Primary Site >> Colorectal Cancer

Gene >> PDE4B

Journal: Physiol Genomics. 2011 May 1;43(10):640-54.
Title: Integrated microRNA and mRNA expression profiling in a rat colon carcinogenesis model: effect of a chemo-protective diet.
Author: Shah, Manasvi S|Schwartz, Scott L|Zhao, Chen|Davidson, Laurie A|Zhou, Beiyan|Lupton, Joanne R|Ivanov, Ivan|Chapkin, Robert S
PMID: 21406606
Journal: Mol Cancer. 2012 Jul 25;11:46.
Title: Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model.
Author: Tsunoda, Toshiyuki|Ota, Takeharu|Fujimoto, Takahiro|Doi, Keiko|Tanaka, Yoko|Yoshida, Yasuhiro|Ogawa, Masahiro|Matsuzaki, Hiroshi|Hamabashiri, Masato|Tyson, Darren R|Kuroki, Masahide|Miyamoto, Shingo|Shirasawa, Senji
PMID: 22830422
Journal: Bioorg Med Chem Lett. 2013 Dec 15;23(24):6721-7.
Title: Synthesis and biological evaluation of nimesulide based new class of triazole derivatives as potential PDE4B inhibitors against cancer cells.
Author: Mareddy, Jyoti|Nallapati, Suresh Babu|Anireddy, Jayasree|Devi, Yumnam Priyadarshini|Mangamoori, Lakshmi Narasu|Kapavarapu, Ravikumar|Pal, Sarbani
PMID: 24215890
Journal: Arch Pharm (Weinheim). 2014 Sep;347(9):650-7.
Title: Novel quinazolin-4(3H)-one/Schiff base hybrids as antiproliferative and phosphodiesterase 4 inhibitors: design, synthesis, and docking studies.
Author: Abdel-Rahman, Hamdy M|Abdel-Aziz, Mohamed|Canzoneri, Joshua C|Gary, Bernard D|Piazza, Gary A
PMID: 24985336
Journal: Chem Biol Drug Des. 2016 Apr;87(4):575-82.
Title: Synthesis of New Congeners of 1-methyl-3-aminoisoquinolines, Evaluation of Their Cytotoxic Activity, In Silico and In Vitro Study of Their Molecular Targets as PDE4B.
Author: Lapa, Gennady B|Tsunoda, Toshiyuki|Shirasawa, Senji|Baryshnikova, Maria A|Evseev, Gregory G|Afanasyeva, Daria A|Chigorina, Elena A
PMID: 26613238
Journal: BMC Cancer. 2016 Dec 7;16(1):938.
Title: Phosphodiesterases in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia.
Author: Mahmood, Badar|Damm, Morten Matthiesen Bach|Jensen, Thorbjorn Soren Ronn|Backe, Marie Balslev|Dahllof, Mattias Salling|Poulsen, Steen Seier|Bindslev, Niels|Hansen, Mark Berner
PMID: 27927168
Journal: PLoS Genet. 2018 Sep 6;14(9):e1007611.
Title: The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer.
Author: Pleiman, Jennifer K|Irving, Amy A|Wang, Zhishi|Toraason, Erik|Clipson, Linda|Dove, William F|Deming, Dustin A|Newton, Michael A
PMID: 30188895