Literatures

Primary Site >> Colorectal Cancer

Gene >> PIK3CD

1.
Journal:	Gastroenterology. 2001 May;120(6):1381-92.
Title:	Inhibition of the phosphatidylinositol 3-kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation.
Author:	Wang, Q\|Wang, X\|Hernandez, A\|Kim, S\|Evers, B M
PMID:	11313308

2.
Journal:	Clin Cancer Res. 2002 Jun;8(6):1940-7.
Title:	Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3'-kinase inhibition in the KM20 human colon cancer cell line.
Author:	Wang, Qingding\|Li, Nan\|Wang, Xiaofu\|Kim, Myung M\|Evers, B Mark
PMID:	12060639

3.
Journal:	Clin Cancer Res. 2002 Jun;8(6):1957-63.
Title:	The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells.
Author:	Semba, Shuho\|Itoh, Nanami\|Ito, Masafumi\|Harada, Masaru\|Yamakawa, Mitsunori
PMID:	12060641

4.
Journal:	Semin Oncol. 2003 Jun;30(3 Suppl 6):56-67.
Title:	Signaling inhibition with radiation in colorectal cancer: clinical trials.
Author:	McKenna, W Gillies\|Muschel, Ruth J\|Gupta, Anjali\|Hahn, Stephen\|Bernhard, Eric J
PMID:	12802796

5.
Journal:	J Nutr. 2003 Aug;133(8):2675-81.
Title:	Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells.
Author:	Kim, Eun Ji\|Kang, Il-Jun\|Cho, Han Jin\|Kim, Woo Kyoung\|Ha, Yeong-Lae\|Park, Jung Han Yoon
PMID:	12888657

6.
Journal:	Cancer Res. 2004 Jan 1;64(1):229-35.
Title:	Roles of phosphatidylinositol 3'-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells.
Author:	Shao, Jinyi\|Evers, B Mark\|Sheng, Hongmiao
PMID:	14729629

7.
Journal:	Cancer Res. 2004 Apr 1;64(7):2601-9.
Title:	Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects.
Author:	Jackson, James G\|St Clair, Patricia\|Sliwkowski, Mark X\|Brattain, Michael G
PMID:	15059917

8.
Journal:	Steroids. 2004 Aug;69(8-9):517-22.
Title:	Rapid signalling pathway activation by androgens in epithelial and stromal cells.
Author:	Castoria, Gabriella\|Lombardi, Maria\|Barone, Maria Vittoria\|Bilancio, Antonio\|Di Domenico, Marina\|De Falco, Antonietta\|Varricchio, Lilian\|Bottero, Daniela\|Nanayakkara, Merlin\|Migliaccio, Antimo\|Auricchio, Ferdinando
PMID:	15288763

9.
Journal:	Blood. 2005 Feb 15;105(4):1734-41. Epub 2004 Oct 19.
Title:	Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis.
Author:	Yu, Joanne L\|May, Linda\|Lhotak, Vladimir\|Shahrzad, Siranoush\|Shirasawa, Senji\|Weitz, Jeffrey I\|Coomber, Brenda L\|Mackman, Nigel\|Rak, Janusz W
PMID:	15494427

10.
Journal:	J Biol Chem. 2005 Apr 8;280(14):13538-44.
Title:	The pro-inflammatory mediator leukotriene D4 induces phosphatidylinositol 3-kinase and Rac-dependent migration of intestinal epithelial cells.
Author:	Paruchuri, Sailaja\|Broom, Oliver\|Dib, Karim\|Sjolander, Anita
PMID:	15657050

11.
Journal:	Mol Cancer Ther. 2005 Feb;4(2):243-55.
Title:	H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.
Author:	Caron, Ruben W\|Yacoub, Adly\|Zhu, Xiaoyu\|Mitchell, Clint\|Han, Song Iy\|Sasazuki, Takehiko\|Shirasawa, Senji\|Hagan, Michael P\|Grant, Steven\|Dent, Paul
PMID:	15713896

12.
Journal:	Carcinogenesis. 2005 Jul;26(7):1207-14.
Title:	Transformation of immortalized colorectal crypt cells by microcystin involving constitutive activation of Akt and MAPK cascade.
Author:	Zhu, Yongliang\|Zhong, Xian\|Zheng, Shu\|Ge, Zhen\|Du, Qin\|Zhang, Suzhang
PMID:	15774489

13.
Journal:	J Cell Biochem. 2005 Sep 1;96(1):155-69.
Title:	Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells.
Author:	Liao, Chiung-Ho\|Sang, Shengmin\|Ho, Chi-Tang\|Lin, Jen-Kun
PMID:	16052481

14.
Journal:	Am J Pathol. 2005 Sep;167(3):761-73.
Title:	Membrane rafts segregate pro- from anti-apoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily.
Author:	Remacle-Bonnet, Maryse\|Garrouste, Francoise\|Baillat, Gilbert\|Andre, Frederic\|Marvaldi, Jacques\|Pommier, Gilbert
PMID:	16127155

15.
Journal:	Cancer Res. 2005 Nov 1;65(21):9899-905.
Title:	Focal adhesion kinase regulates syndecan-2-mediated tumorigenic activity of HT1080 fibrosarcoma cells.
Author:	Park, Haein\|Han, Innoc\|Kwon, Ho Jeong\|Oh, Eok-Soo
PMID:	16267014

16.
Journal:	Cancer Res. 2006 Feb 15;66(4):2376-84.
Title:	Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway.
Author:	Yamaguchi, Kiyoshi\|Lee, Seong-Ho\|Kim, Jong-Sik\|Wimalasena, Jay\|Kitajima, Shigetaka\|Baek, Seung Joon
PMID:	16489044

17.
Journal:	World J Gastroenterol. 2006 Mar 28;12(12):1859-64.
Title:	Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells.
Author:	Ferrand, Audrey\|Kowalski-Chauvel, Aline\|Pannequin, Julie\|Bertrand, Claudine\|Fourmy, Daniel\|Dufresne, Marlene\|Seva, Catherine
PMID:	16609991

18.
Journal:	FEBS Lett. 2006 Dec 11;580(28-29):6565-9.
Title:	Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells.
Author:	Vaculova, Alena\|Hofmanova, Jirina\|Soucek, Karel\|Kozubik, Alois
PMID:	17113582

19.
Journal:	Biochem Pharmacol. 2007 Jan 1;73(1):68-76. Epub 2006 Sep 19.
Title:	Elevated gadd153/chop expression during resveratrol-induced apoptosis in human colon cancer cells.
Author:	Woo, Kyung Jin\|Lee, Tae Jin\|Lee, Sang Han\|Lee, Jin-Man\|Seo, Ji-Hyung\|Jeong, Yong-Jin\|Park, Jong-Wook\|Kwon, Taeg Kyu
PMID:	17049495

20.
Journal:	Br J Surg. 2007 Jan;94(1):106-12.
Title:	Mechanisms of endothelin 1-stimulated proliferation in colorectal cancer cell lines.
Author:	Grant, K\|Knowles, J\|Dawas, K\|Burnstock, G\|Taylor, I\|Loizidou, M
PMID:	17078114

21.
Journal:	Cancer Res. 2007 Apr 1;67(7):2922-6.
Title:	PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition.
Author:	Wang, Haihe\|Quah, Samantha Yiling\|Dong, Jing Ming\|Manser, Edward\|Tang, Jing Ping\|Zeng, Qi
PMID:	17409395

22.
Journal:	Dig Dis Sci. 2007 Sep;52(9):2292-300. Epub 2007 Apr 5.
Title:	Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway.
Author:	Yasuda, Akira\|Sawai, Hirozumi\|Takahashi, Hiroki\|Ochi, Nobuo\|Matsuo, Yoichi\|Funahashi, Hitoshi\|Sato, Mikinori\|Okada, Yuji\|Takeyama, Hiromitsu\|Manabe, Tadao
PMID:	17410437

23.
Journal:	Chin Med J (Engl). 2007 May 5;120(9):743-8.
Title:	Inducing effects of hepatocyte growth factor on the expression of vascular endothelial growth factor in human colorectal carcinoma cells through MEK and PI3K signaling pathways.
Author:	Zhang, Yu-hua\|Wei, Wei\|Xu, Hao\|Wang, Yan-yan\|Wu, Wen-xi
PMID:	17531111

24.
Journal:	Biochim Biophys Acta. 2007 Aug;1770(8):1194-203. Epub 2007 May 3.
Title:	Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylation of Bad.
Author:	Rusovici, Raluca\|Ghaleb, Amr\|Shim, Hyunsuk\|Yang, Vincent W\|Yun, C Chris
PMID:	17544220

25.
Journal:	Mol Pharmacol. 2007 Sep;72(3):704-14. Epub 2007 Jun 19.
Title:	Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling.
Author:	Mitchell, Clint\|Kabolizadeh, Peyman\|Ryan, John\|Roberts, John D\|Yacoub, Adly\|Curiel, David T\|Fisher, Paul B\|Hagan, Michael P\|Farrell, Nicholas P\|Grant, Steven\|Dent, Paul
PMID:	17578896

26.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G673-81.
Title:	PGE2 inhibits apoptosis in human adenocarcinoma Caco-2 cell line through Ras-PI3K association and cAMP-dependent kinase A activation.
Author:	Leone, Vincenza\|di Palma, Antonella\|Ricchi, Paolo\|Acquaviva, Fabio\|Giannouli, Maria\|Di Prisco, Anna Maria\|Iuliano, Francesca\|Acquaviva, Angela M
PMID:	17640974

27.
Journal:	Zhonghua Zhong Liu Za Zhi. 2007 May;29(5):325-8.
Title:	[Effect of lipoteichoic acid of Bifidobacterium on survivin and its regulatory genes].
Author:	Wang, Yue\|Mai, Tao\|Liu, Ming-fang\|Chen, Shu-hui
PMID:	17892124

28.
Journal:	Mol Carcinog. 2008 Apr;47(4):264-74.
Title:	Retinol decreases phosphatidylinositol 3-kinase activity in colon cancer cells.
Author:	Park, Eun Young\|Wilder, Erik T\|Chipuk, Joseph E\|Lane, Michelle A
PMID:	17918208

29.
Journal:	Curr Med Chem. 2008;15(10):978-90.
Title:	ANTI-ADHESION evolves to a promising therapeutic concept in oncology.
Author:	Schmidmaier, R\|Baumann, P
PMID:	18393855

30.
Journal:	Am J Surg. 2008 Jun;195(6):719-25.
Title:	Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: is PTEN loss predictor of local recurrence?
Author:	Colakoglu, Tamer\|Yildirim, Sedat\|Kayaselcuk, Fazilet\|Nursal, Tarik Zafer\|Ezer, Ali\|Noyan, Turgut\|Karakayali, Hamdi\|Haberal, Mehmet
PMID:	18440486

31.
Journal:	Am J Health Syst Pharm. 2008 Jun 1;65(11 Suppl 4):S15-21; quiz S22-4.
Title:	Current and emerging therapies for metastatic colorectal cancer: applying research findings to clinical practice.
Author:	Hecht, J Randolph
PMID:	18499885

32.
Journal:	Curr Opin Oncol. 2008 Jul;20(4):454-8.
Title:	Lessons from Tarceva in pancreatic cancer: where are we now, and how should future trials be designed in pancreatic cancer?
Author:	Laurent-Puig, Pierre\|Taieb, Julien
PMID:	18525343

33.
Journal:	J Proteome Res. 2008 Aug;7(8):3507-15.
Title:	Evaluation of hepatic-metastasis risk of colorectal cancer upon the protein signature of PI3K/AKT pathway.
Author:	Kang, Bin\|Hao, Chunyi\|Wang, Hongyi\|Zhang, Jun\|Xing, Rui\|Shao, Jianmin\|Li, Wenmei\|Xu, Ningzhi\|Lu, Youyong\|Liu, Siqi
PMID:	18570457

34.
Journal:	Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 May;39(3):364-7.
Title:	[Effects of PI3K signaling pathway on pathogenesis of ulcerative colitis].
Author:	Huang, Xiao-Li\|Zheng, Yu-Xia\|Liao, Zai-Bo\|Yin, Jing\|Gan, Hua-Tian
PMID:	18575316

35.
Journal:	Biol Chem. 2008 Jun;389(6):757-64.
Title:	Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells.
Author:	Henkhaus, Rebecca S\|Gerner, Eugene W\|Ignatenko, Natalia A
PMID:	18627290

36.
Journal:	J Cell Biochem. 2008 Oct 1;105(2):546-53.
Title:	Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) through inhibiting protein synthesis.
Author:	Lee, Dae-Hee\|Lee, Yong J
PMID:	18655183

37.
Journal:	Exp Cell Res. 2008 Oct 1;314(16):3017-26.
Title:	Hyperosmotic stress up-regulates the expression of major vault protein in SW620 human colon cancer cells.
Author:	Ikeda, Ryuji\|Iwashita, Ken-ichi\|Sumizawa, Tomoyuki\|Beppu, Shun-ichi\|Tabata, Sho\|Tajitsu, Yusuke\|Shimamoto, Yuichi\|Yoshida, Kenichi\|Furukawa, Tatsuhiko\|Che, Xiao-Fang\|Yamaguchi, Tatsuya\|Ushiyama, Mina\|Miyawaki, Akihiko\|Takeda, Yasuo\|Yamamoto, Masatatsu\|Zha
PMID:	18671966

38.
Journal:	Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13057-62.
Title:	PTEN-deficient cancers depend on PIK3CB.
Author:	Wee, Susan\|Wiederschain, Dmitri\|Maira, Sauveur-Michel\|Loo, Alice\|Miller, Christine\|deBeaumont, Rosalie\|Stegmeier, Frank\|Yao, Yung-Mae\|Lengauer, Christoph
PMID:	18755892

39.
Journal:	Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13427-32.
Title:	Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity.
Author:	Vermeulen, L\|Todaro, M\|de Sousa Mello, F\|Sprick, M R\|Kemper, K\|Perez Alea, M\|Richel, D J\|Stassi, G\|Medema, J P
PMID:	18765800

40.
Journal:	Cancer Biol Ther. 2008 Oct;7(10):1694-9. Epub 2008 Oct 22.
Title:	TGFbeta modulates PTEN expression independently of SMAD signaling for growth proliferation in colon cancer cells.
Author:	Chow, Jimmy Y C\|Cabral, Jennifer A\|Chang, Jessica\|Carethers, John M
PMID:	18769113

41.
Journal:	Cancer Res. 2008 Oct 1;68(19):8004-13.
Title:	Heterogeneity of receptor function in colon carcinoma cells determined by cross-talk between type I insulin-like growth factor receptor and epidermal growth factor receptor.
Author:	Hu, Yi Peter\|Patil, Sandip B\|Panasiewicz, Michelle\|Li, Wenhui\|Hauser, Jennie\|Humphrey, Lisa E\|Brattain, Michael G
PMID:	18829558

42.
Journal:	Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20315-20.
Title:	Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis.
Author:	Rychahou, Piotr G\|Kang, JungHee\|Gulhati, Pat\|Doan, Hung Q\|Chen, L Andy\|Xiao, Shu-Yuan\|Chung, Dai H\|Evers, B Mark
PMID:	19075230

43.
Journal:	Recent Pat Biotechnol. 2008;2(3):181-7.
Title:	ErbB antagonists patenting: "playing chess with cancer".
Author:	Aifa, Sami\|Rebai, Ahmed
PMID:	19075865

44.
Journal:	Ann Oncol. 2009 Jan;20(1):84-90.
Title:	PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients.
Author:	Perrone, F\|Lampis, A\|Orsenigo, M\|Di Bartolomeo, M\|Gevorgyan, A\|Losa, M\|Frattini, M\|Riva, C\|Andreola, S\|Bajetta, E\|Bertario, L\|Leo, E\|Pierotti, M A\|Pilotti, S
PMID:	18669866

45.
Journal:	J Cell Biochem. 2009 Apr 15;106(6):1113-22.
Title:	Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells.
Author:	Lee, Dae-Hee\|Szczepanski, Miroslaw-Jerzy\|Lee, Yong J
PMID:	19229860

46.
Journal:	Drug Resist Updat. 2009 Jun;12(3):55-64.
Title:	Targeting apoptosis as an approach for gastrointestinal cancer therapy.
Author:	Qiao, Liang\|Wong, Benjamin C Y
PMID:	19278896

47.
Journal:	Cancer Lett. 2009 Aug 28;281(2):162-70.
Title:	Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells.
Author:	Xavier, Cristina P R\|Lima, Cristovao F\|Preto, Ana\|Seruca, Raquel\|Fernandes-Ferreira, Manuel\|Pereira-Wilson, Cristina
PMID:	19344998

48.
Journal:	Int J Cancer. 2009 Jul 15;125(2):297-307.
Title:	Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.
Author:	Zhang, Hui-Hua\|Walker, Francesca\|Kiflemariam, Sara\|Whitehead, Robert H\|Williams, David\|Phillips, Wayne A\|Mikeska, Thomas\|Dobrovic, Alexander\|Burgess, Antony W
PMID:	19378335

49.
Journal:	IUBMB Life. 2009 Jun;61(6):685-92.
Title:	Tax1 enhances cancer cell proliferation via Ras-Raf-MEK-ERK signaling pathway.
Author:	Song, Chunjiao\|Wang, Weimin\|Li, Meng\|Liu, Yanxin\|Zheng, Dexian
PMID:	19472191

50.
Journal:	J Cell Physiol. 2009 Oct;221(1):189-94.
Title:	Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells.
Author:	Cascio, Sandra\|Ferla, Rita\|D'Andrea, Aleco\|Gerbino, Aldo\|Bazan, Viviana\|Surmacz, Eva\|Russo, Antonio
PMID:	19492417

51.
Journal:	Cancer Biol Ther. 2009 Jul;8(14):1313-7. Epub 2009 Jul 11.
Title:	The signal pathways in azoxymethane-induced colon cancer and preventive implications.
Author:	Chen, Jiezhong\|Huang, Xu-Feng
PMID:	19502780

52.
Journal:	Carcinogenesis. 2009 Nov;30(11):1832-40.
Title:	Leptin receptor expression in Middle Eastern colorectal cancer and its potential clinical implication.
Author:	Uddin, Shahab\|Bavi, Prashant P\|Hussain, Azhar R\|Alsbeih, Ghazi\|Al-Sanea, Nasser\|Abduljabbar, Alaa\|Ashari, Luai H\|Alhomoud, Samar\|Al-Dayel, Fouad\|Ahmed, Maqbool\|Al-Kuraya, Khawla S
PMID:	19520793

53.
Journal:	Obes Rev. 2009 Nov;10(6):610-6.
Title:	Obesity, the PI3K/Akt signal pathway and colon cancer.
Author:	Huang, X-F\|Chen, J-Z
PMID:	19527447

54.
Journal:	Cancer Sci. 2009 Oct;100(10):1801-8.
Title:	DIXDC1 targets p21 and cyclin D1 via PI3K pathway activation to promote colon cancer cell proliferation.
Author:	Wang, Lei\|Cao, Xi-Xi\|Chen, Qi\|Zhu, Teng-Fang\|Zhu, Hong-Guang\|Zheng, Li
PMID:	19572978

55.
Journal:	Anticancer Res. 2009 Jul;29(7):2473-8.
Title:	Toll-like receptor 4 activation increases Akt phosphorylation in colon cancer cells.
Author:	Doan, Hung Q\|Bowen, Kanika A\|Jackson, Lindsey A\|Evers, B Mark
PMID:	19596916

56.
Journal:	Int J Cancer. 2009 Nov 15;125(10):2332-41.
Title:	Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines.
Author:	Balmanno, Kathryn\|Chell, Simon D\|Gillings, Annette S\|Hayat, Shaista\|Cook, Simon J
PMID:	19637312

57.
Journal:	Carcinogenesis. 2009 Oct;30(10):1796-804.
Title:	HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells.
Author:	Moore, Amy E\|Greenhough, Alexander\|Roberts, Heather R\|Hicks, Diane J\|Patsos, Helena A\|Williams, Ann C\|Paraskeva, Christos
PMID:	19638428

58.
Journal:	Carcinogenesis. 2009 Oct;30(10):1670-7.
Title:	Oncogenic Ras, but not (V600E)B-RAF, protects from cholesterol depletion-induced apoptosis through the PI3K/AKT pathway in colorectal cancer cells.
Author:	Calleros, Laura\|Sanchez-Hernandez, Irene\|Baquero, Pablo\|Toro, Maria Jose\|Chiloeches, Antonio
PMID:	19700418

59.
Journal:	Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Jul;40(4):644-6, 654.
Title:	[The relationship between PTEN expression and PI3K/AKT signal pathway in colon carcinoma].
Author:	Qi, Jian-Kang\|Huang, Xiao-Li\|Meng, Zhang-Ming\|Gan, Hua-Tian\|Fu, Dai-Gang
PMID:	19764563

60.
Journal:	Nutr Cancer. 2009;61(4):564-71.
Title:	Salvia fruticosa, Salvia officinalis, and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines: the role in MAPK/ERK pathway.
Author:	Xavier, Cristina P R\|Lima, Cristovao F\|Fernandes-Ferreira, Manuel\|Pereira-Wilson, Cristina
PMID:	19838929

61.
Journal:	Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Nov;40(6):1021-3, 1052.
Title:	[Change from inflammation to carcinoma in ulcerative colitis: the role of PTEN/PI3K/AKT].
Author:	Fu, Dai-Gang\|Huang, Xiao-Li\|Gan, Hua-Tian\|Zhang, De-Kui\|Zhao, Li-Qiang
PMID:	20067111

62.
Journal:	Int J Cancer. 2010 Jun 15;126(12):2847-57.
Title:	A gastrin precursor, gastrin-gly, upregulates VEGF expression in colonic epithelial cells through an HIF-1-independent mechanism.
Author:	Bertrand, Claudine\|Kowalski-Chauvel, Aline\|Do, Catherine\|Resa, Cecile\|Najib, Souad\|Daulhac, Laurence\|Wang, Timothy C\|Ferrand, Audrey\|Seva, Catherine
PMID:	19876923

63.
Journal:	Mol Carcinog. 2010 Mar;49(3):235-46.
Title:	The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells.
Author:	Yan, Kun-Huang\|Yao, Chih-Jung\|Chang, Hwan-You\|Lai, Gi-Ming\|Cheng, Ann-Lii\|Chuang, Shuang-En
PMID:	19908241

64.
Journal:	Int J Cancer. 2010 Sep 1;127(6):1321-31.
Title:	Additional value of EGFR downstream signaling phosphoprotein expression to KRAS status for response to anti-EGFR antibodies in colorectal cancer.
Author:	Perkins, Geraldine\|Lievre, Astrid\|Ramacci, Carole\|Meatchi, Tchao\|de Reynies, Aurelien\|Emile, Jean-Francois\|Boige, Valerie\|Tomasic, Gorana\|Bachet, Jean-Baptiste\|Bibeau, Frederic\|Bouche, Olivier\|Penault-Llorca, Frederique\|Merlin, Jean-Louis\|Laurent-Puig, Pi
PMID:	20049837

65.
Journal:	Br J Surg. 2010 Mar;97(3):317-27.
Title:	Randomized clinical trial to compare the effects of preoperative oral carbohydrate versus placebo on insulin resistance after colorectal surgery.
Author:	Wang, Z G\|Wang, Q\|Wang, W J\|Qin, H L
PMID:	20101593

66.
Journal:	Int J Oncol. 2010 Mar;36(3):689-98.
Title:	REG4 acts as a mitogenic, motility and pro-invasive factor for colon cancer cells.
Author:	Rafa, Louisa\|Dessein, Anne-Frederique\|Devisme, Louise\|Buob, David\|Truant, Stephanie\|Porchet, Nicole\|Huet, Guillemette\|Buisine, Marie-Pierre\|Lesuffleur, Thecla
PMID:	20126989

67.
Journal:	Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2598-603.
Title:	Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.
Author:	Ericson, Kajsa\|Gan, Christine\|Cheong, Ian\|Rago, Carlo\|Samuels, Yardena\|Velculescu, Victor E\|Kinzler, Kenneth W\|Huso, David L\|Vogelstein, Bert\|Papadopoulos, Nickolas
PMID:	20133737

68.
Journal:	J Agric Food Chem. 2010 Mar 10;58(5):2935-42.
Title:	Benzyl isothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway.
Author:	Lai, Kuang-Chi\|Huang, An-Cheng\|Hsu, Shu-Chun\|Kuo, Chao-Lin\|Yang, Jai-Sing\|Wu, Shin-Hwar\|Chung, Jing-Gung
PMID:	20136087

69.
Journal:	Mol Aspects Med. 2010 Apr;31(2):171-8.
Title:	The molecular therapy of colorectal cancer.
Author:	Waldner, Maximilian J\|Neurath, Markus F
PMID:	20171980

