Primary Site >> Colorectal Cancer
Gene >> PIK3CD
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Ref: Inhibition of the phosphatidylinositol 3-kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation. PMID: 11313308 |
Ref: Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3'-kinase inhibition in the KM20 human colon cancer cell line. PMID: 12060639 Ref: The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells. PMID: 12060641 |
Ref: Signaling inhibition with radiation in colorectal cancer: clinical trials. PMID: 12802796 Ref: Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. PMID: 12888657 |
Ref: Roles of phosphatidylinositol 3'-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells. PMID: 14729629 Ref: Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects. PMID: 15059917 Ref: Rapid signalling pathway activation by androgens in epithelial and stromal cells. PMID: 15288763 |
Ref: Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. PMID: 15494427 Ref: The pro-inflammatory mediator leukotriene D4 induces phosphatidylinositol 3-kinase and Rac-dependent migration of intestinal epithelial cells. PMID: 15657050 Ref: H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent. PMID: 15713896 Ref: Transformation of immortalized colorectal crypt cells by microcystin involving constitutive activation of Akt and MAPK cascade. PMID: 15774489 Ref: Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. PMID: 16052481 Ref: Membrane rafts segregate pro- from anti-apoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily. PMID: 16127155 Ref: Focal adhesion kinase regulates syndecan-2-mediated tumorigenic activity of HT1080 fibrosarcoma cells. PMID: 16267014 |
Ref: Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway. PMID: 16489044 Ref: Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells. PMID: 16609991 Ref: Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells. PMID: 17113582 |
Ref: Elevated gadd153/chop expression during resveratrol-induced apoptosis in human colon cancer cells. PMID: 17049495 Ref: Mechanisms of endothelin 1-stimulated proliferation in colorectal cancer cell lines. PMID: 17078114 Ref: PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition. PMID: 17409395 Ref: Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway. PMID: 17410437 Ref: Inducing effects of hepatocyte growth factor on the expression of vascular endothelial growth factor in human colorectal carcinoma cells through MEK and PI3K signaling pathways. PMID: 17531111 Ref: Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylation of Bad. PMID: 17544220 Ref: Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling. PMID: 17578896 Ref: PGE2 inhibits apoptosis in human adenocarcinoma Caco-2 cell line through Ras-PI3K association and cAMP-dependent kinase A activation. PMID: 17640974 Ref: [Effect of lipoteichoic acid of Bifidobacterium on survivin and its regulatory genes]. PMID: 17892124 |
Ref: Retinol decreases phosphatidylinositol 3-kinase activity in colon cancer cells. PMID: 17918208 Ref: ANTI-ADHESION evolves to a promising therapeutic concept in oncology. PMID: 18393855 Ref: Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: is PTEN loss predictor of local recurrence? PMID: 18440486 Ref: Current and emerging therapies for metastatic colorectal cancer: applying research findings to clinical practice. PMID: 18499885 Ref: Lessons from Tarceva in pancreatic cancer: where are we now, and how should future trials be designed in pancreatic cancer? PMID: 18525343 Ref: Evaluation of hepatic-metastasis risk of colorectal cancer upon the protein signature of PI3K/AKT pathway. PMID: 18570457 Ref: [Effects of PI3K signaling pathway on pathogenesis of ulcerative colitis]. PMID: 18575316 Ref: Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells. PMID: 18627290 Ref: Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) through inhibiting protein synthesis. PMID: 18655183 Ref: Hyperosmotic stress up-regulates the expression of major vault protein in SW620 human colon cancer cells. PMID: 18671966 Ref: PTEN-deficient cancers depend on PIK3CB. PMID: 18755892 Ref: Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. PMID: 18765800 Ref: TGFbeta modulates PTEN expression independently of SMAD signaling for growth proliferation in colon cancer cells. PMID: 18769113 Ref: Heterogeneity of receptor function in colon carcinoma cells determined by cross-talk between type I insulin-like growth factor receptor and epidermal growth factor receptor. PMID: 18829558 Ref: Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis. PMID: 19075230 Ref: ErbB antagonists patenting: "playing chess with cancer". PMID: 19075865 |
