Primary Site >> Pancreatic Cancer
Gene >> PIK3CD
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Ref: PI-3' kinase and NF-kappaB cross-signaling in human pancreatic cancer cells. PMID: 12086898 |
Ref: Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. PMID: 12481421 Ref: Frequent activation of AKT2 kinase in human pancreatic carcinomas. PMID: 14735903 |
Ref: Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. PMID: 12761494 |
Ref: Role of the phosphatidylinositol 3'-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines. PMID: 15084985 Ref: A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-beta in pancreatic carcinogenesis. PMID: 15184872 |
Ref: Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenograf PMID: 15735038 Ref: Epidermal growth factor mediates detachment from and invasion through collagen I and Matrigel in Capan-1 pancreatic cancer cells. PMID: 15801978 Ref: mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer. PMID: 15851011 Ref: Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway. PMID: 15958516 |
Ref: Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway. PMID: 17043657 Ref: Expression and differential signaling of heregulins in pancreatic cancer cells. PMID: 17096356 Ref: K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling. PMID: 17332339 Ref: Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. PMID: 17353198 Ref: siRNA directed against TrkA sensitizes human pancreatic cancer cells to apoptosis induced by gemcitabine through an inactivation of PI3K/Akt-dependent pathway. PMID: 17671718 |
Ref: Pancreatic cancer cell genetics and signaling response to treatment correlate with efficacy of gemcitabine-based molecular targeting strategies. PMID: 18049840 Ref: ANTI-ADHESION evolves to a promising therapeutic concept in oncology. PMID: 18393855 Ref: Lessons from Tarceva in pancreatic cancer: where are we now, and how should future trials be designed in pancreatic cancer? PMID: 18525343 Ref: Phosphatidylinositol 3-kinase-dependent transcriptional silencing of the translational repressor 4E-BP1. PMID: 18810319 Ref: Apigenin inhibits the GLUT-1 glucose transporter and the phosphoinositide 3-kinase/Akt pathway in human pancreatic cancer cells. PMID: 18953257 Ref: Modulating effect of the PI3-kinase inhibitor LY294002 on cisplatin in human pancreatic cancer cells. PMID: 19032736 Ref: [Phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway is critical for survival and proliferation of pancreatic cancer stem-like side population cells]. PMID: 19080079 |
Ref: Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo. PMID: 18949011 Ref: Pancreatic cancer: translating lessons from mouse models. PMID: 19287100 Ref: Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts. PMID: 19319133 Ref: PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells. PMID: 19437103 Ref: Phosphoinositide 3-kinase inhibitor (wortmannin) inhibits pancreatic cancer cell motility and migration induced by hyaluronan in vitro and peritoneal metastasis in vivo. PMID: 19469020 Ref: PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells. PMID: 19603422 Ref: Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth. PMID: 19610136 |
Ref: IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells. PMID: 19560785 Ref: Inhibition of Notch3 enhances sensitivity to gemcitabine in pancreatic cancer through an inactivation of PI3K/Akt-dependent pathway. PMID: 19816816 Ref: Hypoxia-reoxygenation increase invasiveness of PANC-1 cells through Rac1/MMP-2. PMID: 20153729 Ref: [Effect of anti-cancer drugs on the expression of BIC/miR-155 in human pancreatic cancer PANC-1 cells]. PMID: 20356498 Ref: Insulin-like growth factor-I receptor in proliferation and motility of pancreatic cancer. PMID: 20397262 Ref: Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells. PMID: 20423485 Ref: Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies. PMID: 20630061 Ref: Key role of phosphoinositide 3-kinase class IB in pancreatic cancer. PMID: 20876794 |
