Primary Site >> Colorectal Cancer

Gene >> PDCD4

Journal: Oncogene. 2001 Jul 27;20(33):4450-6.
Title: Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor.
Author: Zhang, Z|DuBois, R N
PMID: 11494140
Journal: Am J Physiol Cell Physiol. 2004 Dec;287(6):C1541-6. Epub 2004 Aug 18.
Title: Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1).
Author: Goke, R|Barth, P|Schmidt, A|Samans, B|Lankat-Buttgereit, B
PMID: 15317660
Journal: Oncol Rep. 2006 Oct;16(4):747-54.
Title: Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon.
Author: Lee, Seungkoo|Bang, Seunghyun|Song, Kyuyoung|Lee, Inchul
PMID: 16969489
Journal: Mol Cell Biol. 2006 Feb;26(4):1297-306.
Title: Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion.
Author: Yang, Hsin-Sheng|Matthews, Connie P|Clair, Timothy|Wang, Qing|Baker, Alyson R|Li, Chou-Chi H|Tan, Tse-Hua|Colburn, Nancy H
PMID: 16449643
Journal: Oncogene. 2007 Jul 5;26(31):4550-62.
Title: Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors.
Author: Leupold, J H|Yang, H-S|Colburn, N H|Asangani, I|Post, S|Allgayer, H
PMID: 17297470
Journal: Cancer. 2007 Oct 15;110(8):1697-707.
Title: Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer.
Author: Mudduluru, Giridhar|Medved, Fabian|Grobholz, Rainer|Jost, Camela|Gruber, Anette|Leupold, Joerg H|Post, Stefan|Jansen, Aaron|Colburn, Nancy H|Allgayer, Heike
PMID: 17849461
Journal: Oncogene. 2008 Mar 6;27(11):1527-35. Epub 2007 Sep 10.
Title: Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both beta-catenin/Tcf and AP-1-dependent transcription in colon carcinoma cells.
Author: Wang, Q|Sun, Z|Yang, H-S
PMID: 17828298
Journal: Oncogene. 2008 Apr 3;27(15):2128-36. Epub 2007 Oct 29.
Title: MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer.
Author: Asangani, I A|Rasheed, S A K|Nikolova, D A|Leupold, J H|Colburn, N H|Post, S|Allgayer, H
PMID: 17968323
Journal: Biochem Biophys Res Commun. 2009 Jun 5;383(3):280-5.
Title: MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells.
Author: Li, Tao|Li, Dong|Sha, Jianjun|Sun, Peng|Huang, Yiran
PMID: 19302977
Journal: Clin Cancer Res. 2009 Jun 15;15(12):4009-16.
Title: Locked nucleic acid in situ hybridization analysis of miR-21 expression during colorectal cancer development.
Author: Yamamichi, Nobutake|Shimomura, Ryoichi|Inada, Ken-ichi|Sakurai, Kouhei|Haraguchi, Takeshi|Ozaki, Yuka|Fujita, Shuji|Mizutani, Taketoshi|Furukawa, Chihiro|Fujishiro, Mitsuhiro|Ichinose, Masao|Shiogama, Kazuya|Tsutsumi, Yutaka|Omata, Masao|Iba, Hideo
PMID: 19509156
Journal: Oncology. 2010;79(3-4):313-20.
Title: Clinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer.
Author: Shibuya, Hajime|Iinuma, Hisae|Shimada, Ryu|Horiuchi, Atsushi|Watanabe, Toshiaki
PMID: 21412018
Journal: Hum Pathol. 2010 Nov;41(11):1507-15.
Title: Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation.
Author: Hayashi, Akifumi|Aishima, Shinichi|Miyasaka, Yoshihiro|Nakata, Kohei|Morimatsu, Katsuya|Oda, Yasunori|Nagai, Eishi|Oda, Yoshinao|Tanaka, Masao|Tsuneyoshi, Masazumi
PMID: 20656320
Journal: Biochem Pharmacol. 2010 Dec 15;80(12):2057-65.
Title: Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFbeta signaling pathway in SW480 cells.
Author: Tili, Esmerina|Michaille, Jean-Jacques|Alder, Hansjuerg|Volinia, Stefano|Delmas, Dominique|Latruffe, Norbert|Croce, Carlo M
PMID: 20637737
Journal: BMC Mol Biol. 2010 Feb 1;11:12.
Title: Identification of endogenous control genes for normalisation of real-time quantitative PCR data in colorectal cancer.