Ref: PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. PMID: 18669866 Ref: Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells. PMID: 19229860 Ref: Targeting apoptosis as an approach for gastrointestinal cancer therapy. PMID: 19278896 Ref: Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells. PMID: 19344998 Ref: Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf. PMID: 19378335 Ref: Tax1 enhances cancer cell proliferation via Ras-Raf-MEK-ERK signaling pathway. PMID: 19472191 Ref: Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells. PMID: 19492417 Ref: The signal pathways in azoxymethane-induced colon cancer and preventive implications. PMID: 19502780 Ref: Leptin receptor expression in Middle Eastern colorectal cancer and its potential clinical implication. PMID: 19520793 Ref: Obesity, the PI3K/Akt signal pathway and colon cancer. PMID: 19527447 Ref: DIXDC1 targets p21 and cyclin D1 via PI3K pathway activation to promote colon cancer cell proliferation. PMID: 19572978 Ref: Toll-like receptor 4 activation increases Akt phosphorylation in colon cancer cells. PMID: 19596916 Ref: Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines. PMID: 19637312 Ref: HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells. PMID: 19638428 Ref: Oncogenic Ras, but not (V600E)B-RAF, protects from cholesterol depletion-induced apoptosis through the PI3K/AKT pathway in colorectal cancer cells. PMID: 19700418 Ref: [The relationship between PTEN expression and PI3K/AKT signal pathway in colon carcinoma]. PMID: 19764563 Ref: Salvia fruticosa, Salvia officinalis, and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines: the role in MAPK/ERK pathway. PMID: 19838929 Ref: [Change from inflammation to carcinoma in ulcerative colitis: the role of PTEN/PI3K/AKT]. PMID: 20067111 |
Ref: A gastrin precursor, gastrin-gly, upregulates VEGF expression in colonic epithelial cells through an HIF-1-independent mechanism. PMID: 19876923 Ref: The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells. PMID: 19908241 Ref: Additional value of EGFR downstream signaling phosphoprotein expression to KRAS status for response to anti-EGFR antibodies in colorectal cancer. PMID: 20049837 Ref: Randomized clinical trial to compare the effects of preoperative oral carbohydrate versus placebo on insulin resistance after colorectal surgery. PMID: 20101593 Ref: REG4 acts as a mitogenic, motility and pro-invasive factor for colon cancer cells. PMID: 20126989 Ref: Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation. PMID: 20133737 Ref: Benzyl isothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway. PMID: 20136087 Ref: The molecular therapy of colorectal cancer. PMID: 20171980 Ref: 3-phosphoinositide-dependent protein kinase-1 regulates proliferation and survival of cancer cells with an activated mitogen-activated protein kinase pathway. PMID: 20197379 Ref: Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway. PMID: 20198339 Ref: PI3K/Akt and GSK-3beta prevents in a differential fashion the malignant phenotype of colorectal cancer cells. PMID: 20204404 Ref: Rapamycin-mediated FOXO1 inactivation reduces the anticancer efficacy of rapamycin. PMID: 20392999 Ref: Molecular target class is predictive of in vitro response profile. PMID: 20406975 Ref: Biology of colorectal cancer. PMID: 20526096 Ref: New strategies in colorectal cancer: biomarkers of response to epidermal growth factor receptor monoclonal antibodies and potential therapeutic targets in phosphoinositide 3-kinase and mitogen-activated protein kinase pathways. PMID: 20554751 Ref: Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression. PMID: 20558745 Ref: EP4 upregulation of Ras signaling and feedback regulation of Ras in human colon tissues and cancer cells. PMID: 20571779 Ref: Strategies for overcoming inherent and acquired resistance to EGFR inhibitors by targeting downstream effectors in the RAS/PI3K pathway. PMID: 20718704 Ref: [Effect of anti-EGFR monoclonal antibody on chemosensitivity of human colon cancer cells and the mechanism]. PMID: 20813673 Ref: Phenethyl isothiocyanate inhibited tumor migration and invasion via suppressing multiple signal transduction pathways in human colon cancer HT29 cells. PMID: 20863062 Ref: Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis. PMID: 20971826 Ref: Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL. PMID: 20978316 Ref: B55beta-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer. PMID: 21075311 Ref: Clinical significance of genetic variations in the PI3K/PTEN/AKT/mTOR pathway in Korean patients with colorectal cancer. PMID: 21412012 |