70.
Journal:	Mol Cancer Res. 2010 Mar;8(3):421-32.
Title:	3-phosphoinositide-dependent protein kinase-1 regulates proliferation and survival of cancer cells with an activated mitogen-activated protein kinase pathway.
Author:	Lu, Zhuomei\|Cox-Hipkin, Mary Ann\|Windsor, William T\|Boyapati, Anita
PMID:	20197379

71.
Journal:	Int J Oncol. 2010 Apr;36(4):941-53.
Title:	Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway.
Author:	Lee, Hwa Young\|Crawley, Suzanne\|Hokari, Ryota\|Kwon, Sungwon\|Kim, Young S
PMID:	20198339

72.
Journal:	J Cancer Res Clin Oncol. 2010 Nov;136(11):1773-82.
Title:	PI3K/Akt and GSK-3beta prevents in a differential fashion the malignant phenotype of colorectal cancer cells.
Author:	de Araujo, Wallace Martins\|Vidal, Flavia Castello Branco\|de Souza, Waldemir Fernandes\|de Freitas, Julio Cesar Madureira Jr\|de Souza, Wanderley\|Morgado-Diaz, Jose Andres
PMID:	20204404

73.
Journal:	Anticancer Res. 2010 Mar;30(3):799-804.
Title:	Rapamycin-mediated FOXO1 inactivation reduces the anticancer efficacy of rapamycin.
Author:	Abdelnour-Berchtold, Etienne\|Cerantola, Yannick\|Roulin, Didier\|Dormond-Meuwly, Anne\|Demartines, Nicolas\|Dormond, Olivier
PMID:	20392999

74.
Journal:	Cancer Res. 2010 May 1;70(9):3677-86.
Title:	Molecular target class is predictive of in vitro response profile.
Author:	Greshock, Joel\|Bachman, Kurtis E\|Degenhardt, Yan Y\|Jing, Junping\|Wen, Yuan H\|Eastman, Stephen\|McNeil, Elizabeth\|Moy, Christopher\|Wegrzyn, Ronald\|Auger, Kurt\|Hardwicke, Mary Ann\|Wooster, Richard
PMID:	20406975

75.
Journal:	Cancer J. 2010 May-Jun;16(3):196-201.
Title:	Biology of colorectal cancer.
Author:	Saif, Muhammad Wasif\|Chu, Edward
PMID:	20526096

76.
Journal:	Clin Cancer Res. 2010 Aug 1;16(15):3811-8.
Title:	New strategies in colorectal cancer: biomarkers of response to epidermal growth factor receptor monoclonal antibodies and potential therapeutic targets in phosphoinositide 3-kinase and mitogen-activated protein kinase pathways.
Author:	Dasari, Arvind\|Messersmith, Wells A
PMID:	20554751

77.
Journal:	J Biol Chem. 2010 Aug 13;285(33):25458-66.
Title:	Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression.
Author:	Chen, Jinn-Shiun\|Hsu, Yuan-Ming\|Chen, Chia-Chi\|Chen, Li-Li\|Lee, Chun-Chung\|Huang, Tze-Sing
PMID:	20558745

78.
Journal:	Arch Toxicol. 2010 Sep;84(9):731-40.
Title:	EP4 upregulation of Ras signaling and feedback regulation of Ras in human colon tissues and cancer cells.
Author:	Wu, Cheng-Hsun\|Shih, Yuan-Wei\|Chang, Chun-Hua\|Ou, Ting-Tsz\|Huang, Chi-Chou\|Hsu, Jeng-Dong\|Wang, Chau-Jong
PMID:	20571779

79.
Journal:	Curr Cancer Drug Targets. 2010 Dec;10(8):824-33.
Title:	Strategies for overcoming inherent and acquired resistance to EGFR inhibitors by targeting downstream effectors in the RAS/PI3K pathway.
Author:	Weickhardt, Andrew J\|Tebbutt, Niall C\|Mariadason, John M
PMID:	20718704

80.
Journal:	Nan Fang Yi Ke Da Xue Xue Bao. 2010 Aug;30(8):1817-9, 1823.
Title:	[Effect of anti-EGFR monoclonal antibody on chemosensitivity of human colon cancer cells and the mechanism].
Author:	Cao, Meng-ran\|Li, Xiao-yan\|Zheng, Da-yong\|Yang, Lin\|Lv, Cheng-wei\|Luo, Rong-cheng
PMID:	20813673

81.
Journal:	J Agric Food Chem. 2010 Oct 27;58(20):11148-55.
Title:	Phenethyl isothiocyanate inhibited tumor migration and invasion via suppressing multiple signal transduction pathways in human colon cancer HT29 cells.
Author:	Lai, Kuang-Chi\|Hsu, Shu-Chun\|Kuo, Chao-Lin\|Ip, Siu-Wan\|Yang, Jai-Sing\|Hsu, Yuan-Man\|Huang, Hui-Ying\|Wu, Shin-Hwar\|Chung, Jing-Gung
PMID:	20863062

82.
Journal:	Mol Cancer Ther. 2010 Dec;9(12):3158-63.
Title:	Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis.
Author:	Dumstorf, Chad A\|Konicek, Bruce W\|McNulty, Ann M\|Parsons, Stephen H\|Furic, Luc\|Sonenberg, Nahum\|Graff, Jeremy R
PMID:	20971826

83.
Journal:	Anal Cell Pathol (Amst). 2010;33(5):229-44.
Title:	Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL.
Author:	Pennarun, Bodvael\|Kleibeuker, Jan H\|Oenema, Tjitske\|Stegehuis, Janet H\|de Vries, Elisabeth G E\|de Jong, Steven
PMID:	20978316

84.
Journal:	Cancer Cell. 2010 Nov 16;18(5):459-71.
Title:	B55beta-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer.
Author:	Tan, Jing\|Lee, Puay Leng\|Li, Zhimei\|Jiang, Xia\|Lim, Yaw Chyn\|Hooi, Shing Chuan\|Yu, Qiang
PMID:	21075311

85.
Journal:	Oncology. 2010;79(3-4):278-82.
Title:	Clinical significance of genetic variations in the PI3K/PTEN/AKT/mTOR pathway in Korean patients with colorectal cancer.
Author:	Kim, Jong Gwang\|Chae, Yee Soo\|Sohn, Sang Kyun\|Kang, Byung Woog\|Moon, Joon Ho\|Lee, Soo Jung\|Jeon, Seong Woo\|Park, Jun Seok\|Park, Jin Young\|Choi, Gyu Seog
PMID:	21412012

86.
Journal:	Inflamm Bowel Dis. 2011 May;17(5):1177-88.
Title:	DMBT1 is a novel gene induced by IL-22 in ulcerative colitis.
Author:	Fukui, Hirokazu\|Sekikawa, Akira\|Tanaka, Hiroyuki\|Fujimori, Yukari\|Katake, Yoshinori\|Fujii, Shigehiko\|Ichikawa, Kazuhito\|Tomita, Shigeki\|Imura, Johji\|Chiba, Tsutomu\|Fujimori, Takahiro
PMID:	20824812

87.
Journal:	Pathol Oncol Res. 2011 Jun;17(2):257-61.
Title:	Activation of the PI3K/Akt pathway mediates bone morphogenetic protein 2-induced invasion of pancreatic cancer cells Panc-1.
Author:	Chen, Xiong\|Liao, Jie\|Lu, YeBin\|Duan, XiaoHui\|Sun, WeiJia
PMID:	20848249

88.
Journal:	J Cell Physiol. 2011 Apr;226(4):1060-8.
Title:	Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1alpha translational pathway in colorectal cancer cells.
Author:	Chang, Li-Hsun\|Chen, Chun-Han\|Huang, Der-Yi\|Pai, Hui-Chen\|Pan, Shiow-Lin\|Teng, Che-Ming
PMID:	20857420

89.
Journal:	Eur J Clin Invest. 2011 Mar;41(3):277-84.
Title:	Anti-interleukin-6 receptor antibody inhibits the progression in human colon carcinoma cells.
Author:	Hsu, Chih-Ping\|Chen, Yung-Liang\|Huang, Chiu-Chen\|Chou, Chih-Chung\|Liu, Chia-Ling\|Hung, Chih-Hung\|Kao, Ting-Yu\|Chung, Yuan-Chiang
PMID:	21114487

90.
Journal:	Cancer Res. 2011 Jan 1;71(1):206-15.
Title:	Activation and involvement of Ral GTPases in colorectal cancer.
Author:	Martin, Timothy D\|Samuel, Jonathan C\|Routh, Elizabeth D\|Der, Channing J\|Yeh, Jen Jen
PMID:	21199803

91.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G749-60.
Title:	Muscarinic receptor agonists stimulate human colon cancer cell migration and invasion.
Author:	Belo, Angelica\|Cheng, Kunrong\|Chahdi, Ahmed\|Shant, Jasleen\|Xie, Guofeng\|Khurana, Sandeep\|Raufman, Jean-Pierre
PMID:	21273532

92.
Journal:	Anticancer Res. 2011 Jan;31(1):255-61.
Title:	A phase II study of capecitabine, oxaliplatin, bevacizumab and cetuximab in the treatment of metastatic colorectal cancer.
Author:	Wong, Nan Soon\|Fernando, Nishan H\|Nixon, Andrew B\|Cushman, Stephanie\|Aklilu, Mebea\|Bendell, Johanna C\|Morse, Michael A\|Blobe, Gerard C\|Ashton, Jill\|Pang, Herbert\|Hurwitz, Herbert I
PMID:	21273607

93.
Journal:	Cancer Sci. 2011 May;102(5):999-1006.
Title:	Adiponectin supports cell survival in glucose deprivation through enhancement of autophagic response in colorectal cancer cells.
Author:	Habeeb, Baker S\|Kitayama, Joji\|Nagawa, Hirokazu
PMID:	21299716

94.
Journal:	World J Gastroenterol. 2011 Feb 7;17(5):625-32.
Title:	Influence of CXCR4/SDF-1 axis on E-cadherin/beta-catenin complex expression in HT29 colon cancer cells.
Author:	Wang, Lin\|Li, Cui-Ling\|Wang, Lei\|Yu, Wen-Bin\|Yin, Hai-Peng\|Zhang, Guang-Yong\|Zhang, Li-Feng\|Li, Sheng\|Hu, San-Yuan
PMID:	21350711

95.
Journal:	J Mol Signal. 2011 Mar 3;6:2.
Title:	Activation of K-RAS by co-mutation of codons 19 and 20 is transforming.
Author:	Naguib, Adam\|Wilson, Catherine H\|Adams, David J\|Arends, Mark J
PMID:	21371307

96.
Journal:	Cancer Lett. 2011 Jul 28;306(2):151-60.
Title:	Dual blockade of phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer.
Author:	Xu, Rui\|Nakano, Kenji\|Iwasaki, Hironori\|Kumagai, Michiaki\|Wakabayashi, Rie\|Yamasaki, Akio\|Suzuki, Hiroyuki\|Mibu, Ryuichi\|Onishi, Hideya\|Katano, Mitsuo
PMID:	21429662

97.
Journal:	Cancer Res. 2011 May 1;71(9):3246-56.
Title:	mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways.
Author:	Gulhati, Pat\|Bowen, Kanika A\|Liu, Jianyu\|Stevens, Payton D\|Rychahou, Piotr G\|Chen, Min\|Lee, Eun Y\|Weiss, Heidi L\|O'Connor, Kathleen L\|Gao, Tianyan\|Evers, B Mark
PMID:	21430067

98.
Journal:	J Biol Chem. 2011 May 6;286(18):16082-90.
Title:	Restoration of transforming growth factor-beta receptor II expression in colon cancer cells with microsatellite instability increases metastatic potential in vivo.
Author:	Liu, Xiao-Qiong\|Rajput, Ashwani\|Geng, Liying\|Ongchin, Melanie\|Chaudhuri, Anathbandhu\|Wang, Jing
PMID:	21454688

99.
Journal:	Cell Oncol (Dordr). 2011 Jun;34(3):245-59.
Title:	Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL.
Author:	Pennarun, Bodvael\|Kleibeuker, Jan H\|Oenema, Tjitske\|Stegehuis, Janet H\|de Vries, Elisabeth G E\|de Jong, Steven
PMID:	21538027

100.
Journal:	Clin Chim Acta. 2011 Aug 17;412(17-18):1578-81.
Title:	KRAS mutation detection in colorectal cancer by a commercially available gene chip array compares well with Sanger sequencing.
Author:	French, Deborah\|Smith, Andrew\|Powers, Martin P\|Wu, Alan H B
PMID:	21575616

101.
Journal:	Cell Signal. 2011 Sep;23(9):1505-13.
Title:	An IkappaBalpha phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)-Nrf2-ARE signaling and ROS-PI3K/Akt signaling in an NF-kappaB-independent mechanism.
Author:	Min, Kyoung-jin\|Lee, Jung Tae\|Joe, Eun-hye\|Kwon, Taeg Kyu
PMID:	21620964

102.
Journal:	Mol Cancer Ther. 2011 Aug;10(8):1394-406.
Title:	Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin.
Author:	Bhagwat, Shripad V\|Gokhale, Prafulla C\|Crew, Andrew P\|Cooke, Andy\|Yao, Yan\|Mantis, Christine\|Kahler, Jennifer\|Workman, Jennifer\|Bittner, Mark\|Dudkin, Lorina\|Epstein, David M\|Gibson, Neil W\|Wild, Robert\|Arnold, Lee D\|Houghton, Peter J\|Pachter, Jonathan A
PMID:	21673091

103.
Journal:	BMC Cancer. 2011 Jul 1;11:285.
Title:	Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFkappaB survival axis downstream of Death receptor-3.
Author:	Porquet, Nicolas\|Poirier, Andree\|Houle, Francois\|Pin, Anne-Laure\|Gout, Stephanie\|Tremblay, Pierre-Luc\|Paquet, Eric R\|Klinck, Roscoe\|Auger, Francois A\|Huot, Jacques
PMID:	21722370

104.
Journal:	Gastroenterology. 2011 Jul;141(1):50-61.
Title:	Targeting PI3K signaling as a therapeutic approach for colorectal cancer.
Author:	Zhang, Jing\|Roberts, Thomas M\|Shivdasani, Ramesh A
PMID:	21723986

105.
Journal:	J Agric Food Chem. 2011 Oct 26;59(20):11304-18.
Title:	Cancer chemopreventive effects of lycopene: suppression of MMP-7 expression and cell invasion in human colon cancer cells.
Author:	Lin, Meng-Chiu\|Wang, Fu-Yu\|Kuo, Yueh-Hsiung\|Tang, Feng-Yao
PMID:	21923160

106.
Journal:	Hepatogastroenterology. 2011 Jul-Aug;58(109):1182-8.
Title:	The significance of a group of molecular markers and clinicopathological factors in identifying colorectal liver metastasis.
Author:	Wu, Jian-Hui\|Tian, Xiu-Yun\|Hao, Chun-Yi
PMID:	21937374

107.
Journal:	J Clin Invest. 2011 Nov;121(11):4311-21.
Title:	Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.
Author:	Ebi, Hiromichi\|Corcoran, Ryan B\|Singh, Anurag\|Chen, Zhao\|Song, Youngchul\|Lifshits, Eugene\|Ryan, David P\|Meyerhardt, Jeffrey A\|Benes, Cyril\|Settleman, Jeffrey\|Wong, Kwok-Kin\|Cantley, Lewis C\|Engelman, Jeffrey A
PMID:	21985784

108.
Journal:	Cancers (Basel). 2011 Mar 2;3(1):971-81.
Title:	Muscarinic receptor signaling in colon cancer.
Author:	Von Rosenvinge, Erik C\|Raufman, Jean-Pierre
PMID:	24212649

109.
Journal:	Pathol Oncol Res. 2012 Apr;18(2):191-9.
Title:	Silencing Poly (ADP-Ribose) glycohydrolase (PARG) expression inhibits growth of human colon cancer cells in vitro via PI3K/Akt/NFkappa-B pathway.
Author:	Fauzee, Nilufer Jasmine Selimah\|Li, Qiaozhuan\|Wang, Ya-Lan\|Pan, Juan
PMID:	21713600

110.
Journal:	Mol Carcinog. 2012 Oct;51(10):783-95.
Title:	Celecoxib inactivates epithelial-mesenchymal transition stimulated by hypoxia and/or epidermal growth factor in colon cancer cells.
Author:	Bocca, Claudia\|Bozzo, Francesca\|Cannito, Stefania\|Parola, Maurizio\|Miglietta, Antonella
PMID:	21882253

111.
Journal:	Cell Biochem Biophys. 2012 Jan;62(1):47-54.
Title:	Studies on the expression patterns of class I PI3K catalytic subunits and its prognostic significance in colorectal cancer.
Author:	Cui, Binbin\|Tao, Ji\|Yang, Yanmei
PMID:	21910030

112.
Journal:	Oncogene. 2012 Jul 5;31(27):3277-86.
Title:	p37delta is a new isoform of PI3K p110delta that increases cell proliferation and is overexpressed in tumors.
Author:	Fransson, S\|Uv, A\|Eriksson, H\|Andersson, M K\|Wettergren, Y\|Bergo, M\|Ejeskar, K
PMID:	22020336

113.
Journal:	Clin Cancer Res. 2012 Feb 1;18(3):688-99.
Title:	Primary colorectal cancers and their subsequent hepatic metastases are genetically different: implications for selection of patients for targeted treatment.
Author:	Vermaat, Joost S\|Nijman, Isaac J\|Koudijs, Marco J\|Gerritse, Frank L\|Scherer, Stefan J\|Mokry, Michal\|Roessingh, Wijnand M\|Lansu, Nico\|de Bruijn, Ewart\|van Hillegersberg, Richard\|van Diest, Paul J\|Cuppen, Edwin\|Voest, Emile E
PMID:	22173549

114.
Journal:	Lipids. 2012 Apr;47(4):403-11.
Title:	The "HER2-PI3K/Akt-FASN Axis" regulated malignant phenotype of colorectal cancer cells.
Author:	Li, Nan\|Bu, Xiaodong\|Wu, Peng\|Wu, Pingping\|Huang, Peilin
PMID:	22218925

115.
Journal:	Int J Oncol. 2012 Apr;40(4):1267-76.
Title:	Blockade of irradiation-induced autophagosome formation impairs proliferation but does not enhance cell death in HCT-116 human colorectal carcinoma cells.
Author:	de Albuquerque-Xavier, Ana Cristina\|Bastos, Lilian Goncalves R\|de Freitas, Julio Cesar Madureira Jr\|Leve, Fernanda\|de Souza, Waldemir Fernandez\|de Araujo, Wallace Martins\|Wanderley, Joao Luiz Mendes\|Tanaka, Marcelo Neves\|de Souza, Wanderley\|Morgado-Diaz,
PMID:	22246348

116.
Journal:	Clin Cancer Res. 2012 Apr 15;18(8):2316-25.
Title:	The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer.
Author:	Shimizu, Toshio\|Tolcher, Anthony W\|Papadopoulos, Kyriakos P\|Beeram, Muralidhar\|Rasco, Drew W\|Smith, Lon S\|Gunn, Shelly\|Smetzer, Leslie\|Mays, Theresa A\|Kaiser, Brianne\|Wick, Michael J\|Alvarez, Cathy\|Cavazos, Aracely\|Mangold, Gina L\|Patnaik, Amita
PMID:	22261800

117.
Journal:	J Cell Biochem. 2012 Jun;113(6):2086-97.
Title:	Inhibition of IGF-IR increases chemosensitivity in human colorectal cancer cells through MRP-2 promoter suppression.
Author:	Shen, Ke\|Cui, Daling\|Sun, Liyun\|Lu, Yanhua\|Han, Mingquan\|Liu, Jianwen
PMID:	22275271

118.
Journal:	Int J Oncol. 2012 Mar;40(3):816-24.
Title:	Brassinin induces G1 phase arrest through increase of p21 and p27 by inhibition of the phosphatidylinositol 3-kinase signaling pathway in human colon cancer cells.
Author:	Izutani, Yasuyuki\|Yogosawa, Shingo\|Sowa, Yoshihiro\|Sakai, Toshiyuki
PMID:	22307336

119.
Journal:	J Biosci. 2012 Mar;37(1):91-101.
Title:	Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway.
Author:	Wang, Di\|Chen, Jian\|Chen, Hui\|Duan, Zhi\|Xu, Qimei\|Wei, Meiyan\|Wang, Lianghua\|Zhong, Meizuo
PMID:	22357207

120.
Journal:	Br J Cancer. 2012 Apr 10;106(8):1386-94.
Title:	The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition.
Author:	Haagensen, E J\|Kyle, S\|Beale, G S\|Maxwell, R J\|Newell, D R
PMID:	22415236

121.
Journal:	Toxicol Appl Pharmacol. 2012 May 15;261(1):31-41.
Title:	Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging.
Author:	Yeh, Chi-Tai\|Rao, Yerra Koteswara\|Ye, Min\|Wu, Wen-Shi\|Chang, Tung-Chen\|Wang, Liang-Shun\|Wu, Chih-Hsiung\|Wu, Alexander T H\|Tzeng, Yew-Min
PMID:	22465936

122.
Journal:	PLoS One. 2012;7(4):e35378.
Title:	The extra domain A of fibronectin increases VEGF-C expression in colorectal carcinoma involving the PI3K/AKT signaling pathway.
Author:	Xiang, Lisha\|Xie, Ganfeng\|Ou, Juanjuan\|Wei, Xing\|Pan, Feng\|Liang, Houjie
PMID:	22496919

123.
Journal:	Nutr Cancer. 2012;64(4):617-26.
Title:	Ursodeoxycholic acid protects colon cancer HCT116 cells from deoxycholic acid-induced apoptosis by inhibiting apoptosome formation.
Author:	Saeki, Tohru\|Yui, Satoko\|Hirai, Tadashi\|Fujii, Takami\|Okada, Sawami\|Kanamoto, Ryuhei
PMID:	22497644

124.
Journal:	Curr Cancer Drug Targets. 2012 Sep;12(7):873-98.
Title:	A molecular signature for oncogenic BRAF in human colon cancer cells is revealed by microarray analysis.
Author:	Joyce, T\|Oikonomou, E\|Kosmidou, V\|Makrodouli, E\|Bantounas, I\|Avlonitis, S\|Zografos, G\|Pintzas, A
PMID:	22515520

125.
Journal:	J Surg Res. 2012 Nov;178(1):233-41.
Title:	Nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathways.
Author:	Cucina, Alessandra\|Dinicola, Simona\|Coluccia, Pierpaolo\|Proietti, Sara\|D'Anselmi, Fabrizio\|Pasqualato, Alessia\|Bizzarri, Mariano
PMID:	22520577

126.
Journal:	Cancer Res. 2012 Jun 15;72(12):2931-6.
Title:	Mice expressing activated PI3K rapidly develop advanced colon cancer.
Author:	Leystra, Alyssa A\|Deming, Dustin A\|Zahm, Christopher D\|Farhoud, Mohammed\|Olson, Terrah J Paul\|Hadac, Jamie N\|Nettekoven, Laura A\|Albrecht, Dawn M\|Clipson, Linda\|Sullivan, Ruth\|Washington, Mary Kay\|Torrealba, Jose R\|Weichert, Jamey P\|Halberg, Richard B
PMID:	22525701

127.
Journal:	Int J Oncol. 2012 Jul;41(1):211-8.
Title:	CD44 enhances the epithelial-mesenchymal transition in association with colon cancer invasion.
Author:	Cho, Sang Hyuk\|Park, Yeon Sun\|Kim, Hun Jin\|Kim, Chang Hyun\|Lim, Sang Woo\|Huh, Jung Wook\|Lee, Jae Hyuk\|Kim, Hyeong Rok
PMID:	22552741

128.
Journal:	Curr Pharm Des. 2012;18(20):2901-13.
Title:	Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors in cancer therapy: advances and perspectives.
Author:	Xue, Mengzhu\|Cao, Xianwen\|Zhong, Ye\|Kuang, Dong\|Liu, Xiaofeng\|Zhao, Zhenjiang\|Li, Honglin
PMID:	22571659

129.
Journal:	Anticancer Res. 2012 Jul;32(7):2537-43.
Title:	Impact of Yangzheng Xiaoji on the adhesion and migration of human cancer cells: the role of the AKT signalling pathway.
Author:	Ye, Lin\|Ji, Ke\|Frewer, Natasha\|Ji, Jiafu\|Jiang, Wen G
PMID:	22753711

130.
Journal:	PLoS One. 2012;7(7):e40671.
Title:	Expression of Abelson interactor 1 (Abi1) correlates with inflammation, KRAS mutation and adenomatous change during colonic carcinogenesis.
Author:	Steinestel, Konrad\|Bruderlein, Silke\|Steinestel, Julie\|Markl, Bruno\|Schwerer, Michael J\|Arndt, Annette\|Kraft, Klaus\|Propper, Christian\|Moller, Peter
PMID:	22808230