Ref: Gemcitabine plus enzastaurin or single-agent gemcitabine in locally advanced or metastatic pancreatic cancer: results of a phase II, randomized, noncomparative study. PMID: 19714296 Ref: Activation of the PI3K/Akt pathway mediates bone morphogenetic protein 2-induced invasion of pancreatic cancer cells Panc-1. PMID: 20848249 Ref: Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway. PMID: 21350002 Ref: Targeting phosphoinositide 3-kinase pathways in pancreatic cancer--from molecular signalling to clinical trials. PMID: 21521159 Ref: The role of phosphatidylinositol 3-kinase signaling pathways in pancreatic cancer. PMID: 21625196 Ref: Mesothelin confers pancreatic cancer cell resistance to TNF-alpha-induced apoptosis through Akt/PI3K/NF-kappaB activation and IL-6/Mcl-1 overexpression. PMID: 21880146 Ref: Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phosphatase 2A inhibitors through overactivation of the c-Jun N-terminal kinase pathway. PMID: 21958460 Ref: Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells. PMID: 21961726 Ref: Ras, PI3K/Akt and senescence: Paradoxes provide clues for pancreatic cancer therapy. PMID: 22292129 Ref: Emerging therapies in pancreas cancer. PMID: 22811835 |
Ref: ZSTK474, a PI3K inhibitor, suppresses proliferation and sensitizes human pancreatic adenocarcinoma cells to gemcitabine. PMID: 21993922 Ref: The efficacy of a novel, dual PI3K/mTOR inhibitor NVP-BEZ235 to enhance chemotherapy and antiangiogenic response in pancreatic cancer. PMID: 22020918 Ref: The dual PI3K/mTOR inhibitor NVP-BGT226 induces cell cycle arrest and regulates Survivin gene expression in human pancreatic cancer cell lines. PMID: 22170433 Ref: VEGF-A/VEGFR-2 signaling plays an important role for the motility of pancreas cancer cells. PMID: 22207048 Ref: Phase I study of Rigosertib, an inhibitor of the phosphatidylinositol 3-kinase and Polo-like kinase 1 pathways, combined with gemcitabine in patients with solid tumors and pancreatic cancer. PMID: 22338014 Ref: Cotargeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancer. PMID: 22411900 Ref: Inhibition of mesothelin as a novel strategy for targeting cancer cells. PMID: 22485139 Ref: Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability. PMID: 22762308 Ref: Grape proanthocyanidin inhibit pancreatic cancer cell growth in vitro and in vivo through induction of apoptosis and by targeting the PI3K/Akt pathway. PMID: 22905202 Ref: K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo. PMID: 22952903 Ref: [Simultaneous inhibition of XIAP and survivin expression on EMT and invasion of human pancreatic cancer cells]. PMID: 23000761 Ref: Transcriptional regulation of the interleukin-11 gene by oncogenic Ras. PMID: 23027619 Ref: Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer. PMID: 23232026 |
Ref: EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin. PMID: 22971992 Ref: Advances in the systemic treatment of neuroendocrine tumors in the era of molecular therapy. PMID: 23092266 Ref: Cucurmosin kills human pancreatic cancer SW-1990 cells in vitro and in vivo. PMID: 23157594 Ref: Synergistic anticancer activity of HS-173, a novel PI3K inhibitor in combination with Sorafenib against pancreatic cancer cells. PMID: 23340175 Ref: MicroRNA-100 regulates IGF1-receptor expression in metastatic pancreatic cancer cells. PMID: 23373509 Ref: LY294002 enhances inhibitory effect of gemcitabine on proliferation of human pancreatic carcinoma PANC-1 cells. PMID: 23392708 Ref: Molecular guided therapy for advanced pancreatic cancer patients with PI3K activated mutation: vision or illusion? PMID: 23450148 Ref: Cytotoxic activity and apoptosis-inducing potential of di-spiropyrrolidino and di-spiropyrrolizidino oxindole andrographolide derivatives. PMID: 23472133 Ref: PI3K/AKT/mTOR signaling is involved in (-)-epigallocatechin-3-gallate-induced apoptosis of human pancreatic carcinoma cells. PMID: 23711146 Ref: miRNAs in insulin resistance and diabetes-associated pancreatic cancer: the 'minute and miracle' molecule moving as a monitor