Literatures

Primary Site >> Liver Cancer

Gene >> PIK3CA

1.
Journal:	Genes Dev. 2004 Apr 15;18(8):912-25.
Title:	Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.
Author:	Wang, Guo-Li\|Iakova, Polina\|Wilde, Margie\|Awad, Samir\|Timchenko, Nikolai A
PMID:	15107404

2.
Journal:	Oncogene. 2005 Feb 17;24(8):1477-80.
Title:	PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.
Author:	Lee, Jong Woo\|Soung, Young Hwa\|Kim, Su Young\|Lee, Hae Woo\|Park, Won Sang\|Nam, Suk Woo\|Kim, Sang Ho\|Lee, Jung Young\|Yoo, Nam Jin\|Lee, Sug Hyung
PMID:	15608678

3.
Journal:	Clin Exp Metastasis. 2005;22(2):137-47.
Title:	Establishment and characterization of three novel human gastric cancer cell lines with differentiated intestinal phenotype derived from liver metastasis.
Author:	Nakanishi, Hayao\|Yasui, Kenzo\|Ikehara, Yuzuru\|Yokoyama, Hiroyuki\|Munesue, Seiichi\|Kodera, Yasuhiro\|Tatematsu, Masae
PMID:	16086234

4.
Journal:	Oncogene. 2006 May 11;25(20):2950-2.
Title:	Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients.
Author:	Tanaka, Y\|Kanai, F\|Tada, M\|Asaoka, Y\|Guleng, B\|Jazag, A\|Ohta, M\|Ikenoue, T\|Tateishi, K\|Obi, S\|Kawabe, T\|Yokosuka, O\|Omata, M
PMID:	16331247

5.
Journal:	J Cell Biochem. 2008 Feb 1;103(2):471-8.
Title:	Effects of tyroserleutide on gene expression of calmodulin and PI3K in hepatocellular carcinoma.
Author:	Zhao, Lan\|Zhao, Qian\|Lu, Rong\|Fu, Zheng\|Zhu, Zhifeng\|Jia, Jing\|Wang, Song\|Shi, Linxi\|Jian, Xu\|Yao, Zhi
PMID:	17546603

6.
Journal:	Genes Chromosomes Cancer. 2008 May;47(5):363-7.
Title:	Rare PIK3CA hotspot mutations in carcinomas of the biliary tract.
Author:	Riener, Marc-Oliver\|Bawohl, Marion\|Clavien, Pierre-Alain\|Jochum, Wolfram
PMID:	18181165

7.
Journal:	Gastroenterology. 2008 Oct;135(4):1322-32.
Title:	E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer.
Author:	Ladu, Sara\|Calvisi, Diego F\|Conner, Elizabeth A\|Farina, Miriam\|Factor, Valentina M\|Thorgeirsson, Snorri S
PMID:	18722373

8.
Journal:	Biochem Biophys Res Commun. 2009 Sep 18;387(2):310-5.
Title:	Ablation of phosphoinositide-3-kinase class II alpha suppresses hepatoma cell proliferation.
Author:	Ng, Stanley K L\|Neo, Soek-Ying\|Yap, Yann-Wan\|Karuturi, R Krishna Murthy\|Loh, Evelyn S L\|Liau, Kui-Hin\|Ren, Ee-Chee
PMID:	19591801

9.
Journal:	Clin Cancer Res. 2009 Jul 15;15(14):4538-45.
Title:	Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival.
Author:	Hartmann, Wolfgang\|Kuchler, Jan\|Koch, Arend\|Friedrichs, Nicolaus\|Waha, Anke\|Endl, Elmar\|Czerwitzki, Jacqueline\|Metzger, Dagmar\|Steiner, Susanne\|Wurst, Peter\|Leuschner, Ivo\|von Schweinitz, Dietrich\|Buettner, Reinhard\|Pietsch, Torsten
PMID:	19584164

10.
Journal:	J Hepatol. 2010 Nov;53(5):918-26.
Title:	Phosphatidylinositol-3-kinase p110gamma contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells.
Author:	Hohenester, Simon\|Gates, Anna\|Wimmer, Ralf\|Beuers, Ulrich\|Anwer, M Sawkat\|Rust, Christian\|Webster, Cynthia R L
PMID:	20675006

