Primary Site >> Colorectal Cancer

Gene >> PAK1

Journal: Int J Oncol. 2002 May;20(5):977-82.
Title: Molecular cloning and characterization of WRCH2 on human chromosome 15q15.
Author: Katoh, Masaru
PMID: 11956592
Journal: Clin Cancer Res. 2004 May 15;10(10):3448-56.
Title: Pak-1 expression increases with progression of colorectal carcinomas to metastasis.
Author: Carter, Julia H|Douglass, Larry E|Deddens, James A|Colligan, Bruce M|Bhatt, Tejal R|Pemberton, Jackson O|Konicek, Susan|Hom, Joanne|Marshall, Mark|Graff, Jeremy R
PMID: 15161701
Journal: J Neurosci. 2005 Mar 23;25(12):3132-41.
Title: Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion.
Author: Shekarabi, Masoud|Moore, Simon W|Tritsch, Nicolas X|Morris, Stephen J|Bouchard, Jean-Francois|Kennedy, Timothy E
PMID: 15788770
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2009 Mar;12(2):185-8.
Title: [Clinicopathological significance of expression and amplification of P21-activated kinase 1 gene in colorectal carcinoma].
Author: Li, Zhi-xun|Zeng, Sui-de|Liu, Yong-dong|Liao, Yi-ji|Hua, Wen-feng|Lin, Feng|Xie, Dan
PMID: 19296259
Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jul;29(7):1341-3.
Title: [Effect of p21-activated kinase-1 on the invasiveness of colorectal carcinoma cells in vitro].
Author: Wu, Jin-Bao|Han, Yu-Jing|Nan, Qing-Zhen|Zhang, Zhen-Shu|Zhang, Hong-Quan|Song, Yu-Gang
PMID: 19620048
Journal: J Biol Chem. 2010 Jun 11;285(24):18283-90.
Title: LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain.
Author: Deguchi, Atsuko|Miyoshi, Hiroyuki|Kojima, Yasushi|Okawa, Katsuya|Aoki, Masahiro|Taketo, Makoto M
PMID: 20400510
Journal: Biochim Biophys Acta. 2010 Sep;1803(9):1106-13.
Title: P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways.
Author: Huynh, Nhi|Liu, Kevin H|Baldwin, Graham S|He, Hong
PMID: 20595063
Journal: Int J Oncol. 2010 Oct;37(4):951-62.
Title: P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910.
Author: Li, Liang-Hui|Zheng, Min-Hua|Luo, Qi|Ye, Qing|Feng, Bo|Lu, Ai-Guo|Wang, Ming-Liang|Chen, Xue-Hua|Su, Li-Ping|Liu, Bing-Ya
PMID: 20811717
Journal: Cell Death Dis. 2011 Dec 1;2:e235.
Title: Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1-PUMA pathway.
Author: Lee, S-H|Jung, Y-S|Chung, J-Y|Oh, A Y|Lee, S-J|Choi, D H|Jang, S M|Jang, K-S|Paik, S S|Ha, N-C|Park, B-J
PMID: 22130069
Journal: Biochem Biophys Res Commun. 2012 Mar 16;419(3):543-9.
Title: Phosphorylation of beta-catenin at serine 663 regulates its transcriptional activity.
Author: Park, Mee-Hee|Kim, Duk-Joong|You, Soon-Tae|Lee, Chan-Soo|Kim, Hyong Kyu|Park, Seon Mee|Shin, Eun-Young|Kim, Eung-Gook
PMID: 22369945
Journal: Oncotarget. 2012 Jul;3(7):700-8.
Title: The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes.
Author: Singhal, Ruchi|Kandel, Eugene S
PMID: 22869096
Journal: J Biol Chem. 2012 Aug 3;287(32):27126-38.
Title: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.
Author: Purohit, Anish A|Li, Weiquan|Qu, Chao|Dwyer, Trisha|Shao, Qiangqiang|Guan, Kun-Liang|Liu, Guofa
PMID: 22685302
Journal: Tumour Biol. 2012 Aug;33(4):985-94.
Title: PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation.
Author: Qing, Haitao|Gong, Wei|Che, Yufang|Wang, Xinying|Peng, Liang|Liang, Yan|Wang, Weifei|Deng, Qiliang|Zhang, Hongquan|Jiang, Bo
PMID: 22252525
Journal: Cancer Lett. 2012 Apr 1;317(1):65-71.
Title: P-21 activated kinase 1 knockdown inhibits beta-catenin signalling and blocks colorectal cancer growth.
