Primary Site >> Colorectal Cancer

Gene >> NTRK1

Journal: Proc Natl Acad Sci U S A. 1987 Oct;84(19):6707-11.
Title: Identification and biochemical characterization of p70TRK, product of the human TRK oncogene.
Author: Mitra, G|Martin-Zanca, D|Barbacid, M
PMID: 3477801
Journal: Mol Cell Biol. 1989 Jan;9(1):24-33.
Title: Molecular and biochemical characterization of the human trk proto-oncogene.
Author: Martin-Zanca, D|Oskam, R|Mitra, G|Copeland, T|Barbacid, M
PMID: 2927393
Journal: Oncogene. 1991 Dec;6(12):2237-41.
Title: Mutational analysis of conserved residues in the tyrosine kinase domain of the human trk oncogene.
Author: Mitra, G
PMID: 1837350
Journal: Princess Takamatsu Symp. 1991;22:153-70.
Title: The trk family of oncogenes and neurotrophin receptors.
Author: Lamballe, F|Klein, R|Barbacid, M
PMID: 1844238
Journal: Jpn J Hum Genet. 1997 Jun;42(2):343-51.
Title: Structure and organization of the human TRKA gene encoding a high affinity receptor for nerve growth factor.
Author: Indo, Y|Mardy, S|Tsuruta, M|Karim, M A|Matsuda, I
PMID: 9290260
Journal: Semin Surg Oncol. 1998 Jan-Feb;14(1):3-12.
Title: Molecular changes during the genesis of human gliomas.
Author: Sehgal, A
PMID: 9407626
Journal: Pathol Int. 1998 Feb;48(2):93-101.
Title: Immunohistochemical analysis of TrkA neurotrophin receptor expression in human non-neuronal carcinomas.
Author: Koizumi, H|Morita, M|Mikami, S|Shibayama, E|Uchikoshi, T
PMID: 9589472
Journal: Int J Oncol. 2000 Apr;16(4):757-62.
Title: Ribosomal protein L7a gene is up-regulated but not fused to the tyrosine kinase receptor as chimeric trk oncogene in human colorectal carcinoma.
Author: Wang, Y|Cheong, D|Chan, S|Hooi, S C
PMID: 10717245
Journal: Int J Mol Med. 2002 May;9(5):509-13.
Title: Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors.
Author: Kirikoshi, Hiroyuki|Katoh, Masaru
PMID: 11956658
Journal: Cancer Res. 2003 Apr 1;63(7):1454-7.
Title: High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.
Author: Kimura, Edna T|Nikiforova, Marina N|Zhu, Zhaowen|Knauf, Jeffrey A|Nikiforov, Yuri E|Fagin, James A
PMID: 12670889
Journal: Br J Cancer. 2003 May 19;88(10):1522-6.
Title: Correlation of elevated level of blood midkine with poor prognostic factors of human neuroblastomas.
Author: Ikematsu, S|Nakagawara, A|Nakamura, Y|Sakuma, S|Wakai, K|Muramatsu, T|Kadomatsu, K
PMID: 12771916
Journal: Med Sci (Paris). 2007 Mar;23(3):311-5.
Title: [Netrin-1 and axonal guidance: signaling and asymmetrical translation].
Author: Mehlen, Patrick|Rama, Nicolas
PMID: 17349294
Journal: Oncology. 2010;79(5-6):430-9.
Title: BDNF/TrkB content and interaction with gastrin-releasing peptide receptor blockade in colorectal cancer.
Author: Brunetto de Farias, Caroline|Rosemberg, Denis Broock|Heinen, Tiago Elias|Koehler-Santos, Patricia|Abujamra, Ana Lucia|Kapczinski, Flavio|Brunetto, Algemir Lunardi|Ashton-Prolla, Patricia|Meurer, Luise|Reis Bogo, Mauricio|Damin, Daniel C|Schwartsmann, Gilb
PMID: 21474968
Journal: PLoS One. 2011;6(9):e25097.
Title: Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival.
Author: Akil, Hussein|Perraud, Aurelie|Melin, Carole|Jauberteau, Marie-Odile|Mathonnet, Muriel
PMID: 21966426
Journal: Invest New Drugs. 2012 Apr;30(2):518-23.
Title: Evaluation of a multi-kinase inhibitor KRC-108 as an anti-tumor agent in vitro and in vivo.
