Primary Site >> Liver Cancer
Gene >> NR1I2
| 1. | |||||||||||
| Journal: | Am J Pathol. 1996 Oct;149(4):1167-75. | ||||||||||
| Title: | Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers. Clinical and biological implications. | ||||||||||
| Author: | Wu, P C|Fang, J W|Lau, V K|Lai, C L|Lo, C K|Lau, J Y | ||||||||||
| PMID: | 8863666 | ||||||||||
| 2. | |||||||||||
| Journal: | Drug Metab Dispos. 2000 Jan;28(1):96-101. | ||||||||||
| Title: | Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome P-450 expression: induction of cytochrome P-450 3A4. | ||||||||||
| Author: | Harvey, J L|Paine, A J|Maurel, P|Wright, M C | ||||||||||
| PMID: | 10611146 | ||||||||||
| 3. | |||||||||||
| Journal: | Hepatology. 2003 Mar;37(3):665-73. | ||||||||||
| Title: | CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver. | ||||||||||
| Author: | Iwahori, Tohru|Matsuura, Tomokazu|Maehashi, Haruka|Sugo, Ken|Saito, Masaya|Hosokawa, Masakiyo|Chiba, Kan|Masaki, Takahiro|Aizaki, Hideki|Ohkawa, Kiyoshi|Suzuki, Tetsuro | ||||||||||
| PMID: | 12601364 | ||||||||||
| 4. | |||||||||||
| Journal: | Clin Cancer Res. 2005 Sep 1;11(17):6359-69. | ||||||||||
| Title: | Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents. | ||||||||||
| Author: | Mani, Sridhar|Huang, Haiyan|Sundarababu, Sumathy|Liu, Wenjing|Kalpana, Ganjam|Smith, Amos B|Horwitz, Susan B | ||||||||||
| PMID: | 16144941 | ||||||||||
| 5. | |||||||||||
| Journal: | Chem Biol Interact. 2007 May 20;168(1):66-73. | ||||||||||
| Title: | The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. | ||||||||||
| Author: | Guillouzo, Andre|Corlu, Anne|Aninat, Caroline|Glaise, Denise|Morel, Fabrice|Guguen-Guillouzo, Christiane | ||||||||||
| PMID: | 17241619 | ||||||||||
| 6. | |||||||||||
| Journal: | BMC Genomics. 2008 Oct 16;9:487. | ||||||||||
| Title: | Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT. | ||||||||||
| Author: | Kiyosawa, Naoki|Kwekel, Joshua C|Burgoon, Lyle D|Dere, Edward|Williams, Kurt J|Tashiro, Colleen|Chittim, Brock|Zacharewski, Timothy R | ||||||||||
| PMID: | 18925944 | ||||||||||
| 7. | |||||||||||
| Journal: | Clin Chim Acta. 2009 May;403(1-2):142-4. | ||||||||||
| Title: | The effects of splicing variant of PXR PAR-2 on CYP3A4 and MDR1 mRNA expressions. | ||||||||||
| Author: | Liu, Yan|Ji, Wei|Yin, You|Fan, Lan|Zhang, Jian|Yun, Huang|Wang, Nianci|Li, Qing|Wei, Zhang|Ouyang, Dongshen|Zhou, Hong-Hao | ||||||||||
| PMID: | 19232333 | ||||||||||
| 8. | |||||||||||
| Journal: | J Mol Histol. 2010 Apr;41(2-3):89-99. | ||||||||||
| Title: | Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer. | ||||||||||
| Author: | Elste, Andrea Pia|Petersen, Iver | ||||||||||
| PMID: | 20563836 | ||||||||||
| 9. | |||||||||||
| Journal: | PLoS One. 2011 Feb 14;6(2):e14584. | ||||||||||