11.
Journal:	Clin Cancer Res. 2011 Jun 1;17(11):3551-7.
Title:	Detection of tumor DNA at the margins of colorectal cancer liver metastasis.
Author:	Holdhoff, Matthias\|Schmidt, Kerstin\|Diehl, Frank\|Aggrawal, Nishant\|Angenendt, Philipp\|Romans, Katharine\|Edelstein, Daniel L\|Torbenson, Michael\|Kinzler, Kenneth W\|Vogelstein, Bert\|Choti, Michael A\|Diaz, Luis A Jr
PMID:	21531819

12.
Journal:	Semin Liver Dis. 2011 May;31(2):173-87.
Title:	Genetics of hepatobiliary carcinogenesis.
Author:	Nault, Jean-Charles\|Zucman-Rossi, Jessica
PMID:	21538283

13.
Journal:	Br J Cancer. 2011 Jul 12;105(2):281-7.
Title:	Molecular alterations associated with liver metastases development in colorectal cancer patients.
Author:	Bruin, S C\|He, Y\|Mikolajewska-Hanclich, I\|Liefers, G-J\|Klijn, C\|Vincent, A\|Verwaal, V J\|de Groot, K A\|Morreau, H\|van Velthuysen, M-L F\|Tollenaar, R A E M\|van 't Veer, L J
PMID:	21673680

14.
Journal:	J Hepatol. 2011 Dec;55(6):1400-8.
Title:	Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway.
Author:	Kudo, Yotaro\|Tanaka, Yasuo\|Tateishi, Keisuke\|Yamamoto, Keisuke\|Yamamoto, Shinzo\|Mohri, Dai\|Isomura, Yoshihiro\|Seto, Motoko\|Nakagawa, Hayato\|Asaoka, Yoshinari\|Tada, Motohisa\|Ohta, Miki\|Ijichi, Hideaki\|Hirata, Yoshihiro\|Otsuka, Motoyuki\|Ikenoue, Tsuneo\|Maed
PMID:	21703185

15.
Journal:	Pathol Oncol Res. 2012 Jan;18(1):57-60.
Title:	Low frequency of PIK3CA gene mutations in hepatocellular carcinoma in Chinese population.
Author:	Li, Xun\|Zhang, Quanbao\|He, Wenting\|Meng, Wenbo\|Yan, Jun\|Zhang, Lei\|Zhu, Xiaoliang\|Liu, Tao\|Li, Yumin\|Bai, Zhongtian
PMID:	21667306

16.
Journal:	Zhonghua Wai Ke Za Zhi. 2012 Nov;50(11):1007-10.
Title:	[A study of the relationship between the mutation of PIK3CA, PTEN and the occurrence of liver metastasis of colorectal cancer: survival analysis].
Author:	Liang, Li\|Wei, Ye\|Ren, Li\|Zhong, Yun-shi\|Xu, Jian-min
PMID:	23302486

17.
Journal:	Cell Death Dis. 2012 Jan 19;3:e259.
Title:	BRAF and PIK3CA genes are somatically mutated in hepatocellular carcinoma among patients from South Italy.
Author:	Colombino, M\|Sperlongano, P\|Izzo, F\|Tatangelo, F\|Botti, G\|Lombardi, A\|Accardo, M\|Tarantino, L\|Sordelli, I\|Agresti, M\|Abbruzzese, A\|Caraglia, M\|Palmieri, G
PMID:	22258409

18.
Journal:	Anat Rec (Hoboken). 2012 Mar;295(3):423-31.
Title:	Multivariate analysis of several molecular markers and clinicopathological features in postoperative prognosis of hepatocellular carcinoma.
Author:	Zuo, Qiang\|Huang, Hui\|Shi, Min\|Zhang, Futing\|Sun, Jiping\|Bin, Jianping\|Liao, Yulin\|Liao, Wangjun
PMID:	22190283