Ref: DMBT1 is a novel gene induced by IL-22 in ulcerative colitis. PMID: 20824812 Ref: Activation of the PI3K/Akt pathway mediates bone morphogenetic protein 2-induced invasion of pancreatic cancer cells Panc-1. PMID: 20848249 Ref: Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1alpha translational pathway in colorectal cancer cells. PMID: 20857420 Ref: Anti-interleukin-6 receptor antibody inhibits the progression in human colon carcinoma cells. PMID: 21114487 Ref: Activation and involvement of Ral GTPases in colorectal cancer. PMID: 21199803 Ref: Muscarinic receptor agonists stimulate human colon cancer cell migration and invasion. PMID: 21273532 Ref: A phase II study of capecitabine, oxaliplatin, bevacizumab and cetuximab in the treatment of metastatic colorectal cancer. PMID: 21273607 Ref: Adiponectin supports cell survival in glucose deprivation through enhancement of autophagic response in colorectal cancer cells. PMID: 21299716 Ref: Influence of CXCR4/SDF-1 axis on E-cadherin/beta-catenin complex expression in HT29 colon cancer cells. PMID: 21350711 Ref: Activation of K-RAS by co-mutation of codons 19 and 20 is transforming. PMID: 21371307 Ref: Dual blockade of phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer. PMID: 21429662 Ref: mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. PMID: 21430067 Ref: Restoration of transforming growth factor-beta receptor II expression in colon cancer cells with microsatellite instability increases metastatic potential in vivo. PMID: 21454688 Ref: Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL. PMID: 21538027 Ref: KRAS mutation detection in colorectal cancer by a commercially available gene chip array compares well with Sanger sequencing. PMID: 21575616 Ref: An IkappaBalpha phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)-Nrf2-ARE signaling and ROS-PI3K/Akt signaling in an NF-kappaB-independent mechanism. PMID: 21620964 Ref: Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin. PMID: 21673091 Ref: Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFkappaB survival axis downstream of Death receptor-3. PMID: 21722370 Ref: Targeting PI3K signaling as a therapeutic approach for colorectal cancer. PMID: 21723986 Ref: Cancer chemopreventive effects of lycopene: suppression of MMP-7 expression and cell invasion in human colon cancer cells. PMID: 21923160 Ref: The significance of a group of molecular markers and clinicopathological factors in identifying colorectal liver metastasis. PMID: 21937374 Ref: Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers. PMID: 21985784 Ref: Muscarinic receptor signaling in colon cancer. PMID: 24212649 |
Ref: Silencing Poly (ADP-Ribose) glycohydrolase (PARG) expression inhibits growth of human colon cancer cells in vitro via PI3K/Akt/NFkappa-B pathway. PMID: 21713600 Ref: Celecoxib inactivates epithelial-mesenchymal transition stimulated by hypoxia and/or epidermal growth factor in colon cancer cells. PMID: 21882253 Ref: Studies on the expression patterns of class I PI3K catalytic subunits and its prognostic significance in colorectal cancer. PMID: 21910030 Ref: p37delta is a new isoform of PI3K p110delta that increases cell proliferation and is overexpressed in tumors. PMID: 22020336 Ref: Primary colorectal cancers and their subsequent hepatic metastases are genetically different: implications for selection of patients for targeted treatment. PMID: 22173549 Ref: The "HER2-PI3K/Akt-FASN Axis" regulated malignant phenotype of colorectal cancer cells. PMID: 22218925 Ref: Blockade of irradiation-induced autophagosome formation impairs proliferation but does not enhance cell death in HCT-116 human colorectal carcinoma cells. PMID: 22246348 Ref: The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer. PMID: 22261800 Ref: Inhibition of IGF-IR increases chemosensitivity in human colorectal cancer cells through MRP-2 promoter suppression. PMID: 22275271 Ref: Brassinin induces G1 phase arrest through increase of p21 and p27 by inhibition of the phosphatidylinositol 3-kinase signaling pathway in human colon cancer cells. PMID: 22307336 Ref: Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway. PMID: 22357207 Ref: The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition. PMID: 22415236 Ref: Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging. PMID: 22465936 Ref: The extra domain A of fibronectin increases VEGF-C expression in colorectal carcinoma involving the PI3K/AKT signaling pathway. PMID: 22496919 Ref: Ursodeoxycholic acid protects