
Author: Wu, Wenming|Wu, Qiao|Hong, Xiafei|Zhou, Li|Zhang, Jie|You, Lei|Wang, Wenze|Wu, Huanwen|Dai, Hongmei|Zhao, Yupei
PMID: 25711924
105.
Journal: Naunyn Schmiedebergs Arch Pharmacol. 2015 Jun;388(6):623-34.
Title: Longikaurin E induces apoptosis of pancreatic cancer cells via modulation of the p38 and PI3K/AKT pathways by ROS.
Author: Cheng, Hai-bo|Bo, Yun|Shen, Wei-xing|Ren, Xian-guo|Tan, Jia-ni|Jia, Zhi-rong|Xu, Chang-Liang
PMID: 25743573
106.
Journal: Bioorg Med Chem. 2015 Apr 1;23(7):1386-94.
Title: Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor.
Author: Van Dort, Marcian E|Galban, Stefanie|Wang, Hanxiao|Sebolt-Leopold, Judith|Whitehead, Christopher|Hong, Hao|Rehemtulla, Alnawaz|Ross, Brian D
PMID: 25766633
107.
Journal: Oncotarget. 2015 Aug 28;6(25):21085-99.
Title: Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells.
Author: Lakshmanan, Imayavaramban|Seshacharyulu, Parthasarathy|Haridas, Dhanya|Rachagani, Satyanarayana|Gupta, Suprit|Joshi, Suhasini|Guda, Chittibabu|Yan, Ying|Jain, Maneesh|Ganti, Apar K|Ponnusamy, Moorthy P|Batra, Surinder K
PMID: 26035354
108.
Journal: Adv Biol Regul. 2015 Sep;59:19-35.
Title: Implication of PI3K/Akt pathway in pancreatic cancer: When PI3K isoforms matter?
Author: Baer, Romain|Cintas, Celia|Therville, Nicole|Guillermet-Guibert, Julie
PMID: 26166735
109.
Journal: Adv Biol Regul. 2015 Sep;59:65-81.
Title: Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells.
Author: Fitzgerald, Timothy L|Lertpiriyapong, Kvin|Cocco, Lucio|Martelli, Alberto M|Libra, Massimo|Candido, Saverio|Montalto, Giuseppe|Cervello, Melchiorre|Steelman, Linda|Abrams, Stephen L|McCubrey, James A
PMID: 26257206
110.
Journal: Front Cell Dev Biol. 2015 Aug 5;3:47.
Title: Repression of CD24 surface protein expression by oncogenic Ras is relieved by inhibition of Raf but not MEK or PI3K.
Author: Pallegar, Nikitha K|Ayre, D Craig|Christian, Sherri L
PMID: 26301220
111.
Journal: J Biol Chem. 2015 Nov 6;290(45):27228-38.
Title: Integrin alpha6beta4 Promotes Autocrine Epidermal Growth Factor Receptor (EGFR) Signaling to Stimulate Migration and Invasion toward Hepatocyte Growth Factor (HGF).
Author: Carpenter, Brittany L|Chen, Min|Knifley, Teresa|Davis, Kelley A|Harrison, Susan M W|Stewart, Rachel L|O'Connor, Kathleen L
PMID: 26381405
112.
Journal: Invest New Drugs. 2015 Dec;33(6):1225-31.
Title: A phase I trial of mFOLFOX6 combined with the oral PI3K inhibitor BKM120 in patients with advanced refractory solid tumors.
Author: McRee, Autumn J|Sanoff, Hanna K|Carlson, Cheryl|Ivanova, Anastasia|O'Neil, Bert H
PMID: 26490655
113.
Journal: Int J Clin Exp Pathol. 2015 Nov 1;8(11):14005-12. eCollection 2015.
Title: Knockdown of PFTK1 inhibits tumor cell proliferation, invasion and epithelial-to-mesenchymal transition in pancreatic cancer.
Author: Zheng, Li|Zhou, Zhongyong|He, Zhikuan
PMID: 26823712
114.
Journal: Int J Clin Exp Pathol. 2015 Nov 1;8(11):14028-33. eCollection 2015.
