Primary Site >> Colorectal Cancer
Gene >> PDCD4
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Ref: Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor. PMID: 11494140 |
Ref: Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1). PMID: 15317660 |
Ref: Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. PMID: 16449643 Ref: Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon. PMID: 16969489 |
Ref: Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors. PMID: 17297470 Ref: Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer. PMID: 17849461 |
Ref: Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both beta-catenin/Tcf and AP-1-dependent transcription in colon carcinoma cells. PMID: 17828298 Ref: MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. PMID: 17968323 |
Ref: MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells. PMID: 19302977 Ref: Locked nucleic acid in situ hybridization analysis of miR-21 expression during colorectal cancer development. PMID: 19509156 |
Ref: Downregulation of E-cadherin is an essential event in activating beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells. PMID: 19784072 Ref: Pdcd4, a colon cancer prognostic that is regulated by a microRNA. PMID: 19836969 Ref: Identification of endogenous control genes for normalisation of real-time quantitative PCR data in colorectal cancer. PMID: 20122155 Ref: Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFbeta signaling pathway in SW480 cells. PMID: 20637737 Ref: Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation. PMID: 20656320 Ref: Clinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer. PMID: 21412018 |
Ref: Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer. PMID: 20815812 Ref: PDCD4 nuclear loss inversely correlates with miR-21 levels in colon carcinogenesis. PMID: 21279518 Ref: MicroRNA-21 and PDCD4 expression in colorectal cancer. PMID: 21546206 Ref: Expression patterns of the tumor suppressor PDCD4 and correlation with beta-catenin expression in gastric cancers. PMID: 21894439 Ref: MicroRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4. PMID: 21934092 Ref: Programmed cell death 4 (Pdcd4) expression in colorectal adenocarcinoma: Association with clinical stage. PMID: 23049623 |
Ref: MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFbetaR2) in colon cancer cells. PMID: 22072622 Ref: Prognostic significance of PDCD4 expression and association with microRNA-21 in each Dukes' stage of colorectal cancer patients. PMID: 22267128 Ref: Identification of differential gene expressions in colorectal cancer and polyp by cDNA microarray. PMID: 22363125 |
Ref: PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis. PMID: 23224068 Ref: Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol. PMID: 23411228 Ref: Anticancer activity of olive oil hydroxytyrosyl acetate in human adenocarcinoma Caco-2 cells. PMID: 23452288 Ref: CD24 induces expression of the oncomir miR-21 via Src, and CD24 and Src are both post-transcriptionally downregulated by the tumor suppressor miR-34a. PMID: 23533633 Ref: Clinical applications of gene expression in colorectal cancer. PMID: 23730510 Ref: Early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: a feasibility study. PMID: 23745026 Ref: Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression. PMID: 23827854 Ref: Downregulation of programmed cell death 4 (PDCD4) in tumorigenesis and progression of human digestive tract cancers. PMID: 23838800 |
Ref: Epigenetic regulation of miR-21 in colorectal cancer: ITGB4 as a novel miR-21 target and a three-gene network (miR-21-ITGBeta4-PDCD4) as predictor of metastatic tumor potential. PMID: 24149370 Ref: PDCD4 as a predictor of sensitivity to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients. PMID: 24568503 Ref: Inflammation and MiR-21 pathways functionally interact to downregulate PDCD4 in colorectal cancer. PMID: 25310697 |
Ref: Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells. PMID: 25573956 Ref: [Mechanism of thioridazine-induced apoptosis of human colorectal cancer SW480 cells]. PMID: 25907934 Ref: miR-21 and miR-145 cooperation in regulation of colon cancer stem cells. PMID: 25928322 Ref: [Drug resistance of colon cancer cells to 5-fluorouracil mediated by microRNA-21]. PMID: 26418978 |
Ref: Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer. PMID: 25994220 Ref: SRSF3 represses the expression of PDCD4 protein by coordinated regulation of alternative splicing, export and translation. PMID: 26773498 Ref: PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway in Mice. PMID: 26891257 Ref: miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4. PMID: 27647131 Ref: STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor eIF4A. PMID: 27913706 |
Ref: Assessment of histone tail modifications and transcriptional profiling during colon cancer progression reveals a global decrease in H3K4me3 activity. PMID: 28315775 Ref: Inhibition of microRNA-21 via locked nucleic acid-anti-miR suppressed metastatic features of colorectal cancer cells through modulation of programmed cell death 4. PMID: 28347230 Ref: The Cardiotoxic Mechanism of Doxorubicin (DOX) and Pegylated Liposomal DOX in Mice Bearing C-26 Colon Carcinoma: a Study Focused on microRNA Role for Toxicity Assessment of New Formulations. PMID: 28560697 Ref: Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma. PMID: 28692058 Ref: Evaluation of miRNA-196a2 and apoptosis-related target genes: ANXA1, DFFA and PDCD4 expression in gastrointestinal cancer patients: A pilot study. PMID: 29091952 |
Ref: Berberine regulates the microRNA-21-ITGBeta4-PDCD4 axis and inhibits colon cancer viability. PMID: 29564000 Ref: Asiatic acid inhibits proliferation, migration and induces apoptosis by regulating Pdcd4 via the PI3K/Akt/mTOR/p70S6K signaling pathway in human colon carcinoma cells. PMID: 29805556 Ref: Fluorescent Nanodiamonds are Efficient, Easy-to-Use Cyto-Compatible Vehicles for Monitored Delivery of Non-Coding Regulatory RNAs. PMID: 29883564 Ref: Linc00472 suppresses proliferation and promotes apoptosis through elevating PDCD4 expression by sponging miR-196a in colorectal cancer. PMID: 29930217 Ref: MiR-503 promotes the migration and invasion of colorectal cancer cells by regulating PDCD4. PMID: 30003722 Ref: Overexpression of MEG3 sensitizes colorectal cancer cells to oxaliplatin through regulation of miR-141/PDCD4 axis. PMID: 30119236 Ref: The mechanisms and clinical significance of PDCD4 in colorectal cancer. PMID: 30243936 Ref: MiR-1260b inhibitor enhances the chemosensitivity of colorectal cancer cells to fluorouracil by targeting PDCD4/IGF1. PMID: 30250581 |