Author: Kheirelseid, Elrasheid A H|Chang, Kah Hoong|Newell, John|Kerin, Michael J|Miller, Nicola
PMID: 20122155
Journal: Crit Rev Oncol Hematol. 2010 Mar;73(3):185-91.
Title: Pdcd4, a colon cancer prognostic that is regulated by a microRNA.
Author: Allgayer, Heike
PMID: 19836969
Journal: Oncogene. 2010 Jan 7;29(1):128-38.
Title: Downregulation of E-cadherin is an essential event in activating beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells.
Author: Wang, Q|Sun, Z-X|Allgayer, H|Yang, H-S
PMID: 19784072
Journal: Biosci Rep. 2011 Jun;31(3):185-97.
Title: Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer.
Author: Mudduluru, Giridhar|George-William, Jonahunnatha N|Muppala, Santoshi|Asangani, Irfan A|Kumarswamy, Regalla|Nelson, Laura D|Allgayer, Heike
PMID: 20815812
Journal: Virchows Arch. 2011 Apr;458(4):413-9.
Title: PDCD4 nuclear loss inversely correlates with miR-21 levels in colon carcinogenesis.
Author: Fassan, Matteo|Pizzi, Marco|Giacomelli, Luciano|Mescoli, Claudia|Ludwig, Kathrin|Pucciarelli, Salvatore|Rugge, Massimo
PMID: 21279518
Journal: Eur J Surg Oncol. 2011 Jul;37(7):597-603.
Title: MicroRNA-21 and PDCD4 expression in colorectal cancer.
Author: Chang, K H|Miller, N|Kheirelseid, E A H|Ingoldsby, H|Hennessy, E|Curran, C E|Curran, S|Smith, M J|Regan, M|McAnena, O J|Kerin, M J
PMID: 21546206
Journal: Oncol Rep. 2011 Dec;26(6):1385-92.
Title: Expression patterns of the tumor suppressor PDCD4 and correlation with beta-catenin expression in gastric cancers.
Author: Kakimoto, Takashi|Shiraishi, Ryosuke|Iwakiri, Ryuichi|Fujimoto, Kazuma|Takahashi, Hirokazu|Hamajima, Hiroshi|Mizuta, Toshihiko|Ideguchi, Hiroyuki|Toda, Shuji|Kitajima, Yoshihiko|Ozaki, Iwata|Matsuhashi, Sachiko
PMID: 21894439
Journal: Carcinogenesis. 2011 Dec;32(12):1798-805.
Title: MicroRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4.
Author: Liu, Xiangqiang|Zhang, Zhiyong|Sun, Li|Chai, Na|Tang, Shanhong|Jin, Jiang|Hu, Hao|Nie, Yongzhan|Wang, Xin|Wu, Kaichun|Jin, Haifeng|Fan, Daiming
PMID: 21934092
Journal: Oncol Lett. 2011 Nov;2(6):1053-1057.
Title: Programmed cell death 4 (Pdcd4) expression in colorectal adenocarcinoma: Association with clinical stage.
Author: Lim, Sung-Chul|Hong, Ran
PMID: 23049623
Journal: Carcinogenesis. 2012 Jan;33(1):68-76.
Title: MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFbetaR2) in colon cancer cells.
Author: Yu, Yingjie|Kanwar, Shailender S|Patel, Bhaumik B|Oh, Phil-Sun|Nautiyal, Jyoti|Sarkar, Fazlul H|Majumdar, Adhip P N
PMID: 22072622
Journal: Oncol Rep. 2012 May;27(5):1384-92.
Title: Prognostic significance of PDCD4 expression and association with microRNA-21 in each Dukes' stage of colorectal cancer patients.
Author: Horiuchi, Atsushi|Iinuma, Hisae|Akahane, Takuya|Shimada, Ryu|Watanabe, Toshiaki
PMID: 22267128
Journal: World J Gastroenterol. 2012 Feb 14;18(6):570-5.
Title: Identification of differential gene expressions in colorectal cancer and polyp by cDNA microarray.
Author: Dai, Yi-Chen|Zhu, Xiao-San|Nan, Qing-Zhen|Chen, Zhang-Xin|Xie, Jun-Pei|Fu, Yu-Ka|Lin, Yuan-Yuan|Lian, Qing-Na|Sang, Qiao-Fang|Zhan, Xiao-Juan
PMID: 22363125
Journal: Tumour Biol. 2013 Dec;34(6):3879-85.