| Title: | Using nuclear receptor activity to stratify hepatocarcinogens. | ||||||||||
| Author: | Shah, Imran|Houck, Keith|Judson, Richard S|Kavlock, Robert J|Martin, Matthew T|Reif, David M|Wambaugh, John|Dix, David J | ||||||||||
| PMID: | 21339822 | ||||||||||
| 10. | |||||||||||
| Journal: | Eur J Pharmacol. 2011 Nov 1;669(1-3):45-50. | ||||||||||
| Title: | Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells. | ||||||||||
| Author: | Novotna, Aneta|Doricakova, Aneta|Vrzal, Radim|Pavek, Petr|Dvorak, Zdenek | ||||||||||
| PMID: | 21871880 | ||||||||||
| 11. | |||||||||||
| Journal: | Toxicology. 2012 Mar 11;293(1-3):1-15. | ||||||||||
| Title: | Chronic dietary toxicity and carcinogenicity study with potassium perfluorooctanesulfonate in Sprague Dawley rats. | ||||||||||
| Author: | Butenhoff, John L|Chang, Shu-Ching|Olsen, Geary W|Thomford, Peter J | ||||||||||
| PMID: | 22266392 | ||||||||||
| 12. | |||||||||||
| Journal: | Pharmacol Rep. 2012;64(4):927-39. | ||||||||||
| Title: | Expression of genes involved in xenobiotic metabolism and transport in end-stage liver disease: up-regulation of ABCC4 and CYP1B1. | ||||||||||
| Author: | Kurzawski, Mateusz|Dziedziejko, Violetta|Post, Mariola|Wojcicki, Maciej|Urasinska, Elzbieta|Mietkiewski, Janusz|Drozdzik, Marek | ||||||||||
| PMID: | 23087145 | ||||||||||
| 13. | |||||||||||
| Journal: | Chemosphere. 2012 Oct;89(5):526-9. | ||||||||||
| Title: | Effect of aflatoxin B1 on UDP-glucuronosyltransferase mRNA expression in HepG2 cells. | ||||||||||
| Author: | Hanioka, Nobumitsu|Nonaka, Yuko|Saito, Keita|Negishi, Tomoe|Okamoto, Keinosuke|Kataoka, Hiroyuki|Narimatsu, Shizuo | ||||||||||
| PMID: | 22749127 | ||||||||||
| 14. | |||||||||||
| Journal: | Gene. 2012 May 10;499(1):186-90. | ||||||||||
| Title: | Investigation on the transcription factors of porcine 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase genes. | ||||||||||
| Author: | Dong, Xinxing|Bai, Ying|Xin, Yi|Xu, Qinqin|Chen, Gang|Fang, Meiying | ||||||||||
| PMID: | 22405929 | ||||||||||
| 15. | |||||||||||
| Journal: | Biol Pharm Bull. 2014;37(11):1782-7. | ||||||||||
| Title: | Human hepatocarcinoma functional liver cell-4 cell line exhibits high expression of drug-metabolizing enzymes in three-dimensional culture. | ||||||||||
| Author: | Kato, Ryuji|Shigemoto, Kota|Akiyama, Hiromasa|Ieda, Asaka|Ijiri, Yoshio|Hayashi, Tetsuya | ||||||||||
| PMID: | 25366484 | ||||||||||
| 16. | |||||||||||
| Journal: | Regul Toxicol Pharmacol. 2014 Dec;70(3):648-58. | ||||||||||
| Title: | Liver tumor formation in female rat induced by fluopyram is mediated by CAR/PXR nuclear receptor activation. | ||||||||||
| Author: | Tinwell, H|Rouquie, D|Schorsch, F|Geter, D|Wason, S|Bars, R | ||||||||||
| PMID: | 25305127 | ||||||||||
| 17. | |||||||||||
| Journal: | J Transl Med. 2014 Aug 21;12:230. | ||||||||||