Title: Modulatory role of garlicin in migration and invasion of intrahepatic cholangiocarcinoma via PI3K/AKT pathway.
Author: Xie, Kun|Nian, Jianze|Zhu, Xingyang|Geng, Xiaoping|Liu, Fubao
PMID: 26823715
115.
Journal: Mol Carcinog. 2016 May;55(5):633-45.
Title: Embigin is overexpressed in pancreatic ductal adenocarcinoma and regulates cell motility through epithelial to mesenchymal transition via the TGF-beta pathway.
Author: Jung, Dawoon E|Kim, Jeong Mi|Kim, Chanyang|Song, Si Young
PMID: 25773908
116.
Journal: Neoplasma. 2016;63(1):80-92.
Title: The effect of PI3K inhibitor LY294002 and gemcitabine hydrochloride combined with ionizing radiation on the formation of vasculogenic mimicry of Panc-1 cells in vitro and in vivo.
Author: Bai, R|Ding, T|Zhao, J|Liu, S|Zhang, L|Lan, X|Yu, Y|Yin, L
PMID: 26639237
117.
Journal: Eur J Cancer. 2016 Jan;52:109-19.
Title: Targeting the Janus-activated kinase-2-STAT3 signalling pathway in pancreatic cancer using the HSP90 inhibitor ganetespib.
Author: Nagaraju, Ganji Purnachandra|Mezina, Anya|Shaib, Walid L|Landry, Jerome|El-Rayes, Bassel F
PMID: 26682870
118.
Journal: Sci Rep. 2016 Jan 25;6:19819.
Title: Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition.
Author: Subramani, Ramadevi|Gonzalez, Elizabeth|Arumugam, Arunkumar|Nandy, Sushmita|Gonzalez, Viviana|Medel, Joshua|Camacho, Fernando|Ortega, Andrew|Bonkoungou, Sandrine|Narayan, Mahesh|Dwivedi, Alok kumar|Lakshmanaswamy, Rajkumar
PMID: 26804739
119.
Journal: Oncotarget. 2016 Feb 23;7(8):9586-99.
Title: Polycomb complex protein BMI-1 promotes invasion and metastasis of pancreatic cancer stem cells by activating PI3K/AKT signaling, an ex vivo, in vitro, and in vivo study.
Author: Wang, Min-Cong|Jiao, Min|Wu, Tao|Jing, Li|Cui, Jie|Guo, Hui|Tian, Tao|Ruan, Zhi-ping|Wei, Yong-Chang|Jiang, Li-Li|Sun, Hai-Feng|Huang, Lan-Xuan|Nan, Ke-Jun|Li, Chun-Li
PMID: 26840020
120.
Journal: Mol Cancer Ther. 2016 May;15(5):985-97.
Title: Novel Anti-CRR9/CLPTM1L Antibodies with Antitumorigenic Activity Inhibit Cell Surface Accumulation, PI3K Interaction, and Survival Signaling.
Author: Puskas, Laszlo G|Man, Imola|Szebeni, Gabor|Tiszlavicz, Laszlo|Tsai, Susan|James, Michael A
PMID: 26939707
121.
Journal: Oncol Rep. 2016 Jul;36(1):49-56.
Title: Regulation of cell apoptosis and proliferation in pancreatic cancer through PI3K/Akt pathway via Polo-like kinase 1.
Author: Mao, Yonghuan|Xi, Ling|Li, Quan|Cai, Zeling|Lai, Yimei|Zhang, Xinhua|Yu, Chunzhao
PMID: 27220401
122.
Journal: Neoplasia. 2016 Jul;18(7):425-35.
Title: Upstream and Downstream Co-inhibition of Mitogen-Activated Protein Kinase and PI3K/Akt/mTOR Pathways in Pancreatic Ductal Adenocarcinoma.
Author: Wong, Matthew H|Xue, Aiqun|Baxter, Robert C|Pavlakis, Nick|Smith, Ross C
PMID: 27435925
123.
Journal: Oncol Lett. 2016 Aug;12(2):1139-1143.
