Primary Site >> Colorectal Cancer
Gene >> NTRK1
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Ref: Identification and biochemical characterization of p70TRK, product of the human TRK oncogene. PMID: 3477801 |
Ref: Molecular and biochemical characterization of the human trk proto-oncogene. PMID: 2927393 |
Ref: Mutational analysis of conserved residues in the tyrosine kinase domain of the human trk oncogene. PMID: 1837350 Ref: The trk family of oncogenes and neurotrophin receptors. PMID: 1844238 |
Ref: Structure and organization of the human TRKA gene encoding a high affinity receptor for nerve growth factor. PMID: 9290260 |
Ref: Molecular changes during the genesis of human gliomas. PMID: 9407626 Ref: Immunohistochemical analysis of TrkA neurotrophin receptor expression in human non-neuronal carcinomas. PMID: 9589472 |
Ref: Ribosomal protein L7a gene is up-regulated but not fused to the tyrosine kinase receptor as chimeric trk oncogene in human colorectal carcinoma. PMID: 10717245 |
Ref: Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors. PMID: 11956658 |
Ref: High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. PMID: 12670889 Ref: Correlation of elevated level of blood midkine with poor prognostic factors of human neuroblastomas. PMID: 12771916 |
Ref: [Netrin-1 and axonal guidance: signaling and asymmetrical translation]. PMID: 17349294 |
Ref: BDNF/TrkB content and interaction with gastrin-releasing peptide receptor blockade in colorectal cancer. PMID: 21474968 |
Ref: Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival. PMID: 21966426 |
Ref: Evaluation of a multi-kinase inhibitor KRC-108 as an anti-tumor agent in vitro and in vivo. PMID: 21080208 Ref: BDNF/TrkB signaling protects HT-29 human colon cancer cells from EGFR inhibition. PMID: 22842573 |
Ref: Differential effects of dehydroepiandrosterone and testosterone in prostate and colon cancer cell apoptosis: the role of nerve growth factor (NGF) receptors. PMID: 23696568 |
Ref: Brain-derived neurotrophic factor (BDNF)-induced tropomyosin-related kinase B (Trk B) signaling is a potential therapeutic target for peritoneal carcinomatosis arising from colorectal cancer. PMID: 24801982 Ref: The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition. PMID: 24962792 Ref: Investigation of neurotrophic tyrosine kinase receptor 1 fusions and neurotrophic tyrosine kinase receptor family expression in non-small-cell lung cancer and sensitivity to AZD7451 in vitro. PMID: 25054037 |
Ref: The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets. PMID: 25926053 Ref: Chromosomal rearrangements involving the NTRK1 gene in colorectal carcinoma. PMID: 26001971 Ref: Entrectinib: a potent new TRK, ROS1, and ALK inhibitor. PMID: 26457764 Ref: NTRK1 rearrangement in colorectal cancer patients: evidence for actionable target using patient-derived tumor cell line. PMID: 26472021 Ref: Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer. PMID: 26633560 |
Ref: Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer. PMID: 26546295 Ref: Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer. PMID: 26563355 Ref: NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer. PMID: 26716414 Ref: Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications. PMID: 26939704 Ref: Nerve growth factor & TrkA as novel therapeutic targets in cancer. PMID: 27264679 Ref: Discovery of a Nanomolar Multikinase Inhibitor (KST016366): A New Benzothiazole Derivative with Remarkable Broad-Spectrum Antiproliferative Activity. PMID: 27405013 Ref: How the lab is changing our view of colorectal cancer. PMID: 27647226 Ref: Neuro-neoplastic interrelationships in colorectal level - immunohistochemical aspect in three cases and review of the literature. PMID: 27833955 |
Ref: Clinical and genetic determinants of ovarian metastases from colorectal cancer. PMID: 27875625 Ref: Targeting TRK family proteins in cancer. PMID: 28174090 Ref: Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1). PMID: 28183697 Ref: DNA interaction, antimicrobial, anticancer activities and molecular docking study of some new VO(II), Cr(III), Mn(II) and Ni(II) mononuclear chelates encompassing quaridentate imine ligand. PMID: 28456118 Ref: BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations. PMID: 28591715 Ref: Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions. PMID: 28719467 Ref: Mechanisms of Resistance to NTRK Inhibitors and Therapeutic Strategies in NTRK1-Rearranged Cancers. PMID: 28751539 Ref: Identification and characterization of a novel SCYL3-NTRK1 rearrangement in a colorectal cancer patient. PMID: 28903424 Ref: In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy of targeted drugs. PMID: 29125233 Ref: ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer. PMID: 29370427 |
Ref: A novel in-cell ELISA method for screening of compounds inhibiting TRKA phosphorylation, using KM12cell line harboring TRKA rearrangement. PMID: 29360440 Ref: Foretinib Overcomes Entrectinib Resistance Associated with the NTRK1 G667C Mutation in NTRK1 Fusion-Positive Tumor Cells in a Brain Metastasis Model. PMID: 29463555 Ref: Cytoplasmic TrkA Expression as a Screen for Detecting NTRK1 Fusions in Colorectal Cancer. PMID: 29689458 Ref: Promising New Agents for Colorectal Cancer. PMID: 29752549 Ref: TRKA expression and NTRK1 gene copy number across solid tumours. PMID: 29802225 |