Primary Site >> Esophagus Cancer
Gene >> PIK3CA
| 1. | |||||||||||
| Journal: | Int J Oncol. 2003 Oct;23(4):871-81. | ||||||||||
| Title: | Genotypic analysis of esophageal squamous cell carcinoma by molecular cytogenetics and real-time quantitative polymerase chain reaction. | ||||||||||
| Author: | Yen, Chueh-Chuan|Chen, Yann-Jang|Lu, Kai-Hsi|Hsia, Jiun-Yi|Chen, Jung-Ta|Hu, Cheng-Po|Chen, Po-Min|Liu, Jin-Hwang|Chiou, Tzeon-Jye|Wang, Wei-Shu|Yang, Muh-Hwa|Chao, Ta-Chung|Lin, Chi-Hung | ||||||||||
| PMID: | 12963965 | ||||||||||
| 2. | |||||||||||
| Journal: | Int J Cancer. 2006 May 15;118(10):2644-6. | ||||||||||
| Title: | Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus. | ||||||||||
| Author: | Phillips, Wayne A|Russell, Sarah E|Ciavarella, Marianne L|Choong, David Y H|Montgomery, Karen G|Smith, Katherine|Pearson, Richard B|Thomas, Robert J S|Campbell, Ian G | ||||||||||
| PMID: | 16380997 | ||||||||||
| 3. | |||||||||||
| Journal: | J Clin Oncol. 2006 Apr 1;24(10):1612-9. | ||||||||||
| Title: | Predictive factors for outcome in a phase II study of gefitinib in second-line treatment of advanced esophageal cancer patients. | ||||||||||
| Author: | Janmaat, Maarten L|Gallegos-Ruiz, Marielle I|Rodriguez, Jose A|Meijer, Gerrit A|Vervenne, Walter L|Richel, Dick J|Van Groeningen, Cees|Giaccone, Giuseppe | ||||||||||
| PMID: | 16575012 | ||||||||||
| 4. | |||||||||||
| Journal: | Carcinogenesis. 2007 Nov;28(11):2313-20. | ||||||||||
| Title: | Id-1 activation of PI3K/Akt/NFkappaB signaling pathway and its significance in promoting survival of esophageal cancer cells. | ||||||||||
| Author: | Li, Bin|Cheung, Pak Yan|Wang, Xianghong|Tsao, Sai Wah|Ling, Ming Tat|Wong, Yong Chuan|Cheung, Annie L M | ||||||||||
| PMID: | 17638919 | ||||||||||
| 5. | |||||||||||
| Journal: | Genes Chromosomes Cancer. 2008 Feb;47(2):127-36. | ||||||||||
| Title: | Amplification of PRKCI, located in 3q26, is associated with lymph node metastasis in esophageal squamous cell carcinoma. | ||||||||||
| Author: | Yang, Yi-Ling|Chu, Jia-You|Luo, Man-Li|Wu, Yu-Peng|Zhang, Yu|Feng, Yan-Bin|Shi, Zhi-Zhou|Xu, Xin|Han, Ya-Ling|Cai, Yan|Dong, Jin-Tang|Zhan, Qi-Min|Wu, Min|Wang, Ming-Rong | ||||||||||
| PMID: | 17990328 | ||||||||||
| 6. | |||||||||||
| Journal: | J Surg Res. 2008 Apr;145(2):320-6. | ||||||||||
| Title: | PIK3CA mutation status in Japanese esophageal squamous cell carcinoma. | ||||||||||
| Author: | Mori, Ryota|Ishiguro, Hideyuki|Kimura, Masahiro|Mitsui, Akira|Sasaki, Hidefumi|Tomoda, Keisuke|Mori, Yoichiro|Ogawa, Ryo|Katada, Takeyasu|Kawano, Osamu|Harada, Koshiro|Fujii, Yoshitaka|Kuwabara, Yoshiyuki | ||||||||||
| PMID: | 18262558 | ||||||||||
| 7. | |||||||||||