19.
Journal:	Cancer Lett. 2012 Mar 28;316(2):187-95.
Title:	HS-116, a novel phosphatidylinositol 3-kinase inhibitor induces apoptosis and suppresses angiogenesis of hepatocellular carcinoma through inhibition of the PI3K/AKT/mTOR pathway.
Author:	Jung, Kyung Hee\|Choi, Myung-Joo\|Hong, Seunghee\|Lee, Hyunseung\|Hong, Sang-Won\|Zheng, Hong-Mei\|Lee, Hee-Seung\|Hong, Sungwoo\|Hong, Soon-Sun
PMID:	22182943

20.
Journal:	Cancer Lett. 2013 Feb 1;329(1):99-108.
Title:	IPD-196, a novel phosphatidylinositol 3-kinase inhibitor with potent anticancer activity against hepatocellular carcinoma.
Author:	Lee, Ju-Hee\|Lee, Hyunseung\|Yun, Sun-Mi\|Jung, Kyung Hee\|Jeong, Yujeong\|Yan, Hong Hua\|Hong, Sungwoo\|Hong, Soon-Sun
PMID:	23142281

21.
Journal:	Int J Oncol. 2013 Jul;43(1):201-9.
Title:	Induction of apoptosis and suppression of angiogenesis of hepatocellular carcinoma by HS-159, a novel phosphatidylinositol 3-kinase inhibitor.
Author:	Yun, Sun-Mi\|Lee, Ju-Hee\|Jung, Kyung Hee\|Lee, Hyunseung\|Lee, Soyoung\|Hong, Sungwoo\|Hong, Soon-Sun
PMID:	23604199

22.
Journal:	Mol Cell Biochem. 2013 Jul;379(1-2):191-9.
Title:	SRPK1 contributes to malignancy of hepatocellular carcinoma through a possible mechanism involving PI3K/Akt.
Author:	Zhou, Bo\|Li, Yandong\|Deng, Qing\|Wang, Haixiao\|Wang, Yuping\|Cai, Bing\|Han, Ze-Guang
PMID:	23644876

23.
Journal:	Yonsei Med J. 2013 Jul;54(4):883-7.
Title:	PIK3CA mutations in hepatocellular carcinoma in Korea.
Author:	Kim, Heesue\|Park, Cheol-Keun\|Lee, Su Jin\|Rha, Sun Young\|Park, Kyu Hyun\|Lim, Ho Yeong
PMID:	23709421

24.
Journal:	World J Gastroenterol. 2013 Dec 21;19(47):8873-9.
Title:	Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma.
Author:	Gu, De-Leung\|Chen, Yen-Hsieh\|Shih, Jou-Ho\|Lin, Chi-Hung\|Jou, Yuh-Shan\|Chen, Chian-Feng
PMID:	24379610

25.
Journal:	J Carcinog. 2013 Dec 31;12:22.
Title:	Targeted therapies in development for non-small cell lung cancer.
Author:	Reungwetwattana, Thanyanan\|Dy, Grace Kho
PMID:	24574860

26.
Journal:	Front Physiol. 2014 Oct 15;5:391.
Title:	Targeting p110gamma in gastrointestinal cancers: attack on multiple fronts.
Author:	Falasca, Marco\|Maffucci, Tania
PMID:	25360116

27.
Journal:	PLoS One. 2014 Aug 15;9(8):e104979.
Title:	Reporting tumor molecular heterogeneity in histopathological diagnosis.
Author:	Mafficini, Andrea\|Amato, Eliana\|Fassan, Matteo\|Simbolo, Michele\|Antonello, Davide\|Vicentini, Caterina\|Scardoni, Maria\|Bersani, Samantha\|Gottardi, Marisa\|Rusev, Borislav\|Malpeli, Giorgio\|Corbo, Vincenzo\|Barbi, Stefano\|Sikora, Katarzyna O\|Lawlor, Rita T\|Tor
PMID:	25127237

28.
Journal:	APMIS. 2014 Oct;122(10):1001-6.
Title:	Clinicopathological characteristics of PIK3CA and HBx mutations in Korean patients with hepatocellular carcinomas.
Author:	Kim, Dong Choon\|Chung, Woo Jin\|Lee, Jae-Ho\|Jang, Byung Kuk\|Hwang, Jae Seok\|Kang, Koo Jeong\|Kwon, Sun Young
PMID:	24673525

