Literatures

Primary Site >> Liver Cancer

Gene >> NR1I3

1.
Journal:	Toxicol Sci. 2002 Mar;66(1):54-61.
Title:	Nonadditive hepatic tumor promoting effects by a mixture of two structurally different polychlorinated biphenyls in female rat livers.
Author:	Dean, C E Jr\|Benjamin, S A\|Chubb, L S\|Tessari, J D\|Keefe, T J
PMID:	11861972

2.
Journal:	Cancer Genet Cytogenet. 2003 Sep;145(2):152-60.
Title:	Transcriptional profiling in hepatoblastomas using high-density oligonucleotide DNA array.
Author:	Nagata, Toshihito\|Takahashi, Yasuo\|Ishii, Yukimoto\|Asai, Satoshi\|Nishida, Yayoi\|Murata, Akiko\|Koshinaga, Tsugumichi\|Fukuzawa, Masahiro\|Hamazaki, Minoru\|Asami, Keiko\|Ito, Etsuro\|Ikeda, Hitoshi\|Takamatsu, Hideo\|Koike, Kenichi\|Kikuta, Atsushi\|Kuroiwa, Minoru
PMID:	12935928

3.
Journal:	Cancer Res. 2004 Oct 15;64(20):7197-200.
Title:	The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice.
Author:	Yamamoto, Yukio\|Moore, Rick\|Goldsworthy, Thomas L\|Negishi, Masahiko\|Maronpot, Robert R
PMID:	15492232

4.
Journal:	Toxicol Sci. 2007 Mar;96(1):72-82.
Title:	Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis.
Author:	Phillips, Jennifer M\|Yamamoto, Yukio\|Negishi, Masahiko\|Maronpot, Robert R\|Goodman, Jay I
PMID:	17172636

5.
Journal:	Hepatology. 2007 May;45(5):1146-53.
Title:	Differential regulation of constitutive androstane receptor expression by hepatocyte nuclear factor4alpha isoforms.
Author:	Pascussi, Jean Marc\|Robert, Agnes\|Moreau, Amelie\|Ramos, Jeanne\|Bioulac-Sage, Paulette\|Navarro, Francis\|Blanc, Pierre\|Assenat, Eric\|Maurel, Patrick\|Vilarem, Marie Jose
PMID:	17464991

6.
Journal:	Arch Biochem Biophys. 2007 Nov 1;467(1):132-8.
Title:	Regulation of the human cathepsin E gene by the constitutive androstane receptor.
Author:	Page, Jeanine L\|Strom, Stephen C\|Omiecinski, Curtis J
PMID:	17888866

7.
Journal:	Toxicol Sci. 2009 Apr;108(2):273-89.
Title:	Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors.
Author:	Phillips, Jennifer M\|Goodman, Jay I
PMID:	19233941

8.
Journal:	Toxicol Sci. 2009 Aug;110(2):319-33.
Title:	The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors.
Author:	Phillips, Jennifer M\|Burgoon, Lyle D\|Goodman, Jay I
PMID:	19482888

9.
Journal:	J Biol Chem. 2009 Dec 11;284(50):34785-92.
Title:	Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3).
Author:	Mutoh, Shingo\|Osabe, Makoto\|Inoue, Kaoru\|Moore, Rick\|Pedersen, Lee\|Perera, Lalith\|Rebolloso, Yvette\|Sueyoshi, Tatsuya\|Negishi, Masahiko
PMID:	19858220

10.
Journal:	PLoS One. 2010 Apr 12;5(4):e10121.
Title:	Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B.
Author:	Yamamoto, Yukio\|Moore, Rick\|Flavell, Richard A\|Lu, Binfeng\|Negishi, Masahiko
PMID:	20404936

11.
Journal:	Life Sci. 2010 Sep 25;87(13-14):439-44.
Title:	The increased CAR-dependent metabolism of thyroid hormones in mice with high cancer susceptibility.
Author:	Pakharukova, Maria\|Smetanina, Mariya\|Kaledin, Vasily\|Obut, Timofey\|Merkulova, Tatiana
PMID:	20816995

12.
Journal:	PLoS One. 2011 Feb 14;6(2):e14584.
Title:	Using nuclear receptor activity to stratify hepatocarcinogens.
Author:	Shah, Imran\|Houck, Keith\|Judson, Richard S\|Kavlock, Robert J\|Martin, Matthew T\|Reif, David M\|Wambaugh, John\|Dix, David J
PMID:	21339822