| Journal: | J Clin Oncol. 2009 Feb 20;27(6):857-71. | ||||||||||
| Title: | Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. | ||||||||||
| Author: | Hildebrandt, Michelle A T|Yang, Hushan|Hung, Mien-Chie|Izzo, Julie G|Huang, Maosheng|Lin, Jie|Ajani, Jaffer A|Wu, Xifeng | ||||||||||
| PMID: | 19164214 | ||||||||||
| 8. | |||||||||||
| Journal: | BMC Gastroenterol. 2010 Feb 17;10:20. | ||||||||||
| Title: | Chromosomal imbalances are uncommon in chagasic megaesophagus. | ||||||||||
| Author: | Bellini, Marilanda F|Manzato, Antonio J|Silva, Ana E|Varella-Garcia, Marileila | ||||||||||
| PMID: | 20163722 | ||||||||||
| 9. | |||||||||||
| Journal: | J Transl Med. 2012 Aug 30;10:180. | ||||||||||
| Title: | Trastuzumab anti-tumor efficacy in patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mouse models. | ||||||||||
| Author: | Wu, Xianhua|Zhang, Jingchuan|Zhen, Ruheng|Lv, Jing|Zheng, Li|Su, Xinying|Zhu, Guanshan|Gavine, Paul R|Xu, Songtao|Lu, Shaohua|Hou, Jun|Liu, Yalan|Xu, Chen|Tan, Yunshan|Xie, Liang|Yin, Xiaolu|He, Deming|Ji, Qunsheng|Hou, Yingyong|Ge, Di | ||||||||||
| PMID: | 22935382 | ||||||||||
| 10. | |||||||||||
| Journal: | PLoS One. 2012;7(8):e41655. | ||||||||||
| Title: | High-throughput genotyping in metastatic esophageal squamous cell carcinoma identifies phosphoinositide-3-kinase and BRAF mutations. | ||||||||||
| Author: | Maeng, Chi Hoon|Lee, Jeeyun|van Hummelen, Paul|Park, Se Hoon|Palescandolo, Emanuele|Jang, Jiryeon|Park, Ha Young|Kang, So Young|MacConaill, Laura|Kim, Kyoung-Mee|Shim, Young-Mog | ||||||||||
| PMID: | 22870241 | ||||||||||
| 11. | |||||||||||
| Journal: | Ann Thorac Surg. 2012 Apr;93(4):1101-6. | ||||||||||
| Title: | Comparative genomics of esophageal adenocarcinoma and squamous cell carcinoma. | ||||||||||
| Author: | Bandla, Santhoshi|Pennathur, Arjun|Luketich, James D|Beer, David G|Lin, Lin|Bass, Adam J|Godfrey, Tony E|Litle, Virginia R | ||||||||||
| PMID: | 22450065 | ||||||||||
| 12. | |||||||||||
| Journal: | Nat Genet. 2013 May;45(5):478-86. | ||||||||||
| Title: | Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. | ||||||||||
| Author: | Dulak, Austin M|Stojanov, Petar|Peng, Shouyong|Lawrence, Michael S|Fox, Cameron|Stewart, Chip|Bandla, Santhoshi|Imamura, Yu|Schumacher, Steven E|Shefler, Erica|McKenna, Aaron|Carter, Scott L|Cibulskis, Kristian|Sivachenko, Andrey|Saksena, Gordon|Voet, Dou | ||||||||||
| PMID: | 23525077 | ||||||||||
| 13. | |||||||||||
| Journal: | Clin Cancer Res. 2013 May 1;19(9):2451-9. | ||||||||||
| Title: | PIK3CA mutation is associated with a favorable prognosis among patients with curatively resected esophageal squamous cell carcinoma. | ||||||||||