29.
Journal:	Oncol Lett. 2014 Sep;8(3):1249-1254.
Title:	Mutation analysis of key genes in RAS/RAF and PI3K/PTEN pathways in Chinese patients with hepatocellular carcinoma.
Author:	Hou, Wenmin\|Liu, Jibin\|Chen, Peizhan\|Wang, Hui\|Ye, Bang-Ce\|Qiang, Fulin
PMID:	25120700

30.
Journal:	PLoS One. 2014 May 5;9(5):e95307.
Title:	Transcriptomic characterization of hepatocellular carcinoma with CTNNB1 mutation.
Author:	Ding, Xiao\|Yang, Yuan\|Han, Baoda\|Du, Chengzhi\|Xu, Naiqing\|Huang, Huanwei\|Cai, Tao\|Zhang, Aiqun\|Han, Ze-Guang\|Zhou, Weiping\|Chen, Liang
PMID:	24798046

31.
Journal:	Oncologist. 2014 Mar;19(3):235-42.
Title:	New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing.
Author:	Ross, Jeffrey S\|Wang, Kai\|Gay, Laurie\|Al-Rohil, Rami\|Rand, Janne V\|Jones, David M\|Lee, Hwa J\|Sheehan, Christine E\|Otto, Geoff A\|Palmer, Gary\|Yelensky, Roman\|Lipson, Doron\|Morosini, Deborah\|Hawryluk, Matthew\|Catenacci, Daniel V T\|Miller, Vincent A\|Churi, C
PMID:	24563076

32.
Journal:	Oncogene. 2014 Jun 5;33(23):2949-55.
Title:	Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology.
Author:	Ogino, S\|Lochhead, P\|Giovannucci, E\|Meyerhardt, J A\|Fuchs, C S\|Chan, A T
PMID:	23792451

33.
Journal:	Oncotarget. 2014 May 30;5(10):3012-22.
Title:	Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing.
Author:	Janku, Filip\|Kaseb, Ahmed O\|Tsimberidou, Apostolia M\|Wolff, Robert A\|Kurzrock, Razelle
PMID:	24931142

34.
Journal:	Oncotarget. 2015 Apr 30;6(12):10102-15.
Title:	Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver.
Author:	Li, Xiaolei\|Tao, Junyan\|Cigliano, Antonio\|Sini, Marcella\|Calderaro, Julien\|Azoulay, Daniel\|Wang, Chunmei\|Liu, Yan\|Jiang, Lijie\|Evert, Katja\|Demartis, Maria I\|Ribback, Silvia\|Utpatel, Kirsten\|Dombrowski, Frank\|Evert, Matthias\|Calvisi, Diego F\|Chen, Xin
PMID:	25826091

35.
Journal:	Eur J Pharmacol. 2015 Sep 5;762:55-62.
Title:	A novel mechanism of hepatocellular carcinoma cell apoptosis induced by lupeol via Brain-Derived Neurotrophic Factor Inhibition and Glycogen Synthase Kinase 3 beta reactivation.
Author:	Zhang, Lingli\|Tu, Yi\|He, Wen\|Peng, Yan\|Qiu, Zhenpeng
PMID:	26004524

36.
Journal:	Clin Sci (Lond). 2015 Nov;129(10):839-50.
Title:	Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes.
Author:	Liu, Tong-Yan\|Shi, Chang-Xiang\|Gao, Run\|Sun, Hai-Jian\|Xiong, Xiao-Qing\|Ding, Lei\|Chen, Qi\|Li, Yue-Hua\|Wang, Jue-Jin\|Kang, Yu-Ming\|Zhu, Guo-Qing
PMID:	26201094

37.
Journal:	Hum Pathol. 2015 Jul;46(7):1068-77.
Title:	ARID2, p110alpha, p53, and beta-catenin protein expression in hepatocellular carcinoma and clinicopathologic implications.
Author:	You, Jason\|Yang, Hushan\|Lai, Yinzhi\|Simon, Lindsay\|Au, Jen\|Burkart, Ashlie L
PMID:	26284269

