Primary Site >> Colorectal Cancer
Gene >> PDE4B
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Ref: Integrated microRNA and mRNA expression profiling in a rat colon carcinogenesis model: effect of a chemo-protective diet. PMID: 21406606 |
Ref: Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model. PMID: 22830422 |
Ref: Synthesis and biological evaluation of nimesulide based new class of triazole derivatives as potential PDE4B inhibitors against cancer cells. PMID: 24215890 |
Ref: Novel quinazolin-4(3H)-one/Schiff base hybrids as antiproliferative and phosphodiesterase 4 inhibitors: design, synthesis, and docking studies. PMID: 24985336 |
Ref: Synthesis of New Congeners of 1-methyl-3-aminoisoquinolines, Evaluation of Their Cytotoxic Activity, In Silico and In Vitro Study of Their Molecular Targets as PDE4B. PMID: 26613238 Ref: Phosphodiesterases in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia. PMID: 27927168 |
Ref: The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer. PMID: 30188895 |