Primary Site >> Esophagus Cancer
Gene >> PIK3CA
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Ref: Genotypic analysis of esophageal squamous cell carcinoma by molecular cytogenetics and real-time quantitative polymerase chain reaction. PMID: 12963965 |
Ref: Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus. PMID: 16380997 Ref: Predictive factors for outcome in a phase II study of gefitinib in second-line treatment of advanced esophageal cancer patients. PMID: 16575012 |
Ref: Id-1 activation of PI3K/Akt/NFkappaB signaling pathway and its significance in promoting survival of esophageal cancer cells. PMID: 17638919 |
Ref: Amplification of PRKCI, located in 3q26, is associated with lymph node metastasis in esophageal squamous cell carcinoma. PMID: 17990328 Ref: PIK3CA mutation status in Japanese esophageal squamous cell carcinoma. PMID: 18262558 |
Ref: Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. PMID: 19164214 |
Ref: Chromosomal imbalances are uncommon in chagasic megaesophagus. PMID: 20163722 |
Ref: Comparative genomics of esophageal adenocarcinoma and squamous cell carcinoma. PMID: 22450065 Ref: High-throughput genotyping in metastatic esophageal squamous cell carcinoma identifies phosphoinositide-3-kinase and BRAF mutations. PMID: 22870241 Ref: Trastuzumab anti-tumor efficacy in patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mouse models. PMID: 22935382 |
Ref: Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. PMID: 23525077 Ref: PIK3CA mutation is associated with a favorable prognosis among patients with curatively resected esophageal squamous cell carcinoma. PMID: 23532889 Ref: PIK3CA hypomethylation plays a key role in activation of the PI3K/AKT pathway in esophageal cancer in Chinese patients. PMID: 24241346 |
Ref: Suppressing the formation of lipid raft-associated Rac1/PI3K/Akt signaling complexes by curcumin inhibits SDF-1alpha-induced invasion of human esophageal carcinoma cells. PMID: 23192861 Ref: Genomic and molecular characterization of esophageal squamous cell carcinoma. PMID: 24686850 Ref: Establishment and characterization of esophageal squamous cell carcinoma patient-derived xenograft mouse models for preclinical drug discovery. PMID: 24999713 Ref: Diagnostic application of PIK3CA mutation analysis in Chinese esophageal cancer patients. PMID: 25106743 |
Ref: A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage. PMID: 25214541 Ref: Molecular Characteristics of Basaloid Squamous Cell Carcinoma of the Esophagus: Analysis of KRAS, BRAF, and PIK3CA Mutations and LINE-1 Methylation. PMID: 25691283 Ref: Tumor profiling of gastric and esophageal carcinoma reveal different treatment options. PMID: 25778705 Ref: Immunohistochemical and molecular analysis of PI3K/AKT/mTOR pathway in esophageal carcinoma. PMID: 25912437 Ref: Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and Differences. PMID: 26336083 |
Ref: Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. PMID: 26873401 Ref: Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing. PMID: 26900290 Ref: TP53, PIK3CA, FBXW7 and KRAS Mutations in Esophageal Cancer Identified by Targeted Sequencing. PMID: 27107065 Ref: Wortmannin influences hypoxia-inducible factor-1 alpha expression and glycolysis in esophageal carcinoma cells. PMID: 27239113 Ref: Gene-gene interactions in gastrointestinal cancer susceptibility. PMID: 27588484 |
Ref: PI3K Overexpression and PIK3CA Mutations Are Associated with Age, Tumor Staging, and Other Clinical Characteristics in Chinese Patients with Esophageal Squamous Cell Carcinoma. PMID: 28384037 Ref: Gefitinib and EGFR Gene Copy Number Aberrations in Esophageal Cancer. PMID: 28537764 Ref: Targeted next-generation sequencing supports epidermoid metaplasia of the esophagus as a precursor to esophageal squamous neoplasia. PMID: 28731047 Ref: Anti-tumor efficacy of theliatinib in esophageal cancer patient-derived xenografts models with epidermal growth factor receptor (EGFR) overexpression and gene amplification. PMID: 28881608 Ref: Multiregional sequencing reveals genomic alterations and clonal dynamics in primary malignant melanoma of the esophagus. PMID: 28972077 Ref: Mutation landscape and intra-tumor heterogeneity of two MANECs of the esophagus revealed by multi-region sequencing. PMID: 29050228 |
Ref: Aspirin acts in esophageal cancer: a brief review. PMID: 29850157 Ref: Primary Esophageal Mixed Sarcomatoid and Small Cell Neuroendocrine Carcinoma With Brain Metastasis: A Challenging Diagnosis on Biopsy. PMID: 30009659 Ref: PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue. PMID: 30115035 Ref: What Will We Expect From Novel Therapies to Esophageal and Gastric Malignancies? PMID: 30231398 |