38.
Journal:	Int J Clin Exp Pathol. 2015 Nov 1;8(11):15255-9. eCollection 2015.
Title:	PIK3CA polymorphisms associated with susceptibility to hepatocellular carcinoma.
Author:	Li, Hong-Guang\|Liu, Fang-Feng\|Zhu, Hua-Qiang\|Zhou, Xu\|Lu, Jun\|Chang, Hong\|Hu, Jin-Hua
PMID:	26823876

39.
Journal:	Eur J Med Chem. 2016 Oct 21;122:684-701.
Title:	Structure-based optimization leads to the discovery of NSC765844, a highly potent, less toxic and orally efficacious dual PI3K/mTOR inhibitor.
Author:	Han, Jinsong\|Chen, Ying\|Yang, Chao\|Liu, Ting\|Wang, Mingping\|Xu, Haojie\|Zhang, Ling\|Zheng, Canhui\|Song, Yunlong\|Zhu, Ju
PMID:	27448924

40.
Journal:	BMC Med Genomics. 2016 Dec 12;9(1):75.
Title:	Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes.
Author:	Wong, John K L\|Campbell, Desmond\|Ngo, Ngoc Diem\|Yeung, Fanny\|Cheng, Guo\|Tang, Clara S M\|Chung, Patrick H Y\|Tran, Ngoc Son\|So, Man-Ting\|Cherny, Stacey S\|Sham, Pak C\|Tam, Paul K\|Garcia-Barcelo, Maria-Merce
PMID:	27955658

41.
Journal:	Oncotarget. 2016 Nov 8;7(45):72908-72922.
Title:	Genomic characterization of liver metastases from colorectal cancer patients.
Author:	Sayagues, Jose Maria\|Corchete, Luis Antonio\|Gutierrez, Maria Laura\|Sarasquete, Maria Eugenia\|Del Mar Abad, Maria\|Bengoechea, Oscar\|Ferminan, Encarna\|Anduaga, Maria Fernanda\|Del Carmen, Sofia\|Iglesias, Manuel\|Esteban, Carmen\|Angoso, Maria\|Alcazar, Jose Ant
PMID:	27662660

42.
Journal:	J Gastrointest Oncol. 2016 Aug;7(4):570-9.
Title:	A genetic database can be utilized to identify potential biomarkers for biphenotypic hepatocellular carcinoma-cholangiocarcinoma.
Author:	Mok, Shaffer R S\|Mohan, Sachin\|Grewal, Navjot\|Elfant, Adam B\|Judge, Thomas A
PMID:	27563447

43.
Journal:	Liver Int. 2016 Aug;36(8):1176-86.
Title:	Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade.
Author:	Wang, Chunmei\|Che, Li\|Hu, Junjie\|Zhang, Shanshan\|Jiang, Lijie\|Latte, Gavinella\|Demartis, Maria I\|Tao, Junyan\|Gui, Bing\|Pilo, Maria G\|Ribback, Silvia\|Dombrowski, Frank\|Evert, Matthias\|Calvisi, Diego F\|Chen, Xin
PMID:	26716908

44.
Journal:	Oncotarget. 2016 Feb 2;7(5):5327-41.
Title:	Protein kinase D2 contributes to TNF-alpha-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3beta/beta-catenin pathway in hepatocellular carcinoma.
Author:	Zhu, Yun\|Cheng, Yang\|Guo, YaBin\|Chen, JinZhang\|Chen, FengSheng\|Luo, RongCheng\|Li, AiMin
PMID:	26683365

45.
Journal:	Mol Imaging Biol. 2016 Jun;18(3):360-7.
Title:	[(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice.
Author:	Li, Lei\|Che, Li\|Wang, Chunmei\|Blecha, Joseph E\|Li, Xiaolei\|VanBrocklin, Henry F\|Calvisi, Diego F\|Puchowicz, Michelle\|Chen, Xin\|Seo, Youngho
PMID:	26567114