Author: Han, Sun-Young|Lee, Chong Ock|Ahn, Sung-Hoon|Lee, Mi-Ok|Kang, So-Young|Cha, Hyuk-Jin|Cho, Sung Yun|Ha, Jae Du|Ryu, Jae Wook|Jung, Heejung|Kim, Hyoung Rae|Koh, Jong Sung|Lee, Jongkook
PMID: 21080208
Journal: Biochem Biophys Res Commun. 2012 Aug 24;425(2):328-32. Epub 2012 Jul 25.
Title: BDNF/TrkB signaling protects HT-29 human colon cancer cells from EGFR inhibition.
Author: de Farias, Caroline Brunetto|Heinen, Tiago Elias|dos Santos, Rafael Pereira|Abujamra, Ana Lucia|Schwartsmann, Gilberto|Roesler, Rafael
PMID: 22842573
Journal: Endocrinology. 2013 Jul;154(7):2446-56.
Title: Differential effects of dehydroepiandrosterone and testosterone in prostate and colon cancer cell apoptosis: the role of nerve growth factor (NGF) receptors.
Author: Anagnostopoulou, Vasileia|Pediaditakis, Iosif|Alkahtani, Saad|Alarifi, Saud A|Schmidt, Eva-Maria|Lang, Florian|Gravanis, Achille|Charalampopoulos, Ioannis|Stournaras, Christos
PMID: 23696568
Journal: PLoS One. 2014 May 6;9(5):e96410.
Title: Brain-derived neurotrophic factor (BDNF)-induced tropomyosin-related kinase B (Trk B) signaling is a potential therapeutic target for peritoneal carcinomatosis arising from colorectal cancer.
Author: Tanaka, Koji|Okugawa, Yoshinaga|Toiyama, Yuji|Inoue, Yasuhiro|Saigusa, Susumu|Kawamura, Mikio|Araki, Toshimitsu|Uchida, Keiichi|Mohri, Yasuhiko|Kusunoki, Masato
PMID: 24801982
Journal: Mol Oncol. 2014 Dec;8(8):1495-507.
Title: The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition.
Author: Ardini, Elena|Bosotti, Roberta|Borgia, Andrea Lombardi|De Ponti, Cristina|Somaschini, Alessio|Cammarota, Rosaria|Amboldi, Nadia|Raddrizzani, Laura|Milani, Andrea|Magnaghi, Paola|Ballinari, Dario|Casero, Daniele|Gasparri, Fabio|Banfi, Patrizia|Avanzi, Nill
PMID: 24962792
Journal: Mol Clin Oncol. 2014 Sep;2(5):725-730.
Title: Investigation of neurotrophic tyrosine kinase receptor 1 fusions and neurotrophic tyrosine kinase receptor family expression in non-small-cell lung cancer and sensitivity to AZD7451 in vitro.
Author: Tatematsu, Tsutomu|Sasaki, Hidefumi|Shimizu, Shigeki|Okuda, Katsuhiro|Shitara, Masayuki|Hikosaka, Yu|Moriyama, Satoru|Yano, Motoki|Brown, Jeffrey|Fujii, Yoshitaka
PMID: 25054037
Journal: Br J Cancer. 2015 Dec 22;113(12):1730-4.
Title: Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer.
Author: Amatu, Alessio|Somaschini, Alessio|Cerea, Giulio|Bosotti, Roberta|Valtorta, Emanuele|Buonandi, Pasquale|Marrapese, Giovanna|Veronese, Silvio|Luo, David|Hornby, Zachary|Multani, Pratik|Murphy, Danielle|Shoemaker, Robert|Lauricella, Calogero|Giannetta, Laur
PMID: 26633560
Journal: Oncotarget. 2015 Nov 17;6(36):39028-35.
Title: NTRK1 rearrangement in colorectal cancer patients: evidence for actionable target using patient-derived tumor cell line.
Author: Lee, Su Jin|Li, Gang Gary|Kim, Seung Tae|Hong, Min Eui|Jang, Jiryeon|Yoon, Nara|Ahn, Soo Min|Murphy, Danielle|Christiansen, Jason|Wei, Ge|Hornby, Zachary|Lee, Dong Woo|Park, Joon Oh|Park, Young Suk|Lim, Ho Yeong|Hong, Sung No|Kim, Seok-Hyeong|Kang, Won Ki
PMID: 26472021
Journal: Cancer Lett. 2015 Aug 28;365(1):107-11.