colon cancer HCT116 cells from deoxycholic acid-induced apoptosis by inhibiting apoptosome formation. PMID: 22497644 Ref: A molecular signature for oncogenic BRAF in human colon cancer cells is revealed by microarray analysis. PMID: 22515520 Ref: Nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathways. PMID: 22520577 Ref: Mice expressing activated PI3K rapidly develop advanced colon cancer. PMID: 22525701 Ref: CD44 enhances the epithelial-mesenchymal transition in association with colon cancer invasion. PMID: 22552741 Ref: Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors in cancer therapy: advances and perspectives. PMID: 22571659 Ref: Impact of Yangzheng Xiaoji on the adhesion and migration of human cancer cells: the role of the AKT signalling pathway. PMID: 22753711 Ref: Expression of Abelson interactor 1 (Abi1) correlates with inflammation, KRAS mutation and adenomatous change during colonic carcinogenesis. PMID: 22808230 Ref: Guidelines for biomarker testing in colorectal carcinoma (CRC): a national consensus of the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM). PMID: 22855150 Ref: Fatty acid synthase regulates proliferation and migration of colorectal cancer cells via HER2-PI3K/Akt signaling pathway. PMID: 22860766 Ref: Therapeutic targeting of the phosphatidylinositol 3-kinase signaling pathway: novel targeted therapies and advances in the treatment of colorectal cancer. PMID: 22973417 Ref: Cyclosporin A inhibits colon cancer cell growth independently of the calcineurin pathway. PMID: 22992618 Ref: Signal transduction pathways of the epidermal growth factor receptor in colorectal cancer and their inhibition by small molecules. PMID: 23033949 Ref: The expression and clinical significance of PI3K, pAkt and VEGF in colon cancer. PMID: 23205098 Ref: Alternative dosing of dual PI3K and MEK inhibition in cancer therapy. PMID: 23259591 |
Ref: Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signalling. PMID: 22535374 Ref: NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway. PMID: 22974840 Ref: Single-agent therapy with sorafenib or 5-FU is equally effective in human colorectal cancer xenograft--no benefit of combination therapy. PMID: 22983756 Ref: Protein pathway activation mapping of colorectal metastatic progression reveals metastasis-specific network alterations. PMID: 23053743 Ref: Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling. PMID: 23233484 Ref: Suppression of Src/ERK and GSK-3/beta-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells. PMID: 23333577 Ref: APRIL induces tumorigenesis and metastasis of colorectal cancer cells via activation of the PI3K/Akt pathway. PMID: 23383143 Ref: Analgesic-antitumor peptide induces apoptosis and inhibits the proliferation of SW480 human colon cancer cells. PMID: 23420047 Ref: Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)-reactivating agents enhance efficacy of 5-fluorouracil on human colon cancer cells. PMID: 23438367 Ref: P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in vivo. PMID: 23448150 Ref: Cytotoxic activity and apoptosis-inducing potential of di-spiropyrrolidino and di-spiropyrrolizidino oxindole andrographolide derivatives. PMID: 23472133 Ref: miR-30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma. PMID: 23486085 Ref: PI3K/AKT signaling is essential for communication between tissue-infiltrating mast cells, macrophages, and epithelial cells in colitis-induced cancer. PMID: 23487439 Ref: p55PIK transcriptionally activated by MZF1 promotes colorectal cancer cell proliferation. PMID: 23509792 Ref: Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. PMID: 23549875 Ref: Designer peptide antagonist of the leptin receptor with peripheral antineoplastic activity. PMID: 23567149 Ref: mTOR inhibition elicits a dramatic response in PI3K-dependent colon cancers. PMID: 23593290 Ref: FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density. PMID: 23603907 Ref: PTEN expression profiles in colorectal adenocarcinoma and its precancerous lesions. PMID: 23625595 Ref: Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells. PMID: 23629727 Ref: [Effects and mechanisms of phosphatidylinositol 3 kinase B signal pathway on colon cancer cell SW480]. PMID: 23663347 Ref: Dual inhibition of EGFR and c-Met kinase activation by MJ-56 reduces metastasis of HT29 human colorectal cancer cells. PMID: 23677180 Ref: Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells. PMID: 23725225 Ref: Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors. PMID: 23732517 Ref: Phase II study of everolimus in patients with metastatic colorectal