Title: Downregulation of programmed cell death 4 (PDCD4) in tumorigenesis and progression of human digestive tract cancers.
Author: Ma, Gang|Zhang, Hao|Dong, Ming|Zheng, Xinyu|Ozaki, Iwata|Matsuhashi, Sachiko|Guo, Kejian
PMID: 23838800
Journal: Eur J Cancer. 2013 Oct;49(15):3311-9.
Title: Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression.
Author: Saxena, Ashish|Shoeb, Mohammad|Ramana, Kota V|Srivastava, Satish K
PMID: 23827854
Journal: World J Gastroenterol. 2013 Jun 7;19(21):3249-54.
Title: Early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: a feasibility study.
Author: Supiot, Stephane|Gouraud, Wilfried|Campion, Loic|Jezequel, Pascal|Buecher, Bruno|Charrier, Josiane|Heymann, Marie-Francoise|Mahe, Marc-Andre|Rio, Emmanuel|Cherel, Michel
PMID: 23745026
Journal: J Gastrointest Oncol. 2013 Jun;4(2):144-57.
Title: Clinical applications of gene expression in colorectal cancer.
Author: Kheirelseid, Elrasheid A H|Miller, Nicola|Chang, Kah Hoong|Nugent, Mary|Kerin, Michael J
PMID: 23730510
Journal: J Agric Food Chem. 2013 Apr 3;61(13):3264-9.
Title: Anticancer activity of olive oil hydroxytyrosyl acetate in human adenocarcinoma Caco-2 cells.
Author: Mateos, Raquel|Pereira-Caro, Gema|Bacon, James R|Bongaerts, Roy|Sarria, Beatriz|Bravo, Laura|Kroon, Paul A
PMID: 23452288
Journal: Food Chem. 2013 Jun 1;138(2-3):1172-82.
Title: Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol.
Author: Pereira-Caro, G|Mateos, R|Traka, M H|Bacon, J R|Bongaerts, R|Sarria, B|Bravo, L|Kroon, P A
PMID: 23411228
Journal: Virchows Arch. 2013 Jan;462(1):57-63.
Title: PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis.
Author: Ludwig, Kathrin|Fassan, Matteo|Mescoli, Claudia|Pizzi, Marco|Balistreri, Mariangela|Albertoni, Laura|Pucciarelli, Salvatore|Scarpa, Marco|Sturniolo, Giacomo Carlo|Angriman, Imerio|Rugge, Massimo
PMID: 23224068
Journal: PLoS One. 2013;8(3):e59563.
Title: CD24 induces expression of the oncomir miR-21 via Src, and CD24 and Src are both post-transcriptionally downregulated by the tumor suppressor miR-34a.
Author: Muppala, Santoshi|Mudduluru, Giridhar|Leupold, Jorg H|Buergy, Daniel|Sleeman, Jonathan P|Allgayer, Heike
PMID: 23533633
Journal: Epigenetics. 2014 Jan;9(1):129-41.
Title: Epigenetic regulation of miR-21 in colorectal cancer: ITGB4 as a novel miR-21 target and a three-gene network (miR-21-ITGBeta4-PDCD4) as predictor of metastatic tumor potential.
Author: Ferraro, Angelo|Kontos, Christos K|Boni, Themis|Bantounas, Ioannis|Siakouli, Dimitra|Kosmidou, Vivian|Vlassi, Margarita|Spyridakis, Yannis|Tsipras, Iraklis|Zografos, George|Pintzas, Alexander
PMID: 24149370
Journal: Asian Pac J Cancer Prev. 2014;15(2):825-30.
Title: PDCD4 as a predictor of sensitivity to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients.
Author: Dou, Xue|Wang, Ren-Ben|Meng, Xiang-Jiao|Yan, Hong-Jiang|Jiang, Shu-Mei|Zhu, Kun-Li|Xu, Xiao-Qing|Chen, Dong|Song, Xian-Rang|Mu, Dian-Bin
PMID: 24568503
Journal: PLoS One. 2014 Oct 13;9(10):e110267.
Title: Inflammation and MiR-21 pathways functionally interact to downregulate PDCD4 in colorectal cancer.
Author: Peacock, Oliver|Lee, Andrew C|Cameron, Fraser|Tarbox, Rebecca|Vafadar-Isfahani, Natasha|Tufarelli, Cristina|Lund, Jonathan N
PMID: 25310697
Journal: Mol Cancer Ther. 2015 Mar;14(3):799-809.