Title: Chromosomal rearrangements involving the NTRK1 gene in colorectal carcinoma.
Author: Creancier, Laurent|Vandenberghe, Isabelle|Gomes, Bruno|Dejean, Caroline|Blanchet, Jean-Christophe|Meilleroux, Julie|Guimbaud, Rosine|Selves, Janick|Kruczynski, Anna
PMID: 26001971
Journal: Nat Commun. 2015 Apr 30;6:7002.
Title: The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Author: Medico, Enzo|Russo, Mariangela|Picco, Gabriele|Cancelliere, Carlotta|Valtorta, Emanuele|Corti, Giorgio|Buscarino, Michela|Isella, Claudio|Lamba, Simona|Martinoglio, Barbara|Veronese, Silvio|Siena, Salvatore|Sartore-Bianchi, Andrea|Beccuti, Marco|Mottolese
PMID: 25926053
Journal: Expert Opin Investig Drugs. 2015;24(11):1493-500.
Title: Entrectinib: a potent new TRK, ROS1, and ALK inhibitor.
Author: Rolfo, Christian|Ruiz, Rossana|Giovannetti, Elisa|Gil-Bazo, Ignacio|Russo, Antonio|Passiglia, Francesco|Giallombardo, Marco|Peeters, Marc|Raez, Luis
PMID: 26457764
Journal: Cancer Discov. 2016 Jan;6(1):36-44.
Title: Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer.
Author: Russo, Mariangela|Misale, Sandra|Wei, Ge|Siravegna, Giulia|Crisafulli, Giovanni|Lazzari, Luca|Corti, Giorgio|Rospo, Giuseppe|Novara, Luca|Mussolin, Benedetta|Bartolini, Alice|Cam, Nicholas|Patel, Roopal|Yan, Shunqi|Shoemaker, Robert|Wild, Robert|Di Nicola
PMID: 26546295
Journal: J Natl Cancer Inst. 2015 Nov 12;108(1). pii: djv306.
Title: Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer.
Author: Sartore-Bianchi, Andrea|Ardini, Elena|Bosotti, Roberta|Amatu, Alessio|Valtorta, Emanuele|Somaschini, Alessio|Raddrizzani, Laura|Palmeri, Laura|Banfi, Patrizia|Bonazzina, Erica|Misale, Sandra|Marrapese, Giovanna|Leone, Antonella|Alzani, Rachele|Luo, David|
PMID: 26563355
Journal: Oncotarget. 2016 Feb 16;7(7):8399-412.
Title: NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer.
Author: Park, Do Youn|Choi, Chan|Shin, Eunji|Lee, Jae Hyuk|Kwon, Chae Hwa|Jo, Hong-Jae|Kim, Hyeong-Rok|Kim, Hyun Sung|Oh, Nahmgun|Lee, Ji Shin|Park, Ok Ku|Park, Eok|Park, Jonghoon|Shin, Jong-Yeon|Kim, Jong-Il|Seo, Jeong-Sun|Park, Hee Dong|Park, Joonghoon
PMID: 26716414
Journal: Mol Cancer Ther. 2016 Apr;15(4):628-39.
Title: Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications.
Author: Ardini, Elena|Menichincheri, Maria|Banfi, Patrizia|Bosotti, Roberta|De Ponti, Cristina|Pulci, Romana|Ballinari, Dario|Ciomei, Marina|Texido, Gemma|Degrassi, Anna|Avanzi, Nilla|Amboldi, Nadia|Saccardo, Maria Beatrice|Casero, Daniele|Orsini, Paolo|Bandiera,
PMID: 26939704
Journal: Biochim Biophys Acta. 2016 Aug;1866(1):37-50.
Title: Nerve growth factor & TrkA as novel therapeutic targets in cancer.
Author: Demir, Ihsan Ekin|Tieftrunk, Elke|Schorn, Stephan|Friess, Helmut|Ceyhan, Guralp O
PMID: 27264679
Journal: ChemMedChem. 2016 Aug 5;11(15):1587-95.
Title: Discovery of a Nanomolar Multikinase Inhibitor (KST016366): A New Benzothiazole Derivative with Remarkable Broad-Spectrum Antiproliferative Activity.
