Primary Site >> Colorectal Cancer
Gene >> PDK1
| 1. | |||||||||||
| Journal: | J Biol Chem. 2002 Aug 2;277(31):27613-21. Epub 2002 May 8. | ||||||||||
| Title: | Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line. | ||||||||||
| Author: | Arico, Sebastien|Pattingre, Sophie|Bauvy, Chantal|Gane, Pierre|Barbat, Alain|Codogno, Patrice|Ogier-Denis, Eric | ||||||||||
| PMID: | 12000750 | ||||||||||
| 2. | |||||||||||
| Journal: | J Biol Chem. 2004 Oct 8;279(41):43261-72. Epub 2004 Aug 4. | ||||||||||
| Title: | Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice. | ||||||||||
| Author: | Moran, Amy E|Hunt, Daniel H|Javid, Sara H|Redston, Mark|Carothers, Adelaide M|Bertagnolli, Monica M | ||||||||||
| PMID: | 15294912 | ||||||||||
| 3. | |||||||||||
| Journal: | J Cell Biochem. 2007 May 15;101(2):307-20. | ||||||||||
| Title: | Curcumin-induced GADD153 upregulation: modulation by glutathione. | ||||||||||
| Author: | Scott, David W|Loo, George | ||||||||||
| PMID: | 17171638 | ||||||||||
| 4. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 2008 Jul 18;372(1):236-42. | ||||||||||
| Title: | Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells. | ||||||||||
| Author: | Lee, Jenq-Chang|Won, Shen-Jeu|Chao, Chien-Lin|Wu, Feng-Ling|Liu, Hsiao-Sheng|Ling, Pin|Lin, Chun-Nan|Su, Chun-Li | ||||||||||
| PMID: | 18485277 | ||||||||||
| 5. | |||||||||||
| Journal: | Cancer Microenviron. 2009 Sep 25;2(1):69-80. | ||||||||||
| Title: | The NF-kappaB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1beta. | ||||||||||
| Author: | Kaler, Pawan|Godasi, Bramara N|Augenlicht, Leonard|Klampfer, Lidija | ||||||||||
| PMID: | 19779850 | ||||||||||
| 6. | |||||||||||
| Journal: | Int J Biochem Cell Biol. 2010 Oct;42(10):1571-5. | ||||||||||
| Title: | Colorectal carcinoma cells--regulation of survival and growth by SGK1. | ||||||||||
| Author: | Lang, Florian|Perrotti, Nicola|Stournaras, Christos | ||||||||||
| PMID: | 20541034 | ||||||||||
| 7. | |||||||||||
| Journal: | Cancer Cell. 2010 Nov 16;18(5):459-71. | ||||||||||
| Title: | B55beta-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer. | ||||||||||
| Author: | Tan, Jing|Lee, Puay Leng|Li, Zhimei|Jiang, Xia|Lim, Yaw Chyn|Hooi, Shing Chuan|Yu, Qiang | ||||||||||
| PMID: | 21075311 | ||||||||||
| 8. | |||||||||||
| Journal: | Mutat Res. 2011 Jan 10;706(1-2):13-20. | ||||||||||
| Title: | Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer. | ||||||||||
| Author: | Slattery, Martha L|Lundgreen, Abbie|Herrick, Jennifer S|Wolff, Roger K | ||||||||||
| PMID: | 21035469 | ||||||||||
| 9. | |||||||||||
| Journal: | Am J Pathol. 2011 Sep;179(3):1405-14. | ||||||||||
| Title: | Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer. | ||||||||||
| Author: | Lu, Chun-Wun|Lin, Shau-Chieh|Chien, Chun-Wei|Lin, Shih-Chieh|Lee, Chung-Ta|Lin, Bo-Wen|Lee, Jenq-Chang|Tsai, Shaw-Jenq | ||||||||||
| PMID: | 21763680 | ||||||||||
| 10. | |||||||||||