Title: PREX2 promotes the proliferation, invasion and migration of pancreatic cancer cells by modulating the PI3K signaling pathway.
Author: Yang, Jianyi|Gong, Xuejun|Ouyang, Lu|He, Wen|Xiao, Rou|Tan, Li
PMID: 27446408
124.
Journal: Pharmacol Ther. 2016 Dec;168:29-42.
Title: KRAS-related proteins in pancreatic cancer.
Author: Mann, Karen M|Ying, Haoqiang|Juan, Joseph|Jenkins, Nancy A|Copeland, Neal G
PMID: 27595930
125.
Journal: Sci Rep. 2016 Sep 9;6:32809.
Title: Paeoniflorin Potentiates the Inhibitory Effects of Erlotinib in Pancreatic Cancer Cell Lines by Reducing ErbB3 Phosphorylation.
Author: Hao, Jian|Yang, Xue|Ding, Xiu-Li|Guo, Lei-Ming|Zhu, Cui-Hong|Ji, Wei|Zhou, Tong|Wu, Xiong-Zhi
PMID: 27609096
126.
Journal: Sci Rep. 2016 Sep 29;6:33146.
Title: Interplay between cell cycle and autophagy induced by boswellic acid analog.
Author: Pathania, Anup S|Guru, Santosh K|Kumar, Suresh|Kumar, Ashok|Ahmad, Masroor|Bhushan, Shashi|Sharma, Parduman R|Mahajan, Priya|Shah, Bhahwal A|Sharma, Simmi|Nargotra, Amit|Vishwakarma, Ram|Korkaya, Hasan|Malik, Fayaz
PMID: 27680387
127.
Journal: Tumour Biol. 2016 Oct 11. pii: 10.1007/s13277-016-5432-0.
Title: Downregulation of Smurf2 ubiquitin ligase in pancreatic cancer cells reversed TGF-beta-induced tumor formation.
Author: Wu, Bo|Guo, Bomin|Kang, Jie|Deng, Xianzhao|Fan, Youben|Zhang, Xiaoping|Ai, Kaixing
PMID: 27730540
128.
Journal: Oncol Lett. 2016 Dec;12(6):5059-5067.
Title: Wogonin induces Beclin-1/PI3K and reactive oxygen species-mediated autophagy in human pancreatic cancer cells.
Author: Li, Shao-Jun|Sun, Shi-Jie|Gao, Jie|Sun, Fu-Bo
PMID: 28105213
129.
Journal: Oncotarget. 2016 Jul 13;7(34):55437-55448.
Title: Prorenin receptor acts as a potential molecular target for pancreatic ductal adenocarcinoma diagnosis.
Author: Arundhathi, Arivajiagane|Chuang, Wen-Han|Chen, Jen-Kun|Wang, Shin-E|Shyr, Yi-Ming|Chen, Jiun-Yu|Liao, Wei-Neng|Chen, Hsin-Wei|Teng, Yi-Min|Pai, Chiao-Chih|Wang, Chih-Hong
PMID: 28874965
130.
Journal: Immunobiology. 2017 Jan;222(1):1-10.
Title: Hyaluronan carried by tumor-derived microvesicles induces IL-10 production in classical (CD14(++)CD16(-)) monocytes via PI3K/Akt/mTOR-dependent signalling pathway.
Author: Lenart, Marzena|Rutkowska-Zapala, Magdalena|Baj-Krzyworzeka, Monika|Szatanek, Rafal|Weglarczyk, Kazimierz|Smallie, Timothy|Ziegler-Heitbrock, Loms|Zembala, Marek|Siedlar, Maciej
PMID: 26210045
131.
Journal: Oncotarget. 2017 Feb 21;8(8):14173-14191.
Title: Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer?
Author: Thillai, Kiruthikah|Lam, Hoyin|Sarker, Debashis|Wells, Claire M
PMID: 27845911
132.
Journal: JAMA Oncol. 2017 Apr 1;3(4):516-522.