Author: El-Damasy, Ashraf Kareem|Cho, Nam-Chul|Nam, Ghilsoo|Pae, Ae Nim|Keum, Gyochang
PMID: 27405013
Journal: Tumori. 2016 Dec 1;102(6):541-547.
Title: How the lab is changing our view of colorectal cancer.
Author: Cremolini, Chiara|Pietrantonio, Filippo
PMID: 27647226
Journal: Rom J Morphol Embryol. 2016;57(2 Suppl):639-650.
Title: Neuro-neoplastic interrelationships in colorectal level - immunohistochemical aspect in three cases and review of the literature.
Author: Florescu, Cristina|Istratoaie, Octavian|Tartea, Georgica Costinel|Pirici, Daniel|Streba, Costin Teodor|Catalin, Bogdan|Puiu, Ileana|Tartea, Elena Anca|Caragea, Daniel Cosmin|Ghilusi, Mirela Corina|Comanescu, Maria Victoria|Rogoveanu, Ion|Vere, Cristin Con
PMID: 27833955
Journal: Cancer Discov. 2017 Apr;7(4):400-409.
Title: Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1).
Author: Drilon, Alexander|Siena, Salvatore|Ou, Sai-Hong Ignatius|Patel, Manish|Ahn, Myung Ju|Lee, Jeeyun|Bauer, Todd M|Farago, Anna F|Wheler, Jennifer J|Liu, Stephen V|Doebele, Robert|Giannetta, Laura|Cerea, Giulio|Marrapese, Giovanna|Schirru, Michele|Amatu, Ales
PMID: 28183697
Journal: J Natl Cancer Inst. 2017 Dec 1;109(12). pii: 3860155.
Title: ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer.
Author: Pietrantonio, Filippo|Di Nicolantonio, Federica|Schrock, Alexa B|Lee, Jeeyun|Tejpar, Sabine|Sartore-Bianchi, Andrea|Hechtman, Jaclyn F|Christiansen, Jason|Novara, Luca|Tebbutt, Niall|Fuca, Giovanni|Antoniotti, Carlotta|Kim, Seung Tae|Murphy, Danielle|Bere
PMID: 29370427
Journal: Cancer Med. 2017 Dec;6(12):2972-2983.
Title: In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy of targeted drugs.
Author: Kita, Kenji|Arai, Sachiko|Nishiyama, Akihiro|Taniguchi, Hirokazu|Fukuda, Koji|Wang, Rong|Yamada, Tadaaki|Takeuchi, Shinji|Tange, Shoichiro|Tajima, Atsushi|Nakada, Mitsutoshi|Yasumoto, Kazuo|Motoo, Yoshiharu|Murakami, Takashi|Yano, Seiji
PMID: 29125233
Journal: Oncotarget. 2017 Jul 24;8(33):55353-55360.
Title: Identification and characterization of a novel SCYL3-NTRK1 rearrangement in a colorectal cancer patient.
Author: Milione, Massimo|Ardini, Elena|Christiansen, Jason|Valtorta, Emanuele|Veronese, Silvio|Bosotti, Roberta|Pellegrinelli, Alessio|Testi, Adele|Pietrantonio, Filippo|Fuca, Giovanni|Wei, Ge|Murphy, Danielle|Siena, Salvatore|Isacchi, Antonella|De Braud, Filippo
PMID: 28903424
Journal: Mol Cancer Ther. 2017 Oct;16(10):2130-2143.
Title: Mechanisms of Resistance to NTRK Inhibitors and Therapeutic Strategies in NTRK1-Rearranged Cancers.
Author: Fuse, Miho J|Okada, Koutaroh|Oh-Hara, Tomoko|Ogura, Hayato|Fujita, Naoya|Katayama, Ryohei
PMID: 28751539
Journal: Am J Surg Pathol. 2017 Nov;41(11):1547-1551.
Title: Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions.
Author: Hechtman, Jaclyn F|Benayed, Ryma|Hyman, David M|Drilon, Alexander|Zehir, Ahmet|Frosina, Denise|Arcila, Maria E|Dogan, Snjezana|Klimstra, David S|Ladanyi, Marc|Jungbluth, Achim A
PMID: 28719467
Journal: Oncotarget. 2017 Jun 20;8(25):39945-39962.