| Journal: | Nutr Cancer. 2011 Nov;63(8):1226-34. | ||||||||||
| Title: | Diet and colorectal cancer: analysis of a candidate pathway using SNPS, haplotypes, and multi-gene assessment. | ||||||||||
| Author: | Slattery, Martha L|Lundgreen, Abbie|Herrick, Jennifer S|Caan, Bette J|Potter, John D|Wolff, Roger K | ||||||||||
| PMID: | 21999454 | ||||||||||
| 11. | |||||||||||
| Journal: | PLoS One. 2012;7(2):e32204. | ||||||||||
| Title: | Matrix-bound PAI-1 supports cell blebbing via RhoA/ROCK1 signaling. | ||||||||||
| Author: | Cartier-Michaud, Amandine|Malo, Michel|Charriere-Bertrand, Cecile|Gadea, Gilles|Anguille, Christelle|Supiramaniam, Ajitha|Lesne, Annick|Delaplace, Franck|Hutzler, Guillaume|Roux, Pierre|Lawrence, Daniel A|Barlovatz-Meimon, Georgia | ||||||||||
| PMID: | 22363817 | ||||||||||
| 12. | |||||||||||
| Journal: | Clin Colorectal Cancer. 2012 Dec;11(4):268-74. | ||||||||||
| Title: | Multiplexed protein signal pathway mapping identifies patients with rectal cancer that responds to neoadjuvant treatment. | ||||||||||
| Author: | Mammano, Enzo|Galdi, Francesca|Pierobon, Mariaelena|Tessari, Emanuela|Deng, Jianghong|Pucciarelli, Salvatore|Agostini, Marco|De Marchi, Francesco|Canzonieri, Vincenzo|De Paoli, Antonino|Belluco, Claudio|Liotta, Lance|Petricoin, Emanuel|Pilati, Pierluigi|N | ||||||||||
| PMID: | 22658458 | ||||||||||
| 13. | |||||||||||
| Journal: | Oncol Rep. 2012 Feb;27(2):339-46. | ||||||||||
| Title: | shRNA against CD44 inhibits cell proliferation, invasion and migration, and promotes apoptosis of colon carcinoma cells. | ||||||||||
| Author: | Park, Yeon Sun|Huh, Jung Wook|Lee, Jae Hyuk|Kim, Hyeong Rok | ||||||||||
| PMID: | 22076607 | ||||||||||
| 14. | |||||||||||
| Journal: | Int J Colorectal Dis. 2013 Mar;28(3):375-83. | ||||||||||
| Title: | Glucose transporter 1 (GLUT1) of anaerobic glycolysis as predictive and prognostic values in neoadjuvant chemoradiotherapy and laparoscopic surgery for locally advanced rectal cancer. | ||||||||||
| Author: | Shim, Byoung Yong|Jung, Ji-Han|Lee, Kang-Moon|Kim, Hyung-Jin|Hong, Sook Hee|Kim, Sung Hwan|Sun, Der Sheng|Cho, Hyeon-Min | ||||||||||
| PMID: | 22847606 | ||||||||||
| 15. | |||||||||||
| Journal: | Cancer Res. 2013 Jun 1;73(11):3248-61. | ||||||||||
| Title: | Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation. | ||||||||||
| Author: | Wang, Grace M|Wong, Hong Yuen|Konishi, Hiroyuki|Blair, Brian G|Abukhdeir, Abde M|Gustin, John P|Rosen, D Marc|Denmeade, Samuel Ray|Rasheed, Zeshaan|Matsui, William|Garay, Joseph P|Mohseni, Morassa|Higgins, Michaela J|Cidado, Justin|Jelovac, Danijela|Croes | ||||||||||
| PMID: | 23580570 | ||||||||||
| 16. | |||||||||||
| Journal: | Int J Oncol. 2013 Aug;43(2):629-37. | ||||||||||
| Title: | Phenethyl isothiocyanate suppresses EGF-stimulated SAS human oral squamous carcinoma cell invasion by targeting EGF receptor signaling. | ||||||||||
| Author: | Chen, Hui-Jye|Lin, Chung-Ming|Lee, Chao-Ying|Shih, Nai-Chen|Amagaya, Sakae|Lin, Yung-Chang|Yang, Jai-Sing | ||||||||||