in the 'genomic galaxy'. PMID: 23834149 Ref: Current understanding of the molecular biology of pancreatic neuroendocrine tumors. PMID: 23840053 Ref: The CX3CL1/CX3CR1 reprograms glucose metabolism through HIF-1 pathway in pancreatic adenocarcinoma. PMID: 23857671 Ref: Oncosuppressive suicide gene virotherapy "PVH1-yCD/5-FC" for pancreatic peritoneal carcinomatosis treatment: NFkappaB and Akt/PI3K involvement. PMID: 23967078 Ref: Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models. PMID: 24130864 Ref: PTEN/PI3K/mTOR/B7-H1 signaling pathway regulates cell progression and immuno-resistance in pancreatic cancer. PMID: 24624456 |
Ref: Par-4 downregulation confers cisplatin resistance in pancreatic cancer cells via PI3K/Akt pathway-dependent EMT. PMID: 24144893 Ref: Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-beta to promote proliferation. PMID: 24334458 Ref: High glucose-induced resistance to 5-fluorouracil in pancreatic cancer cells alleviated by 2-deoxy-D-glucose. PMID: 24649094 Ref: Downregulation of mTOR by lentivirus inhibits prostate cancer cell growth. PMID: 24695460 Ref: alpha-Mangostin suppresses the viability and epithelial-mesenchymal transition of pancreatic cancer cells by downregulating the PI3K/Akt pathway. PMID: 24812621 Ref: HS-104, a PI3K inhibitor, enhances the anticancer efficacy of gemcitabine in pancreatic cancer. PMID: 24819705 Ref: The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT. PMID: 24936056 Ref: Anticancer activity of HS-527, a novel inhibitor targeting PI3-kinase in human pancreatic cancer cells. PMID: 25016056 Ref: Nitric oxide increases the invasion of pancreatic cancer cells via activation of the PI3K-AKT and RhoA pathways after carbon ion irradiation. PMID: 25019574 Ref: Expression of Akt kinase-interacting protein 1, a scaffold protein of the PI3K/PDK1/Akt pathway, in pancreatic cancer. PMID: 25036909 Ref: PTEN expression and function in adult cancer stem cells and prospects for therapeutic targeting. PMID: 25088603 Ref: Shikonin promotes autophagy in BXPC-3 human pancreatic cancer cells through the PI3K/Akt signaling pathway. PMID: 25120662 Ref: Emerging role of the KRAS-PDK1 axis in pancreatic cancer. PMID: 25152578 Ref: CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer. PMID: 25156567 Ref: Targeting p110gamma in gastrointestinal cancers: attack on multiple fronts. PMID: 25360116 Ref: Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities. PMID: 25566081 |
Ref: Thymoquinone Pretreatment Overcomes the Insensitivity and Potentiates the Antitumor Effect of Gemcitabine Through Abrogation of Notch1, PI3K/Akt/mTOR Regulated Signaling Pathways in Pancreatic Cancer. PMID: 25344906 Ref: Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer. PMID: 25348516 Ref: Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer. PMID: 25376606 Ref: Synergistic antitumor activity of withaferin A combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the PI3K/AKT pathway in human pancreatic cancer cells. PMID: 25444914 Ref: PBI-05204, a supercritical CO(2) extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway. PMID: 25476893 Ref: A phase Ib dose-escalation study of the oral pan-PI3K inhibitor buparlisib (BKM120) in combination with the oral MEK1/2 inhibitor trametinib (GSK1120212) in patients with selected advanced solid tumors. PMID: 25500057 Ref: Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer. PMID: 25527450 Ref: Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells. PMID: 25632222 Ref: Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells. PMID: 25632225 Ref: Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2. PMID: 25673820 Ref: Genetic variants in the inositol phosphate metabolism pathway and risk of different types of cancer. PMID: 25683757 Ref: Simultaneous silencing of XIAP and survivin causes partial mesenchymal-epithelial transition of human pancreatic cancer cells via the PTEN/PI3K/Akt pathway. PMID: 25707849 Ref: Catechol-O-methyltransferase, a new target for pancreatic cancer