131.
Journal:	Clin Transl Oncol. 2012 Oct;14(10):726-39.
Title:	Guidelines for biomarker testing in colorectal carcinoma (CRC): a national consensus of the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM).
Author:	Garcia-Alfonso, Pilar\|Salazar, Ramon\|Garcia-Foncillas, Jesus\|Musulen, Eva\|Garcia-Carbonero, Rocio\|Paya, Artemio\|Perez-Segura, Pedro\|Ramon y Cajal, Santiago\|Navarro, Samuel
PMID:	22855150

132.
Journal:	Nutr Cancer. 2012 Aug;64(6):864-70.
Title:	Fatty acid synthase regulates proliferation and migration of colorectal cancer cells via HER2-PI3K/Akt signaling pathway.
Author:	Li, Nan\|Bu, Xiaodong\|Tian, Xiaoqiang\|Wu, Peng\|Yang, Lin\|Huang, Peilin
PMID:	22860766

133.
Journal:	Therap Adv Gastroenterol. 2012 Sep;5(5):319-37.
Title:	Therapeutic targeting of the phosphatidylinositol 3-kinase signaling pathway: novel targeted therapies and advances in the treatment of colorectal cancer.
Author:	Yu, Ming\|Grady, William M
PMID:	22973417

134.
Journal:	Cell Cycle. 2012 Nov 1;11(21):3997-4008.
Title:	Cyclosporin A inhibits colon cancer cell growth independently of the calcineurin pathway.
Author:	Werneck, Miriam B F\|Hottz, Eugenio\|Bozza, Patricia T\|Viola, Joao P B
PMID:	22992618

135.
Journal:	Curr Med Chem. 2012;19(33):5735-44.
Title:	Signal transduction pathways of the epidermal growth factor receptor in colorectal cancer and their inhibition by small molecules.
Author:	Efferth, T
PMID:	23033949

136.
Journal:	Oncol Lett. 2012 Oct;4(4):763-766.
Title:	The expression and clinical significance of PI3K, pAkt and VEGF in colon cancer.
Author:	Zhang, Yinxu\|Liu, Xiaomei\|Zhang, Junhua\|Li, Leiyu\|Liu, Chunying
PMID:	23205098

137.
Journal:	BMC Cancer. 2012 Dec 21;12:612.
Title:	Alternative dosing of dual PI3K and MEK inhibition in cancer therapy.
Author:	Jokinen, Elina\|Laurila, Niina\|Koivunen, Jussi P
PMID:	23259591

138.
Journal:	Gut. 2013 Apr;62(4):550-60.
Title:	Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signalling.
Author:	De Boeck, Astrid\|Pauwels, Patrick\|Hensen, Karen\|Rummens, Jean-Luc\|Westbroek, Wendy\|Hendrix, An\|Maynard, Dawn\|Denys, Hannelore\|Lambein, Kathleen\|Braems, Geert\|Gespach, Christian\|Bracke, Marc\|De Wever, Olivier
PMID:	22535374

139.
Journal:	Cell Signal. 2013 Jan;25(1):12-8.
Title:	NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.
Author:	Eide, Peter W\|Cekaite, Lina\|Danielsen, Stine A\|Eilertsen, Ina A\|Kjenseth, Ane\|Fykerud, Tone A\|Agesen, Trude H\|Bruun, Jarle\|Rivedal, Edgar\|Lothe, Ragnhild A\|Leithe, Edward
PMID:	22974840

140.
Journal:	Int J Colorectal Dis. 2013 Mar;28(3):385-98.
Title:	Single-agent therapy with sorafenib or 5-FU is equally effective in human colorectal cancer xenograft--no benefit of combination therapy.
Author:	Wehler, Thomas C\|Hamdi, Swaantje\|Maderer, Annett\|Graf, Claudine\|Gockel, Ines\|Schmidtmann, Irene\|Hainz, Michael\|Berger, Martin R\|Theobald, Matthias\|Galle, Peter R\|Moehler, Markus\|Schimanski, Carl C
PMID:	22983756

141.
Journal:	Clin Exp Metastasis. 2013 Mar;30(3):309-16.
Title:	Protein pathway activation mapping of colorectal metastatic progression reveals metastasis-specific network alterations.
Author:	Silvestri, Alessandra\|Calvert, Valerie\|Belluco, Claudio\|Lipsky, Michael\|De Maria, Ruggero\|Deng, Jianghong\|Colombatti, Alfonso\|De Marchi, Francesco\|Nitti, Donato\|Mammano, Enzo\|Liotta, Lance\|Petricoin, Emanuel\|Pierobon, Mariaelena
PMID:	23053743

142.
Journal:	Mol Cancer Res. 2013 Feb;11(2):109-21.
Title:	Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling.
Author:	Tabusa, Hana\|Brooks, Teresa\|Massey, Andrew J
PMID:	23233484

143.
Journal:	Food Chem Toxicol. 2013 May;55:424-33.
Title:	Suppression of Src/ERK and GSK-3/beta-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells.
Author:	Park, Eun-Jung\|Chung, Hwa-Jin\|Park, Hyen Joo\|Kim, Gi Dae\|Ahn, Yong-Hyun\|Lee, Sang Kook
PMID:	23333577

144.
Journal:	PLoS One. 2013;8(1):e55298.
Title:	APRIL induces tumorigenesis and metastasis of colorectal cancer cells via activation of the PI3K/Akt pathway.
Author:	Wang, Guihua\|Wang, Feng\|Ding, Weifeng\|Wang, Jingchun\|Jing, Rongrong\|Li, Haiquan\|Wang, Xudong\|Wang, Yueguo\|Ju, Shaoqing\|Wang, Huimin
PMID:	23383143

145.
Journal:	Oncol Lett. 2013 Feb;5(2):483-488.
Title:	Analgesic-antitumor peptide induces apoptosis and inhibits the proliferation of SW480 human colon cancer cells.
Author:	Gu, Yu\|Liu, Shen-Lin\|Ju, Wen-Zheng\|Li, Chang-Yin\|Cao, Peng
PMID:	23420047

146.
Journal:	Cancer Sci. 2013 Jun;104(6):687-93.
Title:	Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)-reactivating agents enhance efficacy of 5-fluorouracil on human colon cancer cells.
Author:	Watanabe, Motoki\|Sowa, Yoshihiro\|Yogosawa, Mayumi\|Sakai, Toshiyuki
PMID:	23438367

147.
Journal:	J Agric Food Chem. 2013 Mar 20;61(11):2811-9.
Title:	P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in vivo.
Author:	Chen, Li-Ching\|Lee, Wen-Sen
PMID:	23448150

148.
Journal:	PLoS One. 2013;8(3):e58055.
Title:	Cytotoxic activity and apoptosis-inducing potential of di-spiropyrrolidino and di-spiropyrrolizidino oxindole andrographolide derivatives.
Author:	Dey, Sumit Kumar\|Bose, Dipayan\|Hazra, Abhijit\|Naskar, Subhendu\|Nandy, Abhishek\|Munda, Rudra Narayan\|Das, Subhadip\|Chatterjee, Nabanita\|Mondal, Nirup Bikash\|Banerjee, Sukdeb\|Saha, Krishna Das
PMID:	23472133

149.
Journal:	Cell Physiol Biochem. 2013;31(2-3):209-18.
Title:	miR-30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma.
Author:	Zhong, Ming\|Bian, Zhengqian\|Wu, Zhiyong
PMID:	23486085

150.
Journal:	Clin Cancer Res. 2013 May 1;19(9):2342-54.
Title:	PI3K/AKT signaling is essential for communication between tissue-infiltrating mast cells, macrophages, and epithelial cells in colitis-induced cancer.
Author:	Khan, Mohammad W\|Keshavarzian, Ali\|Gounaris, Elias\|Melson, Joshua E\|Cheon, Eric C\|Blatner, Nichole R\|Chen, Zongmin E\|Tsai, Fu-Nien\|Lee, Goo\|Ryu, Hyunji\|Barrett, Terrence A\|Bentrem, David J\|Beckhove, Philipp\|Khazaie, Khashayarsha
PMID:	23487439

151.
Journal:	Biomed Res Int. 2013;2013:868131.
Title:	p55PIK transcriptionally activated by MZF1 promotes colorectal cancer cell proliferation.
Author:	Deng, Yu\|Wang, Jing\|Wang, Guihua\|Jin, Yuan\|Luo, Xuelai\|Xia, Xianmin\|Gong, Jianping\|Hu, Junbo
PMID:	23509792

152.
Journal:	Clin Cancer Res. 2013 May 15;19(10):2688-98.
Title:	Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.
Author:	Coffee, Erin M\|Faber, Anthony C\|Roper, Jatin\|Sinnamon, Mark J\|Goel, Gautam\|Keung, Lily\|Wang, Wei Vivian\|Vecchione, Loredana\|de Vriendt, Veerle\|Weinstein, Barbara J\|Bronson, Roderick T\|Tejpar, Sabine\|Xavier, Ramnik J\|Engelman, Jeffrey A\|Martin, Eric S\|Hung
PMID:	23549875

153.
Journal:	Peptides. 2013 Jun;44:127-34.
Title:	Designer peptide antagonist of the leptin receptor with peripheral antineoplastic activity.
Author:	Beccari, Serena\|Kovalszky, Ilona\|Wade, John D\|Otvos, Laszlo Jr\|Surmacz, Eva
PMID:	23567149

154.
Journal:	PLoS One. 2013 Apr 9;8(4):e60709.
Title:	mTOR inhibition elicits a dramatic response in PI3K-dependent colon cancers.
Author:	Deming, Dustin A\|Leystra, Alyssa A\|Farhoud, Mohammed\|Nettekoven, Laura\|Clipson, Linda\|Albrecht, Dawn\|Washington, Mary Kay\|Sullivan, Ruth\|Weichert, Jamey P\|Halberg, Richard B
PMID:	23593290

155.
Journal:	J Biol Chem. 2013 Jun 7;288(23):16274-81.
Title:	FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density.
Author:	Qi, Wentao\|Fitchev, Philip S\|Cornwell, Mona L\|Greenberg, Jordan\|Cabe, Maleen\|Weber, Christopher R\|Roy, Hemant K\|Crawford, Susan E\|Savkovic, Suzana D
PMID:	23603907

156.
Journal:	Pol J Pathol. 2013 Apr;64(1):15-20.
Title:	PTEN expression profiles in colorectal adenocarcinoma and its precancerous lesions.
Author:	Waniczek, Dariusz\|Snietura, Miroslaw\|Mlynarczyk-Liszka, Joanna\|Piglowski, Wojciech\|Kopec, Agnieszka\|Lange, Dariusz\|Rudzki, Marek\|Arendt, Jerzy
PMID:	23625595

157.
Journal:	Int J Cancer. 2013 Nov;133(9):2089-101.
Title:	Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells.
Author:	Martinelli, Erika\|Troiani, Teresa\|D'Aiuto, Elena\|Morgillo, Floriana\|Vitagliano, Donata\|Capasso, Anna\|Costantino, Sarah\|Ciuffreda, Loreta Pia\|Merolla, Francesco\|Vecchione, Loredana\|De Vriendt, Veerle\|Tejpar, Sabine\|Nappi, Anna\|Sforza, Vincenzo\|Martini, Giu
PMID:	23629727

158.
Journal:	Zhonghua Yi Xue Za Zhi. 2013 Feb 26;93(8):623-6.
Title:	[Effects and mechanisms of phosphatidylinositol 3 kinase B signal pathway on colon cancer cell SW480].
Author:	Ma, Dong-hua\|Long, Teng\|Wang, Ya-xu\|Shu, Ning-bo\|Bi, De-li
PMID:	23663347

159.
Journal:	Int J Oncol. 2013 Jul;43(1):141-50.
Title:	Dual inhibition of EGFR and c-Met kinase activation by MJ-56 reduces metastasis of HT29 human colorectal cancer cells.
Author:	Chen, Hui-Jye\|Jiang, Yi-Lin\|Lin, Chung-Ming\|Tsai, Shih-Chang\|Peng, Shu-Fen\|Fushiya, Shinji\|Hour, Mann-Jen\|Yang, Jai-Sing
PMID:	23677180

160.
Journal:	Lipids Health Dis. 2013 Jun 1;12:83.
Title:	Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells.
Author:	Li, Nan\|Lu, Heng\|Chen, Chunyan\|Bu, Xiaodong\|Huang, Peilin
PMID:	23725225

161.
Journal:	Free Radic Biol Med. 2013 Oct;63:280-90.
Title:	Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors.
Author:	Shoeb, Mohammad\|Ramana, Kota V\|Srivastava, Satish K
PMID:	23732517

162.
Journal:	Clin Cancer Res. 2013 Jul 15;19(14):3987-95.
Title:	Phase II study of everolimus in patients with metastatic colorectal adenocarcinoma previously treated with bevacizumab-, fluoropyrimidine-, oxaliplatin-, and irinotecan-based regimens.
Author:	Ng, Kimmie\|Tabernero, Josep\|Hwang, Jimmy\|Bajetta, Emilio\|Sharma, Sunil\|Del Prete, Salvatore A\|Arrowsmith, Edward R\|Ryan, David P\|Sedova, Michaela\|Jin, Jin\|Malek, Kamel\|Fuchs, Charles S
PMID:	23743569

163.
Journal:	Asian J Androl. 2013 Nov;15(6):831-4.
Title:	Testosterone induced apoptosis in colon cancer cells is regulated by PI3K/Rac1 signaling.
Author:	Alkahtani, Saad
PMID:	23770942

164.
Journal:	BMC Cancer. 2013 Jul 1;13:321.
Title:	Overexpression of peptide deformylase in breast, colon, and lung cancers.
Author:	Randhawa, Harsharan\|Chikara, Shireen\|Gehring, Drew\|Yildirim, Tuba\|Menon, Jyotsana\|Reindl, Katie M
PMID:	23815882

165.
Journal:	PLoS One. 2013 Jun 18;8(6):e66165.
Title:	Deep Sequencing the MicroRNA Transcriptome in Colorectal Cancer.
Author:	Schee, Kristina\|Lorenz, Susanne\|Worren, Merete Molton\|Gunther, Clara-Cecilie\|Holden, Marit\|Hovig, Eivind\|Fodstad, Oystein\|Meza-Zepeda, Leonardo A\|Flatmark, Kjersti
PMID:	23824282

166.
Journal:	Food Chem. 2013 Dec 1;141(3):1841-6.
Title:	Phenethyl isothiocyanate inhibits hypoxia-induced accumulation of HIF-1alpha and VEGF expression in human glioma cells.
Author:	Gupta, Brinda\|Chiang, Linda\|Chae, KyungMin\|Lee, Dae-Hee
PMID:	23870899

167.
Journal:	Asian Pac J Cancer Prev. 2013;14(6):3631-4.
Title:	MicroRNA-451 inhibits growth of human colorectal carcinoma cells via downregulation of Pi3k/Akt pathway.
Author:	Li, Hong-Yan\|Zhang, Yan\|Cai, Jian-Hui\|Bian, Hong-Lei
PMID:	23886157

168.
Journal:	Cancer Med. 2013 Jun;2(3):277-85.
Title:	Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced colorectal cancer (CRC) receiving bevacizumab.
Author:	Price, Timothy J\|Hardingham, Jennifer E\|Lee, Chee K\|Townsend, Amanda R\|Wrin, Joseph W\|Wilson, Kate\|Weickhardt, Andrew\|Simes, Robert J\|Murone, Carmel\|Tebbutt, Niall C
PMID:	23930204

169.
Journal:	J Nutr Biochem. 2013 Nov;24(11):1849-58.
Title:	Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells.
Author:	Kumazaki, Minami\|Noguchi, Shunsuke\|Yasui, Yuki\|Iwasaki, Junya\|Shinohara, Haruka\|Yamada, Nami\|Akao, Yukihiro
PMID:	23954321

170.
Journal:	J Gastrointest Oncol. 2013 Sep;4(3):285-98.
Title:	Integrating anti-EGFR therapies in metastatic colorectal cancer.
Author:	Haraldsdottir, Sigurdis\|Bekaii-Saab, Tanios
PMID:	23997940

171.
Journal:	Am J Pathol. 2013 Nov;183(5):1667-78.
Title:	Src plays a key role in ADAM28 expression in v-src-transformed epithelial cells and human carcinoma cells.
Author:	Abe, Hitoshi\|Mochizuki, Satsuki\|Ohara, Kentaro\|Ueno, Mari\|Ochiai, Hiroki\|Kitagawa, Yuko\|Hino, Okio\|Sato, Hiroshi\|Okada, Yasunori
PMID:	24007880

172.
Journal:	Med Oncol. 2013 Dec;30(4):724.
Title:	High level of p37delta-mRNA relative to p110delta-mRNA in neuroblastoma tumors correlates with poor patient survival.
Author:	Fransson, Susanne\|Ejeskar, Katarina
PMID:	24026661

173.
Journal:	J Biol Chem. 2013 Oct 25;288(43):31229-40.
Title:	Phosphorylation and mRNA splicing of collapsin response mediator protein-2 determine inhibition of rho-associated protein kinase (ROCK) II function in carcinoma cell migration and invasion.
Author:	Morgan-Fisher, Marie\|Couchman, John R\|Yoneda, Atsuko
PMID:	24036111

174.
Journal:	Clin Ther. 2013 Sep;35(9):1282-303.
Title:	Epidermal growth factor receptor: pathway, therapies, and pipeline.
Author:	Goffin, John R\|Zbuk, Kevin
PMID:	24054705

175.
Journal:	Int J Oncol. 2013 Dec;43(6):1992-8.
Title:	Regulation of YAP through an Akt-dependent process by 3, 3'-diindolylmethane in human colon cancer cells.
Author:	Li, Xiu Juan\|Leem, Sun-Hee\|Park, Man Hee\|Kim, Soo Mi
PMID:	24100865

176.
Journal:	J Clin Oncol. 2013 Dec 20;31(36):4562-8.
Title:	Evaluating many treatments and biomarkers in oncology: a new design.
Author:	Kaplan, Richard\|Maughan, Timothy\|Crook, Angela\|Fisher, David\|Wilson, Richard\|Brown, Louise\|Parmar, Mahesh
PMID:	24248692

177.
Journal:	Cancer Manag Res. 2013 Nov 21;5:387-400.
Title:	Personalized treatment for advanced colorectal cancer: KRAS and beyond.
Author:	Patel, Gargi Surendra\|Karapetis, Christos S
PMID:	24294007

178.
Journal:	Front Oncol. 2013 Nov 15;3:281.
Title:	Toward a Molecular Classification of Colorectal Cancer: The Role of BRAF.
Author:	Thiel, Alexandra\|Ristimaki, Ari
PMID:	24298448

179.
Journal:	PLoS One. 2013 Dec 10;8(12):e81763.
Title:	The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing mice.
Author:	Haagensen, Emma J\|Thomas, Huw D\|Wilson, Ian\|Harnor, Suzannah J\|Payne, Sara L\|Rennison, Tommy\|Smith, Kate M\|Maxwell, Ross J\|Newell, David R
PMID:	24339963

180.
Journal:	PLoS One. 2013 Dec 12;8(12):e82982.
Title:	Comparative analysis of radiosensitizers for K-RAS mutant rectal cancers.
Author:	Kleiman, Laura B\|Krebs, Angela M\|Kim, Stephen Y\|Hong, Theodore S\|Haigis, Kevin M
PMID:	24349411

181.
Journal:	Am J Clin Oncol. 2014 Apr;37(2):117-21.
Title:	A prospective pilot study of target-guided personalized chemotherapy with intensity-modulated radiotherapy in patients with early rectal cancer.
Author:	Cubillo, Antonio\|Hernando-Requejo, Ovidio\|Garcia-Garcia, Elena\|Rodriguez-Pascual, Jesus\|De Vicente, Emilio\|Morelli, Pia\|Rubio, Carmen\|Lopez-Rios, Fernando\|Muro, Avertano\|Lopez, Ulpiano\|Prados, Susana\|Quijano, Yolanda\|Hidalgo, Manuel
PMID:	23211222

182.
Journal:	Mol Carcinog. 2014 Feb;53 Suppl 1:E62-71.
Title:	The molecular chaperone Cosmc enhances malignant behaviors of colon cancer cells via activation of Akt and ERK.
Author:	Huang, John\|Che, Mei-Ieng\|Lin, Neng-Yu\|Hung, Ji-Shiang\|Huang, Yu-Ting\|Lin, Wei-Chou\|Huang, Hsiu-Chin\|Lee, Po-Huang\|Liang, Jin-Tung\|Huang, Min-Chuan
PMID:	23390052

183.
Journal:	Oncogene. 2014 Apr 3;33(14):1828-39.
Title:	ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer.
Author:	Ye, Q\|Cai, W\|Zheng, Y\|Evers, B M\|She, Q-B
PMID:	23624914

184.
Journal:	Mol Carcinog. 2014 Feb;53 Suppl 1:E107-18.
Title:	Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1alpha and glycolysis, by inhibiting PI3K/Akt signaling pathway.
Author:	Wang, Hu\|Zhao, Li\|Zhu, Li-Tao\|Wang, Yu\|Pan, Di\|Yao, Jing\|You, Qi-Dong\|Guo, Qing-Long
PMID:	23761018

185.
Journal:	Oncogene. 2014 Jul 10;33(28):3677-87.
Title:	CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation.
Author:	Nie, J\|Liu, L\|Xing, G\|Zhang, M\|Wei, R\|Guo, M\|Li, X\|Xie, P\|Li, L\|He, F\|Han, W\|Zhang, L
PMID:	23995790

186.
Journal:	Endocr Relat Cancer. 2013 Dec 20;21(1):73-84.
Title:	GDNF increases cell motility in human colon cancer through VEGF-VEGFR1 interaction.
Author:	Huang, Ssu-Ming\|Chen, Tzu-Sheng\|Chiu, Chien-Ming\|Chang, Leang-Kai\|Liao, Kuan-Fu\|Tan, Hsiao-Ming\|Yeh, Wei-Lan\|Chang, Gary Ro-Lin\|Wang, Min-Ying\|Lu, Dah-Yuu
PMID:	24165321

187.
Journal:	J Pathol. 2014 Mar;232(4):415-27.
Title:	MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2.
Author:	Liao, Wen-Ting\|Ye, Ya-Ping\|Zhang, Nian-Jie\|Li, Ting-Ting\|Wang, Shu-Yang\|Cui, Yan-Mei\|Qi, Lu\|Wu, Ping\|Jiao, Hong-Li\|Xie, Yi-Jun\|Zhang, Chi\|Wang, Jun-Xian\|Ding, Yan-Qing
PMID:	24293274

188.
Journal:	Biochim Biophys Acta. 2014 Mar;1840(3):1135-44.
Title:	Powerful tumor cell growth-inhibiting activity of a synthetic derivative of atractyligenin: involvement of PI3K/Akt pathway and thioredoxin system.
Author:	Cotugno, Roberta\|Gallotta, Dario\|Piaz, Fabrizio Dal\|Apicella, Ivana\|De Falco, Sandro\|Rosselli, Sergio\|Bruno, Maurizio\|Belisario, Maria Antonietta
PMID:	24321480

189.
Journal:	Cell Death Differ. 2014 Apr;21(4):568-81.
Title:	Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation.
Author:	Dai, W\|Bai, Y\|Hebda, L\|Zhong, X\|Liu, J\|Kao, J\|Duan, C
PMID:	24336047

190.
Journal:	Oncotarget. 2014 Jan 15;5(1):49-66.
Title:	mTOR pathway in colorectal cancer: an update.
Author:	Francipane, Maria Giovanna\|Lagasse, Eric
PMID:	24393708

191.
Journal:	Int J Clin Oncol. 2014 Apr;19(2):211-9.
Title:	Is biomarker research advancing in the era of personalized medicine for head and neck cancer?
Author:	Yokota, Tomoya
PMID:	24442754

192.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2014 Feb;306(3):G229-43.
Title:	Identification of a microRNA landscape targeting the PI3K/Akt signaling pathway in inflammation-induced colorectal carcinogenesis.
Author:	Josse, Claire\|Bouznad, Nassim\|Geurts, Pierre\|Irrthum, Alexandre\|Huynh-Thu, Van Anh\|Servais, Laurence\|Hego, Alexandre\|Delvenne, Philippe\|Bours, Vincent\|Oury, Cecile
PMID:	24464560

193.
Journal:	Mol Biol Rep. 2014 May;41(5):3359-67.
Title:	PI3K/Akt pathway involving into apoptosis and invasion in human colon cancer cells LoVo.
Author:	Jiang, Qun Guang\|Li, Tai Yuan\|Liu, Dong Ning\|Zhang, Hai Tao
PMID:	24496855

194.
Journal:	PLoS One. 2014 Jan 30;9(1):e86911.
Title:	Lack of association between insulin receptor substrate2 rs1805097 polymorphism and the risk of colorectal and breast cancer: a meta-analysis.
Author:	Hu, Yue\|Zhou, Min\|Zhang, Kai\|Kong, Xiangquan\|Hu, Xiaoyan\|Li, Kang\|Liu, Li
PMID:	24497996