Author: He, Hong|Huynh, Nhi|Liu, Kevin H|Malcontenti-Wilson, Cathy|Zhu, Jin|Christophi, Christopher|Shulkes, Arthur|Baldwin, Graham S
PMID: 22100495
Journal: Oncogene. 2012 Feb 23;31(8):1001-12.
Title: A Rac1/PAK1 cascade controls beta-catenin activation in colon cancer cells.
Author: Zhu, G|Wang, Y|Huang, B|Liang, J|Ding, Y|Xu, A|Wu, W
PMID: 21822311
Journal: Oncol Rep. 2013 Feb;29(2):605-12.
Title: DADS downregulates the Rac1-ROCK1/PAK1-LIMK1-ADF/cofilin signaling pathway, inhibiting cell migration and invasion.
Author: Zhou, Yujuan|Su, Jian|Shi, Ling|Liao, Qianjin|Su, Qi
PMID: 23233092
Journal: Mol Cancer Res. 2013 Feb;11(2):109-21.
Title: Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling.
Author: Tabusa, Hana|Brooks, Teresa|Massey, Andrew J
PMID: 23233484
Journal: Cell Signal. 2013 Jan;25(1):66-73.
Title: Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells.
Author: Gu, Shuchen|Kounenidakis, Michalis|Schmidt, Eva-Maria|Deshpande, Divija|Alkahtani, Saad|Alarifi, Saud|Foller, Michael|Alevizopoulos, Konstantinos|Lang, Florian|Stournaras, Christos
PMID: 23316499
Journal: Bioorg Med Chem Lett. 2013 Jul 15;23(14):4072-5.
Title: Synthesis and structure-activity relationship of 2-arylamino-4-aryl-pyrimidines as potent PAK1 inhibitors.
Author: Xu, Yong|Foulks, Jason M|Clifford, Adrianne|Brenning, Benjamin|Lai, Shuping|Luo, Bai|Parnell, K Mark|Merx, Shannon|McCullar, Michael V|Kanner, Steven B|Ho, Koc-Kan
PMID: 23756368
Journal: Cancer Lett. 2013 Oct 28;340(1):22-9.
Title: P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1alpha.
Author: Liu, Kevin H|Huynh, Nhi|Patel, Oneel|Shulkes, Arthur|Baldwin, Graham|He, Hong
PMID: 23811286
Journal: J Transl Med. 2013 Nov 27;11:295.
Title: Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity.
Author: Zins, Karin|Gunawardhana, Sandun|Lucas, Trevor|Abraham, Dietmar|Aharinejad, Seyedhossein
PMID: 24279335
Journal: BMC Cancer. 2014 Sep 3;14:650.
Title: Reduced expression of p21-activated protein kinase 1 correlates with poor histological differentiation in pancreatic cancer.
Author: Han, Juan|Wang, Feng|Yuan, Shu-qiang|Guo, Ying|Zeng, Zhao-lei|Li, Li-ren|Yang, Jing|Wang, De-sen|Liu, Mei-yuan|Zhao, Han|Liu, Kai-yan|Liao, Jian-wei|Zou, Qing-feng|Xu, Rui-hua
PMID: 25182632
Journal: Mol Cancer. 2014 Aug 29;13:201.
Title: Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer.
Author: El-Baba, Chirine|Mahadevan, Vijayalakshmi|Fahlbusch, Fabian B|Mohan S, Suma|Rau, Tilman T|Gali-Muhtasib, Hala|Schneider-Stock, Regine
PMID: 25174975
Journal: Physiol Rep. 2014 Jun 24;2(6). pii: e12048.
Title: Demonstration and biological significance of a gastrin-P21-activated kinase 1 feedback loop in colorectal cancer cells.
Author: Huynh, Nhi|Liu, Kevin H|Yim, Mildred|Shulkes, Arthur|Baldwin, Graham S|He, Hong
PMID: 24963032
Journal: BMC Cancer. 2014 Mar 19;14:208.
Title: Increased diacylglycerol kinase zeta expression in human metastatic colon cancer cells augments Rho GTPase activity and contributes to enhanced invasion.
Author: Cai, Kun|Mulatz, Kirk|Ard, Ryan|Nguyen, Thanh|Gee, Stephen H
PMID: 24646293
Journal: BMC Complement Altern Med. 2014 Jul 30;14:275.
Title: Essential oil of Pinus koraiensis inhibits cell proliferation and migration via inhibition of p21-activated kinase 1 pathway in HCT116 colorectal cancer cells.