therapy. PMID: 25711924 Ref: Longikaurin E induces apoptosis of pancreatic cancer cells via modulation of the p38 and PI3K/AKT pathways by ROS. PMID: 25743573 Ref: Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor. PMID: 25766633 Ref: Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells. PMID: 26035354 Ref: Implication of PI3K/Akt pathway in pancreatic cancer: When PI3K isoforms matter? PMID: 26166735 Ref: Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells. PMID: 26257206 Ref: Repression of CD24 surface protein expression by oncogenic Ras is relieved by inhibition of Raf but not MEK or PI3K. PMID: 26301220 Ref: Integrin alpha6beta4 Promotes Autocrine Epidermal Growth Factor Receptor (EGFR) Signaling to Stimulate Migration and Invasion toward Hepatocyte Growth Factor (HGF). PMID: 26381405 Ref: A phase I trial of mFOLFOX6 combined with the oral PI3K inhibitor BKM120 in patients with advanced refractory solid tumors. PMID: 26490655 Ref: Knockdown of PFTK1 inhibits tumor cell proliferation, invasion and epithelial-to-mesenchymal transition in pancreatic cancer. PMID: 26823712 Ref: Modulatory role of garlicin in migration and invasion of intrahepatic cholangiocarcinoma via PI3K/AKT pathway. PMID: 26823715 |
Ref: Embigin is overexpressed in pancreatic ductal adenocarcinoma and regulates cell motility through epithelial to mesenchymal transition via the TGF-beta pathway. PMID: 25773908 Ref: The effect of PI3K inhibitor LY294002 and gemcitabine hydrochloride combined with ionizing radiation on the formation of vasculogenic mimicry of Panc-1 cells in vitro and in vivo. PMID: 26639237 Ref: Targeting the Janus-activated kinase-2-STAT3 signalling pathway in pancreatic cancer using the HSP90 inhibitor ganetespib. PMID: 26682870 Ref: Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition. PMID: 26804739 Ref: Polycomb complex protein BMI-1 promotes invasion and metastasis of pancreatic cancer stem cells by activating PI3K/AKT signaling, an ex vivo, in vitro, and in vivo study. PMID: 26840020 Ref: Novel Anti-CRR9/CLPTM1L Antibodies with Antitumorigenic Activity Inhibit Cell Surface Accumulation, PI3K Interaction, and Survival Signaling. PMID: 26939707 Ref: Regulation of cell apoptosis and proliferation in pancreatic cancer through PI3K/Akt pathway via Polo-like kinase 1. PMID: 27220401 Ref: Upstream and Downstream Co-inhibition of Mitogen-Activated Protein Kinase and PI3K/Akt/mTOR Pathways in Pancreatic Ductal Adenocarcinoma. PMID: 27435925 Ref: PREX2 promotes the proliferation, invasion and migration of pancreatic cancer cells by modulating the PI3K signaling pathway. PMID: 27446408 Ref: KRAS-related proteins in pancreatic cancer. PMID: 27595930 Ref: Paeoniflorin Potentiates the Inhibitory Effects of Erlotinib in Pancreatic Cancer Cell Lines by Reducing ErbB3 Phosphorylation. PMID: 27609096 Ref: Interplay between cell cycle and autophagy induced by boswellic acid analog. PMID: 27680387 Ref: Downregulation of Smurf2 ubiquitin ligase in pancreatic cancer cells reversed TGF-beta-induced tumor formation. PMID: 27730540 Ref: Wogonin induces Beclin-1/PI3K and reactive oxygen species-mediated autophagy in human pancreatic cancer cells. PMID: 28105213 Ref: Prorenin receptor acts as a potential molecular target for pancreatic ductal adenocarcinoma diagnosis. PMID: 28874965 |
Ref: Hyaluronan carried by tumor-derived microvesicles induces IL-10 production in classical (CD14(++)CD16(-)) monocytes via PI3K/Akt/mTOR-dependent signalling pathway. PMID: 26210045 Ref: Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer? PMID: 27845911 Ref: Effect of Selumetinib and MK-2206 vs Oxaliplatin and Fluorouracil in Patients With Metastatic Pancreatic Cancer After Prior Therapy: SWOG S1115 Study Randomized Clinical Trial. PMID: 27978579 Ref: The anti-tumor effects of the recombinant toxin protein rLj-RGD3 from Lampetra japonica on pancreatic carcinoma Panc-1 cells in nude mice. PMID: 27988354 Ref: Downregulation of the N-myc downstream regulated gene 1 is related to enhanced