Primary Site >> Colorectal Cancer
Gene >> PDE5A
| 1. | |||||||||||
| Journal: | Cancer Res. 2000 Jul 1;60(13):3338-42. | ||||||||||
| Title: | Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. | ||||||||||
| Author: | Thompson, W J|Piazza, G A|Li, H|Liu, L|Fetter, J|Zhu, B|Sperl, G|Ahnen, D|Pamukcu, R | ||||||||||
| PMID: | 10910034 | ||||||||||
| 2. | |||||||||||
| Journal: | Cancer Res. 2001 May 15;61(10):3961-8. | ||||||||||
| Title: | Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis. | ||||||||||
| Author: | Piazza, G A|Thompson, W J|Pamukcu, R|Alila, H W|Whitehead, C M|Liu, L|Fetter, J R|Gresh, W E Jr|Klein-Szanto, A J|Farnell, D R|Eto, I|Grubbs, C J | ||||||||||
| PMID: | 11358813 | ||||||||||
| 3. | |||||||||||
| Journal: | Cell Signal. 2002 Jan;14(1):45-51. | ||||||||||
| Title: | Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase. | ||||||||||
| Author: | Liu, Li|Underwood, Tashandra|Li, Han|Pamukcu, Rifat|Thompson, W Joseph | ||||||||||
| PMID: | 11747988 | ||||||||||
| 4. | |||||||||||
| Journal: | J Cell Biochem. 2005 Feb 1;94(2):336-50. | ||||||||||
| Title: | Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells. | ||||||||||
| Author: | Zhu, Bing|Vemavarapu, Lakshmi|Thompson, W Joseph|Strada, Samuel J | ||||||||||
| PMID: | 15526282 | ||||||||||
| 5. | |||||||||||
| Journal: | Int J Oncol. 2008 May;32(5):975-83. | ||||||||||
| Title: | Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells. | ||||||||||
| Author: | Luo, Xiaoji|Wang, Chong-Zhi|Chen, Jin|Song, Wen-Xin|Luo, Jinyong|Tang, Ni|He, Bai-Cheng|Kang, Quan|Wang, Yitao|Du, Wei|He, Tong-Chuan|Yuan, Chun-Su | ||||||||||
| PMID: | 18425323 | ||||||||||
| 6. | |||||||||||
| Journal: | Arzneimittelforschung. 2009;59(8):415-21. | ||||||||||
| Title: | Synthesis of novel tadalafil analogues and their evaluation as phosphodiesterase inhibitors and anticancer agents. | ||||||||||
| Author: | Abadi, Ashraf H|Abouel-Ella, Dalal A|Ahmed, Nermin S|Gary, Bernard D|Thaiparambil, Jose T|Tinsley, Heather N|Keeton, Adam B|Piazza, Gary A | ||||||||||
| PMID: | 19813465 | ||||||||||
| 7. | |||||||||||
| Journal: | Eur J Med Chem. 2010 Apr;45(4):1278-86. | ||||||||||
| Title: | Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective. | ||||||||||
| Author: | Abadi, Ashraf H|Gary, Bernard D|Tinsley, Heather N|Piazza, Gary A|Abdel-Halim, Mohammad | ||||||||||
| PMID: | 20206015 | ||||||||||
| 8. | |||||||||||
| Journal: | Cancer Prev Res (Phila). 2010 Oct;3(10):1303-13. | ||||||||||
| Title: | Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition. | ||||||||||
| Author: | Tinsley, Heather N|Gary, Bernard D|Thaiparambil, Jose|Li, Nan|Lu, Wenyan|Li, Yonghe|Maxuitenko, Yulia Y|Keeton, Adam B|Piazza, Gary A | ||||||||||
| PMID: | 20876730 | ||||||||||
| 9. | |||||||||||
| Journal: | Cancer Prev Res (Phila). 2012 Jun;5(6):822-33. | ||||||||||
| Title: | A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and beta-catenin transcriptional activity. | ||||||||||
| Author: | Whitt, Jason D|Li, Nan|Tinsley, Heather N|Chen, Xi|Zhang, Wei|Li, Yonghe|Gary, Bernard D|Keeton, Adam B|Xi, Yaguang|Abadi, Ashraf H|Grizzle, William E|Piazza, Gary A | ||||||||||
| PMID: | 22556201 | ||||||||||
| 10. | |||||||||||
| Journal: | Mol Cancer Ther. 2013 Sep;12(9):1848-59. | ||||||||||
| Title: | Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/beta-catenin signaling. | ||||||||||
| Author: | Li, Nan|Xi, Yaguang|Tinsley, Heather N|Gurpinar, Evrim|Gary, Bernard D|Zhu, Bing|Li, Yonghe|Chen, Xi|Keeton, Adam B|Abadi, Ashraf H|Moyer, Mary P|Grizzle, William E|Chang, Wen-Chi|Clapper, Margie L|Piazza, Gary A | ||||||||||
| PMID: | 23804703 | ||||||||||
| 11. | |||||||||||
| Journal: | J Clin Invest. 2013 Feb;123(2):787-99. | ||||||||||
| Title: | 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis. | ||||||||||
| Author: | Kumazoe, Motofumi|Sugihara, Kaori|Tsukamoto, Shuntaro|Huang, Yuhui|Tsurudome, Yukari|Suzuki, Takashi|Suemasu, Yumi|Ueda, Naoki|Yamashita, Shuya|Kim, Yoonhee|Yamada, Koji|Tachibana, Hirofumi | ||||||||||