Author: Cho, Sun-Mi|Lee, Eun-Ok|Kim, Sung-Hoon|Lee, Hyo-Jeong
PMID: 25074784
Journal: Cell Death Differ. 2015 May;22(5):779-89.
Title: Bcl-2 stabilization by paxillin confers 5-fluorouracil resistance in colorectal cancer.
Author: Wu, D-W|Huang, C-C|Chang, S-W|Chen, T-H|Lee, H
PMID: 25323586
Journal: Biochim Biophys Acta. 2015 Jan;1853(1):157-65.
Title: Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1alpha and beta-catenin via a p-21 activated kinase 1-dependent pathway.
Author: Huynh, Nhi|Beutler, John A|Shulkes, Arthur|Baldwin, Graham S|He, Hong
PMID: 25409929
Journal: Inflamm Bowel Dis. 2015 Feb;21(2):287-96.
Title: Overexpression of PAK1 promotes cell survival in inflammatory bowel diseases and colitis-associated cancer.
Author: Khare, Vineeta|Dammann, Kyle|Asboth, Mario|Krnjic, Anita|Jambrich, Manuela|Gasche, Christoph
PMID: 25569743
Journal: Anticancer Res. 2015 Mar;35(3):1513-20.
Title: Expression of immunohistochemical markers of progression in pre-cancerous and cancerous human colon: correlation with serum vitamin D levels.
Author: Juniku-Shkololli, Argjira|Manxhuka-Kerliu, Suzana|Ahmetaj, Halil|Khare, Vineeta|Zekaj, Sadik
PMID: 25750305
Journal: J Surg Res. 2015 Jun 1;196(1):130-5.
Title: P21-activated kinase 1 and 4 were associated with colorectal cancer metastasis and infiltration.
Author: Song, Bao|Wang, Wei|Zheng, Yan|Yang, Jianshu|Xu, Zhongfa
PMID: 25791829
Journal: Am J Pathol. 2015 Apr;185(4):1135-44.
Title: Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells.
Author: Peng, Hui|Li, Tony W H|Yang, Heping|Moyer, Mary P|Mato, Jose M|Lu, Shelly C
PMID: 25794709
Journal: Oncol Rep. 2015 Oct;34(4):1905-14.
Title: Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer.
Author: Gerceker, Emre|Boyacioglu, Seda Orenay|Kasap, Elmas|Baykan, Ahmed|Yuceyar, Hakan|Yildirim, Hatice|Ayhan, Semin|Ellidokuz, Ender|Korkmaz, Mehmet
PMID: 26259750
Journal: Cancer Prev Res (Phila). 2015 Nov;8(11):1093-101.
Title: PAK1 promotes intestinal tumor initiation.
Author: Dammann, Kyle|Khare, Vineeta|Harpain, Felix|Lang, Michaela|Kurtovic, Azra|Mesteri, Ildiko|Evstatiev, Rayko|Gasche, Christoph
PMID: 26304465
Journal: Int J Clin Exp Pathol. 2015 Dec 1;8(12):15895-902. eCollection 2015.
Title: Overexpression of PAK-1 is an independent predictor of disease recurrence in colorectal carcinoma.
Author: Al-Maghrabi, Jaudah|Emam, Eman|Gomaa, Wafaey|Al-Qaydy, Doaa|Al-Maghrabi, Basim|Buhmeida, Abdelbaset|Abuzenadah, Adel|Al-Qahtani, Mohammed|Al-Ahwal, Mahmoud
PMID: 26884861
Journal: Cancer Biol Ther. 2016 Aug 2;17(8):813-23.
Title: Up-regulation of stem cell markers by P21-activated kinase 1 contributes to 5-fluorouracil resistance of colorectal cancer.
Author: Huynh, Nhi|Shulkes, Arthur|Baldwin, Graham|He, Hong
PMID: 27260988
Journal: Autophagy. 2016 Dec;12(12):2498-2499.
Title: Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer.
Author: Wang, Kui|Gao, Wei|Dou, Qianhui|Chen, Haining|Li, Qifu|Nice, Edouard C|Huang, Canhua
PMID: 27657889
Journal: Tumour Biol. 2016 Mar;37(3):3071-80.
Title: The potential role of the NEK6, AURKA, AURKB, and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma.
Author: Kasap, Elmas|Gerceker, Emre|Boyacioglu, Seda Orenay|Yuceyar, Hakan|Yildirm, Hatice|Ayhan, Semin|Korkmaz, Mehmet
PMID: 26423403
Journal: J Virol. 2017 Apr 28;91(10). pii: JVI.02191-16.