13.
Journal:	Lab Invest. 2011 Nov;91(11):1624-33.
Title:	Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver.
Author:	Yamazaki, Yuichi\|Moore, Rick\|Negishi, Masahiko
PMID:	21826054

14.
Journal:	Arch Toxicol. 2011 Nov;85(11):1475-84.
Title:	Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats.
Author:	Morita, Reiko\|Shimamoto, Keisuke\|Ishii, Yuji\|Kuwata, Kazunori\|Ogawa, Bun-ichiro\|Imaoka, Masako\|Hayashi, Shim-mo\|Suzuki, Kazuhiko\|Shibutani, Makoto\|Mitsumori, Kunitoshi
PMID:	21445586

15.
Journal:	Cancer Res. 2011 Apr 1;71(7):2529-40.
Title:	Helicobacter hepaticus--induced liver tumor promotion is associated with increased serum bile acid and a persistent microbial-induced immune response.
Author:	Garcia, Alexis\|Zeng, Yu\|Muthupalani, Sureshkumar\|Ge, Zhongming\|Potter, Amanda\|Mobley, Melissa W\|Boussahmain, Chakib\|Feng, Yan\|Wishnok, John S\|Fox, James G
PMID:	21335546

16.
Journal:	Carcinogenesis. 2011 Apr;32(4):576-83.
Title:	Constitutive active/androstane receptor promotes hepatocarcinogenesis in a mouse model of non-alcoholic steatohepatitis.
Author:	Takizawa, Daichi\|Kakizaki, Satoru\|Horiguchi, Norio\|Yamazaki, Yuichi\|Tojima, Hiroki\|Mori, Masatomo
PMID:	21173431

17.
Journal:	Mol Carcinog. 2012 Feb;51(2):206-12.
Title:	The nuclear receptor constitutive active/androstane receptor arrests DNA-damaged human hepatocellular carcinoma Huh7 cells at the G2/M phase.
Author:	Kamino, Hiroki\|Negishi, Masahiko
PMID:	21557330

18.
Journal:	J Toxicol Sci. 2012;37(2):297-306.
Title:	Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action.
Author:	Hojo, Yuri\|Shiraki, Ayako\|Tsuchiya, Takuma\|Shimamoto, Keisuke\|Ishii, Yuji\|Suzuki, Kazuhiko\|Shibutani, Makoto\|Mitsumori, Kunitoshi
PMID:	22467020

19.
Journal:	Pharmacol Rep. 2012;64(4):927-39.
Title:	Expression of genes involved in xenobiotic metabolism and transport in end-stage liver disease: up-regulation of ABCC4 and CYP1B1.
Author:	Kurzawski, Mateusz\|Dziedziejko, Violetta\|Post, Mariola\|Wojcicki, Maciej\|Urasinska, Elzbieta\|Mietkiewski, Janusz\|Drozdzik, Marek
PMID:	23087145

20.
Journal:	Crit Rev Toxicol. 2014 Jan;44(1):64-82.
Title:	Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator.
Author:	Elcombe, Clifford R\|Peffer, Richard C\|Wolf, Douglas C\|Bailey, Jason\|Bars, Remi\|Bell, David\|Cattley, Russell C\|Ferguson, Stephen S\|Geter, David\|Goetz, Amber\|Goodman, Jay I\|Hester, Susan\|Jacobs, Abigail\|Omiecinski, Curtis J\|Schoeny, Rita\|Xie, Wen\|Lake, Bria
PMID:	24180433

21.
Journal:	Toxicol Sci. 2014 Apr;138(2):425-45.
Title:	Dose-response modeling of early molecular and cellular key events in the CAR-mediated hepatocarcinogenesis pathway.
Author:	Geter, David R\|Bhat, Virunya S\|Gollapudi, B Bhaskar\|Sura, Radhakrishna\|Hester, Susan D
PMID:	24449422

22.
Journal:	Toxicol Sci. 2014 Aug 1;140(2):259-70.
Title:	Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR.
Author:	Braeuning, Albert\|Gavrilov, Alina\|Brown, Susan\|Wolf, C Roland\|Henderson, Colin J\|Schwarz, Michael
PMID:	24863967

23.
Journal:	Toxicol Sci. 2014 Nov;142(1):137-57.
Title:	Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver.
Author:	Yamada, Tomoya\|Okuda, Yu\|Kushida, Masahiko\|Sumida, Kayo\|Takeuchi, Hayato\|Nagahori, Hirohisa\|Fukuda, Takako\|Lake, Brian G\|Cohen, Samuel M\|Kawamura, Satoshi
PMID:	25145657