195.
Journal:	Asian Pac J Cancer Prev. 2014;15(2):551-60.
Title:	Signal transducer and activator of transcription 3 - a promising target in colitis-associated cancer.
Author:	Pandurangan, Ashok Kumar\|Esa, Norhaizan Mohd
PMID:	24568457

196.
Journal:	Clin Transl Gastroenterol. 2014 Feb 27;5:e51.
Title:	Sphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in South asian population.
Author:	Tan, Sheryl S L\|Khin, Lay W\|Wong, Lingkai\|Yan, Benedict\|Ong, Chee W\|Datta, Arpita\|Salto-Tellez, Manuel\|Lam, Yulin\|Yap, Celestial T
PMID:	24572701

197.
Journal:	BMC Cancer. 2014 Mar 1;14:145.
Title:	Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer.
Author:	Agarwal, Ekta\|Chaudhuri, Anathbandhu\|Leiphrakpam, Premila D\|Haferbier, Katie L\|Brattain, Michael G\|Chowdhury, Sanjib
PMID:	24581231

198.
Journal:	J Exp Clin Cancer Res. 2014 Mar 5;33:24.
Title:	CELLFOOD induces apoptosis in human mesothelioma and colorectal cancer cells by modulating p53, c-myc and pAkt signaling pathways.
Author:	Nuvoli, Barbara\|Santoro, Raffaela\|Catalani, Simona\|Battistelli, Serafina\|Benedetti, Serena\|Canestrari, Franco\|Galati, Rossella
PMID:	24598211

199.
Journal:	Mol Carcinog. 2014 Nov;53(11):926-37.
Title:	PPARdelta deficiency disrupts hypoxia-mediated tumorigenic potential of colon cancer cells.
Author:	Jeong, Eunshil\|Koo, Jung Eun\|Yeon, Sang Hyeon\|Kwak, Mi-Kyoung\|Hwang, Daniel H\|Lee, Joo Young
PMID:	24610641

200.
Journal:	Biomed Rep. 2014 Mar;2(2):250-254.
Title:	Aged black garlic extract inhibits HT29 colon cancer cell growth via the PI3K/Akt signaling pathway.
Author:	Dong, Menghua\|Yang, Guiqing\|Liu, Hanchen\|Liu, Xiaoxu\|Lin, Sixiang\|Sun, Dongning\|Wang, Yishan
PMID:	24649105

201.
Journal:	Cancer Lett. 2014 Jun 28;348(1-2):77-87.
Title:	CCL20 and CXCL8 synergize to promote progression and poor survival outcome in patients with colorectal cancer by collaborative induction of the epithelial-mesenchymal transition.
Author:	Cheng, Xian-Shuo\|Li, Yun-Feng\|Tan, Jing\|Sun, Bin\|Xiao, You-Chuan\|Fang, Xing-Bao\|Zhang, Xiao-Feng\|Li, Qiang\|Dong, Jian-Hua\|Li, Ming\|Qian, Hai-hua\|Yin, Zheng-Feng\|Yang, Zhi-Bin
PMID:	24657657

202.
Journal:	Clin Cancer Res. 2014 May 15;20(10):2631-42.
Title:	Regulation of colorectal carcinoma stemness, growth, and metastasis by an miR-200c-Sox2-negative feedback loop mechanism.
Author:	Lu, Yan-Xia\|Yuan, Li\|Xue, Xiao-Lei\|Zhou, Min\|Liu, Yan\|Zhang, Chao\|Li, Jing-Ping\|Zheng, Lin\|Hong, Min\|Li, Xue-Nong
PMID:	24658157

203.
Journal:	Neoplasia. 2014 Feb;16(2):147-57.
Title:	BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737.
Author:	Potter, Danielle S\|Kelly, Paul\|Denneny, Olive\|Juvin, Veronique\|Stephens, Len R\|Dive, Caroline\|Morrow, Christopher J
PMID:	24709422

204.
Journal:	FEBS Lett. 2014 May 21;588(10):1921-9.
Title:	Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma.
Author:	Wu, Dong-ming\|Zhang, Peng\|Liu, Ru-yan\|Sang, Ya-xiong\|Zhou, Cong\|Xu, Guang-chao\|Yang, Jin-liang\|Tong, Ai-ping\|Wang, Chun-ting
PMID:	24713430

205.
Journal:	Cancer Cell. 2014 Apr 14;25(4):469-83.
Title:	MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer.
Author:	Valeri, Nicola\|Braconi, Chiara\|Gasparini, Pierluigi\|Murgia, Claudio\|Lampis, Andrea\|Paulus-Hock, Viola\|Hart, Jonathan R\|Ueno, Lynn\|Grivennikov, Sergei I\|Lovat, Francesca\|Paone, Alessio\|Cascione, Luciano\|Sumani, Khlea M\|Veronese, Angelo\|Fabbri, Muller\|Caras
PMID:	24735923

206.
Journal:	PLoS One. 2014 Apr 17;9(4):e95588.
Title:	Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability.
Author:	Seo, Bo Ram\|Min, Kyoung-Jin\|Cho, Il Je\|Kim, Sang Chan\|Kwon, Taeg Kyu
PMID:	24743574

207.
Journal:	Int J Oncol. 2014 Jul;45(1):104-12.
Title:	The PTEN/PI3K/Akt and Wnt/beta-catenin signaling pathways are involved in the inhibitory effect of resveratrol on human colon cancer cell proliferation.
Author:	Liu, Ying-Zi\|Wu, Ke\|Huang, Jun\|Liu, Yang\|Wang, Xin\|Meng, Zi-Jun\|Yuan, Shuang-Xue\|Wang, Dong-Xu\|Luo, Jin-Yong\|Zuo, Guo-Wei\|Yin, Liang-Jun\|Chen, Liang\|Deng, Zhong-Liang\|Yang, Jun-Qin\|Sun, Wen-Juan\|He, Bai-Cheng
PMID:	24756222

208.
Journal:	Biochem J. 2014 May 15;460(1):25-34.
Title:	The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway.
Author:	Coomans de Brachene, Alexandra\|Bollaert, Emeline\|Eijkelenboom, Astrid\|de Rocca Serra, Audrey\|van der Vos, Kristan E\|Burgering, Boudewijn M T\|Coffer, Paul J\|Essaghir, Ahmed\|Demoulin, Jean-Baptiste
PMID:	24762137

209.
Journal:	Mol Cancer Ther. 2014 Jul;13(7):1837-47.
Title:	PIK3R3 induces epithelial-to-mesenchymal transition and promotes metastasis in colorectal cancer.
Author:	Wang, Guihua\|Yang, Xi\|Li, Chuan\|Cao, Xiaonian\|Luo, Xuelai\|Hu, Junbo
PMID:	24837077

210.
Journal:	Tumour Biol. 2014 Sep;35(9):8639-43.
Title:	Nrdp1 inhibits growth of colorectal cancer cells by nuclear retention of p27.
Author:	Lu, Hang\|Li, Hua\|Mao, Dong\|Zhu, Zhitu\|Sun, Hongzhi
PMID:	24867101

211.
Journal:	Physiol Rep. 2014 Jun 24;2(6). pii: e12048.
Title:	Demonstration and biological significance of a gastrin-P21-activated kinase 1 feedback loop in colorectal cancer cells.
Author:	Huynh, Nhi\|Liu, Kevin H\|Yim, Mildred\|Shulkes, Arthur\|Baldwin, Graham S\|He, Hong
PMID:	24963032

212.
Journal:	Int J Oncol. 2014 Sep;45(3):995-1010.
Title:	Enhanced anti-colorectal cancer effects of carfilzomib combined with CPT-11 via downregulation of nuclear factor-kappaB in vitro and in vivo.
Author:	Tang, Weiwei\|Su, Guangjian\|Li, Jieyu\|Liao, Jinrong\|Chen, Shuping\|Huang, Chuanzhong\|Liu, Fang\|Chen, Qiang\|Ye, Yunbin
PMID:	24968890

213.
Journal:	Amino Acids. 2014 Oct;46(10):2393-401.
Title:	Kynurenic acid inhibits colon cancer proliferation in vitro: effects on signaling pathways.
Author:	Walczak, Katarzyna\|Turski, Waldemar A\|Rajtar, Grazyna
PMID:	25012123

214.
Journal:	Med Oncol. 2014 Aug;31(8):92.
Title:	The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer.
Author:	Wen, Xiaoxia\|Zhu, Jianjun\|Dong, Lei\|Chen, Yao
PMID:	25023051

215.
Journal:	Biochem Cell Biol. 2014 Aug;92(4):305-15.
Title:	Involvement of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways in the regulation of cell cycle progression by PTHrP in colon adenocarcinoma cells.
Author:	Calvo, Natalia\|Martin, Maria Julia\|de Boland, Ana Russo\|Gentili, Claudia
PMID:	25051885

216.
Journal:	Int J Nanomedicine. 2014 Jul 16;9:3403-11.
Title:	Effective inhibition of colon cancer cell growth with MgAl-layered double hydroxide (LDH) loaded 5-FU and PI3K/mTOR dual inhibitor BEZ-235 through apoptotic pathways.
Author:	Chen, Jiezhong\|Shao, Renfu\|Li, Li\|Xu, Zhi Ping\|Gu, Wenyi
PMID:	25075187

217.
Journal:	Biomed Pharmacother. 2014 Jul;68(6):721-7.
Title:	The PI3K/Akt pathway in colitis associated colon cancer and its chemoprevention with celecoxib, a Cox-2 selective inhibitor.
Author:	Setia, Shruti\|Nehru, Bimla\|Sanyal, Sankar Nath
PMID:	25107843

218.
Journal:	PLoS One. 2014 Aug 14;9(8):e104891.
Title:	Epidermal growth factor stimulates nuclear factor-kappaB activation and heme oxygenase-1 expression via c-Src, NADPH oxidase, PI3K, and Akt in human colon cancer cells.
Author:	Lien, Gi-Shih\|Wu, Ming-Shun\|Bien, Mauo-Ying\|Chen, Chien-Hsin\|Lin, Chien-Huang\|Chen, Bing-Chang
PMID:	25122478

219.
Journal:	J Transl Med. 2014 Sep 8;12:244.
Title:	Tumor suppressor miR-1 restrains epithelial-mesenchymal transition and metastasis of colorectal carcinoma via the MAPK and PI3K/AKT pathway.
Author:	Xu, Lijun\|Zhang, Yue\|Wang, Hui\|Zhang, Guanhua\|Ding, Yanqing\|Zhao, Liang
PMID:	25196260

220.
Journal:	Cancer Lett. 2014 Nov 28;354(2):355-64.
Title:	Synergism of PI3K/Akt inhibition and Fas activation on colon cancer cell death.
Author:	Zhu, Liang\|Derijard, Benoit\|Chakrabandhu, Krittalak\|Wang, Bing-Shun\|Chen, Hong-Zhuan\|Hueber, Anne-Odile
PMID:	25199763

221.
Journal:	Asian Pac J Cancer Prev. 2014;15(17):7245-9.
Title:	GRP78 secreted by colon cancer cells facilitates cell proliferation via PI3K/Akt signaling.
Author:	Fu, Rong\|Yang, Peng\|Wu, Hai-Li\|Li, Zong-Wei\|Li, Zhuo-Yu
PMID:	25227822

222.
Journal:	PLoS One. 2014 Sep 23;9(9):e108193.
Title:	3'-Deoxy-3'-[18F]-Fluorothymidine PET imaging reflects PI3K-mTOR-mediated pro-survival response to targeted therapy in colorectal cancer.
Author:	McKinley, Eliot T\|Zhao, Ping\|Coffey, Robert J\|Washington, M Kay\|Manning, H Charles
PMID:	25247710

223.
Journal:	Anticancer Res. 2014 Oct;34(10):5465-72.
Title:	Lysophosphatidylserine stimulates chemotactic migration of colorectal cancer cells through GPR34 and PI3K/Akt pathway.
Author:	Iida, Yuuki\|H Tsuno, Nelson\|Kishikawa, Junko\|Kaneko, Kensuke\|Murono, Koji\|Kawai, Kazushige\|Ikeda, Toshiyuki\|Ishihara, Soichiro\|Yamaguchi, Hironori\|Sunami, Eiji\|Kitayama, Joji\|Yatomi, Yutaka\|Watanabe, Toshiaki
PMID:	25275042

224.
Journal:	Nutrition. 2014 Nov-Dec;30(11-12):1242-56.
Title:	Colon carcinogenesis: influence of Western diet-induced obesity and targeting stem cells using dietary bioactive compounds.
Author:	Kasdagly, Maria\|Radhakrishnan, Sridhar\|Reddivari, Lavanya\|Veeramachaneni, D N Rao\|Vanamala, Jairam
PMID:	25280404

225.
Journal:	Cancer Sci. 2014 Dec;105(12):1550-9.
Title:	Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase-phosphoinositide 3-kinase-dependent anti-apoptotic signaling.
Author:	Horiguchi, Haruki\|Endo, Motoyoshi\|Miyamoto, Yuji\|Sakamoto, Yasuo\|Odagiri, Haruki\|Masuda, Tetsuro\|Kadomatsu, Tsuyoshi\|Tanoue, Hironori\|Motokawa, Ikuyo\|Terada, Kazutoyo\|Morioka, Masaki Suimye\|Manabe, Ichiro\|Baba, Hideo\|Oike, Yuichi
PMID:	25287946

226.
Journal:	Nat Commun. 2014 Oct 13;5:5191.
Title:	Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X.
Author:	Schulz, Eduard\|Klampfl, Petra\|Holzapfel, Stefanie\|Janecke, Andreas R\|Ulz, Peter\|Renner, Wilfried\|Kashofer, Karl\|Nojima, Satoshi\|Leitner, Anita\|Zebisch, Armin\|Wolfler, Albert\|Hofer, Sybille\|Gerger, Armin\|Lax, Sigurd\|Beham-Schmid, Christine\|Steinke, Verena\|
PMID:	25307848

227.
Journal:	J Cancer Prev. 2014 Sep;19(3):161-9.
Title:	Kaempferol Downregulates Insulin-like Growth Factor-I Receptor and ErbB3 Signaling in HT-29 Human Colon Cancer Cells.
Author:	Lee, Hyun Sook\|Cho, Han Jin\|Kwon, Gyoo Taik\|Park, Jung Han Yoon
PMID:	25337585

228.
Journal:	Nutr Cancer. 2014;66(8):1352-61.
Title:	Phosphatidylinositol 3-kinase mediates the ability of retinol to decrease colorectal cancer cell invasion.
Author:	Lengyel, Jennifer N Griffin\|Park, Eun Young\|Brunson, Anna R\|Pinali, Daniel\|Lane, Michelle A
PMID:	25356626

229.
Journal:	Asian Pac J Cancer Prev. 2014;15(20):8651-6.
Title:	Expression of Ang-2/Tie-2 and PI3K/AKT in colorectal cancer.
Author:	Zhang, Ji-Hong\|Wang, Li-Hua\|Li, Xiang-Jun\|Wang, Ai-Ping\|Reng, Li-Qun\|Xia, Feng-Guo\|Yang, Zhi-Ping\|Jiang, Jing\|Wang, Xiao-Dan\|Wen, Chun-Yang
PMID:	25374184

230.
Journal:	PLoS One. 2014 Nov 12;9(11):e111814.
Title:	Potent anti-cancer effect of 3'-hydroxypterostilbene in human colon xenograft tumors.
Author:	Cheng, Tzu-Chun\|Lai, Ching-Shu\|Chung, Min-Ching\|Kalyanam, Nagabhushanam\|Majeed, Muhammed\|Ho, Chi-Tang\|Ho, Yuan-Soon\|Pan, Min-Hsiung
PMID:	25389774

231.
Journal:	PLoS One. 2014 Nov 17;9(11):e113037.
Title:	Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer.
Author:	Pitts, Todd M\|Newton, Timothy P\|Bradshaw-Pierce, Erica L\|Addison, Rebecca\|Arcaroli, John J\|Klauck, Peter J\|Bagby, Stacey M\|Hyatt, Stephanie L\|Purkey, Alicia\|Tentler, John J\|Tan, Aik Choon\|Messersmith, Wells A\|Eckhardt, S Gail\|Leong, Stephen
PMID:	25401499

232.
Journal:	Biomed Pharmacother. 2014 Oct;68(8):1023-9.
Title:	Upregulation of MAPK/Erk and PI3K/Akt pathways in ulcerative colitis-associated colon cancer.
Author:	Setia, Shruti\|Nehru, Bimla\|Sanyal, Sankar Nath
PMID:	25443414

233.
Journal:	J Cell Physiol. 2015 Apr;230(4):930-46.
Title:	Justicidin A-induced autophagy flux enhances apoptosis of human colorectal cancer cells via class III PI3K and Atg5 pathway.
Author:	Won, Shen-Jeu\|Yen, Cheng-Hsin\|Liu, Hsiao-Sheng\|Wu, Shan-Ying\|Lan, Sheng-Hui\|Jiang-Shieh, Ya-Fen\|Lin, Chun-Nan\|Su, Chun-Li
PMID:	25216025

234.
Journal:	Mol Cell Biochem. 2015 Jan;399(1-2):303-13.
Title:	Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells.
Author:	Umesalma, Syed\|Nagendraprabhu, Ponnuraj\|Sudhandiran, Ganapasam
PMID:	25355159

235.
Journal:	J Appl Genet. 2015 May;56(2):185-92.
Title:	Aberrant methylation of ERBB pathway genes in sporadic colorectal cancer.
Author:	Szmida, Elzbieta\|Karpinski, Pawel\|Leszczynski, Przemyslaw\|Sedziak, Tomasz\|Kielan, Wojciech\|Ostasiewicz, Pawel\|Sasiadek, Maria M
PMID:	25366420

236.
Journal:	Clin Transl Oncol. 2015 Apr;17(4):264-73.
Title:	Updated guidelines for biomarker testing in colorectal carcinoma: a national consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology.
Author:	Garcia-Alfonso, P\|Garcia-Foncillas, J\|Salazar, R\|Perez-Segura, P\|Garcia-Carbonero, R\|Musulen-Palet, E\|Cuatrecasas, M\|Landolfi, S\|Ramon Y Cajal, S\|Navarro, S
PMID:	25373533

237.
Journal:	Tumour Biol. 2015 Mar;36(3):1477-86.
Title:	MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K/Akt pathway.
Author:	Dong, Yongqiang\|Liang, Guojun\|Yuan, Bo\|Yang, Chaoqun\|Gao, Rui\|Zhou, Xuhui
PMID:	25431257

238.
Journal:	Mol Cell Biochem. 2015 Feb;400(1-2):287-95.
Title:	CXCL13-CXCR5 axis promotes the growth and invasion of colon cancer cells via PI3K/AKT pathway.
Author:	Zhu, Zhenyu\|Zhang, Xukui\|Guo, Hongliang\|Fu, Ling\|Pan, Ganlin\|Sun, Yinggang
PMID:	25476740

239.
Journal:	Anticancer Drugs. 2015 Apr;26(4):371-8.
Title:	Effect of KRAS exon 2 mutations on antitumor activity of afatinib and gefitinib.
Author:	Gamba, Sebastian\|Camaj, Peter\|Heinemann, Volker\|Laubender, Rudiger P\|Wang, Yan\|Zhao, Yue\|Stintzing, Sebastian\|Giessen, Clemens\|Boeck, Stefan\|Haertl, Christoph\|Bruns, Christiane J\|Modest, Dominik P
PMID:	25514114

240.
Journal:	Mol Pharmacol. 2015;87(3):465-76.
Title:	The c-MET/PI3K signaling is associated with cancer resistance to doxorubicin and photodynamic therapy by elevating BCRP/ABCG2 expression.
Author:	Jung, Kyeong-Ah\|Choi, Bo-Hyun\|Kwak, Mi-Kyoung
PMID:	25534417

241.
Journal:	Cell Biochem Biophys. 2015 Jun;72(2):453-9.
Title:	Sorcin Enhances Metastasis and Promotes Epithelial-to-Mesenchymal Transition of Colorectal Cancer.
Author:	Tong, Weihua\|Sun, Donghui\|Wang, Quan\|Suo, Jian
PMID:	25567655

242.
Journal:	Inflamm Bowel Dis. 2015 Feb;21(2):287-96.
Title:	Overexpression of PAK1 promotes cell survival in inflammatory bowel diseases and colitis-associated cancer.
Author:	Khare, Vineeta\|Dammann, Kyle\|Asboth, Mario\|Krnjic, Anita\|Jambrich, Manuela\|Gasche, Christoph
PMID:	25569743

243.
Journal:	Crit Rev Oncol Hematol. 2015 Apr;94(1):18-30.
Title:	The role of the PI3K pathway in colorectal cancer.
Author:	Papadatos-Pastos, Dionysios\|Rabbie, Roy\|Ross, Paul\|Sarker, Debashis
PMID:	25591826

244.
Journal:	Cancer Lett. 2015 Apr 1;359(1):136-47.
Title:	IFN-gamma-mediated IRF1/miR-29b feedback loop suppresses colorectal cancer cell growth and metastasis by repressing IGF1.
Author:	Yuan, Li\|Zhou, Chang\|Lu, Yanxia\|Hong, Min\|Zhang, Zuoyang\|Zhang, Zheying\|Chang, Yaya\|Zhang, Chao\|Li, Xuenong
PMID:	25592039

245.
Journal:	Oncotarget. 2015 Feb 20;6(5):2939-50.
Title:	Cathelicidin, an antimicrobial peptide produced by macrophages, promotes colon cancer by activating the Wnt/beta-catenin pathway.
Author:	Li, Dong\|Liu, Wenfang\|Wang, Xuan\|Wu, Junlu\|Quan, Wenqiang\|Yao, Yiwen\|Bals, Robert\|Ji, Shurong\|Wu, Kaiyin\|Guo, Jia\|Wan, Haiying
PMID:	25596747

246.
Journal:	Mol Med Rep. 2015 Jun;11(6):4617-24.
Title:	Oleuropein induces apoptosis via activation of caspases and suppression of phosphatidylinositol 3-kinase/protein kinase B pathway in HepG2 human hepatoma cell line.
Author:	Yan, Chun-Mei\|Chai, Er-Qing\|Cai, Hong-Yi\|Miao, Guo-Ying\|Ma, Wen
PMID:	25634350

247.
Journal:	Oncogene. 2015 Dec 3;34(49):5971-82.
Title:	An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis.
Author:	Zhu, G\|Fan, Z\|Ding, M\|Zhang, H\|Mu, L\|Ding, Y\|Zhang, Y\|Jia, B\|Chen, L\|Chang, Z\|Wu, W
PMID:	25746002

248.
Journal:	Int J Mol Med. 2015 May;35(5):1301-8.
Title:	miR-218 inhibits the invasion and migration of colon cancer cells by targeting the PI3K/Akt/mTOR signaling pathway.
Author:	Zhang, Xiangliang\|Shi, Huijuan\|Tang, Hongsheng\|Fang, Zhiyuan\|Wang, Jiping\|Cui, Shuzhong
PMID:	25760926

249.
Journal:	J Cell Biochem. 2015 Sep;116(9):1837-47.
Title:	Oncogenic and Therapeutic Targeting of PTEN Loss in Bone Malignancies.
Author:	Xi, Yongming\|Chen, Yan
PMID:	25773992

250.
Journal:	Sci Rep. 2015 Mar 24;5:9429.
Title:	HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion.
Author:	Feng, Yingying\|Xu, Xiaojie\|Zhang, Yunjing\|Ding, Jianhua\|Wang, Yonggang\|Zhang, Xiaopeng\|Wu, Zhe\|Kang, Lei\|Liang, Yingchun\|Zhou, LiYing\|Song, Santai\|Zhao, Ke\|Ye, Qinong
PMID:	25800793

251.
Journal:	J Biol Chem. 2015 Jun 12;290(24):15018-29.
Title:	Phosphatase and Tensin Homolog (PTEN) Represses Colon Cancer Progression through Inhibiting Paxillin Transcription via PI3K/AKT/NF-kappaB Pathway.
Author:	Zhang, Ling-Li\|Mu, Gang-Gang\|Ding, Qian-Shan\|Li, Yan-Xia\|Shi, Yun-bo\|Dai, Jin-Fen\|Yu, Hong-Gang
PMID:	25873394

252.
Journal:	Endocr Relat Cancer. 2015 Jun;22(3):455-64.
Title:	Brain-derived neurotrophic factor regulates cell motility in human colon cancer.
Author:	Huang, Ssu-Ming\|Lin, Chingju\|Lin, Hsiao-Yun\|Chiu, Chien-Ming\|Fang, Chia-Wei\|Liao, Kuan-Fu\|Chen, Dar-Ren\|Yeh, Wei-Lan
PMID:	25876647