Title: BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations.
Author: Deihimi, Safoora|Lev, Avital|Slifker, Michael|Shagisultanova, Elena|Xu, Qifang|Jung, Kyungsuk|Vijayvergia, Namrata|Ross, Eric A|Xiu, Joanne|Swensen, Jeffrey|Gatalica, Zoran|Andrake, Mark|Dunbrack, Roland L|El-Deiry, Wafik S
PMID: 28591715
Journal: J Photochem Photobiol B. 2017 May;170:271-285.
Title: DNA interaction, antimicrobial, anticancer activities and molecular docking study of some new VO(II), Cr(III), Mn(II) and Ni(II) mononuclear chelates encompassing quaridentate imine ligand.
Author: Abdel-Rahman, Laila H|Abu-Dief, Ahmed M|Aboelez, Moustafa O|Hassan Abdel-Mawgoud, Azza A
PMID: 28456118
Journal: Pharmacol Ther. 2017 May;173:58-66.
Title: Targeting TRK family proteins in cancer.
Author: Khotskaya, Yekaterina B|Holla, Vijaykumar R|Farago, Anna F|Mills Shaw, Kenna R|Meric-Bernstam, Funda|Hong, David S
PMID: 28174090
Journal: Cancer. 2017 Apr 1;123(7):1134-1143.
Title: Clinical and genetic determinants of ovarian metastases from colorectal cancer.
Author: Ganesh, Karuna|Shah, Ronak H|Vakiani, Efsevia|Nash, Garrett M|Skottowe, Hugh P|Yaeger, Rona|Cercek, Andrea|Lincoln, Anne|Tran, Christina|Segal, Neil H|Reidy, Diane L|Varghese, Anna|Epstein, Andrew S|Sonoda, Yukio|Chi, Dennis|Guillem, Jose|Temple, Larissa|
PMID: 27875625
Journal: Anal Biochem. 2018 Mar 15;545:78-83.
Title: A novel in-cell ELISA method for screening of compounds inhibiting TRKA phosphorylation, using KM12cell line harboring TRKA rearrangement.
Author: Pandre, Manoj Kumar|Shaik, Shama|Satya Pratap, Veera Venkata Valluri|Yadlapalli, Prasad|Yanamandra, Mahesh|Mitra, Sayan
PMID: 29360440
Journal: Clin Cancer Res. 2018 May 15;24(10):2357-2369.
Title: Foretinib Overcomes Entrectinib Resistance Associated with the NTRK1 G667C Mutation in NTRK1 Fusion-Positive Tumor Cells in a Brain Metastasis Model.
Author: Nishiyama, Akihiro|Yamada, Tadaaki|Kita, Kenji|Wang, Rong|Arai, Sachiko|Fukuda, Koji|Tanimoto, Azusa|Takeuchi, Shinji|Tange, Shoichiro|Tajima, Atsushi|Furuya, Noritaka|Kinoshita, Takayoshi|Yano, Seiji
PMID: 29463555
Journal: Transl Oncol. 2018 Jun;11(3):764-770.
Title: Cytoplasmic TrkA Expression as a Screen for Detecting NTRK1 Fusions in Colorectal Cancer.
Author: Choi, Yuri|Won, Yeo-Jin|Lee, Sojeong|Kim, Ahrong|Kim, Younggeum|Park, Won-Young|Jo, Hong-Jae|Song, Geun Am|Kwon, Chae Hwa|Park, Do Youn
PMID: 29689458
Journal: Curr Treat Options Oncol. 2018 May 11;19(6):29.
Title: Promising New Agents for Colorectal Cancer.
Author: Das, Satya|Ciombor, Kristen K|Haraldsdottir, Sigurdis|Goldberg, Richard M
PMID: 29752549
Journal: J Clin Pathol. 2018 Oct;71(10):926-931.
Title: TRKA expression and NTRK1 gene copy number across solid tumours.
Author: Mauri, Gianluca|Valtorta, Emanuele|Cerea, Giulio|Amatu, Alessio|Schirru, Michele|Marrapese, Giovanna|Fiorillo, Vincenzo|Recchimuzzo, Patrizia|Cavenago, Ivana Stella|Bonazzina, Erica Francesca|Motta, Valentina|Lauricella, Calogero|Veronese, Silvio|Tosi, Fe
PMID: 29802225