24.
Journal:	Regul Toxicol Pharmacol. 2014 Dec;70(3):648-58.
Title:	Liver tumor formation in female rat induced by fluopyram is mediated by CAR/PXR nuclear receptor activation.
Author:	Tinwell, H\|Rouquie, D\|Schorsch, F\|Geter, D\|Wason, S\|Bars, R
PMID:	25305127

25.
Journal:	Toxicol Appl Pharmacol. 2015 Oct 1;288(1):26-32.
Title:	Xenosensor CAR mediates down-regulation of miR-122 and up-regulation of miR-122 targets in the liver.
Author:	Kazantseva, Yuliya A\|Yarushkin, Andrei A\|Mostovich, Lyudmila A\|Pustylnyak, Yuliya A\|Pustylnyak, Vladimir O
PMID:	26171734

26.
Journal:	Toxicol Sci. 2015 Oct;147(2):549-61.
Title:	Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors.
Author:	Wang, Zemin\|Neal, Barbara H\|Lamb, James C\|Klaunig, James E
PMID:	26187448

27.
Journal:	Arch Toxicol. 2015 Jul;89(7):1045-55.
Title:	Regulation of gene expression by CAR: an update.
Author:	Kobayashi, Kaoru\|Hashimoto, Mari\|Honkakoski, Paavo\|Negishi, Masahiko
PMID:	25975989

28.
Journal:	Food Chem Toxicol. 2015 Apr;78:86-95.
Title:	Involvement of constitutive androstane receptor in liver hypertrophy and liver tumor development induced by triazole fungicides.
Author:	Tamura, Kei\|Inoue, Kaoru\|Takahashi, Miwa\|Matsuo, Saori\|Irie, Kaoru\|Kodama, Yukio\|Gamo, Toshie\|Ozawa, Shogo\|Yoshida, Midori
PMID:	25656644

29.
Journal:	Pest Manag Sci. 2015 Jun;71(6):829-34.
Title:	Mode of action analysis for pesticide-induced rodent liver tumours involving activation of the constitutive androstane receptor: relevance to human cancer risk.
Author:	Lake, Brian G\|Price, Roger J\|Osimitz, Thomas G
PMID:	25045103

30.
Journal:	Nat Commun. 2015 Feb 9;6:5944.
Title:	Activating CAR and beta-catenin induces uncontrolled liver growth and tumorigenesis.
Author:	Dong, Bingning\|Lee, Ju-Seog\|Park, Yun-Yong\|Yang, Feng\|Xu, Ganyu\|Huang, Wendong\|Finegold, Milton J\|Moore, David D
PMID:	25661872

31.
Journal:	Biochim Biophys Acta. 2016 Sep;1859(9):1228-1237.
Title:	Bioinformatic analysis of microRNA networks following the activation of the constitutive androstane receptor (CAR) in mouse liver.
Author:	Hao, Ruixin\|Su, Shengzhong\|Wan, Yinan\|Shen, Frank\|Niu, Ben\|Coslo, Denise M\|Albert, Istvan\|Han, Xing\|Omiecinski, Curtis J
PMID:	27080131

32.
Journal:	Cancer Cell. 2016 Dec 12;30(6):909-924.
Title:	Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis.
Author:	Kettner, Nicole M\|Voicu, Horatio\|Finegold, Milton J\|Coarfa, Cristian\|Sreekumar, Arun\|Putluri, Nagireddy\|Katchy, Chinenye A\|Lee, Choogon\|Moore, David D\|Fu, Loning
PMID:	27889186

33.
Journal:	J Toxicol Sci. 2016;41(6):801-811.
Title:	A crucial role of constitutive androstane receptor (CAR) in liver tumor development by imazalil in mice.
Author:	Tamura, Kei\|Inoue, Kaoru\|Takahashi, Miwa\|Matsuo, Saori\|Kodama, Yukio\|Yoshida, Midori
PMID:	27853109

34.
Journal:	Regul Toxicol Pharmacol. 2016 Nov;81:421-429.
Title:	Methyl isobutyl ketone-induced hepatocellular carcinogenesis in B6C3F1 mice: A constitutive androstane receptor (CAR)-mediated mode of action.
Author:	Hughes, B J\|Thomas, J\|Lynch, A M\|Borghoff, S J\|Green, S\|Mensing, T\|Sarang, S S\|LeBaron, M J
PMID:	27664318

