Primary Site >> Colorectal Cancer
Gene >> PAK1
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Ref: Molecular cloning and characterization of WRCH2 on human chromosome 15q15. PMID: 11956592 |
Ref: Pak-1 expression increases with progression of colorectal carcinomas to metastasis. PMID: 15161701 |
Ref: Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion. PMID: 15788770 |
Ref: [Clinicopathological significance of expression and amplification of P21-activated kinase 1 gene in colorectal carcinoma]. PMID: 19296259 Ref: [Effect of p21-activated kinase-1 on the invasiveness of colorectal carcinoma cells in vitro]. PMID: 19620048 |
Ref: LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain. PMID: 20400510 Ref: P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways. PMID: 20595063 Ref: P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910. PMID: 20811717 |
Ref: Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1-PUMA pathway. PMID: 22130069 |
Ref: A Rac1/PAK1 cascade controls beta-catenin activation in colon cancer cells. PMID: 21822311 Ref: P-21 activated kinase 1 knockdown inhibits beta-catenin signalling and blocks colorectal cancer growth. PMID: 22100495 Ref: PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation. PMID: 22252525 Ref: Phosphorylation of beta-catenin at serine 663 regulates its transcriptional activity. PMID: 22369945 Ref: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. PMID: 22685302 Ref: The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes. PMID: 22869096 |
Ref: DADS downregulates the Rac1-ROCK1/PAK1-LIMK1-ADF/cofilin signaling pathway, inhibiting cell migration and invasion. PMID: 23233092 Ref: Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling. PMID: 23233484 Ref: Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells. PMID: 23316499 Ref: Synthesis and structure-activity relationship of 2-arylamino-4-aryl-pyrimidines as potent PAK1 inhibitors. PMID: 23756368 Ref: P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1alpha. PMID: 23811286 Ref: Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity. PMID: 24279335 |
Ref: Increased diacylglycerol kinase zeta expression in human metastatic colon cancer cells augments Rho GTPase activity and contributes to enhanced invasion. PMID: 24646293 Ref: Demonstration and biological significance of a gastrin-P21-activated kinase 1 feedback loop in colorectal cancer cells. PMID: 24963032 Ref: Essential oil of Pinus koraiensis inhibits cell proliferation and migration via inhibition of p21-activated kinase 1 pathway in HCT116 colorectal cancer cells. PMID: 25074784 Ref: Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer. PMID: 25174975 Ref: Reduced expression of p21-activated protein kinase 1 correlates with poor histological differentiation in pancreatic cancer. PMID: 25182632 |
Ref: Bcl-2 stabilization by paxillin confers 5-fluorouracil resistance in colorectal cancer. PMID: 25323586 Ref: Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1alpha and beta-catenin via a p-21 activated kinase 1-dependent pathway. PMID: 25409929 Ref: Overexpression of PAK1 promotes cell survival in inflammatory bowel diseases and colitis-associated cancer. PMID: 25569743 Ref: Expression of immunohistochemical markers of progression in pre-cancerous and cancerous human colon: correlation with serum vitamin D levels. PMID: 25750305 Ref: P21-activated kinase 1 and 4 were associated with colorectal cancer metastasis and infiltration. PMID: 25791829 Ref: Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells. PMID: 25794709 Ref: Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer. PMID: 26259750 Ref: PAK1 promotes intestinal tumor initiation. PMID: 26304465 Ref: Overexpression of PAK-1 is an independent predictor of disease recurrence in colorectal carcinoma. PMID: 26884861 |
Ref: The potential role of the NEK6, AURKA, AURKB, and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma. PMID: 26423403 Ref: Up-regulation of stem cell markers by P21-activated kinase 1 contributes to 5-fluorouracil resistance of colorectal cancer. PMID: 27260988 Ref: Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer. PMID: 27657889 |
Ref: Measles Virus Enters Breast and Colon Cancer Cell Lines through a PVRL4-Mediated Macropinocytosis Pathway. PMID: 28250131 Ref: Invasive Fusobacterium nucleatum activates beta-catenin signaling in colorectal cancer via a TLR4/P-PAK1 cascade. PMID: 28423670 Ref: Identification of NCK1 as a novel downstream effector of STAT3 in colorectal cancer metastasis and angiogenesis. PMID: 28455144 Ref: Depletion of p21-activated kinase 1 up-regulates the immune system of APC(14/+) mice and inhibits intestinal tumorigenesis. PMID: 28629331 Ref: Inhibition of cell migration and invasion by miR29a3p in a colorectal cancer cell line through suppression of CDC42BPA mRNA expression. PMID: 29039592 |
Ref: Comparative Proteomics Analysis Identifies Cdc42-Cdc42BPA Signaling as Prognostic Biomarker and Therapeutic Target for Colon Cancer Invasion. PMID: 29072916 Ref: Protein Kinase C-zeta stimulates colorectal cancer cell carcinogenesis via PKC-zeta/Rac1/Pak1/beta-Catenin signaling cascade. PMID: 29408512 Ref: Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis in Mice via a Toll-Like Receptor 4/p21-Activated Kinase 1 Cascade. PMID: 29508166 Ref: The Canonical Wnt Pathway Drives Macropinocytosis in Cancer. PMID: 29871936 Ref: Verbascoside attenuates Rac-1 and HIF-1alpha signaling cascade in colorectal cancer cells. PMID: 29886834 Ref: Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer. PMID: 30150766 |