adenocarcinoma previously treated with bevacizumab-, fluoropyrimidine-, oxaliplatin-, and irinotecan-based regimens. PMID: 23743569 Ref: Testosterone induced apoptosis in colon cancer cells is regulated by PI3K/Rac1 signaling. PMID: 23770942 Ref: Overexpression of peptide deformylase in breast, colon, and lung cancers. PMID: 23815882 Ref: Deep Sequencing the MicroRNA Transcriptome in Colorectal Cancer. PMID: 23824282 Ref: Phenethyl isothiocyanate inhibits hypoxia-induced accumulation of HIF-1alpha and VEGF expression in human glioma cells. PMID: 23870899 Ref: MicroRNA-451 inhibits growth of human colorectal carcinoma cells via downregulation of Pi3k/Akt pathway. PMID: 23886157 Ref: Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced colorectal cancer (CRC) receiving bevacizumab. PMID: 23930204 Ref: Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells. PMID: 23954321 Ref: Integrating anti-EGFR therapies in metastatic colorectal cancer. PMID: 23997940 Ref: Src plays a key role in ADAM28 expression in v-src-transformed epithelial cells and human carcinoma cells. PMID: 24007880 Ref: High level of p37delta-mRNA relative to p110delta-mRNA in neuroblastoma tumors correlates with poor patient survival. PMID: 24026661 Ref: Phosphorylation and mRNA splicing of collapsin response mediator protein-2 determine inhibition of rho-associated protein kinase (ROCK) II function in carcinoma cell migration and invasion. PMID: 24036111 Ref: Epidermal growth factor receptor: pathway, therapies, and pipeline. PMID: 24054705 Ref: Regulation of YAP through an Akt-dependent process by 3, 3'-diindolylmethane in human colon cancer cells. PMID: 24100865 Ref: Evaluating many treatments and biomarkers in oncology: a new design. PMID: 24248692 Ref: Personalized treatment for advanced colorectal cancer: KRAS and beyond. PMID: 24294007 Ref: Toward a Molecular Classification of Colorectal Cancer: The Role of BRAF. PMID: 24298448 Ref: The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing mice. PMID: 24339963 Ref: Comparative analysis of radiosensitizers for K-RAS mutant rectal cancers. PMID: 24349411 |
Ref: A prospective pilot study of target-guided personalized chemotherapy with intensity-modulated radiotherapy in patients with early rectal cancer. PMID: 23211222 Ref: The molecular chaperone Cosmc enhances malignant behaviors of colon cancer cells via activation of Akt and ERK. PMID: 23390052 Ref: ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer. PMID: 23624914 Ref: Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1alpha and glycolysis, by inhibiting PI3K/Akt signaling pathway. PMID: 23761018 Ref: CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation. PMID: 23995790 Ref: GDNF increases cell motility in human colon cancer through VEGF-VEGFR1 interaction. PMID: 24165321 Ref: MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2. PMID: 24293274 Ref: Powerful tumor cell growth-inhibiting activity of a synthetic derivative of atractyligenin: involvement of PI3K/Akt pathway and thioredoxin system. PMID: 24321480 Ref: Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation. PMID: 24336047 Ref: mTOR pathway in colorectal cancer: an update. PMID: 24393708 Ref: Is biomarker research advancing in the era of personalized medicine for head and neck cancer? PMID: 24442754 Ref: Identification of a microRNA landscape targeting the PI3K/Akt signaling pathway in inflammation-induced colorectal carcinogenesis. PMID: 24464560 Ref: PI3K/Akt pathway involving into apoptosis and invasion in human colon cancer cells LoVo. PMID: 24496855 Ref: Lack of association between insulin receptor substrate2 rs1805097 polymorphism and the risk of colorectal and breast cancer: a meta-analysis. PMID: 24497996 Ref: Signal transducer and activator of transcription 3 - a promising target in colitis-associated cancer. PMID: 24568457 Ref: Sphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in South asian population. PMID: 24572701 Ref: Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer. PMID: 24581231 Ref: CELLFOOD induces apoptosis in human mesothelioma and colorectal cancer cells by modulating p53, c-myc and pAkt signaling pathways. PMID: 24598211 Ref: PPARdelta deficiency disrupts hypoxia-mediated tumorigenic potential of colon cancer cells. PMID: 24610641 Ref: Aged black garlic extract inhibits HT29 colon cancer cell growth via the PI3K/Akt signaling pathway. PMID: 24649105 Ref: CCL20 and CXCL8 synergize to promote progression and poor survival outcome in patients with colorectal cancer by collaborative induction of the epithelial-mesenchymal transition. PMID: 