| Author: | Shigaki, Hironobu|Baba, Yoshifumi|Watanabe, Masayuki|Murata, Asuka|Ishimoto, Takatsugu|Iwatsuki, Masaaki|Iwagami, Shiro|Nosho, Katsuhiko|Baba, Hideo | ||||||||||
| PMID: | 23532889 | ||||||||||
| 14. | |||||||||||
| Journal: | Acta Pharmacol Sin. 2013 Dec;34(12):1560-7. | ||||||||||
| Title: | PIK3CA hypomethylation plays a key role in activation of the PI3K/AKT pathway in esophageal cancer in Chinese patients. | ||||||||||
| Author: | Wang, Wei-feng|Xie, Yan|Zhou, Zhi-hua|Qin, Zheng-hong|Wu, Jun-chao|He, Jing-kang | ||||||||||
| PMID: | 24241346 | ||||||||||
| 15. | |||||||||||
| Journal: | Mol Carcinog. 2014 May;53(5):360-79. | ||||||||||
| Title: | Suppressing the formation of lipid raft-associated Rac1/PI3K/Akt signaling complexes by curcumin inhibits SDF-1alpha-induced invasion of human esophageal carcinoma cells. | ||||||||||
| Author: | Lin, Meng-Liang|Lu, Yao-Cheng|Chen, Hung-Yi|Lee, Chuan-Chun|Chung, Jing-Gung|Chen, Shih-Shun | ||||||||||
| PMID: | 23192861 | ||||||||||
| 16. | |||||||||||
| Journal: | Nat Genet. 2014 May;46(5):467-73. | ||||||||||
| Title: | Genomic and molecular characterization of esophageal squamous cell carcinoma. | ||||||||||
| Author: | Lin, De-Chen|Hao, Jia-Jie|Nagata, Yasunobu|Xu, Liang|Shang, Li|Meng, Xuan|Sato, Yusuke|Okuno, Yusuke|Varela, Ana Maria|Ding, Ling-Wen|Garg, Manoj|Liu, Li-Zhen|Yang, Henry|Yin, Dong|Shi, Zhi-Zhou|Jiang, Yan-Yi|Gu, Wen-Yue|Gong, Ting|Zhang, Yu|Xu, Xin|Kalid | ||||||||||
| PMID: | 24686850 | ||||||||||
| 17. | |||||||||||
| Journal: | Lab Invest. 2014 Aug;94(8):917-26. | ||||||||||
| Title: | Establishment and characterization of esophageal squamous cell carcinoma patient-derived xenograft mouse models for preclinical drug discovery. | ||||||||||
| Author: | Zhang, Jingchuan|Jiang, Dongxian|Li, Xiaojing|Lv, Jing|Xie, Liang|Zheng, Li|Gavine, Paul R|Hu, Qin|Shi, Yuan|Tan, Lijie|Ge, Di|Xu, Songtao|Li, Leon|Zhu, Lifang|Hou, Yingyong|Wang, Qun | ||||||||||
| PMID: | 24999713 | ||||||||||
| 18. | |||||||||||
| Journal: | Diagn Pathol. 2014 Aug 9;9:153. | ||||||||||
| Title: | Diagnostic application of PIK3CA mutation analysis in Chinese esophageal cancer patients. | ||||||||||
| Author: | Ming, Zizhen|Jiang, Dongxian|Hu, Qin|Li, Xiaojing|Huang, Jie|Xu, Yifan|Liu, Yalan|Xu, Chen|Hua, Xiuguo|Hou, Yingyong | ||||||||||
| PMID: | 25106743 | ||||||||||
| 19. | |||||||||||
| Journal: | Ann Surg Oncol. 2015 Oct;22(11):3659-65. | ||||||||||
| Title: | Molecular Characteristics of Basaloid Squamous Cell Carcinoma of the Esophagus: Analysis of KRAS, BRAF, and PIK3CA Mutations and LINE-1 Methylation. | ||||||||||
