Primary Site >> Liver Cancer
Gene >> NR1I2
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Ref: Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers. Clinical and biological implications. PMID: 8863666 |
Ref: Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome P-450 expression: induction of cytochrome P-450 3A4. PMID: 10611146 |
Ref: CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver. PMID: 12601364 |
Ref: Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents. PMID: 16144941 |
Ref: The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. PMID: 17241619 |
Ref: Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT. PMID: 18925944 |
Ref: The effects of splicing variant of PXR PAR-2 on CYP3A4 and MDR1 mRNA expressions. PMID: 19232333 |
Ref: Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer. PMID: 20563836 |
Ref: Using nuclear receptor activity to stratify hepatocarcinogens. PMID: 21339822 Ref: Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells. PMID: 21871880 |
Ref: Chronic dietary toxicity and carcinogenicity study with potassium perfluorooctanesulfonate in Sprague Dawley rats. PMID: 22266392 Ref: Investigation on the transcription factors of porcine 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase genes. PMID: 22405929 Ref: Effect of aflatoxin B1 on UDP-glucuronosyltransferase mRNA expression in HepG2 cells. PMID: 22749127 Ref: Expression of genes involved in xenobiotic metabolism and transport in end-stage liver disease: up-regulation of ABCC4 and CYP1B1. PMID: 23087145 |
Ref: MicroRNA-561 promotes acetaminophen-induced hepatotoxicity in HepG2 cells and primary human hepatocytes through downregulation of the nuclear receptor corepressor dosage-sensitive sex-reversal adrenal hypoplasia congenital critical region on the X chromos PMID: 24104199 Ref: Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. PMID: 24180433 Ref: Characterization of a novel PXR isoform with potential dominant-negative properties. PMID: 24798619 Ref: Med1 subunit of the mediator complex in nuclear receptor-regulated energy metabolism, liver regeneration, and hepatocarcinogenesis. PMID: 24801167 Ref: Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR. PMID: 24863967 Ref: Expression of P450 and nuclear receptors in normal and end-stage Chinese livers. PMID: 25024626 Ref: Viral expression and molecular profiling in liver tissue versus microdissected hepatocytes in hepatitis B virus-associated hepatocellular carcinoma. PMID: 25141867 Ref: Liver tumor formation in female rat induced by fluopyram is mediated by CAR/PXR nuclear receptor activation. PMID: 25305127 Ref: Human hepatocarcinoma functional liver cell-4 cell line exhibits high expression of drug-metabolizing enzymes in three-dimensional culture. PMID: 25366484 |
Ref: Mg2+/Mn2+-dependent phosphatase 1A is involved in regulating pregnane X receptor-mediated cytochrome p450 3A4 gene expression. PMID: 25561723 Ref: Suppression of the pregnane X receptor during endoplasmic reticulum stress is achieved by down-regulating hepatocyte nuclear factor-4alpha and up-regulating liver-enriched inhibitory protein. PMID: 25616597 Ref: Cathepsin S silencing induces apoptosis of human hepatocellular carcinoma cells. PMID: 25755832 Ref: Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium. PMID: 25949234 Ref: Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR). PMID: 26215100 Ref: CYP1A1 and CYP1A2 expression levels are differentially regulated in three-dimensional spheroids of liver cancer cells compared to two-dimensional monolayer cultures. PMID: 26643992 |
Ref: Hepatic miRNA profiles and thyroid hormone homeostasis in rats exposed to dietary potassium perfluorooctanesulfonate (PFOS). PMID: 26724606 Ref: Methyl isobutyl ketone-induced hepatocellular carcinogenesis in B6C3F1 mice: A constitutive androstane receptor (CAR)-mediated mode of action. PMID: 27664318 Ref: Role of PXR in Hepatic Cancer: Its Influences on Liver Detoxification Capacity and Cancer Progression. PMID: 27760163 |
Ref: Investigation of the mechanism of triclosan induced mouse liver tumors. PMID: 28267557 Ref: Factor VII-Induced MicroRNA-135a Inhibits Autophagy and Is Associated with Poor Prognosis in Hepatocellular Carcinoma. PMID: 29246306 |
Ref: ETS-1 induces Sorafenib-resistance in hepatocellular carcinoma cells via regulating transcription factor activity of PXR. PMID: 30114438 Ref: Modulation of xenobiotic nuclear receptors in high-fat diet induced non-alcoholic fatty liver disease. PMID: 30120929 Ref: MicroRNA-140-3p enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting pregnenolone X receptor. PMID: 30271172 |