Title: Effect of Selumetinib and MK-2206 vs Oxaliplatin and Fluorouracil in Patients With Metastatic Pancreatic Cancer After Prior Therapy: SWOG S1115 Study Randomized Clinical Trial.
Author: Chung, Vincent|McDonough, Shannon|Philip, Philip A|Cardin, Dana|Wang-Gillam, Andrea|Hui, Laifong|Tejani, Mohamedtaki A|Seery, Tara E|Dy, Irene A|Al Baghdadi, Tareq|Hendifar, Andrew E|Doyle, L Austin|Lowy, Andrew M|Guthrie, Katherine A|Blanke, Charles D|Ho
PMID: 27978579
133.
Journal: Peptides. 2017 Feb;88:8-17.
Title: The anti-tumor effects of the recombinant toxin protein rLj-RGD3 from Lampetra japonica on pancreatic carcinoma Panc-1 cells in nude mice.
Author: Wang, Yue|Zheng, Yuanyuan|Tu, Zuoyu|Dai, Yongguo|Xu, Hong|Lv, Li|Wang, Jihong
PMID: 27988354
134.
Journal: Oncol Rep. 2017 Feb;37(2):1189-1195.
Title: Downregulation of the N-myc downstream regulated gene 1 is related to enhanced proliferation, invasion and migration of pancreatic cancer.
Author: Cen, Gang|Zhang, Kundong|Cao, Jun|Qiu, Zhengjun
PMID: 28075464
135.
Journal: Curr Med Chem. 2017;24(13):1321-1331.
Title: Targeting the Akt/PI3K Signaling Pathway as a Potential Therapeutic Strategy for the Treatment of Pancreatic Cancer.
Author: Ebrahimi, Safieh|Hosseini, Mina|Shahidsales, Soodabeh|Maftouh, Mina|Ferns, Gordon A|Ghayour-Mobarhan, Majid|Hassanian, Seyed Mahdi|Avan, Amir
PMID: 28176634
136.
Journal: Biomed Pharmacother. 2017 May;89:1269-1276.
Title: lncRNA MEG3 had anti-cancer effects to suppress pancreatic cancer activity.
Author: Gu, Lei|Zhang, Jiaqiang|Shi, Minmin|Zhan, Qian|Shen, Baiyong|Peng, Chenghong
PMID: 28320094
137.
Journal: Mol Cancer Res. 2017 Jul;15(7):929-941.
Title: Insulin Receptor and GPCR Crosstalk Stimulates YAP via PI3K and PKD in Pancreatic Cancer Cells.
Author: Hao, Fang|Xu, Qinhong|Zhao, Yinglan|Stevens, Jan V|Young, Steven H|Sinnett-Smith, James|Rozengurt, Enrique
PMID: 28360038
138.
Journal: Oncotarget. 2017 May 16;8(20):33265-33275.
Title: Correlated high expression of FXR and Sp1 in cancer cells confers a poor prognosis for pancreatic cancer: A study based on TCGA and tissue microarray.
Author: Hu, Hai|Wu, Lei-Lei|Han, Ting|Zhuo, Meng|Lei, Wang|Cui, Jiu-Jie|Jiao, Feng|Wang, Li-Wei
PMID: 28402278
139.
Journal: Oncotarget. 2017 Mar 21;8(12):20288-20296.
Title: The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer.
Author: Weng, Min|Luo, Zhu-Lin|Wu, Xiao-Ling|Zeng, Wei-Zheng
PMID: 28423617
140.
Journal: Onco Targets Ther. 2017 Apr 12;10:2115-2126.
Title: A blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/Akt/mTOR signaling pathway.
Author: Zhao, Lei|Li, Cheng|Liu, Fei|Zhao, Yonghong|Liu, Jun|Hua, Ye|Liu, Jinyang|Huang, Jiapeng|Ge, Chunlin
PMID: 28442920
141.
Journal: Clin Res Hepatol Gastroenterol. 2017 Sep;41(4):351-353.
Title: Attenuating PI3K isoforms in pancreatic cancer: Focus on immune PI3Kgamma.
Author: Basset, C|Guillermet-Guibert, J
PMID: 28583586
142.