| Author: | Baba, Yoshifumi|Ishimoto, Takatsugu|Harada, Kazuto|Kosumi, Keisuke|Murata, Asuka|Miyake, Keisuke|Hiyoshi, Yukiharu|Kurashige, Junji|Iwatsuki, Masaaki|Iwagami, Shiro|Miyamoto, Yuji|Sakamoto, Yasuo|Yoshida, Naoya|Oki, Eiji|Iyama, Ken-Ichi|Watanabe, Masayuki | ||||||||||
| PMID: | 25691283 | ||||||||||
| 20. | |||||||||||
| Journal: | Oncologist. 2015 Oct;20(10):1132-9. | ||||||||||
| Title: | Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and Differences. | ||||||||||
| Author: | Wang, Kai|Johnson, Adrienne|Ali, Siraj M|Klempner, Samuel J|Bekaii-Saab, Tanios|Vacirca, Jeffrey L|Khaira, Depinder|Yelensky, Roman|Chmielecki, Juliann|Elvin, Julia A|Lipson, Doron|Miller, Vincent A|Stephens, Philip J|Ross, Jeffrey S | ||||||||||
| PMID: | 26336083 | ||||||||||
| 21. | |||||||||||
| Journal: | APMIS. 2015 Aug;123(8):639-47. | ||||||||||
| Title: | Immunohistochemical and molecular analysis of PI3K/AKT/mTOR pathway in esophageal carcinoma. | ||||||||||
| Author: | Tasioudi, Konstantia E|Sakellariou, Stratigoula|Levidou, Georgia|Theodorou, Dimitrios|Michalopoulos, Nikolaos V|Patsouris, Efstratios|Korkolopoulou, Penelope|Saetta, Angelica A | ||||||||||
| PMID: | 25912437 | ||||||||||
| 22. | |||||||||||
| Journal: | Ann Oncol. 2015 Apr;26(4):624-44. | ||||||||||
| Title: | A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage. | ||||||||||
| Author: | Findlay, J M|Middleton, M R|Tomlinson, I | ||||||||||
| PMID: | 25214541 | ||||||||||
| 23. | |||||||||||
| Journal: | Cancer Biol Ther. 2015;16(5):764-9. | ||||||||||
| Title: | Tumor profiling of gastric and esophageal carcinoma reveal different treatment options. | ||||||||||
| Author: | Miura, John T|Xiu, Joanne|Thomas, James|George, Ben|Carron, Benjamin R|Tsai, Susan|Johnston, Fabian M|Turaga, Kiran K|Gamblin, T Clark | ||||||||||
| PMID: | 25778705 | ||||||||||
| 24. | |||||||||||
| Journal: | Gastroenterology. 2016 May;150(5):1171-1182. | ||||||||||
| Title: | Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. | ||||||||||
| Author: | Sawada, Genta|Niida, Atsushi|Uchi, Ryutaro|Hirata, Hidenari|Shimamura, Teppei|Suzuki, Yutaka|Shiraishi, Yuichi|Chiba, Kenichi|Imoto, Seiya|Takahashi, Yusuke|Iwaya, Takeshi|Sudo, Tomoya|Hayashi, Tomoatsu|Takai, Hiroki|Kawasaki, Yoshihiro|Matsukawa, Takashi | ||||||||||
| PMID: | 26873401 | ||||||||||
| 25. | |||||||||||
| Journal: | World J Gastroenterol. 2016 Feb 21;22(7):2284-93. | ||||||||||
| Title: | Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing. | ||||||||||
| Author: | Sasaki, Yasushi|Tamura, Miyuki|Koyama, Ryota|Nakagaki, Takafumi|Adachi, Yasushi|Tokino, Takashi | ||||||||||
| PMID: | 26900290 | ||||||||||
| 26. | |||||||||||
| Journal: | Cancer Genomics Proteomics. 2016 May-Jun;13(3):231-8. | ||||||||||