253.
Journal:	BMC Cancer. 2015 Apr 8;15:240.
Title:	HGUE-C-1 is an atypical and novel colon carcinoma cell line.
Author:	Grasso, Silvina\|Martinez-Lacaci, Isabel\|Barbera, Victor Manuel\|Castillejo, Adela\|Soto, Jose Luis\|Gallego-Plazas, Javier\|Lopez-Riquelme, Natividad\|Garcia-Morales, Pilar\|Mata-Balaguer, Trinidad\|Ferragut, Jose Antonio\|Saceda, Miguel
PMID:	25885658

254.
Journal:	Nutr J. 2015 Apr 1;14:31.
Title:	Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells.
Author:	Tahir, Analhuda Abdullah\|Sani, Nur Fathiah Abdul\|Murad, Noor Azian\|Makpol, Suzana\|Ngah, Wan Zurinah Wan\|Yusof, Yasmin Anum Mohd
PMID:	25889965

255.
Journal:	Cancer Res. 2015 Jun 15;75(12):2434-44.
Title:	IL13 Receptor alpha2 Signaling Requires a Scaffold Protein, FAM120A, to Activate the FAK and PI3K Pathways in Colon Cancer Metastasis.
Author:	Bartolome, Ruben A\|Garcia-Palmero, Irene\|Torres, Sofia\|Lopez-Lucendo, Maria\|Balyasnikova, Irina V\|Casal, J Ignacio
PMID:	25896327

256.
Journal:	Nan Fang Yi Ke Da Xue Xue Bao. 2015 Apr;35(4):511-5.
Title:	[Mechanism of thioridazine-induced apoptosis of human colorectal cancer SW480 cells].
Author:	Liu, Jin-Kun\|Hao, Ya-Juan\|Huang, Jia-Wei\|Li, Xin\|Cai, Hong-Bing\|Peng, Kang
PMID:	25907934

257.
Journal:	Tumori. 2015 Mar-Apr;101(2):238-45.
Title:	BDE-99 (2,2',4,4',5-pentabromodiphenyl ether) triggers epithelial-mesenchymal transition in colorectal cancer cells via PI3K/Akt/Snail signaling pathway.
Author:	Wang, Fei\|Ruan, Xin-Jian\|Zhang, Hong-Yan
PMID:	25908029

258.
Journal:	Carcinogenesis. 2015 Jul;36(7):710-8.
Title:	ERBB4 is over-expressed in human colon cancer and enhances cellular transformation.
Author:	Williams, Christopher S\|Bernard, Jessica K\|Demory Beckler, Michelle\|Almohazey, Dana\|Washington, Mary Kay\|Smith, Jesse J\|Frey, Mark R
PMID:	25916654

259.
Journal:	J Surg Oncol. 2015 Jun;111(7):905-10.
Title:	Mutations in the RAS and PI3K pathways are associated with metastatic location in colorectal cancers.
Author:	Lan, Yuan-Tzu\|Jen-Kou, Lin\|Lin, Chien-Hsing\|Yang, Shung-Haur\|Lin, Chun-Chi\|Wang, Huann-Sheng\|Chen, Wei-Shone\|Lin, Tzu-Chen\|Jiang, Jeng-Kai\|Chang, Shih-Ching
PMID:	25920435

260.
Journal:	Mol Cancer Res. 2015 Aug;13(8):1248-62.
Title:	Colorectal Carcinogenesis: Connecting K-RAS-Induced Transformation and CREB Activity In Vitro and In Vivo.
Author:	Steven, Andre\|Heiduk, Max\|Recktenwald, Christian V\|Hiebl, Bernhard\|Wickenhauser, Claudia\|Massa, Chiara\|Seliger, Barbara
PMID:	25934695

261.
Journal:	PLoS One. 2015 May 7;10(5):e0121648.
Title:	ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/beta-Catenin, Notch and PI3K/Akt Signaling Pathways.
Author:	Singh, Surendra\|Arcaroli, John\|Chen, Ying\|Thompson, David C\|Messersmith, Wells\|Jimeno, Antonio\|Vasiliou, Vasilis
PMID:	25950950

262.
Journal:	Int J Clin Exp Pathol. 2015 Feb 1;8(2):1402-10. eCollection 2015.
Title:	Inositol hexaphosphate suppresses growth and induces apoptosis in HT-29 colorectal cancer cells in culture: PI3K/Akt pathway as a potential target.
Author:	Liu, Guiyuan\|Song, Yang\|Cui, Lianhua\|Wen, Zhaoxia\|Lu, Xiaoqing
PMID:	25973024

263.
Journal:	Mol Med Rep. 2015 Sep;12(3):3446-3452.
Title:	Fucoidan inhibits the migration and proliferation of HT-29 human colon cancer cells via the phosphoinositide-3 kinase/Akt/mechanistic target of rapamycin pathways.
Author:	Han, Yong-Seok\|Lee, Jun Hee\|Lee, Sang Hun
PMID:	25998232

264.
Journal:	Drug Resist Updat. 2015 May;20:39-70.
Title:	Pharmacogenomics of intrinsic and acquired pharmacoresistance in colorectal cancer: Toward targeted personalized therapy.
Author:	De Mattia, Elena\|Cecchin, Erika\|Toffoli, Giuseppe
PMID:	26027741

265.
Journal:	Oncotarget. 2015 May 30;6(15):13334-46.
Title:	Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancer.
Author:	Gyorffy, Balazs\|Stelniec-Klotz, Iwona\|Sigler, Christian\|Kasack, Katharina\|Redmer, Torben\|Qian, Yu\|Schafer, Reinhold
PMID:	26033452

266.
Journal:	Am J Cancer Res. 2015 Feb 15;5(3):1047-61. eCollection 2015.
Title:	Hispidulin prevents hypoxia-induced epithelial-mesenchymal transition in human colon carcinoma cells.
Author:	Xie, Jing\|Gao, Hui\|Peng, Jianjun\|Han, Yantao\|Chen, Xuehong\|Jiang, Qixiao\|Wang, Chunbo
PMID:	26045985

267.
Journal:	Int J Clin Exp Pathol. 2015 May 1;8(5):4481-91. eCollection 2015.
Title:	Up-regulation of microRNA-302a inhibited the proliferation and invasion of colorectal cancer cells by regulation of the MAPK and PI3K/Akt signaling pathways.
Author:	Wei, Zhi-Jiang\|Tao, Ming-Ling\|Zhang, Wei\|Han, Guo-Da\|Zhu, Zhong-Cheng\|Miao, Zhi-Gang\|Li, Jian-Ye\|Qiao, Zhan-Bing
PMID:	26191138

268.
Journal:	Biomed Pharmacother. 2015 Jul;73:12-8.
Title:	Knockdown of type I insulin-like growth factor receptor inhibits human colorectal cancer cell growth and downstream PI3K/Akt, WNT/beta-catenin signal pathways.
Author:	Zhang, Qian-yun\|Wang, Lu\|Song, Zhi-yu\|Qu, Xian-jun
PMID:	26211576

269.
Journal:	Anticancer Drugs. 2015 Sep;26(8):813-23.
Title:	Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells.
Author:	Fan, Kai\|Li, Xiaolei\|Cao, Yonggang\|Qi, Hanping\|Li, Lei\|Zhang, Qianhui\|Sun, Hongli
PMID:	26214321

270.
Journal:	Pharmacogenomics. 2015;16(10):1189-222.
Title:	Molecular biomarkers in colorectal carcinoma.
Author:	Puerta-Garcia, Elena\|Canadas-Garre, Marisa\|Calleja-Hernandez, Miguel Angel
PMID:	26237292

271.
Journal:	J Transl Med. 2015 Aug 4;13:252.
Title:	MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer.
Author:	Zheng, Lin\|Zhang, Yuqin\|Liu, Yan\|Zhou, Min\|Lu, Yanxia\|Yuan, Li\|Zhang, Chao\|Hong, Min\|Wang, Shuang\|Li, Xuenong
PMID:	26238857

272.
Journal:	Oncogenesis. 2015 Aug 10;4:e162.
Title:	SPINK1 promotes colorectal cancer progression by downregulating Metallothioneins expression.
Author:	Tiwari, R\|Pandey, S K\|Goel, S\|Bhatia, V\|Shukla, S\|Jing, X\|Dhanasekaran, S M\|Ateeq, B
PMID:	26258891

273.
Journal:	Gastroenterology. 2015 Dec;149(7):1884-1895.e4.
Title:	Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice.
Author:	Wang, Dingzhi\|Fu, Lingchen\|Sun, Haiyan\|Guo, Lixia\|DuBois, Raymond N
PMID:	26261008

274.
Journal:	Exp Cell Res. 2015 Oct 15;338(1):10-21.
Title:	Epibrassinolide alters PI3K/MAPK signaling axis via activating Foxo3a-induced mitochondria-mediated apoptosis in colon cancer cells.
Author:	Coskun, Deniz\|Obakan, Pinar\|Arisan, Elif Damla\|Coker-Gurkan, Ajda\|Palavan-Unsal, Narcin
PMID:	26318418

275.
Journal:	Cancer Gene Ther. 2015 Sep;22(9):417-30.
Title:	A 2015 update on predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance.
Author:	Dietel, M\|Johrens, K\|Laffert, M V\|Hummel, M\|Blaker, H\|Pfitzner, B M\|Lehmann, A\|Denkert, C\|Darb-Esfahani, S\|Lenze, D\|Heppner, F L\|Koch, A\|Sers, C\|Klauschen, F\|Anagnostopoulos, I
PMID:	26358176

276.
Journal:	Biomed Res Int. 2015;2015:598386.
Title:	Lysophosphatidic Acid Inhibits Apoptosis Induced by Cisplatin in Cervical Cancer Cells.
Author:	Sui, Yanxia\|Yang, Ya\|Wang, Ji\|Li, Yi\|Ma, Hongbing\|Cai, Hui\|Liu, Xiaoping\|Zhang, Yong\|Wang, Shufeng\|Li, Zongfang\|Zhang, Xiaozhi\|Wang, Jiansheng\|Liu, Rui\|Yan, Yanli\|Xue, Chaofan\|Shi, Xiaowei\|Tan, Li\|Ren, Juan
PMID:	26366416

277.
Journal:	Metallomics. 2015 Oct;7(10):1390-8.
Title:	Activation by zinc of the human gastrin gene promoter in colon cancer cells in vitro and in vivo.
Author:	Marshall, Kathryn M\|Laval, Marie\|Estacio, Ortis\|Hudson, Damien F\|Kalitsis, Paul\|Shulkes, Arthur\|Baldwin, Graham S\|Patel, Oneel
PMID:	26404630

278.
Journal:	Sci Rep. 2015 Oct 8;5:14739.
Title:	Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets.
Author:	Lu, Junyan\|Zeng, Hanlin\|Liang, Zhongjie\|Chen, Limin\|Zhang, Liyi\|Zhang, Hao\|Liu, Hong\|Jiang, Hualiang\|Shen, Bairong\|Huang, Ming\|Geng, Meiyu\|Spiegel, Sarah\|Luo, Cheng
PMID:	26446703

279.
Journal:	Curr Cancer Drug Targets. 2015;15(8):703-15.
Title:	Prognostic and Predictive Biomarkers in Colorectal Cancer. From the Preclinical Setting to Clinical Practice.
Author:	Maurel, Joan\|Postigo, Antonio
PMID:	26452385

280.
Journal:	Cancer Cell Int. 2015 Oct 9;15:96.
Title:	Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy.
Author:	Ramasamy, Thamil Selvee\|Ayob, Ain Zubaidah\|Myint, Hsu Hsu Lynn\|Thiagarajah, Sharmanee\|Amini, Farahnaz
PMID:	26457069

281.
Journal:	Int J Clin Exp Pathol. 2015 Aug 1;8(8):9097-104. eCollection 2015.
Title:	The silence of p66(Shc) in HCT8 cells inhibits the viability via PI3K/AKT/Mdm-2/p53 signaling pathway.
Author:	Zhang, Ling\|Zhu, Shengtao\|Shi, Xuesen\|Sha, Weihong
PMID:	26464652

282.
Journal:	Invest New Drugs. 2015 Dec;33(6):1225-31.
Title:	A phase I trial of mFOLFOX6 combined with the oral PI3K inhibitor BKM120 in patients with advanced refractory solid tumors.
Author:	McRee, Autumn J\|Sanoff, Hanna K\|Carlson, Cheryl\|Ivanova, Anastasia\|O'Neil, Bert H
PMID:	26490655

283.
Journal:	J Control Release. 2015 Dec 28;220(Pt A):160-168.
Title:	Cytotoxicity of PEGylated liposomes co-loaded with novel pro-apoptotic drug NCL-240 and the MEK inhibitor cobimetinib against colon carcinoma in vitro.
Author:	Sriraman, Shravan Kumar\|Geraldo, Vananelia\|Luther, Ed\|Degterev, Alexei\|Torchilin, Vladimir
PMID:	26497930

284.
Journal:	Am J Chin Med. 2015;43(7):1471-86.
Title:	Ursolic Acid Induces Apoptosis of Prostate Cancer Cells via the PI3K/Akt/mTOR Pathway.
Author:	Meng, Yan\|Lin, Zhao-Min\|Ge, Nan\|Zhang, Deng-Lu\|Huang, Jie\|Kong, Feng
PMID:	26503559

285.
Journal:	PLoS One. 2015 Nov 6;10(11):e0141753.
Title:	The Anti-Tumor Activity of Succinyl Macrolactin A Is Mediated through the beta-Catenin Destruction Complex via the Suppression of Tankyrase and PI3K/Akt.
Author:	Regmi, Sushil C\|Park, Su Young\|Kim, Seung Joo\|Banskota, Suhrid\|Shah, Sajita\|Kim, Dong-Hee\|Kim, Jung-Ae
PMID:	26544726

286.
Journal:	Int J Mol Sci. 2015 Dec 29;17(1). pii: ijms17010041.
Title:	Alisertib Induces Cell Cycle Arrest, Apoptosis, Autophagy and Suppresses EMT in HT29 and Caco-2 Cells.
Author:	Ren, Bao-Jun\|Zhou, Zhi-Wei\|Zhu, Da-Jian\|Ju, Yong-Le\|Wu, Jin-Hao\|Ouyang, Man-Zhao\|Chen, Xiao-Wu\|Zhou, Shu-Feng
PMID:	26729093

287.
Journal:	Oncol Lett. 2015 Dec;10(6):3682-3688.
Title:	Functional mechanism of the enhancement of 5-fluorouracil sensitivity by TUSC4 in colon cancer cells.
Author:	Liu, Ming-Na\|Liu, Ai-Yun\|Pei, Feng-Hua\|Ma, Xiao\|Fan, Yu-Jing\|DU, Ya-Ju\|Liu, Bing-Rong
PMID:	26788191

288.
Journal:	J Pathol Clin Res. 2014 Nov 5;1(1):3-17.
Title:	The molecular background of mucinous carcinoma beyond MUC2.
Author:	Hugen, Niek\|Simons, Michiel\|Halilovic, Altuna\|van der Post, Rachel S\|Bogers, Anna J\|Marijnissen-van Zanten, Monica Aj\|de Wilt, Johannes Hw\|Nagtegaal, Iris D
PMID:	27499889

289.
Journal:	Am J Clin Oncol. 2016 Jun;39(3):236-42.
Title:	Phase II Trial of Target-guided Personalized Chemotherapy in First-line Metastatic Colorectal Cancer.
Author:	Cubillo, Antonio\|Rodriguez-Pascual, Jesus\|Lopez-Rios, Fernando\|Plaza, Carlos\|Garcia, Elena\|Alvarez, Rafael\|de Vicente, Emilio\|Quijano, Yolanda\|Hernando, Ovidio\|Rubio, Carmen\|Perea, Sofia\|Sanchez, Gema\|Hidalgo, Manuel
PMID:	24517959

290.
Journal:	Oncogene. 2016 Jan 14;35(2):148-57.
Title:	mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.
Author:	He, K\|Zheng, X\|Li, M\|Zhang, L\|Yu, J
PMID:	25867072

291.
Journal:	J Cancer Res Clin Oncol. 2016 Jan;142(1):59-72.
Title:	Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway.
Author:	Chang, Ligong\|Wu, Peng\|Senthilkumar, Ravichandran\|Tian, Xiaoqiang\|Liu, Hui\|Shen, Xia\|Tao, Zijian\|Huang, Peilin
PMID:	26109148

292.
Journal:	J Cell Biochem. 2016 Feb;117(2):458-69.
Title:	PTEN Overexpression Cooperates With Lithium to Reduce the Malignancy and to Increase Cell Death by Apoptosis via PI3K/Akt Suppression in Colorectal Cancer Cells.
Author:	de Araujo, Wallace Martins\|Robbs, Bruno Kaufmann\|Bastos, Lilian G\|de Souza, Waldemir F\|Vidal, Flavia C B\|Viola, Joao P B\|Morgado-Diaz, Jose A
PMID:	26224641

293.
Journal:	Biochem Biophys Res Commun. 2016 Jan 15;469(3):370-6.
Title:	Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6.
Author:	Penrose, Harrison\|Heller, Sandra\|Cable, Chloe\|Makboul, Rania\|Chadalawada, Gita\|Chen, Ying\|Crawford, Susan E\|Savkovic, Suzana D
PMID:	26657850

294.
Journal:	Food Funct. 2016 Feb;7(2):843-54.
Title:	A serine protease extracted from Trichosanthes kirilowii induces apoptosis via the PI3K/AKT-mediated mitochondrial pathway in human colorectal adenocarcinoma cells.
Author:	Song, Li\|Chang, Jiao\|Li, Zhuoyu
PMID:	26673746

295.
Journal:	Oncol Rep. 2016 Mar;35(3):1501-10.
Title:	Cinnamaldehyde affects the biological behavior of human colorectal cancer cells and induces apoptosis via inhibition of the PI3K/Akt signaling pathway.
Author:	Li, Jiepin\|Teng, Yuhao\|Liu, Shenlin\|Wang, Zifan\|Chen, Yan\|Zhang, Yingying\|Xi, Songyang\|Xu, Song\|Wang, Ruiping\|Zou, Xi
PMID:	26677144

296.
Journal:	Oncol Rep. 2016 Feb;35(2):1075-82.
Title:	MiR-331-3p inhibits proliferation and promotes apoptosis by targeting HER2 through the PI3K/Akt and ERK1/2 pathways in colorectal cancer.
Author:	Zhao, Dongli\|Sui, Yanxia\|Zheng, Xiaoqiang
PMID:	26718987

297.
Journal:	Oncol Rep. 2016 Feb;35(2):999-1005.
Title:	CHRNA7 inhibits cell invasion and metastasis of LoVo human colorectal cancer cells through PI3K/Akt signaling.
Author:	Xiang, Tao\|Yu, Feng\|Fei, Rushan\|Qian, Jing\|Chen, Wenbin
PMID:	26719016

298.
Journal:	Mol Carcinog. 2016 Dec;55(12):2135-2155.
Title:	A novel PI3K axis selective molecule exhibits potent tumor inhibition in colorectal carcinogenesis.
Author:	Hussain, Aashiq\|Qazi, Asif Khurshid\|Mupparapu, Nagaraju\|Kumar, Ashok\|Mintoo, Mubashir Javeed\|Mahajan, Girish\|Sharma, Parduman Raj\|Singh, Shashank Kumar\|Bharate, Sandip B\|Zargar, Mohmmad Afzal\|Ahmed, Qazi Naveed\|Mondhe, Dilip Manikrao\|Vishwakarma, Ram A\|Ha
PMID:	26764221

299.
Journal:	Mol Carcinog. 2016 Dec;55(12):2196-2209.
Title:	The PI3K/Akt pathway is involved in procyanidin-mediated suppression of human colorectal cancer cell growth.
Author:	Choy, Ying Yng\|Fraga, Magdalena\|Mackenzie, Gerardo G\|Waterhouse, Andrew L\|Cremonini, Eleonora\|Oteiza, Patricia I
PMID:	26774105

300.
Journal:	Tumour Biol. 2016 Jul;37(7):9465-72.
Title:	B7-H3 increases thymidylate synthase expression via the PI3k-Akt pathway.
Author:	Jiang, Bo\|Liu, Fen\|Liu, ZhiHui\|Zhang, Ting\|Hua, Dong
PMID:	26787540

301.
Journal:	Molecules. 2016 Jan 30;21(2):169.
Title:	Chemopreventive and Therapeutic Effects of Edible Berries: A Focus on Colon Cancer Prevention and Treatment.
Author:	Afrin, Sadia\|Giampieri, Francesca\|Gasparrini, Massimiliano\|Forbes-Hernandez, Tamara Y\|Varela-Lopez, Alfonso\|Quiles, Jose L\|Mezzetti, Bruno\|Battino, Maurizio
PMID:	26840292

302.
Journal:	Int J Oncol. 2016 Apr;48(4):1391-8.
Title:	Overexpression of KiSS-1 reduces colorectal cancer cell invasion by downregulating MMP-9 via blocking PI3K/Akt/NF-kappaB signal pathway.
Author:	Chen, Shaoqin\|Chen, Wei\|Zhang, Xiang\|Lin, Suyong\|Chen, Zhihua
PMID:	26847533

303.
Journal:	Eur J Pharmacol. 2016 Apr 5;776:124-31.
Title:	Ghrelin induces colon cancer cell proliferation through the GHS-R, Ras, PI3K, Akt, and mTOR signaling pathways.
Author:	Lien, Gi-Shih\|Lin, Chien-Huang\|Yang, You-Lan\|Wu, Ming-Shun\|Chen, Bing-Chang
PMID:	26879868

304.
Journal:	Oncol Lett. 2016 Feb;11(2):1549-1554.
Title:	Downregulation of Foxc2 enhances apoptosis induced by 5-fluorouracil through activation of MAPK and AKT pathways in colorectal cancer.
Author:	Yang, Chao\|Cui, Xiaoxian\|Dai, Xiaoqin\|Liao, Wenting
PMID:	26893778

305.
Journal:	Cell Death Dis. 2016 Feb 25;7:e2108.
Title:	The miR-27a-calreticulin axis affects drug-induced immunogenic cell death in human colorectal cancer cells.
Author:	Colangelo, T\|Polcaro, G\|Ziccardi, P\|Muccillo, L\|Galgani, M\|Pucci, B\|Milone, M Rita\|Budillon, A\|Santopaolo, M\|Mazzoccoli, G\|Matarese, G\|Sabatino, L\|Colantuoni, V
PMID:	26913599

306.
Journal:	Chem Biol Interact. 2016 Apr 5;249:23-35.
Title:	In vitro antiproliferative activity of 2,3-dihydroxy-9,10-anthraquinone induced apoptosis against COLO320 cells through cytochrome c release caspase mediated pathway with PI3K/AKT and COX-2 inhibition.
Author:	Balachandran, C\|Emi, N\|Arun, Y\|Yamamoto, N\|Duraipandiyan, V\|Inaguma, Yoko\|Okamoto, Akinao\|Ignacimuthu, S\|Al-Dhabi, N A\|Perumal, P T
PMID:	26915975

307.
Journal:	Cancer Lett. 2016 May 1;374(2):250-60.
Title:	Modulation of glycolysis and lipogenesis by novel PI3K selective molecule represses tumor angiogenesis and decreases colorectal cancer growth.
Author:	Hussain, Aashiq\|Qazi, Asif Khurshid\|Mupparapu, Nagaraju\|Guru, Santosh Kumar\|Kumar, Ashok\|Sharma, Parduman Raj\|Singh, Shashank Kumar\|Singh, Paramjit\|Dar, Mohd Jamal\|Bharate, Sandip B\|Zargar, Mohmmad Afzal\|Ahmed, Qazi Naveed\|Bhushan, Shashi\|Vishwakarma, Ram
PMID:	26921131

308.
Journal:	Asian Pac J Cancer Prev. 2016;17(2):743-8.
Title:	Impact of Cellular Genetic Make-up on Colorectal Cancer Cell Lines Response to Ellagic Acid: Implications of Small Interfering RNA.
Author:	Yousef, Amany I\|El-Masry, Omar S\|Abdel Mohsen, Mohamed A
PMID:	26925673

309.
Journal:	Mol Med Rep. 2016 Apr;13(4):3243-8.
Title:	Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway.
Author:	Feng, Nan\|Luo, Jianmin\|Guo, Ximin
PMID:	26936429

310.
Journal:	J Korean Med Sci. 2016 Mar;31(3):360-70.
Title:	Dual-Blocking of PI3K and mTOR Improves Chemotherapeutic Effects on SW620 Human Colorectal Cancer Stem Cells by Inducing Differentiation.
Author:	Kim, Min-Jung\|Koo, Jeong-Eun\|Han, Gi-Yeon\|Kim, Buyun\|Lee, Yoo-Sun\|Ahn, Chiyoung\|Kim, Chan-Wha
PMID:	26955235

311.
Journal:	Cell Tissue Res. 2016 Aug;365(2):357-66.
Title:	Mesenchymal-epithelial signalling in tumour microenvironment: role of high-mobility group Box 1.
Author:	Sharma, Sikander\|Evans, Andrew\|Hemers, Elaine
PMID:	26979829