Journal: Ann Oncol. 2017 Nov 1;28(11):2896-2898.
Title: Lack of growth inhibitory synergism with combined MAPK/PI3K inhibition in preclinical models of pancreatic cancer.
Author: Ciuffreda, L|Del Curatolo, A|Falcone, I|Conciatori, F|Bazzichetto, C|Cognetti, F|Corbo, V|Scarpa, A|Milella, M
PMID: 28666315
143.
Journal: Sci Rep. 2017 Oct 10;7(1):12891.
Title: Mechanistic Evaluation and Translational Signature of Gemcitabine-induced Chemoresistance by Quantitative Phosphoproteomics Analysis with iTRAQ Labeling Mass Spectrometry.
Author: Duan, Qingke|Zhao, Hengqiang|Zhang, Zhengle|Li, Hehe|Wu, Heshui|Shen, Qiang|Wang, Chunyou|Yin, Tao
PMID: 29018223
144.
Journal: Biomed Pharmacother. 2017 Dec;96:619-625.
Title: Ginsenoside Rg3 enhances the anti-proliferative activity of erlotinib in pancreatic cancer cell lines by downregulation of EGFR/PI3K/Akt signaling pathway.
Author: Jiang, Jin|Yuan, Zuguo|Sun, Yiqing|Bu, Yuan|Li, Wenfeng|Fei, Zhenghua
PMID: 29035827
145.
Journal: Geburtshilfe Frauenheilkd. 2017 Oct;77(10):1095-1103.
Title: PI3K/AKT/mTOR Pathway in Ovarian Cancer Treatment: Are We on the Right Track?
Author: Gasparri, Maria Luisa|Bardhi, Erlisa|Ruscito, Ilary|Papadia, Andrea|Farooqi, Ammad Ahmad|Marchetti, Claudia|Bogani, Giorgio|Ceccacci, Irene|Mueller, Michael D|Benedetti Panici, Pierluigi
PMID: 29093603
146.
Journal: World J Gastroenterol. 2017 Nov 14;23(42):7551-7562.
Title: Combined treatment of pancreatic cancer xenograft with (90)Y-ITGA6B4-mediated radioimmunotherapy and PI3K/mTOR inhibitor.
Author: Aung, Winn|Tsuji, Atsushi B|Sudo, Hitomi|Sugyo, Aya|Ukai, Yoshinori|Kouda, Katsushi|Kurosawa, Yoshikazu|Furukawa, Takako|Saga, Tsuneo|Higashi, Tatsuya
PMID: 29204055
147.
Journal: Oncotarget. 2017 Oct 9;8(61):103167-103181.
Title: Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling.
Author: Zhou, Jingkai|Zhao, Tiangang|Ma, Linfeng|Liang, Min|Guo, Ying-Jie|Zhao, Li-Mei
PMID: 29262554
148.
Journal: Front Pharmacol. 2017 Dec 22;8:936.
Title: Brucein D, a Naturally Occurring Tetracyclic Triterpene Quassinoid, Induces Apoptosis in Pancreatic Cancer through ROS-Associated PI3K/Akt Signaling Pathway.
Author: Lai, Zheng-Quan|Ip, Siu-Po|Liao, Hui-Jun|Lu, Zheng|Xie, Jian-Hui|Su, Zi-Ren|Chen, Yun-Long|Xian, Yan-Fang|Leung, Po-Sing|Lin, Zhi-Xiu
PMID: 29311937
149.
Journal: Oncotarget. 2017 Dec 1;8(68):112893-112906.
Title: Radiosensitization of the PI3K inhibitor HS-173 through reduction of DNA damage repair in pancreatic cancer.
Author: Park, Jung Hee|Jung, Kyung Hee|Kim, Soo Jung|Fang, Zhenghuan|Yan, Hong Hua|Son, Mi Kwon|Kim, Juyoung|Kang, Yeo Wool|Lee, Ji Eun|Han, Boreum|Lim, Joo Han|Hong, Soon-Sun
PMID: 29348875
150.
Journal: Oncol Lett. 2018 Jan;15(1):175-182.