35.
Journal:	Toxicol In Vitro. 2016 Oct;36:224-237.
Title:	Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation.
Author:	Soldatow, Valerie\|Peffer, Richard C\|Trask, O Joseph\|Cowie, David E\|Andersen, Melvin E\|LeCluyse, Edward\|Deisenroth, Chad
PMID:	27530964

36.
Journal:	Drug Metab Dispos. 2016 Oct;44(10):1643-52.
Title:	Methylation of the Constitutive Androstane Receptor Is Involved in the Suppression of CYP2C19 in Hepatitis B Virus-Associated Hepatocellular Carcinoma.
Author:	Tang, Xiaojing\|Ge, Lele\|Chen, Zhongjian\|Kong, Sisi\|Liu, Wenhui\|Xu, Yingchun\|Zeng, Su\|Chen, Shuqing
PMID:	27440862

37.
Journal:	Toxicol Res. 2016 Jan;32(1):21-33.
Title:	Toxicity and Carcinogenicity of Dichlorodiphenyltrichloroethane (DDT).
Author:	Harada, Takanori\|Takeda, Makio\|Kojima, Sayuri\|Tomiyama, Naruto
PMID:	26977256

38.
Journal:	Biochim Biophys Acta. 2016 Sep;1859(9):1083-1099.
Title:	Nuclear receptors and nonalcoholic fatty liver disease.
Author:	Cave, Matthew C\|Clair, Heather B\|Hardesty, Josiah E\|Falkner, K Cameron\|Feng, Wenke\|Clark, Barbara J\|Sidey, Jennifer\|Shi, Hongxue\|Aqel, Bashar A\|McClain, Craig J\|Prough, Russell A
PMID:	26962021

39.
Journal:	Toxicol Sci. 2016 Jun;151(2):271-85.
Title:	Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development.
Author:	Kuwata, Kazunori\|Inoue, Kaoru\|Ichimura, Ryohei\|Takahashi, Miwa\|Kodama, Yukio\|Shibutani, Makoto\|Yoshida, Midori
PMID:	26928356

40.
Journal:	Mol Genet Genomics. 2016 Jun;291(3):1035-51.
Title:	Identification of important long non-coding RNAs and highly recurrent aberrant alternative splicing events in hepatocellular carcinoma through integrative analysis of multiple RNA-Seq datasets.
Author:	Zhang, Lu\|Liu, Xiaoqiao\|Zhang, Xuegong\|Chen, Ronghua
PMID:	26711644

41.
Journal:	Food Chem Toxicol. 2016 Feb;88:75-86.
Title:	Constitutive active/androstane receptor, peroxisome proliferator-activated receptor alpha, and cytotoxicity are involved in oxadiazon-induced liver tumor development in mice.
Author:	Kuwata, Kazunori\|Inoue, Kaoru\|Ichimura, Ryohei\|Takahashi, Miwa\|Kodama, Yukio\|Yoshida, Midori
PMID:	26710982

42.
Journal:	Regul Toxicol Pharmacol. 2017 Jun;86:137-147.
Title:	Investigation of the mechanism of triclosan induced mouse liver tumors.
Author:	Wang, Zemin\|Li, Xilin\|Klaunig, James E
PMID:	28267557

43.
Journal:	Toxicol Rep. 2017 Oct 28;4:586-597.
Title:	Integration of novel approaches demonstrates simultaneous metabolic inactivation and CAR-mediated hepatocarcinogenesis of a nitrification inhibitor.
Author:	LaRocca, Jessica L\|Rasoulpour, Reza J\|Gollapudi, B Bhaskar\|Eisenbrandt, David L\|Murphy, Lynea A\|LeBaron, Matthew J
PMID:	29159133

44.
Journal:	Toxicol Sci. 2017 Sep 1;159(1):25-41.
Title:	Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver.
Author:	Lodato, Nicholas J\|Melia, Tisha\|Rampersaud, Andy\|Waxman, David J
PMID:	28903501

45.
Journal:	Toxicol Pathol. 2017 Jun;45(4):493-505.
Title:	beta-catenin Mutations Are Not Involved in Early-stage Hepatocarcinogenesis Induced by Protoporphyrinogen Oxidase Inhibitors in Mice.
Author:	Kuwata, Kazunori\|Inoue, Kaoru\|Ichimura, Ryohei\|Takahashi, Miwa\|Kodama, Yukio\|Shibutani, Makoto\|Yoshida, Midori
PMID:	28580885