312.
Journal:	Crit Rev Oncol Hematol. 2016 May;101:151-7.
Title:	Dual targeting of HER3 and EGFR in colorectal tumors might overcome anti-EGFR resistance.
Author:	Temraz, Sally\|Mukherji, Deborah\|Shamseddine, Ali
PMID:	27017409

313.
Journal:	Mol Biol (Mosk). 2016 Jan-Feb;50(1):174-8.
Title:	[Alpha-1 Antitrypsin Affects U0126-Induced Cytotoxicity in Colon Cancer Cell Line (HCT116)].
Author:	Ljujic, M\|Mijatovic, S\|Bulatovic, M Z\|Mojic, M\|Maksimovic-Ivanic, D\|Radojkovic, D\|Topic, A
PMID:	27028823

314.
Journal:	J Gastrointest Oncol. 2016 Apr;7(2):E22-4.
Title:	Genomic profiling of high-grade large-cell neuroendocrine carcinoma of the colon.
Author:	Hammond, William A\|Crozier, Jennifer A\|Nakhleh, Raouf E\|Mody, Kabir
PMID:	27034803

315.
Journal:	Biomed Pharmacother. 2016 Apr;79:112-9.
Title:	Pristimerin inhibits proliferation, migration and invasion, and induces apoptosis in HCT-116 colorectal cancer cells.
Author:	Yousef, Bashir A\|Hassan, Hozeifa M\|Guerram, Mounia\|Hamdi, Aida M\|Wang, Bin\|Zhang, Lu-Yong\|Jiang, Zhen-Zhou
PMID:	27044819

316.
Journal:	J Cancer Prev. 2016 Mar;21(1):26-31.
Title:	Dehydroglyasperin D Inhibits the Proliferation of HT-29 Human Colorectal Cancer Cells Through Direct Interaction With Phosphatidylinositol 3-kinase.
Author:	Jung, Sung Keun\|Jeong, Chul-Ho
PMID:	27051646

317.
Journal:	J Pathol. 2016 May;239(1):60-71.
Title:	TUSC3 promotes colorectal cancer progression and epithelial-mesenchymal transition (EMT) through WNT/beta-catenin and MAPK signalling.
Author:	Gu, Ye\|Wang, Qian\|Guo, Kang\|Qin, Weizhao\|Liao, Wenting\|Wang, Shuang\|Ding, Yanqing\|Lin, Jie
PMID:	27071482

318.
Journal:	Oncotarget. 2016 May 17;7(20):29187-98.
Title:	Acquired resistance to combination treatment through loss of synergy with MEK and PI3K inhibitors in colorectal cancer.
Author:	Bhattacharya, Bhaskar\|Low, Sarah Hong Hui\|Chong, Mei Ling\|Chia, Dilys\|Koh, King Xin\|Sapari, Nur Sabrina\|Kaye, Stanley\|Hung, Huynh\|Benoukraf, Touati\|Soong, Richie
PMID:	27081080

319.
Journal:	Oncol Res. 2016;23(5):249-56.
Title:	IL-17A Promotes the Migration and Invasiveness of Colorectal Cancer Cells Through NF-kappaB-Mediated MMP Expression.
Author:	Ren, Hongtao\|Wang, Zhongwei\|Zhang, Shuqun\|Ma, Hongbing\|Wang, Yali\|Jia, Lijun\|Li, Yiming
PMID:	27098148

320.
Journal:	Sci Rep. 2016 May 9;6:25631.
Title:	Loss of the 14-3-3sigma is essential for LASP1-mediated colorectal cancer progression via activating PI3K/AKT signaling pathway.
Author:	Shao, Ziyun\|Cai, Yanjun\|Xu, Lijun\|Yao, Xueqing\|Shi, Jiaolong\|Zhang, Feifei\|Luo, Yuhao\|Zheng, Kehong\|Liu, Jian\|Deng, Fengliu\|Li, Rui\|Zhang, Lanzhi\|Wang, Hui\|Li, Mingyi\|Ding, Yanqing\|Zhao, Liang
PMID:	27156963

321.
Journal:	J Cell Biochem. 2016 Dec;117(12):2854-2863.
Title:	The ERK1/2 and mTORC1 Signaling Pathways Are Involved in the Muscarinic Acetylcholine Receptor-Mediated Proliferation of SNU-407 Colon Cancer Cells.
Author:	Park, Yang-Seo\|Liu, Ziyu\|Vasamsetti, Bala Murali Krishna\|Cho, Nam Jeong
PMID:	27167250

322.
Journal:	J Clin Immunol. 2016 Jul;36(5):490-501.
Title:	Hyper IgM Syndrome: a Report from the USIDNET Registry.
Author:	Leven, Emily A\|Maffucci, Patrick\|Ochs, Hans D\|Scholl, Paul R\|Buckley, Rebecca H\|Fuleihan, Ramsay L\|Geha, Raif S\|Cunningham, Coleen K\|Bonilla, Francisco A\|Conley, Mary Ellen\|Ferdman, Ronald M\|Hernandez-Trujillo, Vivian\|Puck, Jennifer M\|Sullivan, Kathleen\|S
PMID:	27189378

323.
Journal:	Oncotarget. 2016 Jul 5;7(27):41306-41319.
Title:	microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway.
Author:	Chen, Yiyu\|Jiang, Jingwen\|Zhao, Mengyang\|Luo, Xiaojun\|Liang, Zixi\|Zhen, Yan\|Fu, Qiaofen\|Deng, Xiaojie\|Lin, Xian\|Li, Libo\|Luo, Rongcheng\|Liu, Zhen\|Fang, Weiyi
PMID:	27191497

324.
Journal:	Mol Cancer Ther. 2016 Jun;15(6):1248-60.
Title:	Inhibition of PI3K/BMX Cell Survival Pathway Sensitizes to BH3 Mimetics in SCLC.
Author:	Potter, Danielle S\|Galvin, Melanie\|Brown, Stewart\|Lallo, Alice\|Hodgkinson, Cassandra L\|Blackhall, Fiona\|Morrow, Christopher J\|Dive, Caroline
PMID:	27197306

325.
Journal:	Oncotarget. 2016 Jun 21;7(25):38191-38209.
Title:	Dual PI3K- and mTOR-inhibitor PI-103 can either enhance or reduce the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922 in tumor cells: The role of drug-irradiation schedule.
Author:	Djuzenova, Cholpon S\|Fiedler, Vanessa\|Katzer, Astrid\|Michel, Konstanze\|Deckert, Stefanie\|Zimmermann, Heiko\|Sukhorukov, Vladimir L\|Flentje, Michael
PMID:	27224913

326.
Journal:	J Exp Clin Cancer Res. 2016 May 25;35:84.
Title:	Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication.
Author:	Kaufhold, Samantha\|Garban, Hermes\|Bonavida, Benjamin
PMID:	27225481

327.
Journal:	Int J Nanomedicine. 2016 May 5;11:1947-58.
Title:	Synergistic inhibition of colon cancer cell growth with nanoemulsion-loaded paclitaxel and PI3K/mTOR dual inhibitor BEZ235 through apoptosis.
Author:	Zou, Hong\|Li, Li\|Garcia Carcedo, Ines\|Xu, Zhi Ping\|Monteiro, Michael\|Gu, Wenyi
PMID:	27226714

328.
Journal:	Can J Physiol Pharmacol. 2016 Sep;94(9):929-35.
Title:	Stanniocalcin 2 induces oxaliplatin resistance in colorectal cancer cells by upregulating P-glycoprotein.
Author:	Yuan, Qiong\|Zhan, Lin\|Zhang, Li-Li\|Wang, Qiang\|Liu, Juan\|Jiang, Zhen-Yu\|Hu, Xia-Min\|Yuan, Xin-Chu
PMID:	27245421

329.
Journal:	Dev Reprod. 2016 Mar;20(1):1-10.
Title:	Blockage of Autophagy Rescues the Dual PI3K/mTOR Inhibitor BEZ235-induced Growth Inhibition of Colorectal Cancer Cells.
Author:	Oh, Iljoong\|Cho, Hyunchul\|Lee, Yonghoon\|Cheon, Minseok\|Park, Deokbae\|Lee, Youngki
PMID:	27294206

330.
Journal:	Cancer Biomark. 2016 Jun 7;17(1):1-10.
Title:	Autophagy regulation and its role in gastric cancer and colorectal cancer.
Author:	Zhou, Huangyan\|Yuan, Min\|Yu, Qiongfang\|Zhou, Xiaoyan\|Min, Weiping\|Gao, Dian
PMID:	27314289

331.
Journal:	Oncotarget. 2016 Jul 19;7(29):46219-46229.
Title:	Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer.
Author:	Jang, Hyun Joo\|Hong, Eun Mi\|Kim, Mikang\|Kim, Jae Hyun\|Jang, Juah\|Park, Se Woo\|Byun, Hyun Wu\|Koh, Dong Hee\|Choi, Min Ho\|Kae, Sea Hyub\|Lee, Jin
PMID:	27323826

332.
Journal:	Oncol Lett. 2016 Jul;12(1):102-106.
Title:	Autophagy inhibition enhances colorectal cancer apoptosis induced by dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.
Author:	Yang, Xiaoyu\|Niu, Bingxuan\|Wang, Libo\|Chen, Meiling\|Kang, Xiaochun\|Wang, Luonan\|Ji, Yinghua\|Zhong, Jiateng
PMID:	27347108

333.
Journal:	World J Gastroenterol. 2016 Jun 28;22(24):5532-9.
Title:	MicroRNA-21 promotes phosphatase gene and protein kinase B/phosphatidylinositol 3-kinase expression in colorectal cancer.
Author:	Sheng, Wei-Zhong\|Chen, Yu-Sheng\|Tu, Chuan-Tao\|He, Juan\|Zhang, Bo\|Gao, Wei-Dong
PMID:	27350731

334.
Journal:	Oncotarget. 2016 Jul 26;7(30):47699-47710.
Title:	BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells.
Author:	He, Kan\|Chen, Dongshi\|Ruan, Hang\|Li, Xiangyun\|Tong, Jingshan\|Xu, Xiang\|Zhang, Lin\|Yu, Jian
PMID:	27351224

335.
Journal:	Chin J Integr Med. 2016 Jun 29. pii: 10.1007/s11655-016-2597-8.
Title:	Tounong Powder () extracts induce G1 cell cycle arrest and apoptosis in LoVo cells.
Author:	Fang, Liang-Hua\|Liu, Shen-Lin\|Wang, Rui-Ping\|Hu, Shou-You\|Ju, Wen-Zheng\|Li, Chang-Yin
PMID:	27358203

336.
Journal:	Gene. 2016 Oct 10;591(1):123-128.
Title:	Calycosin induces apoptosis in colorectal cancer cells, through modulating the ERbeta/MiR-95 and IGF-1R, PI3K/Akt signaling pathways.
Author:	Zhao, Xinge\|Li, Xin\|Ren, Qianyao\|Tian, Jing\|Chen, Jian
PMID:	27393650

337.
Journal:	Oncol Rep. 2016 Sep;36(3):1419-26.
Title:	Thyroid hormone receptor beta1 suppresses proliferation and migration by inhibiting PI3K/Akt signaling in human colorectal cancer cells.
Author:	Zhu, Lei\|Tian, Guangang\|Yang, Qin\|De, Gejing\|Zhang, Zhigang\|Wang, Yahui\|Nie, Huizhen\|Zhang, Yanli\|Yang, Xiaomei\|Li, Jun
PMID:	27431682

338.
Journal:	Exp Mol Med. 2016 Jul 29;48(7):e249.
Title:	Sur8 mediates tumorigenesis and metastasis in colorectal cancer.
Author:	Lee, Young-Mi\|Kaduwal, Saluja\|Lee, Kug Hwa\|Park, Jong-Chan\|Jeong, Woo-Jeong\|Choi, Kang-Yell
PMID:	27469030

339.
Journal:	Clin Cancer Res. 2016 Aug 1;22(15):3982.
Title:	Correction: MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer.
Author:
PMID:	27480870

340.
Journal:	Br J Cancer. 2016 Sep 6;115(6):682-90.
Title:	Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer.
Author:	Beale, Gary\|Haagensen, Emma J\|Thomas, Huw D\|Wang, Lan-Zhen\|Revill, Charlotte H\|Payne, Sara L\|Golding, Bernard T\|Hardcastle, Ian R\|Newell, David R\|Griffin, Roger J\|Cano, Celine
PMID:	27529512

341.
Journal:	Oncotarget. 2016 Oct 11;7(41):66660-66678.
Title:	Overexpression of CHKA contributes to tumor progression and metastasis and predicts poor prognosis in colorectal carcinoma.
Author:	Hu, Liang\|Wang, Ruo-Yu\|Cai, Jian\|Feng, Dan\|Yang, Guang-Zhen\|Xu, Qing-Guo\|Zhai, Yan-Xia\|Zhang, Yu\|Zhou, Wei-Ping\|Cai, Qing-Ping
PMID:	27556502

342.
Journal:	Adv Exp Med Biol. 2016;937:239-47.
Title:	MicroRNAs as Therapeutic Targets and Colorectal Cancer Therapeutics.
Author:	Yamamoto, Hirofumi\|Mori, Masaki
PMID:	27573904

343.
Journal:	Int J Oncol. 2016 Nov;49(5):2163-2172.
Title:	GSK-3beta-mediated fatty acid synthesis enhances epithelial to mesenchymal transition of TLR4-activated colorectal cancer cells through regulation of TAp63.
Author:	Park, Ga Bin\|Chung, Yoon Hee\|Gong, Ji Hee\|Jin, Dong-Hoon\|Kim, Daejin
PMID:	27599658

344.
Journal:	Oncotarget. 2016 Oct 18;7(42):68749-68767.
Title:	Exclusive inhibition of PI3K/Akt/mTOR signaling is not sufficient to prevent PDGF-mediated effects on glycolysis and proliferation in colorectal cancer.
Author:	Moench, Romana\|Grimmig, Tanja\|Kannen, Vinicius\|Tripathi, Sudipta\|Faber, Marc\|Moll, Eva-Maria\|Chandraker, Anil\|Lissner, Reinhard\|Germer, Christoph-Thomas\|Waaga-Gasser, Ana Maria\|Gasser, Martin
PMID:	27626684

345.
Journal:	J Exp Clin Cancer Res. 2016 Sep 20;35(1):148.
Title:	TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway.
Author:	Song, Guohe\|Xu, Shifeng\|Zhang, Hong\|Wang, Yupeng\|Xiao, Chao\|Jiang, Tao\|Wu, Leilei\|Zhang, Tao\|Sun, Xing\|Zhong, Lin\|Zhou, Chongzhi\|Wang, Zhaowen\|Peng, Zhihai\|Chen, Jian\|Wang, Xiaoliang
PMID:	27644693

346.
Journal:	Oncotarget. 2016 Nov 1;7(44):71400-71416.
Title:	STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways.
Author:	Chen, Bing\|Zeng, Xiao\|He, Yu\|Wang, Xixi\|Liang, Ziwei\|Liu, Jingjing\|Zhang, Peng\|Zhu, Hongxia\|Xu, Ningzhi\|Liang, Shufang
PMID:	27662663

347.
Journal:	PLoS One. 2016 Sep 26;11(9):e0159927.
Title:	The Association of CXC Receptor 4 Mediated Signaling Pathway with Oxaliplatin-Resistant Human Colorectal Cancer Cells.
Author:	Huang, Wen-Shih\|Hsieh, Meng-Chiao\|Huang, Cheng-Yi\|Kuo, Yi-Hung\|Tung, Shui-Yi\|Shen, Chien-Heng\|Hsieh, Yung-Yu\|Teng, Chih-Chuan\|Lee, Kam-Fai\|Chen, Te-Chuan\|Lee, Ko-Chao\|Kuo, Hsing-Chun
PMID:	27668882

348.
Journal:	Mol Cancer Res. 2016 Dec;14(12):1217-1228.
Title:	Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors.
Author:	Hesson, Luke B\|Ng, Benedict\|Zarzour, Peter\|Srivastava, Sameer\|Kwok, Chau-To\|Packham, Deborah\|Nunez, Andrea C\|Beck, Dominik\|Ryan, Regina\|Dower, Ashraf\|Ford, Caroline E\|Pimanda, John E\|Sloane, Mathew A\|Hawkins, Nicholas J\|Bourke, Michael J\|Wong, Jason W H\|W
PMID:	27671336

349.
Journal:	Apoptosis. 2016 Dec;21(12):1398-1407.
Title:	Oxymatrine synergistically enhances antitumor activity of oxaliplatin in colon carcinoma through PI3K/AKT/mTOR pathway.
Author:	Liu, Yan\|Bi, Tingting\|Wang, Zheng\|Wu, Guoliang\|Qian, Liqiang\|Gao, Quangen\|Shen, Genhai
PMID:	27671687

350.
Journal:	Gastroenterol Res Pract. 2016;2016:2102674.
Title:	Reduced Representation Bisulfite Sequencing Determination of Distinctive DNA Hypermethylated Genes in the Progression to Colon Cancer in African Americans.
Author:	Ashktorab, Hassan\|Shakoori, Afnan\|Zarnogi, Shatha\|Sun, Xueguang\|Varma, Sudhir\|Lee, Edward\|Shokrani, Babak\|Laiyemo, Adeyinka O\|Washington, Kareem\|Brim, Hassan
PMID:	27688749

351.
Journal:	Biomed Pharmacother. 2016 Dec;84:601-607.
Title:	Odontogenic ameloblast-associated protein (ODAM) inhibits human colorectal cancer growth by promoting PTEN elevation and inactivating PI3K/AKT signaling.
Author:	Yu, Minhao\|Mu, Yifei\|Qi, Yang\|Qin, Shaolan\|Qiu, Yier\|Cui, Ran\|Zhong, Ming
PMID:	27694004

352.
Journal:	Oncol Rep. 2016 Dec;36(6):3559-3567.
Title:	Salidroside induces apoptosis and autophagy in human colorectal cancer cells through inhibition of PI3K/Akt/mTOR pathway.
Author:	Fan, Xiang-Jun\|Wang, Yao\|Wang, Lei\|Zhu, Mingyan
PMID:	27748934

353.
Journal:	Biochem Biophys Res Commun. 2016 Nov 18;480(3):450-454.
Title:	Muscarinic acetylcholine receptors mediate eIF4B phosphorylation in SNU-407 colon cancer cells.
Author:	Liu, Ziyu\|Cho, Nam Jeong
PMID:	27773818

354.
Journal:	Oncol Rep. 2016 Dec;36(6):3619-3626.
Title:	Angiomotin promotes the malignant potential of colon cancer cells by activating the YAP-ERK/PI3K-AKT signaling pathway.
Author:	Zhang, Yan\|Yuan, Jun\|Zhang, Xinli\|Yan, Futang\|Huang, Minggang\|Wang, Tao\|Zheng, Xiao\|Zhang, Ming
PMID:	27779692

355.
Journal:	Oncotarget. 2016 Nov 22;7(47):77087-77095.
Title:	Differential role of intravenous anesthetics in colorectal cancer progression: implications for clinical application.
Author:	Deng, Fengliu\|Ouyang, Mingwen\|Wang, Xiaofei\|Yao, Xueqing\|Chen, Yeming\|Tao, Tao\|Sun, Xuegang\|Xu, Lijun\|Tang, Jing\|Zhao, Liang
PMID:	27780923

356.
Journal:	Sci Rep. 2016 Nov 4;6:36544.
Title:	Probing the PI3K/Akt/mTor pathway using (31)P-NMR spectroscopy: routes to glycogen synthase kinase 3.
Author:	Phyu, Su M\|Tseng, Chih-Chung\|Fleming, Ian N\|Smith, Tim A D
PMID:	27811956

357.
Journal:	Oncol Lett. 2016 Nov;12(5):3771-3778.
Title:	Celastrus orbiculatus extract triggers apoptosis and autophagy via PI3K/Akt/mTOR inhibition in human colorectal cancer cells.
Author:	Yang, Lin\|Liu, Yanqing\|Wang, Mei\|Qian, Yayun\|Dai, Xiaojun\|Zhu, Yaodong\|Chen, Jue\|Guo, Shiyu\|Hisamitsu, Tadashi
PMID:	27895729

358.
Journal:	Nat Commun. 2016 Nov 29;7:13615.
Title:	Functional exploration of colorectal cancer genomes using Drosophila.
Author:	Bangi, Erdem\|Murgia, Claudio\|Teague, Alexander G S\|Sansom, Owen J\|Cagan, Ross L
PMID:	27897178

359.
Journal:	Gan To Kagaku Ryoho. 2016 Nov;43(11):1361-1365.
Title:	[New Classification for Advanced Colorectal Cancer Using CancerPlex(R)Genomic Tests].
Author:	Kameyama, Hitoshi\|Shimada, Yoshifumi\|Ichikawa, Hiroshi\|Nagahashi, Masayuki\|Sakata, Jun\|Kobayashi, Takashi\|Nogami, Hitoshi\|Maruyama, Satoshi\|Takii, Yasumasa\|Okuda, Shujiro\|Ling, Yiwei\|Izutsu, Hiroshi\|Kodama, Keisuke\|Nakada, Mitsutaka\|Wakai, Toshifumi
PMID:	27899776

360.
Journal:	Biomed Res Int. 2016;2016:8145495.
Title:	(125)I Seeds Radiation Induces Paraptosis-Like Cell Death via PI3K/AKT Signaling Pathway in HCT116 Cells.
Author:	Hu, Lelin\|Wang, Hao\|Zhao, Yong\|Wang, Junjie
PMID:	28078301

361.
Journal:	Oncol Res. 2016 Oct 27;24(6):437-445.
Title:	Knockdown of SPOCK1 Inhibits the Proliferation and Invasion in Colorectal Cancer Cells by Suppressing the PI3K/Akt Pathway.
Author:	Zhao, Ping\|Guan, Hai-Tao\|Dai, Zhi-Jun\|Ma, Yu-Guang\|Liu, Xiao-Xu\|Wang, Xi-Jing
PMID:	28281964

362.
Journal:	Zhong Yao Cai. 2016 Jul;39(7):1618-22.
Title:	[Experiment on Jianpi Qingre Huoxue Decoction Drug Serum Regulates SW480 Cell Proliferation,Apoptosis,Cycle and the Expression of beta-Catenin by Altering PI3K/Akt Signal Pathway].
Author:	Zhang, Tao\|Chen, Yu\|Wang, Xiao-ping\|Ping, Qian\|Lin, Chun-li\|Zhuo, Shao-yuan
PMID:	30204364

363.
Journal:	Crit Rev Food Sci Nutr. 2017 Jul 24;57(11):2310-2320.
Title:	The role of dietary polyphenols in the moderation of the inflammatory response in early stage colorectal cancer.
Author:	Little, C H\|Combet, E\|McMillan, D C\|Horgan, P G\|Roxburgh, C S D
PMID:	26066365

364.
Journal:	Environ Toxicol. 2017 Feb;32(2):669-678.
Title:	Inhibition of NF-kappaB and metastasis in irinotecan (CPT-11)-resistant LoVo colon cancer cells by thymoquinone via JNK and p38.
Author:	Chen, Ming-Cheng\|Lee, Nien-Hung\|Hsu, Hsi-Hsien\|Ho, Tsung-Jung\|Tu, Chuan-Chou\|Chen, Ray-Jade\|Lin, Yueh-Min\|Viswanadha, Vijaya Padma\|Kuo, Wei-Wen\|Huang, Chih-Yang
PMID:	27060453

365.
Journal:	Clin Cancer Res. 2017 Jan 15;23(2):399-406.
Title:	PI3K/Akt/mTOR Signaling and Plasma Membrane Proteins Are Implicated in Responsiveness to Adjuvant Dendritic Cell Vaccination for Metastatic Colorectal Cancer.
Author:	Qian, David C\|Xiao, Xiangjun\|Byun, Jinyoung\|Suriawinata, Arief A\|Her, Stephanie C\|Amos, Christopher I\|Barth, Richard J Jr
PMID:	27435399

366.
Journal:	Cancer Res. 2017 Jan 1;77(1):142-152.
Title:	Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells.
Author:	Kang, Dong Woo\|Lee, Shin Wha\|Hwang, Won Chan\|Lee, Bo Hui\|Choi, Yong-Seok\|Suh, Young-Ah\|Choi, Kang-Yell\|Min, Do Sik
PMID:	27793841

367.
Journal:	Mol Cancer Ther. 2017 Feb;16(2):344-356.
Title:	Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities.
Author:	Talbert, Erin E\|Yang, Jennifer\|Mace, Thomas A\|Farren, Matthew R\|Farris, Alton B\|Young, Gregory S\|Elnaggar, Omar\|Che, Zheng\|Timmers, Cynthia D\|Rajasekera, Priyani\|Maskarinec, Jennifer M\|Bloomston, Mark\|Bekaii-Saab, Tanios\|Guttridge, Denis C\|Lesinski, Grego
PMID:	27811010