24657657 Ref: Regulation of colorectal carcinoma stemness, growth, and metastasis by an miR-200c-Sox2-negative feedback loop mechanism. PMID: 24658157 Ref: BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737. PMID: 24709422 Ref: Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma. PMID: 24713430 Ref: MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. PMID: 24735923 Ref: Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability. PMID: 24743574 Ref: The PTEN/PI3K/Akt and Wnt/beta-catenin signaling pathways are involved in the inhibitory effect of resveratrol on human colon cancer cell proliferation. PMID: 24756222 Ref: The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway. PMID: 24762137 Ref: PIK3R3 induces epithelial-to-mesenchymal transition and promotes metastasis in colorectal cancer. PMID: 24837077 Ref: Nrdp1 inhibits growth of colorectal cancer cells by nuclear retention of p27. PMID: 24867101 Ref: Demonstration and biological significance of a gastrin-P21-activated kinase 1 feedback loop in colorectal cancer cells. PMID: 24963032 Ref: Enhanced anti-colorectal cancer effects of carfilzomib combined with CPT-11 via downregulation of nuclear factor-kappaB in vitro and in vivo. PMID: 24968890 Ref: Kynurenic acid inhibits colon cancer proliferation in vitro: effects on signaling pathways. PMID: 25012123 Ref: The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer. PMID: 25023051 Ref: Involvement of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways in the regulation of cell cycle progression by PTHrP in colon adenocarcinoma cells. PMID: 25051885 Ref: Effective inhibition of colon cancer cell growth with MgAl-layered double hydroxide (LDH) loaded 5-FU and PI3K/mTOR dual inhibitor BEZ-235 through apoptotic pathways. PMID: 25075187 Ref: The PI3K/Akt pathway in colitis associated colon cancer and its chemoprevention with celecoxib, a Cox-2 selective inhibitor. PMID: 25107843 Ref: Epidermal growth factor stimulates nuclear factor-kappaB activation and heme oxygenase-1 expression via c-Src, NADPH oxidase, PI3K, and Akt in human colon cancer cells. PMID: 25122478 Ref: Tumor suppressor miR-1 restrains epithelial-mesenchymal transition and metastasis of colorectal carcinoma via the MAPK and PI3K/AKT pathway. PMID: 25196260 Ref: Synergism of PI3K/Akt inhibition and Fas activation on colon cancer cell death. PMID: 25199763 Ref: GRP78 secreted by colon cancer cells facilitates cell proliferation via PI3K/Akt signaling. PMID: 25227822 Ref: 3'-Deoxy-3'-[18F]-Fluorothymidine PET imaging reflects PI3K-mTOR-mediated pro-survival response to targeted therapy in colorectal cancer. PMID: 25247710 Ref: Lysophosphatidylserine stimulates chemotactic migration of colorectal cancer cells through GPR34 and PI3K/Akt pathway. PMID: 25275042 Ref: Colon carcinogenesis: influence of Western diet-induced obesity and targeting stem cells using dietary bioactive compounds. PMID: 25280404 Ref: Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase-phosphoinositide 3-kinase-dependent anti-apoptotic signaling. PMID: 25287946 Ref: Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X. PMID: 25307848 Ref: Kaempferol Downregulates Insulin-like Growth Factor-I Receptor and ErbB3 Signaling in HT-29 Human Colon Cancer Cells. PMID: 25337585 Ref: Phosphatidylinositol 3-kinase mediates the ability of retinol to decrease colorectal cancer cell invasion. PMID: 25356626 Ref: Expression of Ang-2/Tie-2 and PI3K/AKT in colorectal cancer. PMID: 25374184 Ref: Potent anti-cancer effect of 3'-hydroxypterostilbene in human colon xenograft tumors. PMID: 25389774 Ref: Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer. PMID: 25401499 Ref: Upregulation of MAPK/Erk and PI3K/Akt pathways in ulcerative colitis-associated colon cancer. PMID: 25443414 |
Ref: Justicidin A-induced autophagy flux enhances apoptosis of human colorectal cancer cells via class III PI3K and Atg5 pathway. PMID: 25216025 Ref: Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells. PMID: 25355159 Ref: Aberrant methylation of ERBB pathway genes in sporadic colorectal cancer. PMID: 25366420 Ref: Updated guidelines for biomarker testing in colorectal carcinoma: a national consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology. PMID: 25373533 Ref: MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K/Akt pathway. PMID: 25431257 Ref: CXCL13-CXCR5 axis promotes the growth and invasion of colon cancer cells via PI3K/AKT pathway. PMID: 25476740 Ref: Effect of KRAS exon 2 mutations on antitumor activity of afatinib and gefitinib. 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