Primary Site >> Colorectal Cancer
Gene >> PDE5A
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Ref: Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. PMID: 10910034 |
Ref: Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis. PMID: 11358813 |
Ref: Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase. PMID: 11747988 |
Ref: Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells. PMID: 15526282 |
Ref: Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells. PMID: 18425323 |
Ref: Synthesis of novel tadalafil analogues and their evaluation as phosphodiesterase inhibitors and anticancer agents. PMID: 19813465 |
Ref: Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective. PMID: 20206015 Ref: Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition. PMID: 20876730 |
Ref: A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and beta-catenin transcriptional activity. PMID: 22556201 |
Ref: 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis. PMID: 23348740 Ref: Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/beta-catenin signaling. PMID: 23804703 |
Ref: Nexavar/Stivarga and viagra interact to kill tumor cells. PMID: 25704960 Ref: Suppression of beta-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10. PMID: 26299804 Ref: Sildenafil inhibits the growth of human colorectal cancer in vitro and in vivo. PMID: 26807313 |
Ref: Phosphodiesterase Type 5 Inhibitors and Risk of Malignant Melanoma: Matched Cohort Study Using Primary Care Data from the UK Clinical Practice Research Datalink. PMID: 27299522 Ref: Phosphodiesterases in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia. PMID: 27927168 |
Ref: Sildenafil Suppresses Inflammation-Driven Colorectal Cancer in Mice. PMID: 28468928 Ref: Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species. PMID: 29245915 |
Ref: Cyclic-GMP-Elevating Agents Suppress Polyposis in Apc(Min) mice by Targeting the Preneoplastic Epithelium. PMID: 29301746 Ref: Mutations of the PDE5A Gene Confer a Survival Advantage in Patients with Colon Cancer. PMID: 29724712 Ref: Targeting the paracrine hormone-dependent guanylate cyclase/cGMP/phosphodiesterases signaling pathway for colorectal cancer prevention. PMID: 30189250 |