Title: Measles Virus Enters Breast and Colon Cancer Cell Lines through a PVRL4-Mediated Macropinocytosis Pathway.
Author: Delpeut, Sebastien|Sisson, Gary|Black, Karen M|Richardson, Christopher D
PMID: 28250131
Journal: Oncotarget. 2017 May 9;8(19):31802-31814.
Title: Invasive Fusobacterium nucleatum activates beta-catenin signaling in colorectal cancer via a TLR4/P-PAK1 cascade.
Author: Chen, Yongyu|Peng, Yan|Yu, Jiahui|Chen, Ting|Wu, Yaxin|Shi, Lei|Li, Qing|Wu, Jiao|Fu, Xiangsheng
PMID: 28423670
Journal: Cell Signal. 2017 Aug;36:67-78.
Title: Identification of NCK1 as a novel downstream effector of STAT3 in colorectal cancer metastasis and angiogenesis.
Author: Zhang, Fan|Lu, Yan-Xia|Chen, Qing|Zou, Hui-Mei|Zhang, Jian-Ming|Hu, Yu-Han|Li, Xiao-Min|Zhang, Wen-Juan|Zhang, Wei|Lin, Chun|Li, Xue-Nong
PMID: 28455144
Journal: BMC Cancer. 2017 Jun 19;17(1):431.
Title: Depletion of p21-activated kinase 1 up-regulates the immune system of APC(14/+) mice and inhibits intestinal tumorigenesis.
Author: Huynh, Nhi|Wang, Kai|Yim, Mildred|Dumesny, Chelsea J|Sandrin, Mauro S|Baldwin, Graham S|Nikfarjam, Mehrdad|He, Hong
PMID: 28629331
Journal: Oncol Rep. 2017 Dec;38(6):3554-3566.
Title: Inhibition of cell migration and invasion by miR29a3p in a colorectal cancer cell line through suppression of CDC42BPA mRNA expression.
Author: He, Pei Yuan|Yip, Wai Kien|Chai, Boon Lee|Chai, Boon Yean|Jabar, Mohd Faisal|Dusa, Noraini|Mohtarrudin, Norhafizah|Seow, Heng Fong
PMID: 29039592
Journal: J Proteome Res. 2018 Jan 5;17(1):265-275.
Title: Comparative Proteomics Analysis Identifies Cdc42-Cdc42BPA Signaling as Prognostic Biomarker and Therapeutic Target for Colon Cancer Invasion.
Author: Hu, Hui-Fang|Xu, Wen Wen|Wang, Yang|Zheng, Can-Can|Zhang, Wei-Xia|Li, Bin|He, Qing-Yu
PMID: 29072916
Journal: Biochim Biophys Acta Mol Cell Res. 2018 Apr;1865(4):650-664.
Title: Protein Kinase C-zeta stimulates colorectal cancer cell carcinogenesis via PKC-zeta/Rac1/Pak1/beta-Catenin signaling cascade.
Author: Islam, S M Anisul|Patel, Rekha|Acevedo-Duncan, Mildred
PMID: 29408512
Journal: Dig Dis Sci. 2018 May;63(5):1210-1218.
Title: Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis in Mice via a Toll-Like Receptor 4/p21-Activated Kinase 1 Cascade.
Author: Wu, Yaxin|Wu, Jiao|Chen, Ting|Li, Qing|Peng, Wei|Li, Huan|Tang, Xiaowei|Fu, Xiangsheng
PMID: 29508166
Journal: Cancer Res. 2018 Aug 15;78(16):4658-4670.
Title: The Canonical Wnt Pathway Drives Macropinocytosis in Cancer.
Author: Redelman-Sidi, Gil|Binyamin, Anna|Gaeta, Isabella|Palm, Wilhelm|Thompson, Craig B|Romesser, Paul B|Lowe, Scott W|Bagul, Mukta|Doench, John G|Root, David E|Glickman, Michael S
PMID: 29871936
Journal: Anticancer Agents Med Chem. 2018 Jun 10. pii: ACAMC-EPUB-91045.
Title: Verbascoside attenuates Rac-1 and HIF-1alpha signaling cascade in colorectal cancer cells.
Author: Nabiuni, Mohammad|Seyfi, Danial|Behzad, Seyed Bahram|Parivar, Kazem|Tahmaseb, Mohammad|Amini, Elaheh
PMID: 29886834
Journal: Nat Commun. 2018 Aug 27;9(1):3473.
Title: Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer.
Author: Chow, H Y|Dong, B|Valencia, C A|Zeng, C T|Koch, J N|Prudnikova, T Y|Chernoff, J
PMID: 30150766