| Title: | Viral expression and molecular profiling in liver tissue versus microdissected hepatocytes in hepatitis B virus-associated hepatocellular carcinoma. | ||||||||||
| Author: | Melis, Marta|Diaz, Giacomo|Kleiner, David E|Zamboni, Fausto|Kabat, Juraj|Lai, Jinping|Mogavero, Giulia|Tice, Ashley|Engle, Ronald E|Becker, Steven|Brown, Charles R|Hanson, Jeffrey C|Rodriguez-Canales, Jaime|Emmert-Buck, Michael|Govindarajan, Sugantha|Kew, | ||||||||||
| PMID: | 25141867 | ||||||||||
| 18. | |||||||||||
| Journal: | World J Gastroenterol. 2014 Jul 14;20(26):8681-90. | ||||||||||
| Title: | Expression of P450 and nuclear receptors in normal and end-stage Chinese livers. | ||||||||||
| Author: | Chen, Hong|Shen, Zhong-Yang|Xu, Wang|Fan, Tie-Yan|Li, Jun|Lu, Yuan-Fu|Cheng, Ming-Liang|Liu, Jie | ||||||||||
| PMID: | 25024626 | ||||||||||
| 19. | |||||||||||
| Journal: | Toxicol Sci. 2014 Aug 1;140(2):259-70. | ||||||||||
| Title: | Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR. | ||||||||||
| Author: | Braeuning, Albert|Gavrilov, Alina|Brown, Susan|Wolf, C Roland|Henderson, Colin J|Schwarz, Michael | ||||||||||
| PMID: | 24863967 | ||||||||||
| 20. | |||||||||||
| Journal: | J Hepatol. 2014 Sep;61(3):609-16. | ||||||||||
| Title: | Characterization of a novel PXR isoform with potential dominant-negative properties. | ||||||||||
| Author: | Breuker, Cyril|Planque, Chris|Rajabi, Fatemeh|Nault, Jean-Charles|Couchy, Gabrielle|Zucman-Rossi, Jessica|Evrard, Alexandre|Kantar, Jovana|Chevet, Eric|Bioulac-Sage, Paulette|Ramos, Jeanne|Assenat, Eric|Joubert, Dominique|Pannequin, Julie|Hollande, Freder | ||||||||||
| PMID: | 24798619 | ||||||||||
| 21. | |||||||||||
| Journal: | Crit Rev Toxicol. 2014 Jan;44(1):64-82. | ||||||||||
| Title: | Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. | ||||||||||
| Author: | Elcombe, Clifford R|Peffer, Richard C|Wolf, Douglas C|Bailey, Jason|Bars, Remi|Bell, David|Cattley, Russell C|Ferguson, Stephen S|Geter, David|Goetz, Amber|Goodman, Jay I|Hester, Susan|Jacobs, Abigail|Omiecinski, Curtis J|Schoeny, Rita|Xie, Wen|Lake, Bria | ||||||||||
| PMID: | 24180433 | ||||||||||
| 22. | |||||||||||
| Journal: | Drug Metab Dispos. 2014 Jan;42(1):44-61. | ||||||||||
| Title: | MicroRNA-561 promotes acetaminophen-induced hepatotoxicity in HepG2 cells and primary human hepatocytes through downregulation of the nuclear receptor corepressor dosage-sensitive sex-reversal adrenal hypoplasia congenital critical region on the X chromos | ||||||||||
| Author: | Li, Minghua|Yang, Yinxue|He, Zhi-Xu|Zhou, Zhi-Wei|Yang, Tianxin|Guo, Peixuan|Zhang, Xueji|Zhou, Shu-Feng | ||||||||||
| PMID: | 24104199 | ||||||||||
| 23. | |||||||||||
| Journal: | Gene Expr. 2014;16(2):63-75. | ||||||||||
| Title: | Med1 subunit of the mediator complex in nuclear receptor-regulated energy metabolism, liver regeneration, and hepatocarcinogenesis. | ||||||||||
