Primary Site >> Liver Cancer
Gene >> PIK3CA
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Ref: Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. PMID: 15107404 |
Ref: PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas. PMID: 15608678 Ref: Establishment and characterization of three novel human gastric cancer cell lines with differentiated intestinal phenotype derived from liver metastasis. PMID: 16086234 |
Ref: Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients. PMID: 16331247 |
Ref: Effects of tyroserleutide on gene expression of calmodulin and PI3K in hepatocellular carcinoma. PMID: 17546603 Ref: Rare PIK3CA hotspot mutations in carcinomas of the biliary tract. PMID: 18181165 Ref: E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer. PMID: 18722373 |
Ref: Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival. PMID: 19584164 Ref: Ablation of phosphoinositide-3-kinase class II alpha suppresses hepatoma cell proliferation. PMID: 19591801 |
Ref: Phosphatidylinositol-3-kinase p110gamma contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. PMID: 20675006 |
Ref: Detection of tumor DNA at the margins of colorectal cancer liver metastasis. PMID: 21531819 Ref: Genetics of hepatobiliary carcinogenesis. PMID: 21538283 Ref: Molecular alterations associated with liver metastases development in colorectal cancer patients. PMID: 21673680 Ref: Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway. PMID: 21703185 |
Ref: Low frequency of PIK3CA gene mutations in hepatocellular carcinoma in Chinese population. PMID: 21667306 Ref: HS-116, a novel phosphatidylinositol 3-kinase inhibitor induces apoptosis and suppresses angiogenesis of hepatocellular carcinoma through inhibition of the PI3K/AKT/mTOR pathway. PMID: 22182943 Ref: Multivariate analysis of several molecular markers and clinicopathological features in postoperative prognosis of hepatocellular carcinoma. PMID: 22190283 Ref: BRAF and PIK3CA genes are somatically mutated in hepatocellular carcinoma among patients from South Italy. PMID: 22258409 Ref: [A study of the relationship between the mutation of PIK3CA, PTEN and the occurrence of liver metastasis of colorectal cancer: survival analysis]. PMID: 23302486 |
Ref: IPD-196, a novel phosphatidylinositol 3-kinase inhibitor with potent anticancer activity against hepatocellular carcinoma. PMID: 23142281 Ref: Induction of apoptosis and suppression of angiogenesis of hepatocellular carcinoma by HS-159, a novel phosphatidylinositol 3-kinase inhibitor. PMID: 23604199 Ref: SRPK1 contributes to malignancy of hepatocellular carcinoma through a possible mechanism involving PI3K/Akt. PMID: 23644876 Ref: PIK3CA mutations in hepatocellular carcinoma in Korea. PMID: 23709421 Ref: Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma. PMID: 24379610 Ref: Targeted therapies in development for non-small cell lung cancer. PMID: 24574860 |
Ref: Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology. PMID: 23792451 Ref: New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing. PMID: 24563076 Ref: Clinicopathological characteristics of PIK3CA and HBx mutations in Korean patients with hepatocellular carcinomas. PMID: 24673525 Ref: Transcriptomic characterization of hepatocellular carcinoma with CTNNB1 mutation. PMID: 24798046 Ref: Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing. PMID: 24931142 Ref: Mutation analysis of key genes in RAS/RAF and PI3K/PTEN pathways in Chinese patients with hepatocellular carcinoma. PMID: 25120700 Ref: Reporting tumor molecular heterogeneity in histopathological diagnosis. PMID: 25127237 Ref: Targeting p110gamma in gastrointestinal cancers: attack on multiple fronts. PMID: 25360116 |
Ref: Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver. PMID: 25826091 Ref: A novel mechanism of hepatocellular carcinoma cell apoptosis induced by lupeol via Brain-Derived Neurotrophic Factor Inhibition and Glycogen Synthase Kinase 3 beta reactivation. PMID: 26004524 Ref: Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes. PMID: 26201094 Ref: ARID2, p110alpha, p53, and beta-catenin protein expression in hepatocellular carcinoma and clinicopathologic implications. PMID: 26284269 Ref: PIK3CA polymorphisms associated with susceptibility to hepatocellular carcinoma. PMID: 26823876 |
Ref: [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice. PMID: 26567114 Ref: Protein kinase D2 contributes to TNF-alpha-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3beta/beta-catenin pathway in hepatocellular carcinoma. PMID: 26683365 Ref: Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade. PMID: 26716908 Ref: Structure-based optimization leads to the discovery of NSC765844, a highly potent, less toxic and orally efficacious dual PI3K/mTOR inhibitor. PMID: 27448924 Ref: A genetic database can be utilized to identify potential biomarkers for biphenotypic hepatocellular carcinoma-cholangiocarcinoma. PMID: 27563447 Ref: Genomic characterization of liver metastases from colorectal cancer patients. PMID: 27662660 Ref: Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes. PMID: 27955658 |
Ref: Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma. PMID: 28302680 Ref: Long noncoding RNA AWPPH promotes hepatocellular carcinoma progression through YBX1 and serves as a prognostic biomarker. PMID: 28428004 Ref: Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation. PMID: 28692045 Ref: Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer. PMID: 28939741 Ref: Establishing a colorectal cancer liver metastasis patient-derived tumor xenograft model for the evaluation of personalized chemotherapy. PMID: 29094026 |
Ref: MicroRNA-203 suppresses proliferation in liver cancer associated with PIK3CA, p38 MAPK, c-Jun, and GSK3 signaling. PMID: 28887744 Ref: Next-Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma. PMID: 29487225 Ref: Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic beta-Catenin, PIK3CA and MET. PMID: 29505847 Ref: PI3Kdelta is a new therapeutic target in hepatocellular carcinoma. PMID: 30300952 |