Primary Site >> Liver Cancer
Gene >> NR1I3
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Ref: Nonadditive hepatic tumor promoting effects by a mixture of two structurally different polychlorinated biphenyls in female rat livers. PMID: 11861972 |
Ref: Transcriptional profiling in hepatoblastomas using high-density oligonucleotide DNA array. PMID: 12935928 |
Ref: The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice. PMID: 15492232 |
Ref: Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis. PMID: 17172636 Ref: Differential regulation of constitutive androstane receptor expression by hepatocyte nuclear factor4alpha isoforms. PMID: 17464991 Ref: Regulation of the human cathepsin E gene by the constitutive androstane receptor. PMID: 17888866 |
Ref: Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors. PMID: 19233941 Ref: The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors. PMID: 19482888 Ref: Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3). PMID: 19858220 |
Ref: Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B. PMID: 20404936 Ref: The increased CAR-dependent metabolism of thyroid hormones in mice with high cancer susceptibility. PMID: 20816995 |
Ref: Constitutive active/androstane receptor promotes hepatocarcinogenesis in a mouse model of non-alcoholic steatohepatitis. PMID: 21173431 Ref: Helicobacter hepaticus--induced liver tumor promotion is associated with increased serum bile acid and a persistent microbial-induced immune response. PMID: 21335546 Ref: Using nuclear receptor activity to stratify hepatocarcinogens. PMID: 21339822 Ref: Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats. PMID: 21445586 Ref: Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver. PMID: 21826054 |
Ref: The nuclear receptor constitutive active/androstane receptor arrests DNA-damaged human hepatocellular carcinoma Huh7 cells at the G2/M phase. PMID: 21557330 Ref: Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action. PMID: 22467020 Ref: Expression of genes involved in xenobiotic metabolism and transport in end-stage liver disease: up-regulation of ABCC4 and CYP1B1. PMID: 23087145 |
Ref: Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. PMID: 24180433 Ref: Dose-response modeling of early molecular and cellular key events in the CAR-mediated hepatocarcinogenesis pathway. PMID: 24449422 Ref: Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR. PMID: 24863967 Ref: Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver. PMID: 25145657 Ref: Liver tumor formation in female rat induced by fluopyram is mediated by CAR/PXR nuclear receptor activation. PMID: 25305127 |
Ref: Mode of action analysis for pesticide-induced rodent liver tumours involving activation of the constitutive androstane receptor: relevance to human cancer risk. PMID: 25045103 Ref: Involvement of constitutive androstane receptor in liver hypertrophy and liver tumor development induced by triazole fungicides. PMID: 25656644 Ref: Activating CAR and beta-catenin induces uncontrolled liver growth and tumorigenesis. PMID: 25661872 Ref: Regulation of gene expression by CAR: an update. PMID: 25975989 Ref: Xenosensor CAR mediates down-regulation of miR-122 and up-regulation of miR-122 targets in the liver. PMID: 26171734 Ref: Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors. PMID: 26187448 |
Ref: Constitutive active/androstane receptor, peroxisome proliferator-activated receptor alpha, and cytotoxicity are involved in oxadiazon-induced liver tumor development in mice. PMID: 26710982 Ref: Identification of important long non-coding RNAs and highly recurrent aberrant alternative splicing events in hepatocellular carcinoma through integrative analysis of multiple RNA-Seq datasets. PMID: 26711644 Ref: Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development. PMID: 26928356 Ref: Nuclear receptors and nonalcoholic fatty liver disease. PMID: 26962021 Ref: Toxicity and Carcinogenicity of Dichlorodiphenyltrichloroethane (DDT). PMID: 26977256 Ref: Bioinformatic analysis of microRNA networks following the activation of the constitutive androstane receptor (CAR) in mouse liver. PMID: 27080131 Ref: Methylation of the Constitutive Androstane Receptor Is Involved in the Suppression of CYP2C19 in Hepatitis B Virus-Associated Hepatocellular Carcinoma. PMID: 27440862 Ref: Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation. PMID: 27530964 Ref: Methyl isobutyl ketone-induced hepatocellular carcinogenesis in B6C3F1 mice: A constitutive androstane receptor (CAR)-mediated mode of action. PMID: 27664318 Ref: A crucial role of constitutive androstane receptor (CAR) in liver tumor development by imazalil in mice. PMID: 27853109 Ref: Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis. PMID: 27889186 |
Ref: Toxaphene-induced mouse liver tumorigenesis is mediated by the constitutive androstane receptor. PMID: 28218408 Ref: Investigation of the mechanism of triclosan induced mouse liver tumors. PMID: 28267557 Ref: Editor's Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes. PMID: 28520973 Ref: beta-catenin Mutations Are Not Involved in Early-stage Hepatocarcinogenesis Induced by Protoporphyrinogen Oxidase Inhibitors in Mice. PMID: 28580885 Ref: Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver. PMID: 28903501 Ref: Integration of novel approaches demonstrates simultaneous metabolic inactivation and CAR-mediated hepatocarcinogenesis of a nitrification inhibitor. PMID: 29159133 |
Ref: Interaction of the phosphorylated DNA-binding domain in nuclear receptor CAR with its ligand-binding domain regulates CAR activation. PMID: 29133527 Ref: Impact of CAR Agonist Ligand TCPOBOP on Mouse Liver Chromatin Accessibility. PMID: 29617930 Ref: Minimum datasets to establish a CAR-mediated mode of action for rodent liver tumors. PMID: 29673940 Ref: Nuclear Receptor CAR Suppresses GADD45B-p38 MAPK Signaling to Promote Phenobarbital-induced Proliferation in Mouse Liver. PMID: 29716964 Ref: Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR. PMID: 29973476 Ref: Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators. PMID: 30090615 Ref: In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets. PMID: 30102401 Ref: Mouse hepatomas with Ha-ras and B-raf mutations differ in mitogen-activated protein kinase signaling and response to constitutive androstane receptor activation. PMID: 30115646 Ref: Modulation of xenobiotic nuclear receptors in high-fat diet induced non-alcoholic fatty liver disease. PMID: 30120929 Ref: High Frequency of beta-Catenin Mutations in Mouse Hepatocellular Carcinomas Induced by a Nongenotoxic Constitutive Androstane Receptor Agonist. PMID: 30201494 |