| Author: | Jia, Yuzhi|Viswakarma, Navin|Reddy, Janardan K | ||||||||||
| PMID: | 24801167 | ||||||||||
| 24. | |||||||||||
| Journal: | Drug Metab Pharmacokinet. 2015 Dec;30(6):434-40. | ||||||||||
| Title: | CYP1A1 and CYP1A2 expression levels are differentially regulated in three-dimensional spheroids of liver cancer cells compared to two-dimensional monolayer cultures. | ||||||||||
| Author: | Terashima, Jun|Goto, Shinpei|Hattori, Hiroki|Hoshi, Sawaka|Ushirokawa, Midori|Kudo, Kenzo|Habano, Wataru|Ozawa, Shogo | ||||||||||
| PMID: | 26643992 | ||||||||||
| 25. | |||||||||||
| Journal: | Toxicology. 2015 Oct 2;336:99-112. | ||||||||||
| Title: | Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR). | ||||||||||
| Author: | Oshida, Keiyu|Vasani, Naresh|Thomas, Russell S|Applegate, Dawn|Gonzalez, Frank J|Aleksunes, Lauren M|Klaassen, Curtis D|Corton, J Christopher | ||||||||||
| PMID: | 26215100 | ||||||||||
| 26. | |||||||||||
| Journal: | Nucl Recept Signal. 2015 Apr 27;13:e002. | ||||||||||
| Title: | Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium. | ||||||||||
| Author: | Oshida, Keiyu|Vasani, Naresh|Jones, Carlton|Moore, Tanya|Hester, Susan|Nesnow, Stephen|Auerbach, Scott|Geter, David R|Aleksunes, Lauren M|Thomas, Russell S|Applegate, Dawn|Klaassen, Curtis D|Corton, J Christopher | ||||||||||
| PMID: | 25949234 | ||||||||||
| 27. | |||||||||||
| Journal: | Am J Transl Res. 2015 Jan 19;7(1):100-10. eCollection 2015. | ||||||||||
| Title: | Cathepsin S silencing induces apoptosis of human hepatocellular carcinoma cells. | ||||||||||
| Author: | Wang, Xuedi|Xiong, Li|Yu, Guotang|Li, Dongdong|Peng, Tao|Luo, Daqing|Xu, Jing | ||||||||||
| PMID: | 25755832 | ||||||||||
| 28. | |||||||||||
| Journal: | Toxicol Sci. 2015 Apr;144(2):382-92. | ||||||||||
| Title: | Suppression of the pregnane X receptor during endoplasmic reticulum stress is achieved by down-regulating hepatocyte nuclear factor-4alpha and up-regulating liver-enriched inhibitory protein. | ||||||||||
| Author: | Vachirayonsti, Thaveechai|Ho, Karen W|Yang, Dongfang|Yan, Bingfang | ||||||||||
| PMID: | 25616597 | ||||||||||
| 29. | |||||||||||
| Journal: | Drug Metab Dispos. 2015 Mar;43(3):385-91. | ||||||||||
| Title: | Mg2+/Mn2+-dependent phosphatase 1A is involved in regulating pregnane X receptor-mediated cytochrome p450 3A4 gene expression. | ||||||||||
| Author: | Pondugula, Satyanarayana R|Flannery, Patrick C|Apte, Udayan|Babu, Jeganathan Ramesh|Geetha, Thangiah|Rege, Shraddha D|Chen, Taosheng|Abbott, Kodye L | ||||||||||
| PMID: | 25561723 | ||||||||||
| 30. | |||||||||||
| Journal: | Environ Toxicol Pharmacol. 2016 Jan;41:201-10. | ||||||||||
| Title: | Hepatic miRNA profiles and thyroid hormone homeostasis in rats exposed to dietary potassium perfluorooctanesulfonate (PFOS). | ||||||||||