46.
Journal:	Cancer Res. 2017 May 1;77(9):2255-2265.
Title:	Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma.
Author:	Lin, De-Chen\|Mayakonda, Anand\|Dinh, Huy Q\|Huang, Pinbo\|Lin, Lehang\|Liu, Xiaoping\|Ding, Ling-Wen\|Wang, Jie\|Berman, Benjamin P\|Song, Er-Wei\|Yin, Dong\|Koeffler, H Phillip
PMID:	28302680

47.
Journal:	Biochim Biophys Acta Mol Basis Dis. 2017 Jul;1863(7):1805-1816.
Title:	Long noncoding RNA AWPPH promotes hepatocellular carcinoma progression through YBX1 and serves as a prognostic biomarker.
Author:	Zhao, Xiaodong\|Liu, Yanbo\|Yu, Shuo
PMID:	28428004

48.
Journal:	Oncogene. 2017 Nov 9;36(45):6262-6271.
Title:	Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation.
Author:	Nakatsuka, T\|Tateishi, K\|Kudo, Y\|Yamamoto, K\|Nakagawa, H\|Fujiwara, H\|Takahashi, R\|Miyabayashi, K\|Asaoka, Y\|Tanaka, Y\|Ijichi, H\|Hirata, Y\|Otsuka, M\|Kato, M\|Sakai, J\|Tachibana, M\|Aburatani, H\|Shinkai, Y\|Koike, K
PMID:	28692045

49.
Journal:	Clin Cancer Res. 2017 Dec 1;23(23):7209-7216.
Title:	Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer.
Author:	Joung, Je-Gun\|Oh, Bo Young\|Hong, Hye Kyung\|Al-Khalidi, Hisham\|Al-Alem, Faisal\|Lee, Hae-Ock\|Bae, Joon Seol\|Kim, Jinho\|Cha, Hong-Ui\|Alotaibi, Maram\|Cho, Yong Beom\|Hassanain, Mazen\|Park, Woong-Yang\|Lee, Woo Yong
PMID:	28939741

50.
Journal:	Ann Surg Treat Res. 2017 Oct;93(4):173-180.
Title:	Establishing a colorectal cancer liver metastasis patient-derived tumor xenograft model for the evaluation of personalized chemotherapy.
Author:	Jung, Joohee\|Kim, Jisup\|Lim, Hyun Kyung\|Kim, Kyoung Mee\|Lee, Yun Sun\|Park, Joon Seong\|Yoon, Dong Sup
PMID:	29094026

51.
Journal:	Mol Cell Biochem. 2018 Apr;441(1-2):89-98.
Title:	MicroRNA-203 suppresses proliferation in liver cancer associated with PIK3CA, p38 MAPK, c-Jun, and GSK3 signaling.
Author:	Zhang, Annie\|Lakshmanan, Jaganathan\|Motameni, Amirreza\|Harbrecht, Brian G
PMID:	28887744

52.
Journal:	Oncologist. 2018 May;23(5):586-593.
Title:	Next-Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma.
Author:	Ikeda, Sadakatsu\|Tsigelny, Igor F\|Skjevik, Age A\|Kono, Yuko\|Mendler, Michel\|Kuo, Alexander\|Sicklick, Jason K\|Heestand, Gregory\|Banks, Kimberly C\|Talasaz, AmirAli\|Lanman, Richard B\|Lippman, Scott\|Kurzrock, Razelle
PMID:	29487225

53.
Journal:	J Hepatol. 2018 Jul;69(1):79-88.
Title:	Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic beta-Catenin, PIK3CA and MET.
Author:	Liu, Jacey J\|Li, Yanjie\|Chen, Wendy S\|Liang, Yan\|Wang, Gaowei\|Zong, Min\|Kaneko, Kota\|Xu, Ruiyun\|Karin, Michael\|Feng, Gen-Sheng
PMID:	29505847

54.
Journal:	Hepatology. 2018 Oct 9.
Title:	PI3Kdelta is a new therapeutic target in hepatocellular carcinoma.
Author:	Ko, Eunkyong\|Seo, Hyun-Wook\|Jung, Eun Sun\|Ju, Soomi\|Kim, Baek-Hui\|Cho, Hyeki\|Kim, Yoon Jun\|Park, Young Min\|Kim, Jong-Seo\|Jung, Guhung
PMID:	30300952