| Title: | TP53, PIK3CA, FBXW7 and KRAS Mutations in Esophageal Cancer Identified by Targeted Sequencing. | ||||||||||
| Author: | Zheng, Huili|Wang, Yan|Tang, Chuanning|Jones, Lindsey|Ye, Hua|Zhang, Guangchun|Cao, Weihai|Li, Jingwen|Liu, Lifeng|Liu, Zhencong|Zhang, Chao|Lou, Feng|Liu, Zhiyuan|Li, Yangyang|Shi, Zhenfen|Zhang, Jingbo|Zhang, Dandan|Sun, Hong|Dong, Haichao|Dong, Zhishou | ||||||||||
| PMID: | 27107065 | ||||||||||
| 27. | |||||||||||
| Journal: | World J Gastroenterol. 2016 May 28;22(20):4868-80. | ||||||||||
| Title: | Wortmannin influences hypoxia-inducible factor-1 alpha expression and glycolysis in esophageal carcinoma cells. | ||||||||||
| Author: | Zeng, Ling|Zhou, Hai-Yun|Tang, Na-Na|Zhang, Wei-Feng|He, Gui-Jun|Hao, Bo|Feng, Ya-Dong|Zhu, Hong | ||||||||||
| PMID: | 27239113 | ||||||||||
| 28. | |||||||||||
| Journal: | Oncotarget. 2016 Oct 11;7(41):67612-67625. | ||||||||||
| Title: | Gene-gene interactions in gastrointestinal cancer susceptibility. | ||||||||||
| Author: | Kim, Jineun|Yum, Seoyun|Kang, Changwon|Kang, Suk-Jo | ||||||||||
| PMID: | 27588484 | ||||||||||
| 29. | |||||||||||
| Journal: | J Clin Oncol. 2017 Jul 10;35(20):2279-2287. | ||||||||||
| Title: | Gefitinib and EGFR Gene Copy Number Aberrations in Esophageal Cancer. | ||||||||||
| Author: | Petty, Russell D|Dahle-Smith, Asa|Stevenson, David A J|Osborne, Aileen|Massie, Doreen|Clark, Caroline|Murray, Graeme I|Dutton, Susan J|Roberts, Corran|Chong, Irene Y|Mansoor, Wasat|Thompson, Joyce|Harrison, Mark|Chatterjee, Anirban|Falk, Stephen J|Elyan, | ||||||||||
| PMID: | 28537764 | ||||||||||
| 30. | |||||||||||
| Journal: | Oncotarget. 2017 Jun 27;8(41):69610-69621. | ||||||||||
| Title: | Mutation landscape and intra-tumor heterogeneity of two MANECs of the esophagus revealed by multi-region sequencing. | ||||||||||
| Author: | Yuan, Wenqing|Liu, Zhen|Lei, Wanjun|Sun, Li|Yang, Haijun|Wang, Yu|Ramdas, Shweta|Dong, Xiao|Xu, Ruiping|Cai, Hong|Li, Jun Z|Ke, Yang | ||||||||||
| PMID: | 29050228 | ||||||||||
| 31. | |||||||||||
| Journal: | Cancer Res. 2017 Sep 29. pii: canres.0938.2017. | ||||||||||
| Title: | Multiregional sequencing reveals genomic alterations and clonal dynamics in primary malignant melanoma of the esophagus. | ||||||||||
| Author: | Li, Jingjing|Yan, Shi|Liu, Zhen|Zhou, Yong|Pan, Yaqi|Yuan, Wenqing|Liu, Mengfei|Tan, Qin|Tian, Geng|Dong, Bin|Cai, Hong|Wu, Nan|Ke, Yang | ||||||||||
| PMID: | 28972077 | ||||||||||
| 32. | |||||||||||
| Journal: | Oncotarget. 2017 Apr 19;8(31):50832-50844. | ||||||||||
| Title: | Anti-tumor efficacy of theliatinib in esophageal cancer patient-derived xenografts models with epidermal growth factor receptor (EGFR) overexpression and gene amplification. | ||||||||||