| Author: | Dong, Hongyan|Curran, Ivan|Williams, Andrew|Bondy, Genevieve|Yauk, Carole L|Wade, Michael G | ||||||||||
| PMID: | 26724606 | ||||||||||
| 31. | |||||||||||
| Journal: | Regul Toxicol Pharmacol. 2016 Nov;81:421-429. | ||||||||||
| Title: | Methyl isobutyl ketone-induced hepatocellular carcinogenesis in B6C3F1 mice: A constitutive androstane receptor (CAR)-mediated mode of action. | ||||||||||
| Author: | Hughes, B J|Thomas, J|Lynch, A M|Borghoff, S J|Green, S|Mensing, T|Sarang, S S|LeBaron, M J | ||||||||||
| PMID: | 27664318 | ||||||||||
| 32. | |||||||||||
| Journal: | PLoS One. 2016 Oct 19;11(10):e0164087. | ||||||||||
| Title: | Role of PXR in Hepatic Cancer: Its Influences on Liver Detoxification Capacity and Cancer Progression. | ||||||||||
| Author: | Kotiya, Deepak|Jaiswal, Bharti|Ghose, Sampa|Kaul, Rachna|Datta, Kasturi|Tyagi, Rakesh K | ||||||||||
| PMID: | 27760163 | ||||||||||
| 33. | |||||||||||
| Journal: | Regul Toxicol Pharmacol. 2017 Jun;86:137-147. | ||||||||||
| Title: | Investigation of the mechanism of triclosan induced mouse liver tumors. | ||||||||||
| Author: | Wang, Zemin|Li, Xilin|Klaunig, James E | ||||||||||
| PMID: | 28267557 | ||||||||||
| 34. | |||||||||||
| Journal: | Mol Ther Nucleic Acids. 2017 Dec 15;9:274-283. | ||||||||||
| Title: | Factor VII-Induced MicroRNA-135a Inhibits Autophagy and Is Associated with Poor Prognosis in Hepatocellular Carcinoma. | ||||||||||
| Author: | Huang, Kuang-Tzu|Kuo, I-Ying|Tsai, Ming-Chao|Wu, Chun-Hsien|Hsu, Li-Wen|Chen, Li-Yu|Kung, Chao-Pin|Cheng, Yu-Fan|Goto, Shigeru|Chou, Yu-Wei|Chen, Chao-Long|Lin, Chih-Che|Chen, Kuang-Den | ||||||||||
| PMID: | 29246306 | ||||||||||
| 35. | |||||||||||
| Journal: | Pharmacol Res. 2018 Sep;135:188-200. | ||||||||||
| Title: | ETS-1 induces Sorafenib-resistance in hepatocellular carcinoma cells via regulating transcription factor activity of PXR. | ||||||||||
| Author: | Shao, Zhiyi|Li, Yibo|Dai, Wenjie|Jia, Hui|Zhang, Yingshi|Jiang, Qiyu|Chai, Yantao|Li, Xiaojuan|Sun, Huiwei|Yang, Ruichuang|Cao, Yu|Feng, Fan|Guo, Yingjie | ||||||||||
| PMID: | 30114438 | ||||||||||
| 36. | |||||||||||
| Journal: | Toxicology. 2018 Aug 16. pii: S0300-483X(18)30243-9. | ||||||||||
| Title: | Modulation of xenobiotic nuclear receptors in high-fat diet induced non-alcoholic fatty liver disease. | ||||||||||
| Author: | Li, Xilin|Wang, Zemin|Klaunig, James E | ||||||||||
| PMID: | 30120929 | ||||||||||
| 37. | |||||||||||
| Journal: | Onco Targets Ther. 2018 Sep 17;11:5885-5894. | ||||||||||
| Title: | MicroRNA-140-3p enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting pregnenolone X receptor. | ||||||||||
| Author: | Li, Jiaqi|Zhao, Jing|Wang, Huan|Li, Xiaohan|Liu, Aixia|Qin, Qin|Li, Boan | ||||||||||
| PMID: | 30271172 | ||||||||||