proliferation, invasion and migration of pancreatic cancer. PMID: 28075464 Ref: Targeting the Akt/PI3K Signaling Pathway as a Potential Therapeutic Strategy for the Treatment of Pancreatic Cancer. PMID: 28176634 Ref: lncRNA MEG3 had anti-cancer effects to suppress pancreatic cancer activity. PMID: 28320094 Ref: Insulin Receptor and GPCR Crosstalk Stimulates YAP via PI3K and PKD in Pancreatic Cancer Cells. PMID: 28360038 Ref: Correlated high expression of FXR and Sp1 in cancer cells confers a poor prognosis for pancreatic cancer: A study based on TCGA and tissue microarray. PMID: 28402278 Ref: The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer. PMID: 28423617 Ref: A blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/Akt/mTOR signaling pathway. PMID: 28442920 Ref: Attenuating PI3K isoforms in pancreatic cancer: Focus on immune PI3Kgamma. PMID: 28583586 Ref: Lack of growth inhibitory synergism with combined MAPK/PI3K inhibition in preclinical models of pancreatic cancer. PMID: 28666315 Ref: Mechanistic Evaluation and Translational Signature of Gemcitabine-induced Chemoresistance by Quantitative Phosphoproteomics Analysis with iTRAQ Labeling Mass Spectrometry. PMID: 29018223 Ref: Ginsenoside Rg3 enhances the anti-proliferative activity of erlotinib in pancreatic cancer cell lines by downregulation of EGFR/PI3K/Akt signaling pathway. PMID: 29035827 Ref: PI3K/AKT/mTOR Pathway in Ovarian Cancer Treatment: Are We on the Right Track? PMID: 29093603 Ref: Combined treatment of pancreatic cancer xenograft with (90)Y-ITGA6B4-mediated radioimmunotherapy and PI3K/mTOR inhibitor. PMID: 29204055 Ref: Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling. PMID: 29262554 Ref: Brucein D, a Naturally Occurring Tetracyclic Triterpene Quassinoid, Induces Apoptosis in Pancreatic Cancer through ROS-Associated PI3K/Akt Signaling Pathway. PMID: 29311937 Ref: Radiosensitization of the PI3K inhibitor HS-173 through reduction of DNA damage repair in pancreatic cancer. PMID: 29348875 |
Ref: S100A11 promotes human pancreatic cancer PANC-1 cell proliferation and is involved in the PI3K/AKT signaling pathway. PMID: 29375710 Ref: Phosphoglycerate Mutase 1 (PGAM1) Promotes Pancreatic Ductal Adenocarcinoma (PDAC) Metastasis by Acting as a Novel Downstream Target of the PI3K/Akt/mTOR Pathway. PMID: 29386088 Ref: Metformin influences drug sensitivity in pancreatic cancer cells. PMID: 29482945 Ref: Curcumin inhibits superoxide dismutase-induced epithelial-to-mesenchymal transition via the PI3K/Akt/NF-kappaB pathway in pancreatic cancer cells. PMID: 29512729 Ref: A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology. PMID: 29757973 Ref: Girdin regulates the proliferation and apoptosis of pancreatic cancer cells via the PI3K/Akt signalling pathway. PMID: 29901184 Ref: Anticancer effect of HOTTIP regulates human pancreatic cancer via the metabotropic glutamate receptor 1 pathway. PMID: 30008887 Ref: Hotspot DAXX, PTCH2 and CYFIP2 mutations in pancreatic neuroendocrine neoplasms. PMID: 30021865 Ref: Mitofusin2 Induces Cell Autophagy of Pancreatic Cancer through Inhibiting the PI3K/Akt/mTOR Signaling Pathway. PMID: 30046371 Ref: NOX4, A New Genetic Target for Anti-cancer Therapy in Digestive System Cancer. PMID: 30058122 Ref: Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations. PMID: 30206226 Ref: KRAS targeting antibody synergizes anti-cancer activity of gemcitabine against pancreatic cancer. PMID: 30217561 Ref: CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression. PMID: 30224636 Ref: Tanshinone IIA can inhibit MiaPaCa2 human pancreatic cancer cells by dual blockade of the Ras/Raf/MEK/ERK and PI3K/AKT/mTOR pathways. PMID: 30226540 Ref: Combined inhibition of the PI3K/mTOR/MEK pathway induces Bim/Mcl-2-regulated apoptosis in pancreatic cancer cells. PMID: 30261145 Ref: Preprogramming therapeutic response of PI3K/mTOR dual inhibitor via the regulation of EHMT2 and p27 in pancreatic cancer. PMID: 30323973 Ref: Functions and mechanisms of microRNA-31 in human cancers. PMID: 30372817 |