| Author: | Ren, Yongxin|Zheng, Jianming|Fan, Shiming|Wang, Linfang|Cheng, Min|Shi, Dongxia|Zhang, Wei|Tang, Renxiang|Yu, Ying|Jiao, Longxian|Ni, Jun|Yang, Haibin|Cai, Huaqing|Yin, Fang|Chen, Yunxin|Zhou, Feng|Zhang, Weihan|Qing, Weiguo|Su, Weiguo | ||||||||||
| PMID: | 28881608 | ||||||||||
| 33. | |||||||||||
| Journal: | Mod Pathol. 2017 Jul 21. | ||||||||||
| Title: | Targeted next-generation sequencing supports epidermoid metaplasia of the esophagus as a precursor to esophageal squamous neoplasia. | ||||||||||
| Author: | Singhi, Aatur D|Arnold, Christina A|Lam-Himlin, Dora M|Nikiforova, Marina N|Voltaggio, Lysandra|Canto, Marcia I|McGrath, Kevin M|Montgomery, Elizabeth A | ||||||||||
| PMID: | 28731047 | ||||||||||
| 34. | |||||||||||
| Journal: | Genet Test Mol Biomarkers. 2017 Apr;21(4):236-241. | ||||||||||
| Title: | PI3K Overexpression and PIK3CA Mutations Are Associated with Age, Tumor Staging, and Other Clinical Characteristics in Chinese Patients with Esophageal Squamous Cell Carcinoma. | ||||||||||
| Author: | Lin, Jing-Wei|Li, Xu|Qiu, Ming-Lian|Luo, Rong-Gang|Lin, Jian-Bo|Liu, Bo | ||||||||||
| PMID: | 28384037 | ||||||||||
| 35. | |||||||||||
| Journal: | J Thorac Dis. 2018 Apr;10(4):2490-2497. | ||||||||||
| Title: | Aspirin acts in esophageal cancer: a brief review. | ||||||||||
| Author: | Hao, Weiming|Shen, Yaxing|Feng, Mingxiang|Wang, Hao|Lin, Miao|Fang, Yong|Tan, Lijie | ||||||||||
| PMID: | 29850157 | ||||||||||
| 36. | |||||||||||
| Journal: | Int J Surg Pathol. 2018 Jun 1:1066896918782426. | ||||||||||
| Title: | Primary Esophageal Mixed Sarcomatoid and Small Cell Neuroendocrine Carcinoma With Brain Metastasis: A Challenging Diagnosis on Biopsy. | ||||||||||
| Author: | Schwartz, Christopher J|Hickman, Richard|Zhang, Xuchen|Galvao Neto, Antonio|Adler, Esther | ||||||||||
| PMID: | 30009659 | ||||||||||
| 37. | |||||||||||
| Journal: | BMC Cancer. 2018 Aug 16;18(1):826. | ||||||||||
| Title: | PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue. | ||||||||||
| Author: | Yokota, Tomoya|Serizawa, Masakuni|Hosokawa, Ayumu|Kusafuka, Kimihide|Mori, Keita|Sugiyama, Toshiro|Tsubosa, Yasuhiro|Koh, Yasuhiro | ||||||||||
| PMID: | 30115035 | ||||||||||
| 38. | |||||||||||
| Journal: | Am Soc Clin Oncol Educ Book. 2018 May 23;(38):249-261. | ||||||||||
| Title: | What Will We Expect From Novel Therapies to Esophageal and Gastric Malignancies? | ||||||||||
| Author: | De Mello, Ramon Andrade|Castelo-Branco, Luis|Castelo-Branco, Pedro|Pozza, Daniel Humberto|Vermeulen, Louis|Palacio, Sofia|Salzberg, Matthew|Lockhart, A Craig | ||||||||||
| PMID: | 30231398 | ||||||||||