368.
Journal:	Oncol Rep. 2017 Jan;37(1):115-122.
Title:	TGF-beta1 induces PGP9.5 expression in CAFs to promote the growth of colorectal cancer cells.
Author:	Wen, Wei\|Liu, Ge\|Jin, Ke\|Hu, Xiang
PMID:	27840994

369.
Journal:	Biochem Biophys Res Commun. 2017 Jan 22;482(4):870-876.
Title:	SPOCK1 is up-regulated and promotes tumor growth via the PI3K/AKT signaling pathway in colorectal cancer.
Author:	Zhang, Jiaxuan\|Zhi, Xiaofei\|Shi, Shiyu\|Tao, Ran\|Chen, Peisheng\|Sun, Shiyu\|Bian, Longjun\|Xu, Zhangyan\|Ma, Lilin
PMID:	27889608

370.
Journal:	Curr Drug Targets. 2017;18(6):734-750.
Title:	Is Metformin a Therapeutic Paradigm for Colorectal Cancer: Insight into the Molecular Pathway?
Author:	Thent, Zar Chi\|Zaidun, Nurul Hannim\|Azmi, Muhammad Fairuz\|Senin, Mu Izuddin\|Haslan, Haszianaliza\|Salehuddin, Ruzain
PMID:	27919208

371.
Journal:	Oncogene. 2017 May 18;36(20):2857-2867.
Title:	Evolution and heterogeneity of non-hereditary colorectal cancer revealed by single-cell exome sequencing.
Author:	Wu, H\|Zhang, X-Y\|Hu, Z\|Hou, Q\|Zhang, H\|Li, Y\|Li, S\|Yue, J\|Jiang, Z\|Weissman, S M\|Pan, X\|Ju, B-G\|Wu, S
PMID:	27941887

372.
Journal:	J Agric Food Chem. 2017 Jan 11;65(1):51-59.
Title:	Antroquinonol, a Ubiquinone Derivative from the Mushroom Antrodia camphorata, Inhibits Colon Cancer Stem Cell-like Properties: Insights into the Molecular Mechanism and Inhibitory Targets.
Author:	Lin, Hsien-Chun\|Lin, Mei-Hsiang\|Liao, Jiahn-Haur\|Wu, Tzu-Hua\|Lee, Tzong-Huei\|Mi, Fwu-Long\|Wu, Chi-Hao\|Chen, Ku-Chung\|Cheng, Chia-Hsiung\|Lin, Cheng-Wei
PMID:	27997180

373.
Journal:	Oncotarget. 2017 Jan 24;8(4):6102-6113.
Title:	Idelalisib induces PUMA-dependent apoptosis in colon cancer cells.
Author:	Yang, Shida\|Zhu, Zhiyong\|Zhang, Xiaobing\|Zhang, Ning\|Yao, Zhicheng
PMID:	28008149

374.
Journal:	Biosci Rep. 2017 Feb 10;37(1). pii: BSR20160432.
Title:	Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases.
Author:	Rodgers, Samuel J\|Ferguson, Daniel T\|Mitchell, Christina A\|Ooms, Lisa M
PMID:	28082369

375.
Journal:	Int J Oncol. 2017 Feb;50(2):736-744.
Title:	Insulin induction instigates cell proliferation and metastasis in human colorectal cancer cells.
Author:	Lu, Chi-Cheng\|Chu, Pei-Yi\|Hsia, Shih-Min\|Wu, Chi-Hao\|Tung, Yu-Tang\|Yen, Gow-Chin
PMID:	28101572

376.
Journal:	PLoS One. 2017 Jan 20;12(1):e0170551.
Title:	Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway.
Author:	Soo, Hsien-Chuen\|Chung, Felicia Fei-Lei\|Lim, Kuan-Hon\|Yap, Veronica Alicia\|Bradshaw, Tracey D\|Hii, Ling-Wei\|Tan, Si-Hoey\|See, Sze-Jia\|Tan, Yuen-Fen\|Leong, Chee-Onn\|Mai, Chun-Wai
PMID:	28107519

377.
Journal:	Curr Pharm Des. 2017;23(13):2002-2008.
Title:	Current Status and Perspectives Regarding the Therapeutic Potential of Targeting EGFR Pathway by Curcumin in Lung Cancer.
Author:	Shafiee, Mojtaba\|Mohamadzade, Elham\|ShahidSales, Soudabeh\|Khakpouri, Samaneh\|Maftouh, Mina\|Parizadeh, Seyed Alireza\|Hasanian, Seyed Mahdi\|Avan, Amir
PMID:	28117012

378.
Journal:	Oncol Lett. 2017 Jan;13(1):342-346.
Title:	Tumor necrosis factor receptor 2 promotes growth of colorectal cancer via the PI3K/AKT signaling pathway.
Author:	Zhao, Tao\|Li, Huihui\|Liu, Zifeng
PMID:	28123565

379.
Journal:	Int J Oncol. 2017 Mar;50(3):1011-1021.
Title:	TGF-beta1/PTEN/PI3K signaling plays a critical role in the anti-proliferation effect of tetrandrine in human colon cancer cells.
Author:	Chen, Qian-Zhao\|Li, Yang\|Shao, Ying\|Zeng, Yu-Hua\|Ren, Wen-Yan\|Liu, Rong-Xing\|Zhou, Lin-Yun\|Hu, Xue-Lian\|Huang, Ming\|He, Fang\|Sun, Wen-Juan\|Wu, Ke\|He, Bai-Cheng
PMID:	28197642

380.
Journal:	Oncol Rep. 2017 Apr;37(4):2095-2100.
Title:	CXCL8 induces epithelial-mesenchymal transition in colon cancer cells via the PI3K/Akt/NF-kappaB signaling pathway.
Author:	Shen, Tao\|Yang, Zhibin\|Cheng, Xianshuo\|Xiao, Youchuan\|Yu, Kun\|Cai, Xinyi\|Xia, Cuifeng\|Li, Yunfeng
PMID:	28259918

381.
Journal:	Cancer Lett. 2017 Jun 28;396:94-102.
Title:	Co-targeting of EGFR and autophagy signaling is an emerging treatment strategy in metastatic colorectal cancer.
Author:	Koustas, Evangelos\|Karamouzis, Michalis V\|Mihailidou, Chrysovalantou\|Schizas, Dimitrios\|Papavassiliou, Athanasios G
PMID:	28323034

382.
Journal:	Nan Fang Yi Ke Da Xue Xue Bao. 2017 Mar 20;37(3):367-372.
Title:	[Inhibitory effect of apatinib on HCT-116 cells and its mechanism].
Author:	Yin, Liang\|Wang, Jin\|Huang, Feng-Chang\|Zhang, Yun-Fei\|Xu, Ning\|Wen, Zheng-Qi\|Li, Wen-Liang\|Dong, Jian
PMID:	28377354

383.
Journal:	Biosci Rep. 2017 May 11;37(3). pii: BSR20160447.
Title:	Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway.
Author:	Xu, Jun\|Zhang, Shouru\|Wang, Rong\|Wu, Xingye\|Zeng, Li\|Fu, Zhongxue
PMID:	28432271

384.
Journal:	Cell Death Differ. 2017 Jun;24(6):1045-1062.
Title:	mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism.
Author:	Lampada, Aikaterini\|O'Prey, James\|Szabadkai, Gyorgy\|Ryan, Kevin M\|Hochhauser, Daniel\|Salomoni, Paolo
PMID:	28475179

385.
Journal:	Oncotarget. 2017 Jul 11;8(28):45898-45917.
Title:	Molecular dissection of effector mechanisms of RAS-mediated resistance to anti-EGFR antibody therapy.
Author:	Kasper, Stefan\|Reis, Henning\|Ziegler, Sophie\|Nothdurft, Silke\|Mueller, Andre\|Goetz, Moritz\|Wiesweg, Marcel\|Phasue, Jeannette\|Ting, Saskia\|Wieczorek, Sarah\|Even, Anna\|Worm, Karl\|Pogorzelski, Michael\|Breitenbuecher, Sandra\|Meiler, Johannes\|Paul, Andreas\|Tra
PMID:	28507280

386.
Journal:	Semin Cancer Biol. 2017 Oct;46:132-137.
Title:	Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signalling pathway and the aryl hydrocarbon receptor.
Author:	Popolo, Ada\|Pinto, Aldo\|Daglia, Maria\|Nabavi, Seyed Fazel\|Farooqi, Ammad Ahmad\|Rastrelli, Luca
PMID:	28596013

387.
Journal:	J Cell Mol Med. 2017 Oct;21(10):2610-2622.
Title:	Dual inhibition of BDNF/TrkB and autophagy: a promising therapeutic approach for colorectal cancer.
Author:	Mazouffre, Clement\|Geyl, Sophie\|Perraud, Aurelie\|Blondy, Sabrina\|Jauberteau, Marie-Odile\|Mathonnet, Muriel\|Verdier, Mireille
PMID:	28597984

388.
Journal:	J Ethnopharmacol. 2017 Jul 31;207:19-29.
Title:	8-methoxypsoralen reduces AKT phosphorylation, induces intrinsic and extrinsic apoptotic pathways, and suppresses cell growth of SK-N-AS neuroblastoma and SW620 metastatic colon cancer cells.
Author:	Bartnik, Magdalena\|Slawinska-Brych, Adrianna\|Zurek, Aleksandra\|Kandefer-Szerszen, Martyna\|Zdzisinska, Barbara
PMID:	28627461

389.
Journal:	Integr Med Res. 2017 Jun;6(2):179-189.
Title:	Induction of apoptosis by Dae-Hwang-Mok-Dan-Tang in HCT-116 colon cancer cells through activation of caspases and inactivation of the phosphatidylinositol 3-kinase/Akt signaling.
Author:	Park, Cheol\|Hong, Su Hyun\|Choi, Yung Hyun
PMID:	28664141

390.
Journal:	Ann Clin Lab Sci. 2017 May;47(3):264-270.
Title:	HtrA1 Down-regulation Induces Cisplatin Resistance in Colon Cancer by Increasing XIAP and Activating PI3K/Akt Pathway.
Author:	Xiong, Zhenfang\|Fu, Zhonghua\|Shi, Jun\|Jiang, Xiaozhen\|Wan, Hongping
PMID:	28667026

391.
Journal:	Biochem Biophys Res Commun. 2017 Sep 2;490(4):1244-1249.
Title:	Feedback autophagy activation as a key resistance factor of Ku-0060648 in colorectal cancer cells.
Author:	Mao, Mintao\|Liu, Yumei\|Gao, Xinhai
PMID:	28676397

392.
Journal:	Oncogene. 2017 Nov 2;36(44):6132-6142.
Title:	Cellular prion protein (PrP(C)) in the development of Merlin-deficient tumours.
Author:	Provenzano, L\|Ryan, Y\|Hilton, D A\|Lyons-Rimmer, J\|Dave, F\|Maze, E A\|Adams, C L\|Rigby-Jones, R\|Ammoun, S\|Hanemann, C O
PMID:	28692055

393.
Journal:	Biomed Pharmacother. 2017 Sep;93:1230-1237.
Title:	LncRNA AB073614 regulates proliferation and metastasis of colorectal cancer cells via the PI3K/AKT signaling pathway.
Author:	Wang, Yanan\|Kuang, Haoyu\|Xue, Jinfang\|Liao, Liya\|Yin, Fang\|Zhou, Xiaojun
PMID:	28738539

394.
Journal:	Mol Carcinog. 2017 Dec;56(12):2669-2680.
Title:	Upregulation of microRNA-135b and microRNA-182 promotes chemoresistance of colorectal cancer by targeting ST6GALNAC2 via PI3K/AKT pathway.
Author:	Liu, Bing\|Liu, Yanfeng\|Zhao, Lifen\|Pan, Yue\|Shan, Yujia\|Li, Yang\|Jia, Li
PMID:	28767179

395.
Journal:	Cell Death Dis. 2017 Aug 3;8(8):e2968.
Title:	miR-125a-3p/FUT5-FUT6 axis mediates colorectal cancer cell proliferation, migration, invasion and pathological angiogenesis via PI3K-Akt pathway.
Author:	Liang, Leilei\|Gao, Chengshun\|Li, Yang\|Sun, Mingming\|Xu, Jingchao\|Li, Huairui\|Jia, Li\|Zhao, Yongfu
PMID:	28771224

396.
Journal:	Mol Cancer Ther. 2017 Nov;16(11):2340-2350.
Title:	A Bifunctional MAPK/PI3K Antagonist for Inhibition of Tumor Growth and Metastasis.
Author:	Galban, Stefanie\|Apfelbaum, April A\|Espinoza, Carlos\|Heist, Kevin\|Haley, Henry\|Bedi, Karan\|Ljungman, Mats\|Galban, Craig J\|Luker, Gary D\|Dort, Marcian Van\|Ross, Brian D
PMID:	28775144

397.
Journal:	PLoS Genet. 2017 Aug 14;13(8):e1006942.
Title:	A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds.
Author:	Cairney, Claire J\|Godwin, Lauren S\|Bilsland, Alan E\|Burns, Sharon\|Stevenson, Katrina H\|McGarry, Lynn\|Revie, John\|Moore, Jon D\|Wiggins, Ceri M\|Collinson, Rebecca S\|Mudd, Clare\|Tsonou, Elpida\|Sadaie, Mahito\|Bennett, Dorothy C\|Narita, Masashi\|Torrance, Chris
PMID:	28806777

398.
Journal:	World J Gastroenterol. 2017 Jul 28;23(28):5167-5178.
Title:	Fibroblast-derived CXCL12/SDF-1alpha promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer.
Author:	Ma, Jia-Chi\|Sun, Xiao-Wen\|Su, He\|Chen, Quan\|Guo, Tian-Kang\|Li, Yuan\|Chen, Xiao-Chang\|Guo, Jin\|Gong, Zhen-Qiang\|Zhao, Xiao-Dan\|Qi, Jian-Bo
PMID:	28811711

399.
Journal:	Proteomics. 2017 Dec;17(23-24).
Title:	Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles.
Author:	Liem, Michael\|Ang, Ching-Seng\|Mathivanan, Suresh
PMID:	28842968

400.
Journal:	Biosystems. 2017 Dec;162:12-23.
Title:	Mathematical models in cancer therapy.
Author:	Jordao, Giuseppe\|Tavares, Joao Nuno
PMID:	28866047

401.
Journal:	Oncotarget. 2016 Jun 8;8(31):50476-50488.
Title:	Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis.
Author:	Chen, Sugong\|Fisher, Robert C\|Signs, Steven\|Molina, L Alex\|Shenoy, Anitha K\|Lopez, Maria-Cecilia\|Baker, Henry V\|Koomen, John M\|Chen, Yi\|Gittleman, Haley\|Barnholtz-Sloan, Jill\|Berg, Annamarie\|Appelman, Henry D\|Huang, Emina H
PMID:	28881576

402.
Journal:	J Inorg Biochem. 2017 Dec;177:27-38.
Title:	In vitro anticancer activity of new gold(III) porphyrin complexes in colon cancer cells.
Author:	Dandash, Fatima\|Leger, David Yannick\|Fidanzi-Dugas, Chloe\|Nasri, Soumaya\|Bregier, Frederique\|Granet, Robert\|Karam, Walid\|Diab-Assaf, Mona\|Sol, Vincent\|Liagre, Bertrand
PMID:	28923355

403.
Journal:	Oncol Lett. 2017 Sep;14(3):3741-3747.
Title:	Catalpol promotes cellular apoptosis in human HCT116 colorectal cancer cells via microRNA-200 and the downregulation of PI3K-Akt signaling pathway.
Author:	Liu, Lan\|Gao, Hongwei\|Wang, Hongbo\|Zhang, Yuan\|Xu, Weihua\|Lin, Sen\|Wang, Hongjuan\|Wu, Qiong\|Guo, Jianqiang
PMID:	28927141

404.
Journal:	Clin Cancer Res. 2017 Dec 1;23(23):7340-7350.
Title:	Phospholipase D1 Inhibition Linked to Upregulation of ICAT Blocks Colorectal Cancer Growth Hyperactivated by Wnt/beta-Catenin and PI3K/Akt Signaling.
Author:	Kang, Dong Woo\|Lee, Bo Hui\|Suh, Young-Ah\|Choi, Yong-Seok\|Jang, Se Jin\|Kim, Yong Man\|Choi, Kang-Yell\|Min, Do Sik
PMID:	28939743

405.
Journal:	Mol Med Rep. 2017 Dec;16(6):8747-8754.
Title:	MACC1 facilitates chemoresistance and cancer stem celllike properties of colon cancer cells through the PI3K/AKT signaling pathway.
Author:	Wang, Jiankai\|Wang, Wenjuan\|Cai, Hongyi\|Du, Binbin\|Zhang, Lijuan\|Ma, Wen\|Hu, Yongguo\|Feng, Shifang\|Miao, Guoying
PMID:	28990068

406.
Journal:	Br J Cancer. 2017 Dec 5;117(12):1819-1827.
Title:	Protein biomarkers predictive for response to anti-EGFR treatment in RAS wild-type metastatic colorectal carcinoma.
Author:	Lievre, Astrid\|Ouine, Berengere\|Canet, Jim\|Cartier, Aurelie\|Amar, Yael\|Cacheux, Wulfran\|Mariani, Odette\|Guimbaud, Rosine\|Selves, Janick\|Lecomte, Thierry\|Guyetant, Serge\|Bieche, Ivan\|Berger, Frederique\|de Koning, Leanne
PMID:	29024937

407.
Journal:	Dig Dis Sci. 2017 Dec;62(12):3447-3459.
Title:	miR-182 and miR-135b Mediate the Tumorigenesis and Invasiveness of Colorectal Cancer Cells via Targeting ST6GALNAC2 and PI3K/AKT Pathway.
Author:	Jia, Li\|Luo, Shihua\|Ren, Xiang\|Li, Yang\|Hu, Jialei\|Liu, Bing\|Zhao, Lifen\|Shan, Yujia\|Zhou, Huimin
PMID:	29030743

408.
Journal:	Biomed Pharmacother. 2017 Dec;96:634-641.
Title:	MiR-129 inhibits cell proliferation and metastasis by targeting ETS1 via PI3K/AKT/mTOR pathway in prostate cancer.
Author:	Xu, Song\|Ge, Jingping\|Zhang, Zhengyu\|Zhou, Wenquan
PMID:	29035829

409.
Journal:	Cancer Biomark. 2017 Dec 12;21(1):123-133.
Title:	Knockdown of lncRNA CCAT2 inhibits endometrial cancer cells growth and metastasis via sponging miR-216b.
Author:	Xie, Pengmu\|Cao, Hongying\|Li, Ying\|Wang, Jianhua\|Cui, Zhumei
PMID:	29036788

410.
Journal:	Target Oncol. 2017 Dec;12(6):775-785.
Title:	A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer.
Author:	Wainberg, Zev A\|Alsina, Maria\|Soares, Heloisa P\|Brana, Irene\|Britten, Carolyn D\|Del Conte, Gianluca\|Ezeh, Patrick\|Houk, Brett\|Kern, Kenneth A\|Leong, Stephen\|Pathan, Nuzhat\|Pierce, Kristen J\|Siu, Lillian L\|Vermette, Jennifer\|Tabernero, Josep
PMID:	29067643

411.
Journal:	Cancer Cell Int. 2017 Oct 28;17:91.
Title:	miR-422a inhibits cell proliferation in colorectal cancer by targeting AKT1 and MAPK1.
Author:	Wei, Wen-Ting\|Nian, Xin-Xin\|Wang, Shu-Yang\|Jiao, Hong-Li\|Wang, Yong-Xia\|Xiao, Zhi-Yuan\|Yang, Run-Wei\|Ding, Yan-Qing\|Ye, Ya-Ping\|Liao, Wen-Ting
PMID:	29118671

412.
Journal:	Oncol Rep. 2017 Dec;38(6):3545-3553.
Title:	Upregulation of miR-542-3p inhibits the growth and invasion of human colon cancer cells through PI3K/AKT/survivin signaling.
Author:	Yang, Chuang\|Wang, Ming-Huan\|Zhou, Jun-De\|Chi, Qiang
PMID:	29130099

413.
Journal:	Oncotarget. 2017 Sep 5;8(60):101224-101243.
Title:	Separation of low and high grade colon and rectum carcinoma by eukaryotic translation initiation factors 1, 5 and 6.
Author:	Golob-Schwarzl, Nicole\|Schweiger, Caroline\|Koller, Carina\|Krassnig, Stefanie\|Gogg-Kamerer, Margit\|Gantenbein, Nadine\|Toeglhofer, Anna M\|Wodlej, Christina\|Bergler, Helmut\|Pertschy, Brigitte\|Uranitsch, Stefan\|Holter, Magdalena\|El-Heliebi, Amin\|Fuchs, Julia\|
PMID:	29254159

414.
Journal:	Exp Ther Med. 2017 Dec;14(6):5527-5534.
Title:	Scutellaria barbata D. Don inhibits migration and invasion of colorectal cancer cells via suppression of PI3K/AKT and TGF-beta/Smad signaling pathways.
Author:	Jin, Yiyi\|Chen, Wujin\|Yang, Hong\|Yan, Zhaokun\|Lai, Zijun\|Feng, Jianyu\|Peng, Jun\|Lin, Jiumao
PMID:	29285087

415.
Journal:	Oncotarget. 2017 Nov 14;8(64):107932-107946.
Title:	NCOA5 promotes proliferation, migration and invasion of colorectal cancer cells via activation of PI3K/AKT pathway.
Author:	Sun, Kailv\|Wang, Sheng\|He, Jun\|Xie, Yufeng\|He, Yang\|Wang, Zhenxin\|Qin, Lei
PMID:	29296214

416.
Journal:	Oncotarget. 2016 Aug 19;8(65):108463-108479.
Title:	Dual targeting of HER3 and MEK may overcome HER3-dependent drug-resistance of colon cancers.
Author:	Bon, Giulia\|Loria, Rossella\|Amoreo, Carla Azzurra\|Verdina, Alessandra\|Sperduti, Isabella\|Mastrofrancesco, Arianna\|Soddu, Silvia\|Diodoro, Maria Grazia\|Mottolese, Marcella\|Todaro, Matilde\|Stassi, Giorgio\|Milella, Michele\|De Maria, Ruggero\|Falcioni, Rita
PMID:	29312543

417.
Journal:	J Cell Biochem. 2018 Mar;119(3):2460-2469.
Title:	Therapeutic Potential of Targeting PI3K/AKT Pathway in Treatment of Colorectal Cancer: Rational and Progress.
Author:	Bahrami, Afsane\|Khazaei, Majid\|Hasanzadeh, Malihe\|ShahidSales, Soodabeh\|Joudi Mashhad, Mona\|Farazestanian, Marjaneh\|Sadeghnia, Hamid Reza\|Rezayi, Majid\|Maftouh, Mina\|Hassanian, Seyed Mahdi\|Avan, Amir
PMID:	28230287

418.
Journal:	J Cell Physiol. 2018 Jan;233(1):497-505.
Title:	Autophagy mediates cytotoxicity of human colorectal cancer cells treated with garcinielliptone FC.
Author:	Won, Shen-Jeu\|Yen, Cheng-Hsin\|Lin, Ting-Yu\|Jiang-Shieh, Ya-Fen\|Lin, Chun-Nan\|Chen, Jyun-Ti\|Su, Chun-Li
PMID:	28294332

419.
Journal:	J Ethnopharmacol. 2018 Jan 10;210:1-9.
Title:	Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3beta/cyclin D1 pathway.
Author:	Wang, Juan\|Li, Xu-Mei\|Bai, Zhun\|Chi, Bi-Xia\|Wei, Yan\|Chen, Xu
PMID:	28684297

420.
Journal:	Mol Cell Biochem. 2018 Feb;439(1-2):199-211.
Title:	Insulin-like growth factor-1 activates different catalytic subunits p110 of PI3K in a cell-type-dependent manner to induce lipogenesis-dependent epithelial-mesenchymal transition through the regulation of ADAM10 and ADAM17.
Author:	Park, Ga Bin\|Kim, Daejin
PMID:	28819788

421.
Journal:	Oncol Res. 2018 Mar 5;26(2):261-268.
Title:	Long Noncoding RNA PlncRNA-1 Promotes Colorectal Cancer Cell Progression by Regulating the PI3K/Akt Signaling Pathway.
Author:	Song, Wei\|Mei, Jia-Zhuan\|Zhang, Mingzhi
PMID:	28835319

422.
Journal:	J Cell Biochem. 2018 Feb;119(2):2356-2367.
Title:	Effects of Glut1 gene silencing on proliferation, differentiation, and apoptosis of colorectal cancer cells by targeting the TGF-beta/PI3K-AKT-mTOR signaling pathway.
Author:	Wu, Xue-Liang\|Wang, Li-Kun\|Yang, Dong-Dong\|Qu, Ming\|Yang, Yong-Jiang\|Guo, Fei\|Han, Lei\|Xue, Jun
PMID:	28884839