Title: Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells.
Author: Zhang, Yan|Wang, Qing|Chen, Li|Yang, Hsin-Sheng
PMID: 25573956
Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2015 Apr;35(4):511-5.
Title: [Mechanism of thioridazine-induced apoptosis of human colorectal cancer SW480 cells].
Author: Liu, Jin-Kun|Hao, Ya-Juan|Huang, Jia-Wei|Li, Xin|Cai, Hong-Bing|Peng, Kang
PMID: 25907934
Journal: Mol Cancer. 2015 May 1;14:98.
Title: miR-21 and miR-145 cooperation in regulation of colon cancer stem cells.
Author: Yu, Yingjie|Nangia-Makker, Pratima|Farhana, Lulu|G Rajendra, Sindhu|Levi, Edi|Majumdar, Adhip P N
PMID: 25928322
Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015 Oct;32(5):620-4.
Title: [Drug resistance of colon cancer cells to 5-fluorouracil mediated by microRNA-21].
Author: Wu, Liyuan|Li, Si|Peng, Rui|Gong, Shu|Xu, Liu|Zou, Fangdong
PMID: 26418978
Journal: Protein Cell. 2016 Oct;7(10):722-734.
Title: miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4.
Author: Liu, Yanqing|Uzair-Ur-Rehman|Guo, Yu|Liang, Hongwei|Cheng, Rongjie|Yang, Fei|Hong, Yeting|Zhao, Chihao|Liu, Minghui|Yu, Mengchao|Zhou, Xinyan|Yin, Kai|Chen, Jiangning|Zhang, Junfeng|Zhang, Chen-Yu|Zhi, Feng|Chen, Xi
PMID: 27647131
Journal: Mol Cancer Ther. 2016 Dec;15(12):3055-3063.
Title: STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor eIF4A.
Author: Wang, Shuo|Darini, Cedric|Desaubry, Laurent|Koromilas, Antonis E
PMID: 27913706
Journal: Inflamm Bowel Dis. 2016 May;22(5):1107-18.
Title: PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway in Mice.
Author: Wang, Liyang|Zhao, Mingsheng|Guo, Chun|Wang, Guannan|Zhu, Faliang|Wang, Jianing|Wang, Xiaoyan|Wang, Qun|Zhao, Wei|Shi, Yongyu|Chen, Youhai H|Zhang, Lining
PMID: 26891257
Journal: Biochem Biophys Res Commun. 2016 Feb 5;470(2):431-438.
Title: SRSF3 represses the expression of PDCD4 protein by coordinated regulation of alternative splicing, export and translation.
Author: Park, Seung Kuk|Jeong, Sunjoo
PMID: 26773498
Journal: Gut. 2016 Sep;65(9):1470-81.
Title: Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer.
Author: Shi, Chenzhang|Yang, Yongzhi|Xia, Yang|Okugawa, Yoshinaga|Yang, Jun|Liang, Yong|Chen, Hongqi|Zhang, Peng|Wang, Feng|Han, Huazhong|Wu, Wen|Gao, Renyuan|Gasche, Christoph|Qin, Huanlong|Ma, Yanlei|Goel, Ajay
PMID: 25994220
Journal: Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1392-1402.
Title: Assessment of histone tail modifications and transcriptional profiling during colon cancer progression reveals a global decrease in H3K4me3 activity.
Author: Triff, Karen|McLean, Mathew W|Konganti, Kranti|Pang, Jiahui|Callaway, Evelyn|Zhou, Beiyan|Ivanov, Ivan|Chapkin, Robert S
PMID: 28315775
Journal: Tumour Biol. 2017 Mar;39(3):1010428317692261.
Title: Inhibition of microRNA-21 via locked nucleic acid-anti-miR suppressed metastatic features of colorectal cancer cells through modulation of programmed cell death 4.
Author: Nedaeinia, Reza|Sharifi, Mohammadreza|Avan, Amir|Kazemi, Mohammad|Nabinejad, Abdolreza|Ferns, Gordon A|Ghayour-Mobarhan, Majid|Salehi, Rasoul
PMID: 28347230
Journal: Pharm Res. 2017 Sep;34(9):1849-1856.
Title: The Cardiotoxic Mechanism of Doxorubicin (DOX) and Pegylated Liposomal DOX in Mice Bearing C-26 Colon Carcinoma: a Study Focused on microRNA Role for Toxicity Assessment of New Formulations.