| PMID: | 23348740 | ||||||||||
| 12. | |||||||||||
| Journal: | J Cell Physiol. 2015 Sep;230(9):2281-98. | ||||||||||
| Title: | Nexavar/Stivarga and viagra interact to kill tumor cells. | ||||||||||
| Author: | Tavallai, Mehrad|Hamed, Hossein A|Roberts, Jane L|Cruickshanks, Nichola|Chuckalovcak, John|Poklepovic, Andrew|Booth, Laurence|Dent, Paul | ||||||||||
| PMID: | 25704960 | ||||||||||
| 13. | |||||||||||
| Journal: | Oncotarget. 2015 Sep 29;6(29):27403-15. | ||||||||||
| Title: | Suppression of beta-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10. | ||||||||||
| Author: | Li, Nan|Chen, Xi|Zhu, Bing|Ramirez-Alcantara, Veronica|Canzoneri, Joshua C|Lee, Kevin|Sigler, Sara|Gary, Bernard|Li, Yonghe|Zhang, Wei|Moyer, Mary P|Salter, E Alan|Wierzbicki, Andrzej|Keeton, Adam B|Piazza, Gary A | ||||||||||
| PMID: | 26299804 | ||||||||||
| 14. | |||||||||||
| Journal: | Am J Cancer Res. 2015 Oct 15;5(11):3311-24. eCollection 2015. | ||||||||||
| Title: | Sildenafil inhibits the growth of human colorectal cancer in vitro and in vivo. | ||||||||||
| Author: | Mei, Xiao-Long|Yang, Yang|Zhang, Yao-Jun|Li, Yong|Zhao, Jin-Ming|Qiu, Jian-Ge|Zhang, Wen-Ji|Jiang, Qi-Wei|Xue, You-Qiu|Zheng, Di-Wei|Chen, Yao|Qin, Wu-Ming|Wei, Meng-Ning|Shi, Zhi | ||||||||||
| PMID: | 26807313 | ||||||||||
| 15. | |||||||||||
| Journal: | PLoS Med. 2016 Jun 14;13(6):e1002037. | ||||||||||
| Title: | Phosphodiesterase Type 5 Inhibitors and Risk of Malignant Melanoma: Matched Cohort Study Using Primary Care Data from the UK Clinical Practice Research Datalink. | ||||||||||
| Author: | Matthews, Anthony|Langan, Sinead M|Douglas, Ian J|Smeeth, Liam|Bhaskaran, Krishnan | ||||||||||
| PMID: | 27299522 | ||||||||||
| 16. | |||||||||||
| Journal: | BMC Cancer. 2016 Dec 7;16(1):938. | ||||||||||
| Title: | Phosphodiesterases in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia. | ||||||||||
| Author: | Mahmood, Badar|Damm, Morten Matthiesen Bach|Jensen, Thorbjorn Soren Ronn|Backe, Marie Balslev|Dahllof, Mattias Salling|Poulsen, Steen Seier|Bindslev, Niels|Hansen, Mark Berner | ||||||||||
| PMID: | 27927168 | ||||||||||
| 17. | |||||||||||
| Journal: | Cancer Prev Res (Phila). 2017 Jul;10(7):377-388. | ||||||||||
| Title: | Sildenafil Suppresses Inflammation-Driven Colorectal Cancer in Mice. | ||||||||||
| Author: | Islam, Bianca N|Sharman, Sarah K|Hou, Yali|Bridges, Allison E|Singh, Nagendra|Kim, Sangmi|Kolhe, Ravindra|Trillo-Tinoco, Jimena|Rodriguez, Paulo C|Berger, Franklin G|Sridhar, Subbaramiah|Browning, Darren D | ||||||||||
| PMID: | 28468928 | ||||||||||
| 18. | |||||||||||
| Journal: | Oncotarget. 2017 Aug 2;8(59):99451-99469. | ||||||||||
| Title: | Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species. | ||||||||||
| Author: | Roberts, Jane L|Poklepovic, Andrew|Booth, Laurence | ||||||||||
| PMID: | 29245915 | ||||||||||
| 19. | |||||||||||
| Journal: | Cancer Prev Res (Phila). 2018 Feb;11(2):81-92. | ||||||||||
| Title: | Cyclic-GMP-Elevating Agents Suppress Polyposis in Apc(Min) mice by Targeting the Preneoplastic Epithelium. | ||||||||||
| Author: | Sharman, Sarah K|Islam, Bianca N|Hou, Yali|Singh, Nagendra|Berger, Franklin G|Sridhar, Subbaramiah|Yoo, Wonsuk|Browning, Darren D | ||||||||||
| PMID: | 29301746 | ||||||||||
| 20. | |||||||||||
| Journal: | Cancer Prev Res (Phila). 2018 Jul;11(7):439-440. | ||||||||||
| Title: | Mutations of the PDE5A Gene Confer a Survival Advantage in Patients with Colon Cancer. | ||||||||||
| Author: | Lehrer, Steven|Rheinstein, Peter H|Rosenzweig, Kenneth E | ||||||||||
| PMID: | 29724712 | ||||||||||
| 21. | |||||||||||
| Journal: | Semin Cancer Biol. 2018 Sep 3. pii: S1044-579X(18)30064-6. | ||||||||||
| Title: | Targeting the paracrine hormone-dependent guanylate cyclase/cGMP/phosphodiesterases signaling pathway for colorectal cancer prevention. | ||||||||||
| Author: | Yarla, N S|Gali, H|Pathuri, G|Smriti, S|Farooqui, M|Panneerselvam, J|Kumar, G|Madka, V|Rao, C V | ||||||||||
| PMID: | 30189250 | ||||||||||