| PMID: | 23754208 | ||||||||||
| 17. | |||||||||||
| Journal: | Cancer Discov. 2013 Oct;3(10):1156-71. | ||||||||||
| Title: | PDK1 signaling toward PLK1-MYC activation confers oncogenic transformation, tumor-initiating cell activation, and resistance to mTOR-targeted therapy. | ||||||||||
| Author: | Tan, Jing|Li, Zhimei|Lee, Puay Leng|Guan, Peiyong|Aau, Mei Yee|Lee, Shuet Theng|Feng, Min|Lim, Cheryl Zihui|Lee, Eric Yong Jing|Wee, Zhen Ning|Lim, Yaw Chyn|Karuturi, R K Murthy|Yu, Qiang | ||||||||||
| PMID: | 23887393 | ||||||||||
| 18. | |||||||||||
| Journal: | Biomed Pharmacother. 2014 Oct;68(8):1023-9. | ||||||||||
| Title: | Upregulation of MAPK/Erk and PI3K/Akt pathways in ulcerative colitis-associated colon cancer. | ||||||||||
| Author: | Setia, Shruti|Nehru, Bimla|Sanyal, Sankar Nath | ||||||||||
| PMID: | 25443414 | ||||||||||
| 19. | |||||||||||
| Journal: | Theranostics. 2014 Sep 19;4(12):1193-208. | ||||||||||
| Title: | MiR-194 deregulation contributes to colorectal carcinogenesis via targeting AKT2 pathway. | ||||||||||
| Author: | Zhao, Hui-Jun|Ren, Lin-Lin|Wang, Zhen-Hua|Sun, Tian-Tian|Yu, Ya-Nan|Wang, Ying-Chao|Yan, Ting-Ting|Zou, Weiping|He, Jie|Zhang, Yaou|Hong, Jie|Fang, Jing-Yuan | ||||||||||
| PMID: | 25285168 | ||||||||||
| 20. | |||||||||||
| Journal: | Int J Mol Epidemiol Genet. 2014 May 29;5(2):100-11. eCollection 2014. | ||||||||||
| Title: | Influence of CHIEF pathway genes on gene expression: a pathway approach to functionality. | ||||||||||
| Author: | Slattery, Martha L|Lundgreen, Abbie|Mullany, Lila E|Penney, Rosalind B|Wolff, Roger K | ||||||||||
| PMID: | 24959314 | ||||||||||
| 21. | |||||||||||
| Journal: | EMBO J. 2014 Jul 1;33(13):1454-73. | ||||||||||
| Title: | Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. | ||||||||||
| Author: | Pate, Kira T|Stringari, Chiara|Sprowl-Tanio, Stephanie|Wang, Kehui|TeSlaa, Tara|Hoverter, Nate P|McQuade, Miriam M|Garner, Chad|Digman, Michelle A|Teitell, Michael A|Edwards, Robert A|Gratton, Enrico|Waterman, Marian L | ||||||||||
| PMID: | 24825347 | ||||||||||
| 22. | |||||||||||
| Journal: | Cell Death Differ. 2014 Apr;21(4):568-81. | ||||||||||
| Title: | Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation. | ||||||||||
| Author: | Dai, W|Bai, Y|Hebda, L|Zhong, X|Liu, J|Kao, J|Duan, C | ||||||||||
| PMID: | 24336047 | ||||||||||
| 23. | |||||||||||
| Journal: | Biomed Pharmacother. 2014 Jul;68(6):721-7. | ||||||||||
| Title: | The PI3K/Akt pathway in colitis associated colon cancer and its chemoprevention with celecoxib, a Cox-2 selective inhibitor. | ||||||||||
| Author: | Setia, Shruti|Nehru, Bimla|Sanyal, Sankar Nath | ||||||||||
| PMID: | 25107843 | ||||||||||
| 24. | |||||||||||
| Journal: | J Cell Physiol. 2015 Apr;230(4):930-46. | ||||||||||
| Title: | Justicidin A-induced autophagy flux enhances apoptosis of human colorectal cancer cells via class III PI3K and Atg5 pathway. | ||||||||||