Title: S100A11 promotes human pancreatic cancer PANC-1 cell proliferation and is involved in the PI3K/AKT signaling pathway.
Author: Xiao, Mingbing|Li, Tao|Ji, Yifei|Jiang, Feng|Ni, Wenkai|Zhu, Jing|Bao, Baijun|Lu, Cuihua|Ni, Runzhou
PMID: 29375710
151.
Journal: Oncol Res. 2018 Aug 23;26(7):1123-1131.
Title: Phosphoglycerate Mutase 1 (PGAM1) Promotes Pancreatic Ductal Adenocarcinoma (PDAC) Metastasis by Acting as a Novel Downstream Target of the PI3K/Akt/mTOR Pathway.
Author: Liu, Xinlu|Tan, Xiaodong|Liu, Peng|Wu, Yunhao|Qian, Songying|Zhang, Xiaobo
PMID: 29386088
152.
Journal: Adv Biol Regul. 2018 May;68:13-30.
Title: Metformin influences drug sensitivity in pancreatic cancer cells.
Author: Candido, Saverio|Abrams, Stephen L|Steelman, Linda|Lertpiriyapong, Kvin|Martelli, Alberto M|Cocco, Lucio|Ratti, Stefano|Follo, Matilde Y|Murata, Ramiro M|Rosalen, Pedro L|Lombardi, Paolo|Montalto, Giuseppe|Cervello, Melchiorre|Gizak, Agnieszka|Rakus, Dari
PMID: 29482945
153.
Journal: Int J Oncol. 2018 Mar 1.
Title: Curcumin inhibits superoxide dismutase-induced epithelial-to-mesenchymal transition via the PI3K/Akt/NF-kappaB pathway in pancreatic cancer cells.
Author: Li, Wei|Jiang, Zhengdong|Xiao, Xue|Wang, Zheng|Wu, Zheng|Ma, Qingyong|Cao, Lei
PMID: 29512729
154.
Journal: Cancers (Basel). 2018 May 14;10(5). pii: cancers10050142.
Title: A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology.
Author: Van Sciver, Robert E|Lee, Michael P|Lee, Caroline Dasom|Lafever, Alex C|Svyatova, Elizaveta|Kanda, Kevin|Colliver, Amber L|Siewertsz van Reesema, Lauren L|Tang-Tan, Angela M|Zheleva, Vasilena|Bwayi, Monicah N|Bian, Minglei|Schmidt, Rebecca L|Matrisian, Ly
PMID: 29757973
155.
Journal: Oncol Rep. 2018 Aug;40(2):599-608.
Title: Girdin regulates the proliferation and apoptosis of pancreatic cancer cells via the PI3K/Akt signalling pathway.
Author: Wang, Sheng|Lei, Yiqun|Cai, Zeling|Ye, Xiaoman|Li, Lianhong|Luo, Xiagang|Yu, Chunzhao
PMID: 29901184
156.
Journal: Oncol Lett. 2018 Aug;16(2):1937-1942.
Title: Anticancer effect of HOTTIP regulates human pancreatic cancer via the metabotropic glutamate receptor 1 pathway.
Author: Ye, Yibiao|Li, Yanshan|Wei, Yunping|Xu, Yunxiuxiu|Wang, Ruomei|Fu, Zhiqiang|Zheng, Shangyou|Zhou, Quanbo|Zhou, Yu|Chen, Rufu|Chen, Tao
PMID: 30008887
157.
Journal: Endocr Relat Cancer. 2018 Jul 18. pii: ERC-18-0120.
Title: Hotspot DAXX, PTCH2 and CYFIP2 mutations in pancreatic neuroendocrine neoplasms.
Author: Vandamme, Timon|Beyens, Matthias|Boons, Gitta|Schepers, Anne|Kamp, Kimberly|Biermann, Katharina|Pauwels, Patrick|de Herder, Wouter W|Hofland, Leo|Peeters, Marc|Van Camp, Guy|Op de Beeck, Ken
PMID: 30021865
158.
Journal: Oxid Med Cell Longev. 2018 Jun 26;2018:2798070.