46.
Journal:	Toxicol Sci. 2017 Aug 1;158(2):412-430.
Title:	Editor's Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes.
Author:	Okuda, Yu\|Kushida, Masahiko\|Sumida, Kayo\|Nagahori, Hirohisa\|Nakamura, Yoshimasa\|Higuchi, Hashihiro\|Kawamura, Satoshi\|Lake, Brian G\|Cohen, Samuel M\|Yamada, Tomoya
PMID:	28520973

47.
Journal:	J Appl Toxicol. 2017 Aug;37(8):967-975.
Title:	Toxaphene-induced mouse liver tumorigenesis is mediated by the constitutive androstane receptor.
Author:	Wang, Zemin\|Li, Xilin\|Wu, Qiangen\|Lamb, James C 4th\|Klaunig, James E
PMID:	28218408

48.
Journal:	J Biol Chem. 2018 Jan 5;293(1):333-344.
Title:	Interaction of the phosphorylated DNA-binding domain in nuclear receptor CAR with its ligand-binding domain regulates CAR activation.
Author:	Shizu, Ryota\|Min, Jungki\|Sobhany, Mack\|Pedersen, Lars C\|Mutoh, Shingo\|Negishi, Masahiko
PMID:	29133527

49.
Journal:	Toxicol Sci. 2018 Jul 1;164(1):115-128.
Title:	Impact of CAR Agonist Ligand TCPOBOP on Mouse Liver Chromatin Accessibility.
Author:	Lodato, Nicholas J\|Rampersaud, Andy\|Waxman, David J
PMID:	29617930

50.
Journal:	Regul Toxicol Pharmacol. 2018 Jul;96:106-120.
Title:	Minimum datasets to establish a CAR-mediated mode of action for rodent liver tumors.
Author:	Peffer, Richard C\|LeBaron, Matthew J\|Battalora, Michael\|Bomann, Werner H\|Werner, Christoph\|Aggarwal, Manoj\|Rowe, Rocky R\|Tinwell, Helen
PMID:	29673940

51.
Journal:	Mol Cancer Res. 2018 Aug;16(8):1309-1318.
Title:	Nuclear Receptor CAR Suppresses GADD45B-p38 MAPK Signaling to Promote Phenobarbital-induced Proliferation in Mouse Liver.
Author:	Hori, Takeshi\|Saito, Kosuke\|Moore, Rick\|Flake, Gordon P\|Negishi, Masahiko
PMID:	29716964

52.
Journal:	J Toxicol Sci. 2018;43(7):443-450.
Title:	Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR.
Author:	Yoshimaru, Shohei\|Shizu, Ryota\|Tsuruta, Satoshi\|Amaike, Yuto\|Kano, Makoto\|Hosaka, Takuomi\|Sasaki, Takamitsu\|Yoshinari, Kouichi
PMID:	29973476

53.
Journal:	Toxicol Res (Camb). 2018 Mar 12;7(4):697-717.
Title:	Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators.
Author:	Lake, Brian G
PMID:	30090615

54.
Journal:	Nucleic Acids Res. 2018 Sep 19;46(16):8385-8403.
Title:	In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets.
Author:	Niu, Ben\|Coslo, Denise M\|Bataille, Alain R\|Albert, Istvan\|Pugh, B Franklin\|Omiecinski, Curtis J
PMID:	30102401

55.
Journal:	Drug Metab Dispos. 2018 Aug 16. pii: dmd.118.083014.
Title:	Mouse hepatomas with Ha-ras and B-raf mutations differ in mitogen-activated protein kinase signaling and response to constitutive androstane receptor activation.
Author:	Braeuning, Albert\|Kollotzek, Ferdinand\|Zeller, Eva\|Knorpp, Thomas\|Templin, Markus F\|Schwarz, Michael
PMID:	30115646

56.
Journal:	Toxicology. 2018 Aug 16. pii: S0300-483X(18)30243-9.
Title:	Modulation of xenobiotic nuclear receptors in high-fat diet induced non-alcoholic fatty liver disease.
Author:	Li, Xilin\|Wang, Zemin\|Klaunig, James E
PMID:	30120929

57.
Journal:	Am J Pathol. 2018 Sep 8. pii: S0002-9440(17)31145-8.
Title:	High Frequency of beta-Catenin Mutations in Mouse Hepatocellular Carcinomas Induced by a Nongenotoxic Constitutive Androstane Receptor Agonist.
Author:	Mattu, Sandra\|Saliba, Christian\|Sulas, Pia\|Zavattari, Patrizia\|Perra, Andrea\|Kowalik, Marta A\|Monga, Satdarshan P\|Columbano, Amedeo
PMID:	30201494