| Author: | Won, Shen-Jeu|Yen, Cheng-Hsin|Liu, Hsiao-Sheng|Wu, Shan-Ying|Lan, Sheng-Hui|Jiang-Shieh, Ya-Fen|Lin, Chun-Nan|Su, Chun-Li | ||||||||||
| PMID: | 25216025 | ||||||||||
| 25. | |||||||||||
| Journal: | Nihon Rinsho. 2015 May;73(5):745-50. | ||||||||||
| Title: | [Metabolism enzyme controls cancer stemness]. | ||||||||||
| Author: | Konno, Masamitsu|Doki, Yuichiro|Mori, Masaki|Ishii, Hideshi | ||||||||||
| PMID: | 25985625 | ||||||||||
| 26. | |||||||||||
| Journal: | Oncology. 2015;89(6):351-9. | ||||||||||
| Title: | Clinical Implication of Serine Metabolism-Associated Enzymes in Colon Cancer. | ||||||||||
| Author: | Yoon, Shinkyo|Kim, Jong Gwang|Seo, An Na|Park, Soo Yeun|Kim, Hye Jin|Park, Jun Seok|Choi, Gyu Seog|Jeong, Ji Yun|Jun, Do Youn|Yoon, Ghil Suk|Kang, Byung Woog | ||||||||||
| PMID: | 26439504 | ||||||||||
| 27. | |||||||||||
| Journal: | Int J Oncol. 2016 Mar;48(3):1305. | ||||||||||
| Title: | [Corrigendum] Brassinin induces G1 phase arrest through increase of p21 and p27 by inhibition of the phosphatidylinositol 3-kinase signaling pathway in human colon cancer cells. | ||||||||||
| Author: | Izutani, Yasuyuki|Yogosawa, Shingo|Sowa, Yoshihiro|Sakai, Toshiyuki | ||||||||||
| PMID: | 26718100 | ||||||||||
| 28. | |||||||||||
| Journal: | Nat Commun. 2016 Jun 20;7:11971. | ||||||||||
| Title: | Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer. | ||||||||||
| Author: | Hao, Yujun|Samuels, Yardena|Li, Qingling|Krokowski, Dawid|Guan, Bo-Jhih|Wang, Chao|Jin, Zhicheng|Dong, Bohan|Cao, Bo|Feng, Xiujing|Xiang, Min|Xu, Claire|Fink, Stephen|Meropol, Neal J|Xu, Yan|Conlon, Ronald A|Markowitz, Sanford|Kinzler, Kenneth W|Velculesc | ||||||||||
| PMID: | 27321283 | ||||||||||
| 29. | |||||||||||
| Journal: | Cancer Metab. 2016 Oct 3;4:20. | ||||||||||
| Title: | Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer. | ||||||||||
| Author: | Sprowl-Tanio, Stephanie|Habowski, Amber N|Pate, Kira T|McQuade, Miriam M|Wang, Kehui|Edwards, Robert A|Grun, Felix|Lyou, Yung|Waterman, Marian L | ||||||||||
| PMID: | 27729975 | ||||||||||
| 30. | |||||||||||
| Journal: | Mol Syst Biol. 2017 Feb 9;13(2):912. | ||||||||||
| Title: | Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer. | ||||||||||
| Author: | Lee, Mary|Chen, George T|Puttock, Eric|Wang, Kehui|Edwards, Robert A|Waterman, Marian L|Lowengrub, John | ||||||||||
| PMID: | 28183841 | ||||||||||
| 31. | |||||||||||
| Journal: | J Gastrointest Cancer. 2017 Nov 7. pii: 10.1007/s12029-017-0024-9. | ||||||||||
| Title: | A Deregulated PI3K-AKT Signaling Pathway in Patients with Colorectal Cancer. | ||||||||||
| Author: | Zhang, Tao|Ma, Yuanping|Fang, Jiansong|Liu, Chang|Chen, Liangrong | ||||||||||
| PMID: | 29110225 | ||||||||||
| 32. | |||||||||||
| Journal: | Biomed Pharmacother. 2017 Oct;94:767-773. | ||||||||||
| Title: | MTDH and MAP3K1 are direct targets of apoptosis-regulating miRNAs in colorectal carcinoma. | ||||||||||