Title: Mitofusin2 Induces Cell Autophagy of Pancreatic Cancer through Inhibiting the PI3K/Akt/mTOR Signaling Pathway.
Author: Xue, Ran|Meng, Qinghua|Lu, Di|Liu, Xinjuan|Wang, Yanbin|Hao, Jianyu
PMID: 30046371
159.
Journal: J Dig Dis. 2018 Jul 29.
Title: NOX4, A New Genetic Target for Anti-cancer Therapy in Digestive System Cancer.
Author: Tang, Chao-Tao|Gao, Yun-Jie|Ge, Zhi-Zheng
PMID: 30058122
160.
Journal: Nat Commun. 2018 Sep 11;9(1):3688.
Title: Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations.
Author: Chang, Jiang|Tian, Jianbo|Zhu, Ying|Zhong, Rong|Zhai, Kan|Li, Jiaoyuan|Ke, Juntao|Han, QiangQiang|Lou, Jiao|Chen, Wei|Zhu, Beibei|Shen, Na|Zhang, Yi|Gong, Yajie|Yang, Yang|Zou, Danyi|Peng, Xiating|Zhang, Zhi|Zhang, Xuemei|Huang, Kun|Yang, Ming|Wang, Li|Wu
PMID: 30206226
161.
Journal: Cancer Lett. 2018 Sep 11;438:174-186.
Title: KRAS targeting antibody synergizes anti-cancer activity of gemcitabine against pancreatic cancer.
Author: Kang, Yeo Wool|Lee, Ji Eun|Jung, Kyung Hee|Son, Mi Kwon|Shin, Seung-Min|Kim, Soo Jung|Fang, Zhenghuan|Yan, Hong Hua|Park, Jung Hee|Han, Boreum|Cheon, Min Ji|Woo, Min Gyu|Lim, Joo Han|Kim, Yong-Sung|Hong, Soon-Sun
PMID: 30217561
162.
Journal: Acta Pharmacol Sin. 2018 Sep 17. pii: 10.1038/s41401-018-0108-5.
Title: CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression.
Author: Fu, Xu-Hong|Zhang, Xiong|Yang, Hong|Xu, Xiao-Wei|Hu, Zong-Long|Yan, Juan|Zheng, Xing-Ling|Wei, Rong-Rui|Zhang, Zhu-Qing|Tang, Shi-Rui|Geng, Mei-Yu|Huang, Xun
PMID: 30224636
163.
Journal: Oncol Rep. 2018 Nov;40(5):3102-3111.
Title: Tanshinone IIA can inhibit MiaPaCa2 human pancreatic cancer cells by dual blockade of the Ras/Raf/MEK/ERK and PI3K/AKT/mTOR pathways.
Author: Su, Chin-Cheng
PMID: 30226540
164.
Journal: Cancer Biol Ther. 2018 Sep 27:1-10.
Title: Combined inhibition of the PI3K/mTOR/MEK pathway induces Bim/Mcl-2-regulated apoptosis in pancreatic cancer cells.
Author: Burmi, Rajpal S|Maginn, Elaina N|Gabra, Hani|Stronach, Euan A|Wasan, Harpreet S
PMID: 30261145
165.
Journal: Am J Cancer Res. 2018 Sep 1;8(9):1812-1822. eCollection 2018.
Title: Preprogramming therapeutic response of PI3K/mTOR dual inhibitor via the regulation of EHMT2 and p27 in pancreatic cancer.
Author: Tian, Yu-Feng|Wang, Hui-Ching|Luo, Chi-Wen|Hung, Wen-Chun|Lin, Yu-Han|Chen, Tzu-Yi|Li, Chien-Feng|Lin, Chen-Yi|Pan, Mei-Ren
PMID: 30323973
166.
Journal: Biomed Pharmacother. 2018 Oct 1;108:1162-1169.
Title: Functions and mechanisms of microRNA-31 in human cancers.
Author: Yu, Tao|Ma, Pei|Wu, Deqin|Shu, Yongqian|Gao, Wen
PMID: 30372817