Primary Site >> Colorectal Cancer
Gene >> PDK1
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Ref: Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line. PMID: 12000750 |
Ref: Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice. PMID: 15294912 |
Ref: Curcumin-induced GADD153 upregulation: modulation by glutathione. PMID: 17171638 |
Ref: Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells. PMID: 18485277 |
Ref: The NF-kappaB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1beta. PMID: 19779850 |
Ref: Colorectal carcinoma cells--regulation of survival and growth by SGK1. PMID: 20541034 Ref: B55beta-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer. PMID: 21075311 |
Ref: Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer. PMID: 21035469 Ref: Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer. PMID: 21763680 Ref: Diet and colorectal cancer: analysis of a candidate pathway using SNPS, haplotypes, and multi-gene assessment. PMID: 21999454 |
Ref: shRNA against CD44 inhibits cell proliferation, invasion and migration, and promotes apoptosis of colon carcinoma cells. PMID: 22076607 Ref: Matrix-bound PAI-1 supports cell blebbing via RhoA/ROCK1 signaling. PMID: 22363817 Ref: Multiplexed protein signal pathway mapping identifies patients with rectal cancer that responds to neoadjuvant treatment. PMID: 22658458 |
Ref: Glucose transporter 1 (GLUT1) of anaerobic glycolysis as predictive and prognostic values in neoadjuvant chemoradiotherapy and laparoscopic surgery for locally advanced rectal cancer. PMID: 22847606 Ref: Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation. PMID: 23580570 Ref: Phenethyl isothiocyanate suppresses EGF-stimulated SAS human oral squamous carcinoma cell invasion by targeting EGF receptor signaling. PMID: 23754208 Ref: PDK1 signaling toward PLK1-MYC activation confers oncogenic transformation, tumor-initiating cell activation, and resistance to mTOR-targeted therapy. PMID: 23887393 |
Ref: Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation. PMID: 24336047 Ref: Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. PMID: 24825347 Ref: Influence of CHIEF pathway genes on gene expression: a pathway approach to functionality. PMID: 24959314 Ref: The PI3K/Akt pathway in colitis associated colon cancer and its chemoprevention with celecoxib, a Cox-2 selective inhibitor. PMID: 25107843 Ref: MiR-194 deregulation contributes to colorectal carcinogenesis via targeting AKT2 pathway. PMID: 25285168 Ref: Upregulation of MAPK/Erk and PI3K/Akt pathways in ulcerative colitis-associated colon cancer. PMID: 25443414 |
Ref: Justicidin A-induced autophagy flux enhances apoptosis of human colorectal cancer cells via class III PI3K and Atg5 pathway. PMID: 25216025 Ref: [Metabolism enzyme controls cancer stemness]. PMID: 25985625 Ref: Clinical Implication of Serine Metabolism-Associated Enzymes in Colon Cancer. PMID: 26439504 |
Ref: [Corrigendum] Brassinin induces G1 phase arrest through increase of p21 and p27 by inhibition of the phosphatidylinositol 3-kinase signaling pathway in human colon cancer cells. PMID: 26718100 Ref: Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer. PMID: 27321283 Ref: Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer. PMID: 27729975 |
Ref: Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer. PMID: 28183841 Ref: Pharmacogenomic Characterization and Isobologram Analysis of the Combination of Ascorbic Acid and Curcumin-Two Main Metabolites of Curcuma longa-in Cancer Cells. PMID: 28210221 Ref: Apoptosis-induced effects of extract from Artemisia annua Linne by modulating PTEN/p53/PDK1/Akt/ signal pathways through PTEN/p53-independent manner in HCT116 colon cancer cells. PMID: 28454566 Ref: M4IDP, a zoledronic acid derivative, induces G1 arrest, apoptosis and autophagy in HCT116 colon carcinoma cells via blocking PI3K/Akt/mTOR pathway. PMID: 28751160 Ref: MTDH and MAP3K1 are direct targets of apoptosis-regulating miRNAs in colorectal carcinoma. PMID: 28802228 Ref: A Deregulated PI3K-AKT Signaling Pathway in Patients with Colorectal Cancer. PMID: 29110225 |
Ref: Assessment of PI3K/AKT/PTEN signaling pathway activity in colorectal cancer using quantum dot-conjugated antibodies. PMID: 29422975 Ref: Methyl-beta-cyclodextrin potentiates the BITC-induced anti-cancer effect through modulation of the Akt phosphorylation in human colorectal cancer cells. PMID: 30200817 Ref: Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer. PMID: 30234098 Ref: LncRNA MAFG-AS1 promotes the progression of colorectal cancer by sponging miR-147b and activation of NDUFA4. PMID: 30348529 |