423.
Journal:	Mol Carcinog. 2018 Feb;57(2):243-261.
Title:	The PI3K/AKT signaling pathway: Associations of miRNAs with dysregulated gene expression in colorectal cancer.
Author:	Slattery, Martha L\|Mullany, Lila E\|Sakoda, Lori C\|Wolff, Roger K\|Stevens, John R\|Samowitz, Wade S\|Herrick, Jennifer S
PMID:	29068474

424.
Journal:	Mol Med Rep. 2018 Jan;17(1):358-365.
Title:	Hedyotis diffusa Willd inhibits proliferation and induces apoptosis of 5FU resistant colorectal cancer cells by regulating the PI3K/AKT signaling pathway.
Author:	Li, Qiongyu\|Lai, Zijun\|Yan, Zhaokun\|Peng, Jun\|Jin, Yiyi\|Wei, Lihui\|Lin, Jiumao
PMID:	29115462

425.
Journal:	Mol Cancer Res. 2018 Mar;16(3):543-553.
Title:	TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting beta-CATENIN and AKT Signaling in Colorectal Cancer.
Author:	Solberg, Nina T\|Waaler, Jo\|Lund, Kaja\|Mygland, Line\|Olsen, Petter A\|Krauss, Stefan
PMID:	29222171

426.
Journal:	Int J Cancer. 2018 May 1;142(9):1853-1864.
Title:	COPS5 and LASP1 synergistically interact to downregulate 14-3-3sigma expression and promote colorectal cancer progression via activating PI3K/AKT pathway.
Author:	Zhou, Rui\|Shao, Ziyun\|Liu, Jian\|Zhan, Wanqi\|Gao, Qingzu\|Pan, Zhihua\|Wu, Ling\|Xu, Lijun\|Ding, Yanqing\|Zhao, Liang
PMID:	29226323

427.
Journal:	Dig Dis Sci. 2018 Feb;63(2):395-402.
Title:	Speckle-Type POZ Protein Down-Regulates Matrix Metalloproteinase 2 Expression via Sp1/PI3K/Akt Signaling Pathway in Colorectal Cancer.
Author:	Zhang, Shouhua\|Xiao, Juhua\|Chai, Yong\|Hong, Zhengdong\|Liu, Zhiqiang\|Yuan, Rongfa\|Luo, Zhipeng\|Zhou, Xin\|Lucero-Prisno, Don Eliseo III\|Huang, Kai
PMID:	29260353

428.
Journal:	Int J Cancer. 2018 May 15;142(10):2068-2079.
Title:	DCLK1 promotes epithelial-mesenchymal transition via the PI3K/Akt/NF-kappaB pathway in colorectal cancer.
Author:	Liu, Weiying\|Wang, Shixing\|Sun, Qi\|Yang, Zhen\|Liu, Min\|Tang, Hua
PMID:	29277893

429.
Journal:	Biochemistry. 2018 Feb 6;57(5):839-851.
Title:	A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist.
Author:	Riccio, Gennaro\|Bottone, Sara\|La Regina, Giuseppe\|Badolati, Nadia\|Passacantilli, Sara\|Rossi, Giovanni Battista\|Accardo, Antonella\|Dentice, Monica\|Silvestri, Romano\|Novellino, Ettore\|Stornaiuolo, Mariano
PMID:	29293331

430.
Journal:	Clin Transl Oncol. 2018 Aug;20(8):1035-1045.
Title:	CXCL12 gene silencing down-regulates metastatic potential via blockage of MAPK/PI3K/AP-1 signaling pathway in colon cancer.
Author:	Ma, J\|Su, H\|Yu, B\|Guo, T\|Gong, Z\|Qi, J\|Zhao, X\|Du, J
PMID:	29305742

431.
Journal:	Oncol Res. 2018 Jan 10.
Title:	MicroRNA-511 inhibits cellular proliferation and invasion in colorectal cancer by directly targeting hepatoma-derived growth factor.
Author:	He, Saifei\|Wang, Guangdong\|Ni, Jing\|Zhuang, Juhua\|Zhuang, Suiliang\|Wang, Guoyu\|Ye, Ying\|Xia, Wei
PMID:	29321086

432.
Journal:	Oncol Rep. 2018 Mar;39(3):1516-1522.
Title:	Fucoidan downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells.
Author:	Kim, In-Hye\|Nam, Taek-Jeong
PMID:	29328495

433.
Journal:	Biomed Pharmacother. 2018 Mar;99:176-183.
Title:	Schizandrin A enhances chemosensitivity of colon carcinoma cells to 5-fluorouracil through up-regulation of miR-195.
Author:	Kong, Dongfang\|Zhang, Deyong\|Chu, Xianqun\|Wang, Jing
PMID:	29331856

434.
Journal:	Cancer. 2018 Apr 1;124(7):1358-1373.
Title:	Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3.
Author:	Ross, Jeffrey S\|Fakih, Marwan\|Ali, Siraj M\|Elvin, Julia A\|Schrock, Alexa B\|Suh, James\|Vergilio, Jo-Anne\|Ramkissoon, Shakti\|Severson, Eric\|Daniel, Sugganth\|Fabrizio, David\|Frampton, Garrett\|Sun, James\|Miller, Vincent A\|Stephens, Philip J\|Gay, Laurie M
PMID:	29338072

435.
Journal:	Oncol Res. 2018 Sep 14;26(8):1295-1305.
Title:	MicroRNA-204 Inhibits the Growth and Motility of Colorectal Cancer Cells by Downregulation of CXCL8.
Author:	Shuai, Feng\|Wang, Bo\|Dong, Shuxiao
PMID:	29402343

436.
Journal:	Eur J Cancer. 2018 Mar;92:1-10.
Title:	Human epidermal receptor family inhibitors in patients with ERBB3 mutated cancers: Entering the back door.
Author:	Verlingue, Loic\|Hollebecque, Antoine\|Lacroix, Ludovic\|Postel-Vinay, Sophie\|Varga, Andrea\|El Dakdouki, Yolla\|Baldini, Capucine\|Balheda, Rastilav\|Gazzah, Anas\|Michot, Jean-Marie\|Marabelle, Aurelien\|Mir, Olivier\|Arnedos, Monica\|Rouleau, Etienne\|Solary, Eric\|
PMID:	29413684

437.
Journal:	J Control Release. 2018 Apr 10;275:85-91.
Title:	Colorectal cancer lung metastasis treatment with polymer-drug nanoparticles.
Author:	Rychahou, Piotr\|Bae, Younsoo\|Reichel, Derek\|Zaytseva, Yekaterina Y\|Lee, Eun Y\|Napier, Dana\|Weiss, Heidi L\|Roller, Nick\|Frohman, Heather\|Le, Anh-Thu\|Mark Evers, B
PMID:	29421609

438.
Journal:	Oncol Lett. 2018 Jan;15(1):1236-1240.
Title:	Assessment of PI3K/AKT/PTEN signaling pathway activity in colorectal cancer using quantum dot-conjugated antibodies.
Author:	Waniczek, Dariusz\|Snietura, Miroslaw\|Lorenc, Zbigniew\|Nowakowska-Zajdel, Ewa\|Muc-Wierzgon, Malgorzata
PMID:	29422975

439.
Journal:	Oncol Lett. 2018 Mar;15(3):3127-3132.
Title:	Effect of silencing colon cancer-associated transcript 2 on the proliferation, apoptosis and autophagy of gastric cancer BGC-823 cells.
Author:	Yu, Zhao-Yan\|Wang, Zi\|Lee, Ke-Yue\|Yuan, Ping\|Ding, Jie
PMID:	29435046

440.
Journal:	Oncol Res. 2018 Feb 22.
Title:	Liquiritigenin inhibits colorectal cancer proliferation, invasion and epithelial to mesenchymal transition by decreasing expression of runt-related transcription factor 2.
Author:	Meng, Fan-Chun\|Lin, Jun-Kai
PMID:	29471888

441.
Journal:	Clin Colorectal Cancer. 2018 Jun;17(2):e331-e352.
Title:	Phosphorylation of p70 Ribosomal Protein S6 Kinase beta-1 is an Independent Prognostic Parameter in Metastatic Colorectal Cancer.
Author:	Wiesweg, Marcel\|Reis, Henning\|Koster, Tobias\|Goetz, Moritz\|Worm, Karl\|Herold, Thomas\|Paul, Andreas\|Dechene, Alexander\|Schumacher, Brigitte\|Markus, Peter\|Virchow, Isabel\|Kostbade, Karina\|Wolf, Nathalie\|Zaun, Gregor\|Metzenmacher, Martin\|Schmid, Kurt W\|Schul
PMID:	29526493

442.
Journal:	World J Gastroenterol. 2018 Mar 7;24(9):1004-1012.
Title:	Long noncoding RNA RP4 functions as a competing endogenous RNA through miR-7-5p sponge activity in colorectal cancer.
Author:	Liu, Mu-Lin\|Zhang, Qiao\|Yuan, Xiao\|Jin, Long\|Wang, Li-Li\|Fang, Tao-Tao\|Wang, Wen-Bin
PMID:	29531464

443.
Journal:	Oncol Lett. 2018 Apr;15(4):4463-4470.
Title:	Wogonoside inhibits cell growth and induces mitochondrial-mediated autophagy-related apoptosis in human colon cancer cells through the PI3K/AKT/mTOR/p70S6K signaling pathway.
Author:	Han, Chengzheng\|Xing, Guozheng\|Zhang, Mengying\|Zhong, Min\|Han, Zhen\|He, Chiyi\|Liu, Xiaoping
PMID:	29541215

444.
Journal:	Zhongguo Zhong Yao Za Zhi. 2018 Jan;43(1):168-173.
Title:	[Killing effect of Huaier combined with DC-CIK on nude mice bearing colon cancer HT29 stem cells in vivo].
Author:	Sun, Wen-Wen\|Dou, Jin-Xia\|Zhang, Lin\|Qiao, Li-Kui\|Shen, Na\|Gao, Wen-Yuan
PMID:	29552828

445.
Journal:	Anticancer Drugs. 2018 Jul;29(6):530-538.
Title:	Celastrol inhibits colorectal cancer cell proliferation and migration through suppression of MMP3 and MMP7 by the PI3K/AKT signaling pathway.
Author:	Bufu, Tang\|Di, Xu\|Yilin, Zhao\|Gege, Liang\|Xi, Chen\|Ling, Wang
PMID:	29553945

446.
Journal:	Oncotarget. 2018 Feb 16;9(18):14306-14310.
Title:	TP53 mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [(18)F] fluorodeoxyglucose ((18)F-FDG PET).
Author:	Chang, Geraldine H\|Kurzrock, Razelle\|Tran, Lisa\|Schwaederle, Maria\|Hoh, Carl K
PMID:	29581845

447.
Journal:	Int J Biol Macromol. 2018 Jul 15;114:1127-1133.
Title:	Anti-colon-cancer effects of polysaccharides: A mini-review of the mechanisms.
Author:	Ji, Xiaolong\|Peng, Qiang\|Wang, Min
PMID:	29627471

448.
Journal:	Am J Cancer Res. 2018 Mar 1;8(3):435-449. eCollection 2018.
Title:	microRNA-532 suppresses the PI3K/Akt signaling pathway to inhibit colorectal cancer progression by directly targeting IGF-1R.
Author:	Song, Ying\|Zhao, Yue\|Ding, Xiangfu\|Wang, Xiaodong
PMID:	29636999

449.
Journal:	Oncogene. 2018 Jul;37(28):3790-3805.
Title:	Collagen IV-conveyed signals can regulate chemokine production and promote liver metastasis.
Author:	Vaniotis, George\|Rayes, Roni F\|Qi, Shu\|Milette, Simon\|Wang, Ni\|Perrino, Stephanie\|Bourdeau, France\|Nystrom, Hanna\|He, Yi\|Lamarche-Vane, Nathalie\|Brodt, Pnina
PMID:	29651051

450.
Journal:	Int J Mol Med. 2018 Jul;42(1):625-632.
Title:	Downregulation of Lgr6 inhibits proliferation and invasion and increases apoptosis in human colorectal cancer.
Author:	Wang, Fei\|Dai, Chun-Qian\|Zhang, Li-Rong\|Bing, Cao\|Qin, Jun\|Liu, Yi-Fei
PMID:	29693156

451.
Journal:	J BUON. 2018 Mar-Apr;23(2):340-345.
Title:	Boswellic acid exerts potent anticancer effects in HCT-116 human colon cancer cells mediated via induction of apoptosis, cell cycle arrest, cell migration inhibition and inhibition of PI3K/AKT signalling pathway.
Author:	Wang, Dan\|Ge, Shuke\|Bai, Jichang\|Song, Yongwei
PMID:	29745074

452.
Journal:	Cancer Res. 2018 Aug 15;78(16):4627-4641.
Title:	Mapping the HLA Ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation.
Author:	Loffler, Markus W\|Kowalewski, Daniel J\|Backert, Linus\|Bernhardt, Jorg\|Adam, Patrick\|Schuster, Heiko\|Dengler, Florian\|Backes, Daniel\|Kopp, Hans-Georg\|Beckert, Stefan\|Wagner, Silvia\|Konigsrainer, Ingmar\|Kohlbacher, Oliver\|Kanz, Lothar\|Konigsrainer, Alfred\|R
PMID:	29789417

453.
Journal:	Braz J Med Biol Res. 2018;51(6):e7046.
Title:	lncRNA CCAT1 promotes cell proliferation, migration, and invasion by down-regulation of miR-143 in FTC-133 thyroid carcinoma cell line.
Author:	Yang, Tianzheng\|Zhai, Hongyan\|Yan, Ruihong\|Zhou, Zhenhu\|Gao, Lei\|Wang, Luqing
PMID:	29791590

454.
Journal:	Cell Physiol Biochem. 2018;47(2):680-693.
Title:	Efficacy of the MEK Inhibitor Cobimetinib and its Potential Application to Colorectal Cancer Cells.
Author:	Gong, Shu\|Xu, Dongsheng\|Zhu, Jialin\|Zou, Fangdong\|Peng, Rui
PMID:	29794421

455.
Journal:	Oncol Lett. 2018 Jun;15(6):8223-8230.
Title:	Asiatic acid inhibits proliferation, migration and induces apoptosis by regulating Pdcd4 via the PI3K/Akt/mTOR/p70S6K signaling pathway in human colon carcinoma cells.
Author:	Hao, Yajuan\|Huang, Jiawei\|Ma, Yun\|Chen, Wancheng\|Fan, Qin\|Sun, Xuegang\|Shao, Meng\|Cai, Hongbing
PMID:	29805556

456.
Journal:	Oncol Rep. 2018 Aug;40(2):1083-1092.
Title:	Dual mTOR/PI3K inhibitor NVPBEZ235 arrests colorectal cancer cell growth and displays differential inhibition of 4EBP1.
Author:	Alqurashi, Naif\|Hashimi, Saeed M\|Alowaidi, Faisal\|Ivanovski, Saso\|Wei, Ming Q
PMID:	29845289

457.
Journal:	Food Nutr Res. 2018 May 11;62. pii: 1384.
Title:	Genistein and daidzein induce apoptosis of colon cancer cells by inhibiting the accumulation of lipid droplets.
Author:	Liang, Yu-Si\|Qi, Wen-Tao\|Guo, Weiqun\|Wang, Chun-Ling\|Hu, Ze-Bin\|Li, Ai-Ke
PMID:	29849534

458.
Journal:	Med Oncol. 2018 May 31;35(7):101.
Title:	Phase II study of panitumumab combined with capecitabine and oxaliplatin as first-line treatment in metastatic colorectal cancer patients: clinical results including extended tumor genotyping.
Author:	Papaxoinis, George\|Kotoula, Vassiliki\|Giannoulatou, Eleni\|Koliou, Georgia-Angeliki\|Karavasilis, Vasilios\|Lakis, Sotirios\|Koureas, Andreas\|Bobos, Mattheos\|Chalaralambous, Elpida\|Daskalaki, Emily\|Chatzopoulos, Kyriakos\|Tsironis, George\|Pazarli, Elisavet\|Chr
PMID:	29855806

459.
Journal:	JCI Insight. 2018 Jun 7;3(11). pii: 120631.
Title:	Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.
Author:	Gyori, David\|Lim, Ee Lyn\|Grant, Francis M\|Spensberger, Dominik\|Roychoudhuri, Rahul\|Shuttleworth, Stephen J\|Okkenhaug, Klaus\|Stephens, Len R\|Hawkins, Phillip T
PMID:	29875321

460.
Journal:	Oncol Rep. 2018 Aug;40(2):1119-1128.
Title:	uc.338 targets p21 and cyclin D1 via PI3K/AKT pathway activation to promote cell proliferation in colorectal cancer.
Author:	Zhang, Yue\|Wang, Shijia\|Qian, Wenwei\|Ji, Dongjian\|Wang, Qingyuan\|Zhang, Zhiyuan\|Wang, Sen\|Ji, Bing\|Fu, Zan\|Sun, Yueming
PMID:	29901203

461.
Journal:	Biol Chem. 2018 Jul 10.
Title:	Down-regulated paxillin suppresses cell proliferation and invasion by inhibiting M2 macrophage polarization in colon cancer.
Author:	Zhang, Ling-Li\|Zhang, Lian-Feng\|Shi, Yun-Bo
PMID:	29924724

462.
Journal:	J Cell Biochem. 2018 Jun 22.
Title:	IL-1beta promotes the nuclear translocaiton of S100A4 protein in gastric cancer cells MGC803 and the cell's stem-like properties through PI3K pathway.
Author:	Yu, Aiwen\|Wang, Yu\|Bian, Yue\|Chen, Lisha\|Guo, Junfu\|Shen, Wei\|Chen, Danqi\|Liu, Shanshan\|Sun, Xiuju
PMID:	29932233

463.
Journal:	Zhongguo Zhong Yao Za Zhi. 2018 Jun;43(11):2358-2364.
Title:	[Study of isobutyrylshikonin inhibiting proliferation of colon carcinoma cells through PI3K/Akt/m-TOR pathway].
Author:	Zhong, Yu\|Zheng, Xue-Bao\|Cai, Kang-Rong\|Huang, Qiong-Lin\|Ye, Hua\|Huang, Zhe\|Wang, Yong-Cun\|Zhu, Yu-Zhen
PMID:	29945391

464.
Journal:	Biochem Biophys Res Commun. 2018 Sep 18;503(4):2333-2339.
Title:	Knockdown of ADAM17 inhibits cell proliferation and increases oxaliplatin sensitivity in HCT-8 colorectal cancer through EGFR-PI3K-AKT activation.
Author:	Zhang, Qi\|Wang, Changyou\|Han, Xuechao\|Yang, Guanghua\|Ge, Zhipeng\|Zhang, Guozhi
PMID:	29964008

465.
Journal:	J Hematol Oncol. 2018 Jul 3;11(1):89.
Title:	Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression.
Author:	Li, Yang\|Zeng, Changqian\|Hu, Jialei\|Pan, Yue\|Shan, Yujia\|Liu, Bing\|Jia, Li
PMID:	29970122

466.
Journal:	J BUON. 2018 May-Jun;23(3):574-578.
Title:	Anticancer activity of safranal against colon carcinoma is due to induction of apoptosis and G2/M cell cycle arrest mediated by suppression of mTOR/PI3K/Akt pathway.
Author:	Zhang, Yibing\|Zhao, Yong\|Guo, Jianyou\|Cui, Haifeng\|Liu, Sha
PMID:	30003721

467.
Journal:	J BUON. 2018 May-Jun;23(3):587-591.
Title:	Antitumor effects of emodin in CACO-2 human colon carcinoma cells are mediated via apoptosis, cell cycle arrest and downregulation of PI3K/AKT signalling pathway.
Author:	Ma, Qianzhang\|Ding, Yuanquan\|Wu, Zhenqi\|Li, Yan
PMID:	30003723

468.
Journal:	J Dig Dis. 2018 Jul 29.
Title:	NOX4, A New Genetic Target for Anti-cancer Therapy in Digestive System Cancer.
Author:	Tang, Chao-Tao\|Gao, Yun-Jie\|Ge, Zhi-Zheng
PMID:	30058122

469.
Journal:	Biochem Biophys Res Commun. 2018 Sep 18;503(4):3198-3204.
Title:	The influence of aberrant expression of GLI1/p-S6K on colorectal cancer.
Author:	Wang, Xuchao\|Yao, Yizhou\|Zhu, Xinguo
PMID:	30143258

470.
Journal:	Cell Death Dis. 2018 Aug 28;9(9):857.
Title:	MALAT1-miR663a negative feedback loop in colon cancer cell functions through direct miRNA-lncRNA binding.
Author:	Tian, Wei\|Du, Yantao\|Ma, Yuwan\|Gu, Liankun\|Zhou, Jing\|Deng, Dajun
PMID:	30154407

471.
Journal:	Exp Ther Med. 2018 Sep;16(3):1758-1765.
Title:	Gambogic acid regulates the migration and invasion of colorectal cancer via microRNA-21-mediated activation of phosphatase and tensin homolog.
Author:	Gao, Guangyi\|Bian, Yinzhu\|Qian, Hanqing\|Yang, Mi\|Hu, Jing\|Li, Li\|Yu, Lixia\|Liu, Baorui\|Qian, Xiaoping
PMID:	30186399

472.
Journal:	Cancers (Basel). 2018 Sep 6;10(9). pii: cancers10090314.
Title:	PTPRT and PTPRD Deleterious Mutations and Deletion Predict Bevacizumab Resistance in Metastatic Colorectal Cancer Patients.
Author:	Hsu, Hung-Chih\|Lapke, Nina\|Chen, Shu-Jen\|Lu, Yen-Jung\|Jhou, Ren-Shiang\|Yeh, Chien-Yuh\|Tsai, Wen-Sy\|Hung, Hsin-Yuan\|Hsieh, Jason Chia-Hsun\|Yang, Tsai-Sheng\|Thiam, Tan Kien\|You, Jeng-Fu
PMID:	30200630

473.
Journal:	Int J Mol Med. 2018 Nov;42(5):2503-2514.
Title:	MicroRNA-7 inhibits colorectal cancer cell proliferation, migration and invasion via TYRO3 and phosphoinositide 3-kinase/protein B kinase/mammalian target of rapamycin pathway suppression.
Author:	Qin, Ancheng\|Qian, Weifeng
PMID:	30226533

474.
Journal:	J Exp Clin Cancer Res. 2018 Sep 19;37(1):231.
Title:	HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways.
Author:	Li, Qing\|Wang, Cong\|Wang, Yufeng\|Sun, Liankang\|Liu, Zhikui\|Wang, Liang\|Song, Tao\|Yao, Yingmin\|Liu, Qingguang\|Tu, Kangsheng
PMID:	30231922

475.
Journal:	EBioMedicine. 2018 Sep 19. pii: S2352-3964(18)30379-7.
Title:	Profiles of alternative splicing in colorectal cancer and their clinical significance: A study based on large-scale sequencing data.
Author:	Xiong, Yongfu\|Deng, Ying\|Wang, Kang\|Zhou, He\|Zheng, Xiangru\|Si, Liangyi\|Fu, Zhongxue
PMID:	30243491

476.
Journal:	Biomed Pharmacother. 2018 Nov;107:1712-1719.
Title:	F-box and leucine-rich repeat protein 5 promotes colon cancer progression by modulating PTEN/PI3K/AKT signaling pathway.
Author:	Yao, Hui\|Su, Song\|Xia, Dong\|Wang, Mingming\|Li, Zonglin\|Chen, Wangsheng\|Ren, Lei\|Xu, Liang
PMID:	30257389

477.
Journal:	J Cell Biochem. 2018 Oct 15.
Title:	Silencing of FOXO6 inhibits the proliferation, invasion, and glycolysis in colorectal cancer cells.
Author:	Li, Quanying\|Tang, Hongna\|Hu, Fangfang\|Qin, Changjiang
PMID:	30321450

478.
Journal:	Neoplasma. 2018 Sep 4. pii: 171225N841.
Title:	Long non-coding RNA CRNDE may be associated with poor prognosis by promoting proliferation and inhibiting apoptosis of cervical cancer cells through targeting PI3K/AKT.
Author:	Yang, H Y\|Huang, C P\|Cao, M M\|Wang, Y F\|Liu, Y
PMID:	30334449

479.
Journal:	Eur Rev Med Pharmacol Sci. 2018 Oct;22(19):6315-6323.
Title:	LINC00657 promotes the development of colon cancer by activating PI3K/AKT pathway.
Author:	Lei, Y\|Wang, Y-H\|Wang, X-F\|Bai, J
PMID:	30338799

480.
Journal:	Biomed Pharmacother. 2018 Oct 1;108:1162-1169.
Title:	Functions and mechanisms of microRNA-31 in human cancers.
Author:	Yu, Tao\|Ma, Pei\|Wu, Deqin\|Shu, Yongqian\|Gao, Wen
PMID:	30372817