| Author: | Salem, Sohair M|Hamed, Ahmed R|Mosaad, Rehab M | ||||||||||
| PMID: | 28802228 | ||||||||||
| 33. | |||||||||||
| Journal: | Life Sci. 2017 Sep 15;185:63-72. | ||||||||||
| Title: | M4IDP, a zoledronic acid derivative, induces G1 arrest, apoptosis and autophagy in HCT116 colon carcinoma cells via blocking PI3K/Akt/mTOR pathway. | ||||||||||
| Author: | Peng, Ying|Qiu, Ling|Xu, Dong|Zhang, Li|Yu, Huixin|Ding, Yuedi|Deng, Lili|Lin, Jianguo | ||||||||||
| PMID: | 28751160 | ||||||||||
| 34. | |||||||||||
| Journal: | BMC Complement Altern Med. 2017 Apr 28;17(1):236. | ||||||||||
| Title: | Apoptosis-induced effects of extract from Artemisia annua Linne by modulating PTEN/p53/PDK1/Akt/ signal pathways through PTEN/p53-independent manner in HCT116 colon cancer cells. | ||||||||||
| Author: | Kim, Eun Ji|Kim, Guen Tae|Kim, Bo Min|Lim, Eun Gyeong|Kim, Sang-Yong|Kim, Young Min | ||||||||||
| PMID: | 28454566 | ||||||||||
| 35. | |||||||||||
| Journal: | Front Pharmacol. 2017 Feb 2;8:38. | ||||||||||
| Title: | Pharmacogenomic Characterization and Isobologram Analysis of the Combination of Ascorbic Acid and Curcumin-Two Main Metabolites of Curcuma longa-in Cancer Cells. | ||||||||||
| Author: | Ooko, Edna|Kadioglu, Onat|Greten, Henry J|Efferth, Thomas | ||||||||||
| PMID: | 28210221 | ||||||||||
| 36. | |||||||||||
| Journal: | Oncol Lett. 2018 Jan;15(1):1236-1240. | ||||||||||
| Title: | Assessment of PI3K/AKT/PTEN signaling pathway activity in colorectal cancer using quantum dot-conjugated antibodies. | ||||||||||
| Author: | Waniczek, Dariusz|Snietura, Miroslaw|Lorenc, Zbigniew|Nowakowska-Zajdel, Ewa|Muc-Wierzgon, Malgorzata | ||||||||||
| PMID: | 29422975 | ||||||||||
| 37. | |||||||||||
| Journal: | Biosci Biotechnol Biochem. 2018 Sep 10:1-10. | ||||||||||
| Title: | Methyl-beta-cyclodextrin potentiates the BITC-induced anti-cancer effect through modulation of the Akt phosphorylation in human colorectal cancer cells. | ||||||||||
| Author: | Yang, Qifu|Miyagawa, Miku|Liu, Xiaoyang|Zhu, Beiwei|Munemasa, Shintaro|Nakamura, Toshiyuki|Murata, Yoshiyuki|Nakamura, Yoshimasa | ||||||||||
| PMID: | 30200817 | ||||||||||
| 38. | |||||||||||
| Journal: | Front Chem. 2018 Aug 23;6:373. | ||||||||||
| Title: | Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer. | ||||||||||
| Author: | Mioc, Marius|Avram, Sorin|Bercean, Vasile|Kurunczi, Ludovic|Ghiulai, Roxana M|Oprean, Camelia|Coricovac, Dorina E|Dehelean, Cristina|Mioc, Alexandra|Balan-Porcarasu, Mihaela|Tatu, Calin|Soica, Codruta | ||||||||||
| PMID: | 30234098 | ||||||||||
| 39. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 2018 Oct 19. pii: S0006-291X(18)32274-5. | ||||||||||
| Title: | LncRNA MAFG-AS1 promotes the progression of colorectal cancer by sponging miR-147b and activation of NDUFA4. | ||||||||||
| Author: | Cui, Shanshan|Yang, Xi|Zhang, Lihong|Zhao, Yi|Yan, Weiqun | ||||||||||
| PMID: | 30348529 | ||||||||||