Author: Razavi-Azarkhiavi, Kamal|Jaafari, Mahmoud Reza|Abnous, Khalil|Razavi, Bibi Marjan|Jafarian, Amir Hossein|Hassani, Faezeh Vahdati|Shirani, Kobra|Karimi, Gholamreza
PMID: 28560697
Journal: Oncogene. 2017 Nov 9;36(45):6225-6234.
Title: Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma.
Author: Wang, Q|Zhu, J|Wang, Y-W|Dai, Y|Wang, Y-L|Wang, C|Liu, J|Baker, A|Colburn, N H|Yang, H-S
PMID: 28692058
Journal: PLoS One. 2017 Nov 1;12(11):e0187310.
Title: Evaluation of miRNA-196a2 and apoptosis-related target genes: ANXA1, DFFA and PDCD4 expression in gastrointestinal cancer patients: A pilot study.
Author: Fawzy, Manal S|Toraih, Eman A|Ibrahiem, Afaf|Abdeldayem, Hala|Mohamed, Amany O|Abdel-Daim, Mohamed M
PMID: 29091952
Journal: Oncol Lett. 2018 Apr;15(4):5971-5976.
Title: Berberine regulates the microRNA-21-ITGBeta4-PDCD4 axis and inhibits colon cancer viability.
Author: Lu, Yanfeng|Han, Bingbing|Yu, Hualong|Cui, Zhenghua|Li, Zhiwen|Wang, Jianxin
PMID: 29564000
Journal: Oncol Lett. 2018 Jun;15(6):8223-8230.
Title: Asiatic acid inhibits proliferation, migration and induces apoptosis by regulating Pdcd4 via the PI3K/Akt/mTOR/p70S6K signaling pathway in human colon carcinoma cells.
Author: Hao, Yajuan|Huang, Jiawei|Ma, Yun|Chen, Wancheng|Fan, Qin|Sun, Xuegang|Shao, Meng|Cai, Hongbing
PMID: 29805556
Journal: J Biomed Nanotechnol. 2018 May 1;14(5):946-958.
Title: Fluorescent Nanodiamonds are Efficient, Easy-to-Use Cyto-Compatible Vehicles for Monitored Delivery of Non-Coding Regulatory RNAs.
Author: Lukowski, Sonja|Neuhoferova, Eva|Kinderman, Marek|Krivohlava, Romana|Mineva, Andrea|Petrakova, Vladimira|Benson, Veronika
PMID: 29883564
Journal: Aging (Albany NY). 2018 Jun 21;10(6):1523-1533.
Title: Linc00472 suppresses proliferation and promotes apoptosis through elevating PDCD4 expression by sponging miR-196a in colorectal cancer.
Author: Ye, Yafei|Yang, Shengnan|Han, Yanping|Sun, Jingjing|Xv, Lijuan|Wu, Lina|Wang, Yongfeng|Ming, Liang
PMID: 29930217
Journal: J BUON. 2018 May-Jun;23(3):579-586.
Title: MiR-503 promotes the migration and invasion of colorectal cancer cells by regulating PDCD4.
Author: Li, Lihua|Zhang, Xiaolian|Yi, Zengxing|Liang, Xiaofang|Yin, Weihua|Li, Shaoyuan
PMID: 30003722
Journal: Biomed Pharmacother. 2018 Oct;106:1607-1615.
Title: Overexpression of MEG3 sensitizes colorectal cancer cells to oxaliplatin through regulation of miR-141/PDCD4 axis.
Author: Wang, Hongjian|Li, Hui|Zhang, Lei|Yang, Desheng
PMID: 30119236
Journal: Gene. 2018 Sep 20;680:59-64.
Title: The mechanisms and clinical significance of PDCD4 in colorectal cancer.
Author: Long, Jiali|Yin, Yuting|Guo, Haina|Li, Shuling|Sun, Yanqin|Zeng, Chao|Zhu, Wei
PMID: 30243936
Journal: Oncol Lett. 2018 Oct;16(4):5131-5139.
Title: MiR-1260b inhibitor enhances the chemosensitivity of colorectal cancer cells to fluorouracil by targeting PDCD4/IGF1.
Author: Zhao, Jun|Cao, Jingjie|Zhou, Lurong|Du, Yunyi|Zhang, Xiaoling|Yang, Bo|Gao, Yangjun|Wang, Yu|Ma, Ning|Yang, Wei
PMID: 30250581